TY  - CONF
AU  - Ćupić, Vitomir
AU  - Ivanović, Saša
AU  - Borozan, Sunčica
AU  - Prevendar Crnić, Andreja
AU  - Mujezinović, Indira
AU  - Žugić, Gordana
AU  - Velev, Romel
PY  - 2022
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2420
AB  - Proizvodnja ribe dramatično je porasla širom sveta i zauzima sve
veći udeo (a time i značaj) u ukupnoj proizvodnji hrane animalnog porekla. Da bi se osigurala ovako velika proizvodnja, treba umanjiti štetni
uticaj brojnih faktora spoljašnje sredine, a pre svega stresova, drastičnih promena u temperaturi, mikroorganizama, kao i raznih hemijskih
supstancija, koje mogu itekako ugroziti život ribe. Od svih nabrojanih
faktora poseban problem predstavljaju infektivne bolesti, uzrokovane
raznim bakterijama. Većina bakterija, koje uzrokuju bolesti kod riba
su normalni stanovnici vodenih sistema, i obično ne uzrokuju bolesti,
odnosno (kao takve) ne predstavljaju problem. Međutim, kada su ribe
izložene stresu, sa jednim od već navedenih faktora, isti mogu ugroziti
imuni sistem jedinke, a usled toga olakšati rast bakterija, te tako povećati rizik za nastajanje bolesti.
Za lečenje bakterijskih infekcija koriste se antimikrobni lekovi, koji imaju veliki značaj u upravljanju zdravljem riba. Efikasnost antimikrobnih lekova u uklanjanju raznih infektivnih bolesti kod riba, zavisi
od više faktora, odnosno ispunjenja više uslova, a to su: a) da li je zaista prisutna bakterijska infekcija? b) da li su identifikovane bakterije
osetljive na izabrani antibiotik? c) da li je lek pravilno doziran i primenjen u odgovarajućim intervalima? i d) da li su dodatni stresovi uklonjeni ili smanjeni?
AB  - Fish production has increased dramatically around the world and occupies an
increasing share (and thus importance) in the total production of food of animal origin. In
order to ensure such a large production, it is necessary to reduce the harmful impact of
numerous environmental factors, and above all stress, drastic changes in temperature,
microorganisms, as well as various chemical substances that can endanger the life of fish. Of all the listed factors, infectious diseases caused by various bacteria are a special
problem. Most bacteria that cause disease in fish are normal inhabitants of aquatic systems,
and usually do not cause disease, or (as such) are not a problem. However, when fish
are exposed to stress, with one of the already mentioned factors, they can endanger the
individual’s immune system, and consequently facilitate the growth of bacteria, and thus
increase the risk of developing the disease.
Antimicrobial drugs, which are of great importance in managing fish health are
used to treat bacterial infections. The effectiveness of antimicrobial drugs in eliminating
various infectious diseases in fish depends on several factors, ie the fulfillment of several
conditions: a) is a bacterial infection really present? b) are the identified bacteria sensitive
to the chosen antibiotic? c) is the drug properly dosed and administered at appropriate
intervals? and d) have additional stresses been removed or reduced?
PB  - Fakultet veterinarske medicine, Centar za izdavačku delatnost i promet učila
C3  - Zbornik radova - XLIII seminar inovacija znanja veterinara
T1  - Specifičnost primene antimikrobnih lekova kod riba
T1  - Specificity of application of antimicrobial drugs in fish
SP  - 93
EP  - 106
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_2420
ER  - 

@conference{
author = "Ćupić, Vitomir and Ivanović, Saša and Borozan, Sunčica and Prevendar Crnić, Andreja and Mujezinović, Indira and Žugić, Gordana and Velev, Romel",
year = "2022",
abstract = "Proizvodnja ribe dramatično je porasla širom sveta i zauzima sve
veći udeo (a time i značaj) u ukupnoj proizvodnji hrane animalnog porekla. Da bi se osigurala ovako velika proizvodnja, treba umanjiti štetni
uticaj brojnih faktora spoljašnje sredine, a pre svega stresova, drastičnih promena u temperaturi, mikroorganizama, kao i raznih hemijskih
supstancija, koje mogu itekako ugroziti život ribe. Od svih nabrojanih
faktora poseban problem predstavljaju infektivne bolesti, uzrokovane
raznim bakterijama. Većina bakterija, koje uzrokuju bolesti kod riba
su normalni stanovnici vodenih sistema, i obično ne uzrokuju bolesti,
odnosno (kao takve) ne predstavljaju problem. Međutim, kada su ribe
izložene stresu, sa jednim od već navedenih faktora, isti mogu ugroziti
imuni sistem jedinke, a usled toga olakšati rast bakterija, te tako povećati rizik za nastajanje bolesti.
Za lečenje bakterijskih infekcija koriste se antimikrobni lekovi, koji imaju veliki značaj u upravljanju zdravljem riba. Efikasnost antimikrobnih lekova u uklanjanju raznih infektivnih bolesti kod riba, zavisi
od više faktora, odnosno ispunjenja više uslova, a to su: a) da li je zaista prisutna bakterijska infekcija? b) da li su identifikovane bakterije
osetljive na izabrani antibiotik? c) da li je lek pravilno doziran i primenjen u odgovarajućim intervalima? i d) da li su dodatni stresovi uklonjeni ili smanjeni?, Fish production has increased dramatically around the world and occupies an
increasing share (and thus importance) in the total production of food of animal origin. In
order to ensure such a large production, it is necessary to reduce the harmful impact of
numerous environmental factors, and above all stress, drastic changes in temperature,
microorganisms, as well as various chemical substances that can endanger the life of fish. Of all the listed factors, infectious diseases caused by various bacteria are a special
problem. Most bacteria that cause disease in fish are normal inhabitants of aquatic systems,
and usually do not cause disease, or (as such) are not a problem. However, when fish
are exposed to stress, with one of the already mentioned factors, they can endanger the
individual’s immune system, and consequently facilitate the growth of bacteria, and thus
increase the risk of developing the disease.
Antimicrobial drugs, which are of great importance in managing fish health are
used to treat bacterial infections. The effectiveness of antimicrobial drugs in eliminating
various infectious diseases in fish depends on several factors, ie the fulfillment of several
conditions: a) is a bacterial infection really present? b) are the identified bacteria sensitive
to the chosen antibiotic? c) is the drug properly dosed and administered at appropriate
intervals? and d) have additional stresses been removed or reduced?",
publisher = "Fakultet veterinarske medicine, Centar za izdavačku delatnost i promet učila",
journal = "Zbornik radova - XLIII seminar inovacija znanja veterinara",
title = "Specifičnost primene antimikrobnih lekova kod riba, Specificity of application of antimicrobial drugs in fish",
pages = "93-106",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_2420"
}

Ćupić, V., Ivanović, S., Borozan, S., Prevendar Crnić, A., Mujezinović, I., Žugić, G.,& Velev, R.. (2022). Specifičnost primene antimikrobnih lekova kod riba. in Zbornik radova - XLIII seminar inovacija znanja veterinara
Fakultet veterinarske medicine, Centar za izdavačku delatnost i promet učila., 93-106.
https://hdl.handle.net/21.15107/rcub_veterinar_2420

Ćupić V, Ivanović S, Borozan S, Prevendar Crnić A, Mujezinović I, Žugić G, Velev R. Specifičnost primene antimikrobnih lekova kod riba. in Zbornik radova - XLIII seminar inovacija znanja veterinara. 2022;:93-106.
https://hdl.handle.net/21.15107/rcub_veterinar_2420 .

Ćupić, Vitomir, Ivanović, Saša, Borozan, Sunčica, Prevendar Crnić, Andreja, Mujezinović, Indira, Žugić, Gordana, Velev, Romel, "Specifičnost primene antimikrobnih lekova kod riba" in Zbornik radova - XLIII seminar inovacija znanja veterinara (2022):93-106,
https://hdl.handle.net/21.15107/rcub_veterinar_2420 .

TY  - CONF
AU  - Velev, Romel
AU  - Trajkovski, F.
AU  - Krleska-Veleva, Nataša
AU  - Ćupić, Vitomir
AU  - Ćupić Miladinović, Dejana
PY  - 2018
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1674
AB  - Introduction: 3D printing has numerous applications and has gained
much interest in the medical world. The current medical and veterinary medicine uses of 3D printing can be organized into several
broad categories: tissue and organs fabrication; creating of implants,
prosthetics and anatomical models; and pharmaceutical research
concerning drug discovery, delivery, and dosage forms. The purpose
of our work was to gain a better perspective of how 3D printing
technology works by getting a first-hand look at this process and
then strategize ways that this technology can potentially be used in
development of animal health products.
What Is 3D Printing and How Does It Work?: 3D printing is a type of additive manufacturing. It is a process that creates a three-dimensional
object by building successive layers of raw material. Objects are produced from a digital 3D file, such as a computer-aided design (CAD)
drawing or a Magnetic Resonance Image. 3D printing can create
a solid object of virtually any shape and can use an assortment of
starting materials, including plastic, metal, ceramic, tissue and organ
cells.
Exploring the Possibilities of 3D Printing in Development of Animal
Health Products: The purpose of veterinary drug development in the
future should be production of personalized animal health products
that can be achieved through the application of 3D printing. The
application of 3D printing in veterinary medicine, including tablets, holds promise for made-to-order drugs, and removes mass product
manufacturing from the production line, although the technology
in pharmaceutical industry is still in infancy. 3D printing promises
a future of drugs printed on demand, to custom doses, especially in
companion animals.
Conclusions: Prototype projects demonstrated that it is possible to
use 3D printing techniques to generate and manufacture chemical
compounds. In applying this technology to animal health products,
the first generation technology is already a reality. Proof of this is recently approved 3D-printed oral drug Spritam (levetiracetam) by US
FDA in human medicine. The second-generation efforts will involve
getting a digital prescription, buying the “blueprint” and chemical
“materials” needed, and then printing the drug with the software and
a 3D molecular printer. Hence, 3D drug printing will have important
repercussions in the realm of distribution of animal health products.
However, even more profound are the eventual implications for new
drug discovery and personalized therapy for animals. Indeed, thirdgeneration 3D drug printing would entail the creation of new drugs
that maximize efficacy and minimize toxicity. But there are a number
of questions. Approval of a 3D-printed veterinary drugs opens up
a new world of customised medication, but also the possibility of
counterfeit drugs, mislabelling and a regulatory vacuum.
PB  - Wiley, Hoboken
C3  - Journal of Veterinary Pharmacology and Therapeutics
T1  - 3D printing and the future of development of animal health products
VL  - 41
SP  - 68
EP  - 69
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_1674
ER  - 

@conference{
author = "Velev, Romel and Trajkovski, F. and Krleska-Veleva, Nataša and Ćupić, Vitomir and Ćupić Miladinović, Dejana",
year = "2018",
abstract = "Introduction: 3D printing has numerous applications and has gained
much interest in the medical world. The current medical and veterinary medicine uses of 3D printing can be organized into several
broad categories: tissue and organs fabrication; creating of implants,
prosthetics and anatomical models; and pharmaceutical research
concerning drug discovery, delivery, and dosage forms. The purpose
of our work was to gain a better perspective of how 3D printing
technology works by getting a first-hand look at this process and
then strategize ways that this technology can potentially be used in
development of animal health products.
What Is 3D Printing and How Does It Work?: 3D printing is a type of additive manufacturing. It is a process that creates a three-dimensional
object by building successive layers of raw material. Objects are produced from a digital 3D file, such as a computer-aided design (CAD)
drawing or a Magnetic Resonance Image. 3D printing can create
a solid object of virtually any shape and can use an assortment of
starting materials, including plastic, metal, ceramic, tissue and organ
cells.
Exploring the Possibilities of 3D Printing in Development of Animal
Health Products: The purpose of veterinary drug development in the
future should be production of personalized animal health products
that can be achieved through the application of 3D printing. The
application of 3D printing in veterinary medicine, including tablets, holds promise for made-to-order drugs, and removes mass product
manufacturing from the production line, although the technology
in pharmaceutical industry is still in infancy. 3D printing promises
a future of drugs printed on demand, to custom doses, especially in
companion animals.
Conclusions: Prototype projects demonstrated that it is possible to
use 3D printing techniques to generate and manufacture chemical
compounds. In applying this technology to animal health products,
the first generation technology is already a reality. Proof of this is recently approved 3D-printed oral drug Spritam (levetiracetam) by US
FDA in human medicine. The second-generation efforts will involve
getting a digital prescription, buying the “blueprint” and chemical
“materials” needed, and then printing the drug with the software and
a 3D molecular printer. Hence, 3D drug printing will have important
repercussions in the realm of distribution of animal health products.
However, even more profound are the eventual implications for new
drug discovery and personalized therapy for animals. Indeed, thirdgeneration 3D drug printing would entail the creation of new drugs
that maximize efficacy and minimize toxicity. But there are a number
of questions. Approval of a 3D-printed veterinary drugs opens up
a new world of customised medication, but also the possibility of
counterfeit drugs, mislabelling and a regulatory vacuum.",
publisher = "Wiley, Hoboken",
journal = "Journal of Veterinary Pharmacology and Therapeutics",
title = "3D printing and the future of development of animal health products",
volume = "41",
pages = "68-69",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_1674"
}

Velev, R., Trajkovski, F., Krleska-Veleva, N., Ćupić, V.,& Ćupić Miladinović, D.. (2018). 3D printing and the future of development of animal health products. in Journal of Veterinary Pharmacology and Therapeutics
Wiley, Hoboken., 41, 68-69.
https://hdl.handle.net/21.15107/rcub_veterinar_1674

Velev R, Trajkovski F, Krleska-Veleva N, Ćupić V, Ćupić Miladinović D. 3D printing and the future of development of animal health products. in Journal of Veterinary Pharmacology and Therapeutics. 2018;41:68-69.
https://hdl.handle.net/21.15107/rcub_veterinar_1674 .

Velev, Romel, Trajkovski, F., Krleska-Veleva, Nataša, Ćupić, Vitomir, Ćupić Miladinović, Dejana, "3D printing and the future of development of animal health products" in Journal of Veterinary Pharmacology and Therapeutics, 41 (2018):68-69,
https://hdl.handle.net/21.15107/rcub_veterinar_1674 .

TY  - CONF
AU  - Ćupić Miladinović, Dejana
AU  - Borozan, Sunčica
AU  - Peković, S.
AU  - Dačić, S.
AU  - Đukić-Ćosić, Danijela
AU  - Ćupić, Vitomir
AU  - Ivanović, Saša
PY  - 2018
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1568
PB  - Elsevier Ireland Ltd, Clare
C3  - Toxicology Letters
T1  - The effect of thiamine on oxidative stress and apoptosis in the liver of Japanese quails treated with chlorpyrifos
VL  - 295
SP  - S264
EP  - S264
DO  - 10.1016/j.toxlet.2018.06.1062
ER  - 

@conference{
author = "Ćupić Miladinović, Dejana and Borozan, Sunčica and Peković, S. and Dačić, S. and Đukić-Ćosić, Danijela and Ćupić, Vitomir and Ivanović, Saša",
year = "2018",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "The effect of thiamine on oxidative stress and apoptosis in the liver of Japanese quails treated with chlorpyrifos",
volume = "295",
pages = "S264-S264",
doi = "10.1016/j.toxlet.2018.06.1062"
}

Ćupić Miladinović, D., Borozan, S., Peković, S., Dačić, S., Đukić-Ćosić, D., Ćupić, V.,& Ivanović, S.. (2018). The effect of thiamine on oxidative stress and apoptosis in the liver of Japanese quails treated with chlorpyrifos. in Toxicology Letters
Elsevier Ireland Ltd, Clare., 295, S264-S264.
https://doi.org/10.1016/j.toxlet.2018.06.1062

Ćupić Miladinović D, Borozan S, Peković S, Dačić S, Đukić-Ćosić D, Ćupić V, Ivanović S. The effect of thiamine on oxidative stress and apoptosis in the liver of Japanese quails treated with chlorpyrifos. in Toxicology Letters. 2018;295:S264-S264.
doi:10.1016/j.toxlet.2018.06.1062 .

Ćupić Miladinović, Dejana, Borozan, Sunčica, Peković, S., Dačić, S., Đukić-Ćosić, Danijela, Ćupić, Vitomir, Ivanović, Saša, "The effect of thiamine on oxidative stress and apoptosis in the liver of Japanese quails treated with chlorpyrifos" in Toxicology Letters, 295 (2018):S264-S264,
https://doi.org/10.1016/j.toxlet.2018.06.1062 . .

TY  - JOUR
AU  - Mujezinović, Indira
AU  - Smajlović, Ahmed
AU  - Zuko, A.
AU  - Dukić, B.
AU  - Ćupić, Vitomir
PY  - 2018
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1599
AB  - Extract of chestnut is a mixture of tannic and non-tannic components. The most common tannic components are the glycosides castalagin and vescalagin, which have a therapeutic effect. In conducted studies in vitro and in vivo, it was found that the tannin extract of chestnut has anti-diarrhoeal, astringent, antiviral, antimicrobial, antiprotozoal and anthelmintic properties. At the same time, it was found that the tannin extract of chestnut has anti-carcinogenic properties. Tannin interacts with the membrane structures of certain microorganisms, and thus decreases the permeability of the cell membrane. This antimicrobial activity is advantageous in terms of the action of antibiotics, because tannins only cause the inhibition of microflora growth but not its destruction. Ingested tannins at therapeutic concentrations (2-5%) cannot be absorbed and so cannot cause pharmacodynamic effects on the other organic systems. In the intestines, by means of hydrolysis, they are completely biotransformed into polyphenols (gallic, digallic and elastic acids) and glucose. In the urine, only the degradation products of tannin in the form of glucuronide can be identified. In therapeutic concentrations, tannins have an insignificant effect on the skin, while on mucous membranes they act astringently. At higher concentrations, tannins may lead to degradation of superficial, and even deeper layers of mucous membranes and granulation tissue. Given that they do not show teratogenic, mutagenic or carcinogenic effects, everything indicates that tannins should be more often and more extensively used as safe veterinary drugs.
PB  - Croatian Veterinary Institute
T2  - Veterinarska Stanica
T1  - Tannins from Sweet Chestnut (Castanea sativa)
T1  - Tanini pitomog kestena (Castanea sativa)
VL  - 49
IS  - 5
SP  - 371
EP  - 377
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_1599
ER  - 

@article{
author = "Mujezinović, Indira and Smajlović, Ahmed and Zuko, A. and Dukić, B. and Ćupić, Vitomir",
year = "2018",
abstract = "Extract of chestnut is a mixture of tannic and non-tannic components. The most common tannic components are the glycosides castalagin and vescalagin, which have a therapeutic effect. In conducted studies in vitro and in vivo, it was found that the tannin extract of chestnut has anti-diarrhoeal, astringent, antiviral, antimicrobial, antiprotozoal and anthelmintic properties. At the same time, it was found that the tannin extract of chestnut has anti-carcinogenic properties. Tannin interacts with the membrane structures of certain microorganisms, and thus decreases the permeability of the cell membrane. This antimicrobial activity is advantageous in terms of the action of antibiotics, because tannins only cause the inhibition of microflora growth but not its destruction. Ingested tannins at therapeutic concentrations (2-5%) cannot be absorbed and so cannot cause pharmacodynamic effects on the other organic systems. In the intestines, by means of hydrolysis, they are completely biotransformed into polyphenols (gallic, digallic and elastic acids) and glucose. In the urine, only the degradation products of tannin in the form of glucuronide can be identified. In therapeutic concentrations, tannins have an insignificant effect on the skin, while on mucous membranes they act astringently. At higher concentrations, tannins may lead to degradation of superficial, and even deeper layers of mucous membranes and granulation tissue. Given that they do not show teratogenic, mutagenic or carcinogenic effects, everything indicates that tannins should be more often and more extensively used as safe veterinary drugs.",
publisher = "Croatian Veterinary Institute",
journal = "Veterinarska Stanica",
title = "Tannins from Sweet Chestnut (Castanea sativa), Tanini pitomog kestena (Castanea sativa)",
volume = "49",
number = "5",
pages = "371-377",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_1599"
}

Mujezinović, I., Smajlović, A., Zuko, A., Dukić, B.,& Ćupić, V.. (2018). Tannins from Sweet Chestnut (Castanea sativa). in Veterinarska Stanica
Croatian Veterinary Institute., 49(5), 371-377.
https://hdl.handle.net/21.15107/rcub_veterinar_1599

Mujezinović I, Smajlović A, Zuko A, Dukić B, Ćupić V. Tannins from Sweet Chestnut (Castanea sativa). in Veterinarska Stanica. 2018;49(5):371-377.
https://hdl.handle.net/21.15107/rcub_veterinar_1599 .

Mujezinović, Indira, Smajlović, Ahmed, Zuko, A., Dukić, B., Ćupić, Vitomir, "Tannins from Sweet Chestnut (Castanea sativa)" in Veterinarska Stanica, 49, no. 5 (2018):371-377,
https://hdl.handle.net/21.15107/rcub_veterinar_1599 .

TY  - JOUR
AU  - Mujezinović, Indira
AU  - Smajlović, Ahmed
AU  - Ćupić, Vitomir
PY  - 2018
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1611
AB  - Introduction. Tetanus, also known as lockjaw, is a very dangerous, infectious, acute, usually afebrile disease characterised by muscle spasms. The causative agent of the disease is the bacterium Clostridium tetani. This pathogen produces a specifc neurotoxin, termed tetanus toxin, with two components: tetanospasmin and tetanolysin. Light chains of tetanospasmin cleavage synaptobrevin, which in turn prevent release of the inhibitory neurotransmitter GABA into the synaptic cleft. The α-motor neurons are, therefore, under no inhibitory control, as a result of which they undergo sustained excitatory discharge causing the characteristic motor spasms of tetanus. Materials and Methods. In this research, we attempted to normalise disorders caused by tetanus toxin by using haloperidol (at doses of 4, 5, 6, 7 and 8 mg/kg b.w.), alone and in combination with (-)-nuciferine (at a dose of 5 mg/kg b.w.) or aminooxyacetic acid (at a dose of 20 mg/kg b.w.). Experiments were conducted on albino mice. Experimental tetanus was induced by application of tetanus toxin. Results and Conclusions. Application of haloperidol (alone and in combination with (-)-nuciferine and aminooxyacetic acid) was carried out 24 h following the application of tetanus toxin. It was found that haloperidol, given alone in a dose of 4 mg/kg, prolonged the average survival time of mice with experimental tetanus by 24.35 h compared to the control animals. Additionally, the combination of haloperidol with (-)-nuciferine slightly, but non-signifcantly, extended survival time , while the combination of haloperidol with aminooxyacetic acid produced the best effect on extension of survival time (mice survived on average 27.74 h longer than control mice).
AB  - Uvod. Tetanus je veoma opasna, akutna, obično afebrilna bolest koju karakteriše mišićni spazam. Uzročnik obolenja je bakterija Clostridium tetani, koja proizvodi specifčan neurotoksin ili tetanus toksin. Toksin se sastoji od dve komponente: tetanospazmina i tetanolizina. Laki lanac tetanospazmina cepa sinaptobrevin, što za posledicu ima sprečavanje oslobađanje inhibitornog neurotransmitera GABA u sinaptički procep. Funkcija ekscitatornih neurotransmitera ostaje očuvana, te pod njihovim uticajem dolazi do grča skeletne muskulature. Materijali i metode. U ovom istraživanju pokušali smo normalizovati poremećaje uzrokovane tetanus toksinom koristeći haloperidol (u dozama od 4, 5, 6, 7 i 8 mg/ kg t.m.), samostalno i u kombinaciji sa (-)-nuciferinom (u dozi od 5 mg/kg t.m.) i aminooksirćetnom kiselinom (u dozi od 20 mg/kg t.m.). Kompletno istraživanje je sprovedeno na albino miševima. Eksperimentalni tetanus izazvan je aplikacijom tetanus toksina. Rezultati i zaključak. Primena haloperidola (samo i u kombinaciji sa (-)-nuciferinom i aminooksirćetnom kiselinom) vršena je 24 sata nakon aplikacije tetanus toksina. Haloperidol, aplikovan u dozi od 4 mg/kg t.m., produžio je vreme preživljavanja miševa s eksperimentalnim tetanusom za oko 24.35 sati u odnosu na kontrolnu grupu životinja, te smo ovu dozu smatrali jedino opravdanom za dalja istraživanja. Kombinacija haloperidola s (-)-nuciferinom neznatno produžava vreme preživljavanja, dok je kombinacija haloperidola sa aminooksirćetnom kiselinom imala nabolji efekt na produženje ovog perioda. Period preživljavanja je produžen oko 27.74 sata u odnosu na kontrolnu grupu životinja.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Veterinarski Glasnik
T1  - The effect of haloperidol, aminooxyacetic acid and (-)-nuciferine on prolonged survival time of mice with tetanus
T1  - Delovanje haloperidola, aminooksisirćetne kiseline i (-)-nuciferina na produženje preživljavanja miševa s tetanusom
VL  - 72
IS  - 2
SP  - 122
EP  - 128
DO  - 10.2298/VETGL171023005M
ER  - 

@article{
author = "Mujezinović, Indira and Smajlović, Ahmed and Ćupić, Vitomir",
year = "2018",
abstract = "Introduction. Tetanus, also known as lockjaw, is a very dangerous, infectious, acute, usually afebrile disease characterised by muscle spasms. The causative agent of the disease is the bacterium Clostridium tetani. This pathogen produces a specifc neurotoxin, termed tetanus toxin, with two components: tetanospasmin and tetanolysin. Light chains of tetanospasmin cleavage synaptobrevin, which in turn prevent release of the inhibitory neurotransmitter GABA into the synaptic cleft. The α-motor neurons are, therefore, under no inhibitory control, as a result of which they undergo sustained excitatory discharge causing the characteristic motor spasms of tetanus. Materials and Methods. In this research, we attempted to normalise disorders caused by tetanus toxin by using haloperidol (at doses of 4, 5, 6, 7 and 8 mg/kg b.w.), alone and in combination with (-)-nuciferine (at a dose of 5 mg/kg b.w.) or aminooxyacetic acid (at a dose of 20 mg/kg b.w.). Experiments were conducted on albino mice. Experimental tetanus was induced by application of tetanus toxin. Results and Conclusions. Application of haloperidol (alone and in combination with (-)-nuciferine and aminooxyacetic acid) was carried out 24 h following the application of tetanus toxin. It was found that haloperidol, given alone in a dose of 4 mg/kg, prolonged the average survival time of mice with experimental tetanus by 24.35 h compared to the control animals. Additionally, the combination of haloperidol with (-)-nuciferine slightly, but non-signifcantly, extended survival time , while the combination of haloperidol with aminooxyacetic acid produced the best effect on extension of survival time (mice survived on average 27.74 h longer than control mice)., Uvod. Tetanus je veoma opasna, akutna, obično afebrilna bolest koju karakteriše mišićni spazam. Uzročnik obolenja je bakterija Clostridium tetani, koja proizvodi specifčan neurotoksin ili tetanus toksin. Toksin se sastoji od dve komponente: tetanospazmina i tetanolizina. Laki lanac tetanospazmina cepa sinaptobrevin, što za posledicu ima sprečavanje oslobađanje inhibitornog neurotransmitera GABA u sinaptički procep. Funkcija ekscitatornih neurotransmitera ostaje očuvana, te pod njihovim uticajem dolazi do grča skeletne muskulature. Materijali i metode. U ovom istraživanju pokušali smo normalizovati poremećaje uzrokovane tetanus toksinom koristeći haloperidol (u dozama od 4, 5, 6, 7 i 8 mg/ kg t.m.), samostalno i u kombinaciji sa (-)-nuciferinom (u dozi od 5 mg/kg t.m.) i aminooksirćetnom kiselinom (u dozi od 20 mg/kg t.m.). Kompletno istraživanje je sprovedeno na albino miševima. Eksperimentalni tetanus izazvan je aplikacijom tetanus toksina. Rezultati i zaključak. Primena haloperidola (samo i u kombinaciji sa (-)-nuciferinom i aminooksirćetnom kiselinom) vršena je 24 sata nakon aplikacije tetanus toksina. Haloperidol, aplikovan u dozi od 4 mg/kg t.m., produžio je vreme preživljavanja miševa s eksperimentalnim tetanusom za oko 24.35 sati u odnosu na kontrolnu grupu životinja, te smo ovu dozu smatrali jedino opravdanom za dalja istraživanja. Kombinacija haloperidola s (-)-nuciferinom neznatno produžava vreme preživljavanja, dok je kombinacija haloperidola sa aminooksirćetnom kiselinom imala nabolji efekt na produženje ovog perioda. Period preživljavanja je produžen oko 27.74 sata u odnosu na kontrolnu grupu životinja.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Veterinarski Glasnik",
title = "The effect of haloperidol, aminooxyacetic acid and (-)-nuciferine on prolonged survival time of mice with tetanus, Delovanje haloperidola, aminooksisirćetne kiseline i (-)-nuciferina na produženje preživljavanja miševa s tetanusom",
volume = "72",
number = "2",
pages = "122-128",
doi = "10.2298/VETGL171023005M"
}

Mujezinović, I., Smajlović, A.,& Ćupić, V.. (2018). The effect of haloperidol, aminooxyacetic acid and (-)-nuciferine on prolonged survival time of mice with tetanus. in Veterinarski Glasnik
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 72(2), 122-128.
https://doi.org/10.2298/VETGL171023005M

Mujezinović I, Smajlović A, Ćupić V. The effect of haloperidol, aminooxyacetic acid and (-)-nuciferine on prolonged survival time of mice with tetanus. in Veterinarski Glasnik. 2018;72(2):122-128.
doi:10.2298/VETGL171023005M .

Mujezinović, Indira, Smajlović, Ahmed, Ćupić, Vitomir, "The effect of haloperidol, aminooxyacetic acid and (-)-nuciferine on prolonged survival time of mice with tetanus" in Veterinarski Glasnik, 72, no. 2 (2018):122-128,
https://doi.org/10.2298/VETGL171023005M . .

TY  - JOUR
AU  - Mujezinović, Indira
AU  - Smajlović, Ahmed
AU  - Zuko, A.
AU  - Dukić, B.
AU  - Ćupić, Vitomir
PY  - 2018
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1600
AB  - Thymol (2-isopropyl-5-methylphenol) is a natural compound from a group of monotherpentinic phenols. These phenols are present in the essential oils of many plants of the Labiateae family, which are used in the folk medicine for centuries. During this long-term period, it is established that thymol has, together with antiseptic and spasmolytic, also antihelmintic action. Thymol antimicrobial spectrum is wide because it acts on Gram-positive and Gramnegative bacteria, fungi and yeasts. As a natural alternative to antibiotics, unlike many traditional antibiotics with bactericidal action, thymol attacks bacterial organelles, especially respiratory chain enzymes, which are linked to mesosomes of the cell membranes, which leads to complete destruction of pathogenic aerobic bacteria results due to a blockage of the cellular respiration and death of the bacteria. During numerous in vitro and in vivo studies conducted with thymol, it has been proved that thymol has antibacterial, antifungal, anti-inflammatory, antiseptic, spasmolytic and anthelmintic effects. It has a wide spectrum of effects against both, Gram-positive and Gram-negative bacteria, yeasts and molds. Nowadays, thymol is used successfully both in human and in veterinary medicine. In veterinary practice, it is used with different species of animals in the treatment of respiratory diseases. Also, it is widely used in beekeeping as a good acaricide at very low concentrations. The exact mechanism of acaridical action of thymol is still not sufficiently known. General idea is that timol acaricidal action is mediated via GABA (A) receptor-R, leading to a neurotoxic effect on the octopaminergic nerves of ticks and insects. Most likely, the death of the ticks is the result of their choking. Thymol is rapidly absorbed from the gastrointestinal system, metabolized by oxidation and glucuronidation, and rapidly (in the first 24 hours of application) excreted via urine, and to a small extent in the unchanged and in large part in the form of glucuronides and /or conjugated sulphates. Additionally, it was found that thymol is quickly reabsorbed from the site of administration, promptly metabolized and rapidly excreted from the organism. Thymol is a natural and safe active substance for which MRL is not established, and it is listed in Annex II of the List of substances without withdrawal period. During the investigation of thymol residues in some bee products (honey and wax) it was found that treatments with this natural substance can be considered to be good alternatives for synthetic acaricides, especially because they do not represent a sanitary risk. Thymol has been evaluated 1992 by the Committee of Expert on Flavorings Substances of the Council of Europe. Thymol is listed among the substances that are permitted as flavouring agents. An upper limit for inclusion of thymol in food has been established at 50 mg/kg and in beverages at 10 mg/kg. During clinical trials of the various medicinal preparations containing thymol on bee-keeping communities, at the established therapeutic concentrations, no adverse effects have been observed. Thymol did not show any theratogenic, mutagenic or carcinogenic effects.
PB  - Croatian Veterinary Institute
T2  - Veterinarska Stanica
T1  - Importance of clinical applications of thymol
T1  - Značenje kliničke primjene timola
VL  - 49
IS  - 2
SP  - 123
EP  - 129
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_1600
ER  - 

@article{
author = "Mujezinović, Indira and Smajlović, Ahmed and Zuko, A. and Dukić, B. and Ćupić, Vitomir",
year = "2018",
abstract = "Thymol (2-isopropyl-5-methylphenol) is a natural compound from a group of monotherpentinic phenols. These phenols are present in the essential oils of many plants of the Labiateae family, which are used in the folk medicine for centuries. During this long-term period, it is established that thymol has, together with antiseptic and spasmolytic, also antihelmintic action. Thymol antimicrobial spectrum is wide because it acts on Gram-positive and Gramnegative bacteria, fungi and yeasts. As a natural alternative to antibiotics, unlike many traditional antibiotics with bactericidal action, thymol attacks bacterial organelles, especially respiratory chain enzymes, which are linked to mesosomes of the cell membranes, which leads to complete destruction of pathogenic aerobic bacteria results due to a blockage of the cellular respiration and death of the bacteria. During numerous in vitro and in vivo studies conducted with thymol, it has been proved that thymol has antibacterial, antifungal, anti-inflammatory, antiseptic, spasmolytic and anthelmintic effects. It has a wide spectrum of effects against both, Gram-positive and Gram-negative bacteria, yeasts and molds. Nowadays, thymol is used successfully both in human and in veterinary medicine. In veterinary practice, it is used with different species of animals in the treatment of respiratory diseases. Also, it is widely used in beekeeping as a good acaricide at very low concentrations. The exact mechanism of acaridical action of thymol is still not sufficiently known. General idea is that timol acaricidal action is mediated via GABA (A) receptor-R, leading to a neurotoxic effect on the octopaminergic nerves of ticks and insects. Most likely, the death of the ticks is the result of their choking. Thymol is rapidly absorbed from the gastrointestinal system, metabolized by oxidation and glucuronidation, and rapidly (in the first 24 hours of application) excreted via urine, and to a small extent in the unchanged and in large part in the form of glucuronides and /or conjugated sulphates. Additionally, it was found that thymol is quickly reabsorbed from the site of administration, promptly metabolized and rapidly excreted from the organism. Thymol is a natural and safe active substance for which MRL is not established, and it is listed in Annex II of the List of substances without withdrawal period. During the investigation of thymol residues in some bee products (honey and wax) it was found that treatments with this natural substance can be considered to be good alternatives for synthetic acaricides, especially because they do not represent a sanitary risk. Thymol has been evaluated 1992 by the Committee of Expert on Flavorings Substances of the Council of Europe. Thymol is listed among the substances that are permitted as flavouring agents. An upper limit for inclusion of thymol in food has been established at 50 mg/kg and in beverages at 10 mg/kg. During clinical trials of the various medicinal preparations containing thymol on bee-keeping communities, at the established therapeutic concentrations, no adverse effects have been observed. Thymol did not show any theratogenic, mutagenic or carcinogenic effects.",
publisher = "Croatian Veterinary Institute",
journal = "Veterinarska Stanica",
title = "Importance of clinical applications of thymol, Značenje kliničke primjene timola",
volume = "49",
number = "2",
pages = "123-129",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_1600"
}

Mujezinović, I., Smajlović, A., Zuko, A., Dukić, B.,& Ćupić, V.. (2018). Importance of clinical applications of thymol. in Veterinarska Stanica
Croatian Veterinary Institute., 49(2), 123-129.
https://hdl.handle.net/21.15107/rcub_veterinar_1600

Mujezinović I, Smajlović A, Zuko A, Dukić B, Ćupić V. Importance of clinical applications of thymol. in Veterinarska Stanica. 2018;49(2):123-129.
https://hdl.handle.net/21.15107/rcub_veterinar_1600 .

Mujezinović, Indira, Smajlović, Ahmed, Zuko, A., Dukić, B., Ćupić, Vitomir, "Importance of clinical applications of thymol" in Veterinarska Stanica, 49, no. 2 (2018):123-129,
https://hdl.handle.net/21.15107/rcub_veterinar_1600 .

TY  - JOUR
AU  - Jović, Slavoljub
AU  - Ćupić, Vitomir
AU  - Ristić, Gordana
AU  - Vakanjac, Slobodanka
AU  - Dimitrijević, Blagoje
AU  - Ćupić Miladinović, Dejana
AU  - Živković, Lada
PY  - 2016
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1337
AB  - The objective of this work was to investigate the influence of the day of farrowing induction on the number of newborn piglets (live born and dead born), body mass and mortality of neonatal pigs in litter by the tenth day of age. For the investigation purpose, there were chosen 167 pregnant animals, 34 gilts and 133 sows, divided into 3 groups each, according to the day of pregnancy when prostaglandin analogue, dinoprost-tromethamine, was applied (from 112th to 114th day). Fastest-induced parturition was in gilts which were administered dinoprost on the 113th day of pregnancy, (34,30 ± 6,23) h after application, that is, in sows which were administered prostaglandin on the 114th day of pregnancy, (29,57 ± 4,14) h after application of dinoprost. Most gilts (75 %) and sows (90,91%) started farrowing 24-36 h after dinoprost application, when it was given on the 113th day of pregnancy. During daily twelve-hour working time (7-19 h), 67,07% out of all the treated animals started farrowing. When farrowing was induced on the 112th day of pregnancy, 17 sows (12,78%) needed obstetric assistance for dystocia, while 47 (35,34 %) sows had troublesome farrowing. Along with the delayed induction, body mass of newborn pigs increased, and the largest recorded weight was 1,27 kg in sows, that is 1,38 kg in gilts, which were given dinoprost on the 114th day of pregnancy, with the lowest number of live born pigs of body mass less than 1 kg (23,76%). In this experiment there was determined the connection between the body mass and vitality of newborn piglets, so the lowest mortality rate of the pigs by the 10th day of age was noticed in sows and gilts which were given dinoprost on the 114th day of pregnancy (11,05%), in regard to the pigs born of sows and gilts which were given dinoprost on the 112th day of pregnancy (15,39 %).
AB  - Cilj ovog rada bio je da se ispita uticaj izbora dana indukcije prašenja na broj novorođene prasadi (živo i mrtvorođene), telesnu masu i mortalitet neonatalne prasadi u leglu do 10. dana starosti. Za ispitivanje je izabrano 167 gravidnih životinja, 34 nazimica i 133 krmača, podeljenih u po 3 grupe, prema danu graviditeta kada je aplikovan analog prostaglandina, dinoprost-trometamin (od 112­114. dana). Najbrže je indukovan partus kod nazimica kojima je aplikovan dinoprost 113. dana graviditeta (34,30 ± 6,23) h nakon aplikacije, odnosno kod krmača kojima je aplikovan prostaglandin 114. dana graviditeta (29,57 ± 4,14) h nakon aplikacije dinoprosta. Najviše nazimica (75 %) i krmača (90,91%) započelo je prašenje 24-36 h nakon aplikacije dinoprosta, kada je on aplikovan 113. dana graviditeta. U toku dnevnog dvanaestočasovnog radnog vremena (7-19 h) započelo je prašenje 67,07% od ukupno tretiranih životinja. Kada je indukovano prašenje na 112 dan graviditeta 17 krmača (12,78%) zahtevalo je akušersku pomoć zbog distocije, dok je od ukupnog broja krmača 47 (35,34 %) bilo sa problematičnim prašenjem. Sa odlaganjem indukcije rasla je telesna masa novorođene prasadi, pri čemu je najveća zabeležena iznosila 1,27 kg kod krmača, odnosno 1,38 kg kod nazimica, kojima je dinoprost aplikovan 114. dana graviditeta, sa najmanje živorođene prasadi telesne mase ispod 1 kg (23,76%). U ogledu je utvrđena povezanost telesne mase sa vitalnošću novorođene prasadi, tako da je najmanja stopa smrtnosti prasadi do 10. dana života, zabeležena kod krmača i nazimica kojima je dinoprost aplikovan 114. dana graviditeta (11,05%), u odnosu na prasad rođenu kod krmača i nazimica kojima je dinoprost aplikovan 112. dana graviditeta (15,39%).
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Veterinarski Glasnik
T1  - The influence of the induction of farrowing on live birth, body mass, appearance of dystocia, mortality and surviving of neonatal pigs in litter during the first ten days
T1  - Vlijanie indukcii oporosa na živoroždenie, massu tela, vozniknovenie distocii, smertnost' i vyživanie novoroždennyh porosjat v pervye desjat' dnej
T1  - Uticaj indukcije prašenja na živorođenost, telesnu masu, pojavu distocije, mortalitet i preživljavanje neonatalne prasadi u leglu u prvih deset dana
VL  - 70
IS  - 1-2
SP  - 13
EP  - 29
DO  - 10.2298/VETGL1602013J
ER  - 

@article{
author = "Jović, Slavoljub and Ćupić, Vitomir and Ristić, Gordana and Vakanjac, Slobodanka and Dimitrijević, Blagoje and Ćupić Miladinović, Dejana and Živković, Lada",
year = "2016",
abstract = "The objective of this work was to investigate the influence of the day of farrowing induction on the number of newborn piglets (live born and dead born), body mass and mortality of neonatal pigs in litter by the tenth day of age. For the investigation purpose, there were chosen 167 pregnant animals, 34 gilts and 133 sows, divided into 3 groups each, according to the day of pregnancy when prostaglandin analogue, dinoprost-tromethamine, was applied (from 112th to 114th day). Fastest-induced parturition was in gilts which were administered dinoprost on the 113th day of pregnancy, (34,30 ± 6,23) h after application, that is, in sows which were administered prostaglandin on the 114th day of pregnancy, (29,57 ± 4,14) h after application of dinoprost. Most gilts (75 %) and sows (90,91%) started farrowing 24-36 h after dinoprost application, when it was given on the 113th day of pregnancy. During daily twelve-hour working time (7-19 h), 67,07% out of all the treated animals started farrowing. When farrowing was induced on the 112th day of pregnancy, 17 sows (12,78%) needed obstetric assistance for dystocia, while 47 (35,34 %) sows had troublesome farrowing. Along with the delayed induction, body mass of newborn pigs increased, and the largest recorded weight was 1,27 kg in sows, that is 1,38 kg in gilts, which were given dinoprost on the 114th day of pregnancy, with the lowest number of live born pigs of body mass less than 1 kg (23,76%). In this experiment there was determined the connection between the body mass and vitality of newborn piglets, so the lowest mortality rate of the pigs by the 10th day of age was noticed in sows and gilts which were given dinoprost on the 114th day of pregnancy (11,05%), in regard to the pigs born of sows and gilts which were given dinoprost on the 112th day of pregnancy (15,39 %)., Cilj ovog rada bio je da se ispita uticaj izbora dana indukcije prašenja na broj novorođene prasadi (živo i mrtvorođene), telesnu masu i mortalitet neonatalne prasadi u leglu do 10. dana starosti. Za ispitivanje je izabrano 167 gravidnih životinja, 34 nazimica i 133 krmača, podeljenih u po 3 grupe, prema danu graviditeta kada je aplikovan analog prostaglandina, dinoprost-trometamin (od 112­114. dana). Najbrže je indukovan partus kod nazimica kojima je aplikovan dinoprost 113. dana graviditeta (34,30 ± 6,23) h nakon aplikacije, odnosno kod krmača kojima je aplikovan prostaglandin 114. dana graviditeta (29,57 ± 4,14) h nakon aplikacije dinoprosta. Najviše nazimica (75 %) i krmača (90,91%) započelo je prašenje 24-36 h nakon aplikacije dinoprosta, kada je on aplikovan 113. dana graviditeta. U toku dnevnog dvanaestočasovnog radnog vremena (7-19 h) započelo je prašenje 67,07% od ukupno tretiranih životinja. Kada je indukovano prašenje na 112 dan graviditeta 17 krmača (12,78%) zahtevalo je akušersku pomoć zbog distocije, dok je od ukupnog broja krmača 47 (35,34 %) bilo sa problematičnim prašenjem. Sa odlaganjem indukcije rasla je telesna masa novorođene prasadi, pri čemu je najveća zabeležena iznosila 1,27 kg kod krmača, odnosno 1,38 kg kod nazimica, kojima je dinoprost aplikovan 114. dana graviditeta, sa najmanje živorođene prasadi telesne mase ispod 1 kg (23,76%). U ogledu je utvrđena povezanost telesne mase sa vitalnošću novorođene prasadi, tako da je najmanja stopa smrtnosti prasadi do 10. dana života, zabeležena kod krmača i nazimica kojima je dinoprost aplikovan 114. dana graviditeta (11,05%), u odnosu na prasad rođenu kod krmača i nazimica kojima je dinoprost aplikovan 112. dana graviditeta (15,39%).",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Veterinarski Glasnik",
title = "The influence of the induction of farrowing on live birth, body mass, appearance of dystocia, mortality and surviving of neonatal pigs in litter during the first ten days, Vlijanie indukcii oporosa na živoroždenie, massu tela, vozniknovenie distocii, smertnost' i vyživanie novoroždennyh porosjat v pervye desjat' dnej, Uticaj indukcije prašenja na živorođenost, telesnu masu, pojavu distocije, mortalitet i preživljavanje neonatalne prasadi u leglu u prvih deset dana",
volume = "70",
number = "1-2",
pages = "13-29",
doi = "10.2298/VETGL1602013J"
}

Jović, S., Ćupić, V., Ristić, G., Vakanjac, S., Dimitrijević, B., Ćupić Miladinović, D.,& Živković, L.. (2016). The influence of the induction of farrowing on live birth, body mass, appearance of dystocia, mortality and surviving of neonatal pigs in litter during the first ten days. in Veterinarski Glasnik
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 70(1-2), 13-29.
https://doi.org/10.2298/VETGL1602013J

Jović S, Ćupić V, Ristić G, Vakanjac S, Dimitrijević B, Ćupić Miladinović D, Živković L. The influence of the induction of farrowing on live birth, body mass, appearance of dystocia, mortality and surviving of neonatal pigs in litter during the first ten days. in Veterinarski Glasnik. 2016;70(1-2):13-29.
doi:10.2298/VETGL1602013J .

Jović, Slavoljub, Ćupić, Vitomir, Ristić, Gordana, Vakanjac, Slobodanka, Dimitrijević, Blagoje, Ćupić Miladinović, Dejana, Živković, Lada, "The influence of the induction of farrowing on live birth, body mass, appearance of dystocia, mortality and surviving of neonatal pigs in litter during the first ten days" in Veterinarski Glasnik, 70, no. 1-2 (2016):13-29,
https://doi.org/10.2298/VETGL1602013J . .

TY  - JOUR
AU  - Ivanović, Saša
AU  - Dimitrijević, Blagoje
AU  - Ćupić, Vitomir
AU  - Jezdimirović, Milanka
AU  - Borozan, Sunčica
AU  - Savić, Mila
AU  - Savić, Đorđe
PY  - 2016
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1347
AB  - Diazinon (DZN) is an organophosphate insecticide which exerts its effect through the inhibition of acetyl cholinesterase enzyme (AChE). In this work, we studied the development of tolerance to subchronic p.o. administration of DZN in rats, under both in vivo and in vitro conditions. A group of 20 rats (2 groups, n = 10) was administered p.o. the 1/10 of established LD50 DZN (namely 55.87 mg/kg bw) for 28 days. On the 14th and 28th day of study with isolated diaphragm and ileum, we examined the downregulation of nicotinic and muscarinic receptor function through Electrical Field Stimulation (EFS). Maximum contractility of the diaphragm was recorded on the 14th day of the study (25% higher compared to the non-treated rats), while on the 28th day the contractions almost did not differ from the values found in non-treated rats. EFS of isolated ileum on the 14th day of study caused significantly higher contractions compared to the non treated rats, but after 28 days, ileum contractions decreased approximately to the level of contractions in non-treated rats. On the 14th study day, we also recorded increased amplitude of spontaneous ileum contractions, compared to non-treated rats. The application of increasing ACh concentrations caused dose-dependent ileum contractions, without statistically significant differences of median effective concentration (EC50) values in non-treated and treated rats. Tolerance to subchronic DZN administration develops due to various adaptation mechanisms, including the most important one downregulation of nicotinic and muscarinic receptor function.
PB  - Elsevier Science Bv, Amsterdam
T2  - Toxicology Reports
T1  - Downregulation of nicotinic and muscarinic receptor function in rats after subchronic exposure to diazinon
VL  - 3
SP  - 523
EP  - 530
DO  - 10.1016/j.toxrep.2016.06.002
ER  - 

@article{
author = "Ivanović, Saša and Dimitrijević, Blagoje and Ćupić, Vitomir and Jezdimirović, Milanka and Borozan, Sunčica and Savić, Mila and Savić, Đorđe",
year = "2016",
abstract = "Diazinon (DZN) is an organophosphate insecticide which exerts its effect through the inhibition of acetyl cholinesterase enzyme (AChE). In this work, we studied the development of tolerance to subchronic p.o. administration of DZN in rats, under both in vivo and in vitro conditions. A group of 20 rats (2 groups, n = 10) was administered p.o. the 1/10 of established LD50 DZN (namely 55.87 mg/kg bw) for 28 days. On the 14th and 28th day of study with isolated diaphragm and ileum, we examined the downregulation of nicotinic and muscarinic receptor function through Electrical Field Stimulation (EFS). Maximum contractility of the diaphragm was recorded on the 14th day of the study (25% higher compared to the non-treated rats), while on the 28th day the contractions almost did not differ from the values found in non-treated rats. EFS of isolated ileum on the 14th day of study caused significantly higher contractions compared to the non treated rats, but after 28 days, ileum contractions decreased approximately to the level of contractions in non-treated rats. On the 14th study day, we also recorded increased amplitude of spontaneous ileum contractions, compared to non-treated rats. The application of increasing ACh concentrations caused dose-dependent ileum contractions, without statistically significant differences of median effective concentration (EC50) values in non-treated and treated rats. Tolerance to subchronic DZN administration develops due to various adaptation mechanisms, including the most important one downregulation of nicotinic and muscarinic receptor function.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Toxicology Reports",
title = "Downregulation of nicotinic and muscarinic receptor function in rats after subchronic exposure to diazinon",
volume = "3",
pages = "523-530",
doi = "10.1016/j.toxrep.2016.06.002"
}

Ivanović, S., Dimitrijević, B., Ćupić, V., Jezdimirović, M., Borozan, S., Savić, M.,& Savić, Đ.. (2016). Downregulation of nicotinic and muscarinic receptor function in rats after subchronic exposure to diazinon. in Toxicology Reports
Elsevier Science Bv, Amsterdam., 3, 523-530.
https://doi.org/10.1016/j.toxrep.2016.06.002

Ivanović S, Dimitrijević B, Ćupić V, Jezdimirović M, Borozan S, Savić M, Savić Đ. Downregulation of nicotinic and muscarinic receptor function in rats after subchronic exposure to diazinon. in Toxicology Reports. 2016;3:523-530.
doi:10.1016/j.toxrep.2016.06.002 .

Ivanović, Saša, Dimitrijević, Blagoje, Ćupić, Vitomir, Jezdimirović, Milanka, Borozan, Sunčica, Savić, Mila, Savić, Đorđe, "Downregulation of nicotinic and muscarinic receptor function in rats after subchronic exposure to diazinon" in Toxicology Reports, 3 (2016):523-530,
https://doi.org/10.1016/j.toxrep.2016.06.002 . .

TY  - JOUR
AU  - Ćupić, Vitomir
AU  - Jezdimirović, Milanka
AU  - Dobrić, Silva
AU  - Ivanović, Saša
AU  - Ćupić Miladinović, Dejana
PY  - 2016
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1340
AB  - The discovery and introduction of antimicrobial drugs in clinical practice has been recorded as one of the greatest achievements in the history of medicine. The application of these drugs, made a big, almost revolutionary upheaval in treatment of many infectious diseases. Its significance for the humanity lies in the fact that hundreds of thousands of people, until then condemned to a certain death, has been saved now. However, it was shown that antimicrobial therapy carries some risk of possible occurrence of undesirable and toxic effects, such as direct toxic effects, development of resistance, the impact on the normal microflora or disorder of micropopulation metabolic functions in digestive tract of ruminants, unwanted interactions with other drugs, damage or necrosis of the tissue at the injection site, residues in foodstuff intended for human consumption, suppression of immune system or defense mechanisms of the body, and damage of fetal or neonatal tissue. All mentioned, directly or indirectly, to a greater or lesser degree can reduce the safety of these drugs.
AB  - Otkriće i uvođenje antimikrobnih lekova u kliničku praksu zabeleženo je kao jedno od najvećih dostignuća u istoriji razvoja medicine. Primenom ovih lekova, napravljen je veliki, gotovo revolucionarni preokret u lečenju brojnih infektivnih bolesti. Kolikije to značaj za čovečanstvo, najbolje govori podatak da je na stotine hiljada ljudi, do tada osuđeno na sigurnu smrt, sada bilo spašeno. Međutim, s vremenom se pokazalo da antimikrobna terapija nosi sa sobom i određeni rizik od moguće pojave neželjenih i toksičnih efekata, kao što su: direktno toksično delovanje, razvoj rezistencije, uticaj na normalnu mikrofloru ili poremećaj metaboličke funkcije mikropopulacije u digestivnom traktu preživara, neželjene interakcije sa drugim lekovima, oštećenje ili nekroza tkiva na injekcionom mestu, rezidue u namirnicama namenjenim za ishranu ljudi, supresija imunog sistema, odnosno odbrambenih mehanizama organizma, te oštećenje fetalnih ili neonatalnih tkiva. Svi oni na direktan ili indirektan način, u manjem ili većem stepenu mogu da umanje bezbednost primene ovih lekova.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Veterinarski Glasnik
T1  - The safety of antimicrobial drugs
T1  - Bezopasnost' primenenija antimikrobnyh lekarstvennyh preparatov
T1  - Bezbednost primene antimikrobnih lekova
VL  - 70
IS  - 1-2
SP  - 59
EP  - 73
DO  - 10.2298/VETGL1602059C
ER  - 

@article{
author = "Ćupić, Vitomir and Jezdimirović, Milanka and Dobrić, Silva and Ivanović, Saša and Ćupić Miladinović, Dejana",
year = "2016",
abstract = "The discovery and introduction of antimicrobial drugs in clinical practice has been recorded as one of the greatest achievements in the history of medicine. The application of these drugs, made a big, almost revolutionary upheaval in treatment of many infectious diseases. Its significance for the humanity lies in the fact that hundreds of thousands of people, until then condemned to a certain death, has been saved now. However, it was shown that antimicrobial therapy carries some risk of possible occurrence of undesirable and toxic effects, such as direct toxic effects, development of resistance, the impact on the normal microflora or disorder of micropopulation metabolic functions in digestive tract of ruminants, unwanted interactions with other drugs, damage or necrosis of the tissue at the injection site, residues in foodstuff intended for human consumption, suppression of immune system or defense mechanisms of the body, and damage of fetal or neonatal tissue. All mentioned, directly or indirectly, to a greater or lesser degree can reduce the safety of these drugs., Otkriće i uvođenje antimikrobnih lekova u kliničku praksu zabeleženo je kao jedno od najvećih dostignuća u istoriji razvoja medicine. Primenom ovih lekova, napravljen je veliki, gotovo revolucionarni preokret u lečenju brojnih infektivnih bolesti. Kolikije to značaj za čovečanstvo, najbolje govori podatak da je na stotine hiljada ljudi, do tada osuđeno na sigurnu smrt, sada bilo spašeno. Međutim, s vremenom se pokazalo da antimikrobna terapija nosi sa sobom i određeni rizik od moguće pojave neželjenih i toksičnih efekata, kao što su: direktno toksično delovanje, razvoj rezistencije, uticaj na normalnu mikrofloru ili poremećaj metaboličke funkcije mikropopulacije u digestivnom traktu preživara, neželjene interakcije sa drugim lekovima, oštećenje ili nekroza tkiva na injekcionom mestu, rezidue u namirnicama namenjenim za ishranu ljudi, supresija imunog sistema, odnosno odbrambenih mehanizama organizma, te oštećenje fetalnih ili neonatalnih tkiva. Svi oni na direktan ili indirektan način, u manjem ili većem stepenu mogu da umanje bezbednost primene ovih lekova.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Veterinarski Glasnik",
title = "The safety of antimicrobial drugs, Bezopasnost' primenenija antimikrobnyh lekarstvennyh preparatov, Bezbednost primene antimikrobnih lekova",
volume = "70",
number = "1-2",
pages = "59-73",
doi = "10.2298/VETGL1602059C"
}

Ćupić, V., Jezdimirović, M., Dobrić, S., Ivanović, S.,& Ćupić Miladinović, D.. (2016). The safety of antimicrobial drugs. in Veterinarski Glasnik
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 70(1-2), 59-73.
https://doi.org/10.2298/VETGL1602059C

Ćupić V, Jezdimirović M, Dobrić S, Ivanović S, Ćupić Miladinović D. The safety of antimicrobial drugs. in Veterinarski Glasnik. 2016;70(1-2):59-73.
doi:10.2298/VETGL1602059C .

Ćupić, Vitomir, Jezdimirović, Milanka, Dobrić, Silva, Ivanović, Saša, Ćupić Miladinović, Dejana, "The safety of antimicrobial drugs" in Veterinarski Glasnik, 70, no. 1-2 (2016):59-73,
https://doi.org/10.2298/VETGL1602059C . .

TY  - JOUR
AU  - Novaković, Radmila
AU  - Radunović, Nebojša
AU  - Rajković, Jovana
AU  - Đokić, Vladimir
AU  - Petrović, Aleksandar
AU  - Ivković, Branka
AU  - Ćupić, Vitomir
AU  - Kanjuh, Vladimir
AU  - Helmut, Heinlev
AU  - Gojković-Bukarica, Ljiljana
PY  - 2016
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1343
AB  - Resveratrol is a phytoalexin produced in a number of plant species including grapes. The benefit of resveratrol to health is widely reported. Resveratrol has been found to promote relaxation of non-pregnant and pregnant uterus, but its mechanism of action is unclear. The aims of our study were to investigate the involvement of inwardly rectifying potassium channels (Kir) in inhibitory effects of resveratrol on three models of contractions of non-pregnant rat uterus: the spontaneous rhythmic contractions (SRC), oxytocin-elicited phasic contractions and tonic oxytocin-elicited contractions. Uterine strips were obtained from virgin female Wistar rats in oestrus. Strips were mounted into organ bath for recording isometric tension in Krebs-Ringer solution. Experiments followed a multiple curve design. In order to test the involvement of Kirchannels in a mechanism of action of resveratrol (1-100 μM),BaCl2 (1 mM),a antagonist of inwardly rectifying potassium channels was used. Resveratrol induced a concentration-dependent relaxation of all models of contractions. BaCl2 antagonized the response to resveratrolon SRC and oxytocin-elicited phasic contractions. Relaxation achieved by resveratrolon tonic oxytocin-elicited concentrations was insensitive to BaCl2.The antagonism of resveratrol effects by inwardly rectifying potassium channels antagonist suggests that Kir channels are involved in resveratrol action on phasic contractions of rat uterus. Inhibitory effect of resveratrol on tonic contractions did not include Kir channels.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Veterinarski Glasnik
T1  - Wine polyphenol resveratrol inhibits contractions of isolated rat uterus by activation of smooth muscle inwardly rectifying potassium channels
VL  - 70
IS  - 3-4
SP  - 121
EP  - 129
DO  - 10.2298/VETGL1604121N
ER  - 

@article{
author = "Novaković, Radmila and Radunović, Nebojša and Rajković, Jovana and Đokić, Vladimir and Petrović, Aleksandar and Ivković, Branka and Ćupić, Vitomir and Kanjuh, Vladimir and Helmut, Heinlev and Gojković-Bukarica, Ljiljana",
year = "2016",
abstract = "Resveratrol is a phytoalexin produced in a number of plant species including grapes. The benefit of resveratrol to health is widely reported. Resveratrol has been found to promote relaxation of non-pregnant and pregnant uterus, but its mechanism of action is unclear. The aims of our study were to investigate the involvement of inwardly rectifying potassium channels (Kir) in inhibitory effects of resveratrol on three models of contractions of non-pregnant rat uterus: the spontaneous rhythmic contractions (SRC), oxytocin-elicited phasic contractions and tonic oxytocin-elicited contractions. Uterine strips were obtained from virgin female Wistar rats in oestrus. Strips were mounted into organ bath for recording isometric tension in Krebs-Ringer solution. Experiments followed a multiple curve design. In order to test the involvement of Kirchannels in a mechanism of action of resveratrol (1-100 μM),BaCl2 (1 mM),a antagonist of inwardly rectifying potassium channels was used. Resveratrol induced a concentration-dependent relaxation of all models of contractions. BaCl2 antagonized the response to resveratrolon SRC and oxytocin-elicited phasic contractions. Relaxation achieved by resveratrolon tonic oxytocin-elicited concentrations was insensitive to BaCl2.The antagonism of resveratrol effects by inwardly rectifying potassium channels antagonist suggests that Kir channels are involved in resveratrol action on phasic contractions of rat uterus. Inhibitory effect of resveratrol on tonic contractions did not include Kir channels.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Veterinarski Glasnik",
title = "Wine polyphenol resveratrol inhibits contractions of isolated rat uterus by activation of smooth muscle inwardly rectifying potassium channels",
volume = "70",
number = "3-4",
pages = "121-129",
doi = "10.2298/VETGL1604121N"
}

Novaković, R., Radunović, N., Rajković, J., Đokić, V., Petrović, A., Ivković, B., Ćupić, V., Kanjuh, V., Helmut, H.,& Gojković-Bukarica, L.. (2016). Wine polyphenol resveratrol inhibits contractions of isolated rat uterus by activation of smooth muscle inwardly rectifying potassium channels. in Veterinarski Glasnik
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 70(3-4), 121-129.
https://doi.org/10.2298/VETGL1604121N

Novaković R, Radunović N, Rajković J, Đokić V, Petrović A, Ivković B, Ćupić V, Kanjuh V, Helmut H, Gojković-Bukarica L. Wine polyphenol resveratrol inhibits contractions of isolated rat uterus by activation of smooth muscle inwardly rectifying potassium channels. in Veterinarski Glasnik. 2016;70(3-4):121-129.
doi:10.2298/VETGL1604121N .

Novaković, Radmila, Radunović, Nebojša, Rajković, Jovana, Đokić, Vladimir, Petrović, Aleksandar, Ivković, Branka, Ćupić, Vitomir, Kanjuh, Vladimir, Helmut, Heinlev, Gojković-Bukarica, Ljiljana, "Wine polyphenol resveratrol inhibits contractions of isolated rat uterus by activation of smooth muscle inwardly rectifying potassium channels" in Veterinarski Glasnik, 70, no. 3-4 (2016):121-129,
https://doi.org/10.2298/VETGL1604121N . .

TY  - JOUR
AU  - Ćupić, Vitomir
AU  - Jović, Slavoljub
AU  - Ristić, Gordana
AU  - Vakanjac, Slobodanka
AU  - Dimitrijević, Blagoje
AU  - Ćupić Miladinović, Dejana
PY  - 2015
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1209
AB  - sows, induction of partus, prostaglandin, oxyitocin, duration of partus, number of born piglets, period between two expulsions of piglets.
AB  - Cilj ovog rada bio je da se ispita uticaj kombinovane primene prostaglandina i oksitocina na dužinu trajanja prašenja, broj živorođene prasadi i vremenski interval između ekspulzije dva praseta kod krmača. Ogled je izveden na 133 gravidne krmače, rase danski landras-veliki jorkšir, koje su (u zavisnosti od dana indukovanja partusa - 112, 113. i 114. dan graviditeta) podeljene u 3 grupe. U okviru svake grupe jedinke su podeljene u tri podgrupe i njima je primenjivan sintetički analog prostaglandina PGF2-alfa (dinoprost-DINOLYTIC) u dozi od 10 mg (ekv. 2 ml preparata)/životinja (I-podgrupa) sam ili u kombinaciji sa jednokratnom (nakon rađanja petog praseta) (II-pod­grupa), odnosno dvokratnom (nakon rađanja petog i desetog prase­ta) (III-podgrupa) aplikacijom oksitocina (OXYTOKEL) u dozi od 20 i.j. (ekv. 2 ml preparata/životinja (jednokratna aplikacija), odnosno 20 i.j.+ 15 i.j. (ekv. 2 ml + 1,5 ml preparata/životinja), (dvokratna aplikacija). Dobijeni rezultati pokazali su da je kod jedinki tretiranih samo prostaglandinom najduže prašenje (6,41 ± 2,20 h) trajalo kod krmača kojima je ovaj lek aplikovan 112. dana graviditeta, a najkraće (4,56 ± 1,30 h) kod jedinki tretiranih 114. dana graviditeta. Kod krmača kojima je (pored prostaglandina) aplikovan jednokratno oksitocin, najduže prašenje (6,38 ± 1,30) je zabeleženo kod jedinki tretiranih 113. dana graviditeta, a najkraće (5,26 ± 1,20) kod onih koje su tretirane 114. dana graviditeta. Kada su krmače (pored prostaglandina) tretirane dvokratno oksitocinom, najduže prašenje (7,17 ± 2,30) je utvrđeno u grupi tretiranoj 112. dana graviditeta, a najkraće (5,10 ± 1,20) kod jedinki tretiranih 113. dana graviditeta. Ukupno posmatrano, najduže prašenje (7,17 ± 2,30) je trajalo kod jedinki koje su (pored prostaglandina) dobile dvokratno oksitocin, a najkraće (4,56 ± 1,30), kod jedinki koje su tretirane samo prostaglandinom. Najveći broj živorođene prasadi (358) zabeležen je kod krmača kojima je aplikovan prostaglandin 114. dana graviditeta u kombinaciji sa jednokratnom aplikacijom oksitocina, a najmanji (250) kod krmača kojima je aplikovan prostaglandin 112. dana graviditeta u kombinaciji sa dvokratnom aplikacijom oksitocina. Najduži interval (0,22 ± 0,06) između ekspulzije dva praseta zabeležen je kod krmača kojima je indukovan partus 112. dana graviditeta u kombinaciji sa dvokratnom aplikacijom oksitocina, a najkraći (0,11 ± 0,03) kod krmača kojima je indukcija prašenja vršena 114. dana graviditeta, bez naknadne primene oksitocina.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Veterinarski Glasnik
T1  - The effect of combined use of prostaglandin and oxytocin in sows, on the duration of partus, number of pigs and period between two expulsions of piglets
T1  - Efekat kombinovane primene prostaglandina i oksitocina na dužinu trajanja partusa, broj prasadi i vreme između ekspulzije dva praseta kod krmača
VL  - 69
IS  - 3-4
SP  - 177
EP  - 193
DO  - 10.2298/VETGL1504177C
ER  - 

@article{
author = "Ćupić, Vitomir and Jović, Slavoljub and Ristić, Gordana and Vakanjac, Slobodanka and Dimitrijević, Blagoje and Ćupić Miladinović, Dejana",
year = "2015",
abstract = "sows, induction of partus, prostaglandin, oxyitocin, duration of partus, number of born piglets, period between two expulsions of piglets., Cilj ovog rada bio je da se ispita uticaj kombinovane primene prostaglandina i oksitocina na dužinu trajanja prašenja, broj živorođene prasadi i vremenski interval između ekspulzije dva praseta kod krmača. Ogled je izveden na 133 gravidne krmače, rase danski landras-veliki jorkšir, koje su (u zavisnosti od dana indukovanja partusa - 112, 113. i 114. dan graviditeta) podeljene u 3 grupe. U okviru svake grupe jedinke su podeljene u tri podgrupe i njima je primenjivan sintetički analog prostaglandina PGF2-alfa (dinoprost-DINOLYTIC) u dozi od 10 mg (ekv. 2 ml preparata)/životinja (I-podgrupa) sam ili u kombinaciji sa jednokratnom (nakon rađanja petog praseta) (II-pod­grupa), odnosno dvokratnom (nakon rađanja petog i desetog prase­ta) (III-podgrupa) aplikacijom oksitocina (OXYTOKEL) u dozi od 20 i.j. (ekv. 2 ml preparata/životinja (jednokratna aplikacija), odnosno 20 i.j.+ 15 i.j. (ekv. 2 ml + 1,5 ml preparata/životinja), (dvokratna aplikacija). Dobijeni rezultati pokazali su da je kod jedinki tretiranih samo prostaglandinom najduže prašenje (6,41 ± 2,20 h) trajalo kod krmača kojima je ovaj lek aplikovan 112. dana graviditeta, a najkraće (4,56 ± 1,30 h) kod jedinki tretiranih 114. dana graviditeta. Kod krmača kojima je (pored prostaglandina) aplikovan jednokratno oksitocin, najduže prašenje (6,38 ± 1,30) je zabeleženo kod jedinki tretiranih 113. dana graviditeta, a najkraće (5,26 ± 1,20) kod onih koje su tretirane 114. dana graviditeta. Kada su krmače (pored prostaglandina) tretirane dvokratno oksitocinom, najduže prašenje (7,17 ± 2,30) je utvrđeno u grupi tretiranoj 112. dana graviditeta, a najkraće (5,10 ± 1,20) kod jedinki tretiranih 113. dana graviditeta. Ukupno posmatrano, najduže prašenje (7,17 ± 2,30) je trajalo kod jedinki koje su (pored prostaglandina) dobile dvokratno oksitocin, a najkraće (4,56 ± 1,30), kod jedinki koje su tretirane samo prostaglandinom. Najveći broj živorođene prasadi (358) zabeležen je kod krmača kojima je aplikovan prostaglandin 114. dana graviditeta u kombinaciji sa jednokratnom aplikacijom oksitocina, a najmanji (250) kod krmača kojima je aplikovan prostaglandin 112. dana graviditeta u kombinaciji sa dvokratnom aplikacijom oksitocina. Najduži interval (0,22 ± 0,06) između ekspulzije dva praseta zabeležen je kod krmača kojima je indukovan partus 112. dana graviditeta u kombinaciji sa dvokratnom aplikacijom oksitocina, a najkraći (0,11 ± 0,03) kod krmača kojima je indukcija prašenja vršena 114. dana graviditeta, bez naknadne primene oksitocina.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Veterinarski Glasnik",
title = "The effect of combined use of prostaglandin and oxytocin in sows, on the duration of partus, number of pigs and period between two expulsions of piglets, Efekat kombinovane primene prostaglandina i oksitocina na dužinu trajanja partusa, broj prasadi i vreme između ekspulzije dva praseta kod krmača",
volume = "69",
number = "3-4",
pages = "177-193",
doi = "10.2298/VETGL1504177C"
}

Ćupić, V., Jović, S., Ristić, G., Vakanjac, S., Dimitrijević, B.,& Ćupić Miladinović, D.. (2015). The effect of combined use of prostaglandin and oxytocin in sows, on the duration of partus, number of pigs and period between two expulsions of piglets. in Veterinarski Glasnik
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 69(3-4), 177-193.
https://doi.org/10.2298/VETGL1504177C

Ćupić V, Jović S, Ristić G, Vakanjac S, Dimitrijević B, Ćupić Miladinović D. The effect of combined use of prostaglandin and oxytocin in sows, on the duration of partus, number of pigs and period between two expulsions of piglets. in Veterinarski Glasnik. 2015;69(3-4):177-193.
doi:10.2298/VETGL1504177C .

Ćupić, Vitomir, Jović, Slavoljub, Ristić, Gordana, Vakanjac, Slobodanka, Dimitrijević, Blagoje, Ćupić Miladinović, Dejana, "The effect of combined use of prostaglandin and oxytocin in sows, on the duration of partus, number of pigs and period between two expulsions of piglets" in Veterinarski Glasnik, 69, no. 3-4 (2015):177-193,
https://doi.org/10.2298/VETGL1504177C . .

TY  - CONF
AU  - Ćupić, Vitomir
AU  - Jović, Slavoljub
AU  - Ristić, Gordana
AU  - Vakanjac, Slobodanka
AU  - Velev, Romel
AU  - Ćupić Miladinović, Dejana
PY  - 2015
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1292
AB  - INTRODUCTION
Process of farrowing in sows on farms represents the most delicate stage in the production of piglets. It is best to finish the
delivery as soon as possible, because in this way sows recover
as soon as possible, and allows the piglets to suck colostrum.
In order to achieve the shortest duration of parturation, in the
control farrowing most often are applied uterotonics, such as
oxytocin in combination with drugs for induction of parturition
(prostaglandin analogues, PGF2-alpha).
The aim of this study was to examine the extent to which prostaglandins F2-alfa (applied alone or in combination with oxytocin) influence on the duration of parturition, and the
number of liveborn piglets.
MATERIALS AND METHODS
The experiments were performed in vivo on 133 pregnant
sows, breeds Landrace-Yorkshire, which were divided into nine
groups. The animals of the first three groups were administered
prostaglandin F2-alfa (Dinoprost), i.m. at a single dose of 2 ml,
at 112 days of gestation and once (after farrowing fifth pigletsecond group) oxytocin (Oxytokel), i.m., at a dose of 2 ml per
animal (eq. 20 units per animal) or twice (after farrowing fifth
and tenth piglet-third group) oxytocin, i.m., at a dose of 2 ml
per animal (eq. 20 units per animal) first time and then
1.5 ml per animal (eq. 15 units per animal) second time. All
of this was done at 113 days (groups IV, V, VI) and at
114 days of gestation (groups VII, VIII, IX).
RESULTS
The obtained results showed that average duration of farrowing was the shortest (4.56 h) in sows which is applied only
prostaglandin at 114 days of gestation, and the longest
(7.17 h) in sows treated with prostaglandin at 112 day of gestation with twofold application of oxytocin. The largest number
of newborn piglets (20, 47) have been reported in sows which
were treated with prostaglandin at 113th day of pregnancy in
combination with twofold application of oxytocin.
CONCLUSION
On the base of all results it may be concluded that the best
effect is achieved (duration of partus and number of newborn
piglet) when prostaglandin applied in combination of oxytocin
(twofold) at 113th day of pregnancy.
PB  - Wiley-Blackwell, Hoboken
C3  - Journal of Veterinary Pharmacology and Therapeutics
T1  - Effect of combined application of prostaglandins and oxytocin on the duration of parturition and number of newborn piglets of sows
VL  - 38
SP  - 151
EP  - 151
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_1292
ER  - 

@conference{
author = "Ćupić, Vitomir and Jović, Slavoljub and Ristić, Gordana and Vakanjac, Slobodanka and Velev, Romel and Ćupić Miladinović, Dejana",
year = "2015",
abstract = "INTRODUCTION
Process of farrowing in sows on farms represents the most delicate stage in the production of piglets. It is best to finish the
delivery as soon as possible, because in this way sows recover
as soon as possible, and allows the piglets to suck colostrum.
In order to achieve the shortest duration of parturation, in the
control farrowing most often are applied uterotonics, such as
oxytocin in combination with drugs for induction of parturition
(prostaglandin analogues, PGF2-alpha).
The aim of this study was to examine the extent to which prostaglandins F2-alfa (applied alone or in combination with oxytocin) influence on the duration of parturition, and the
number of liveborn piglets.
MATERIALS AND METHODS
The experiments were performed in vivo on 133 pregnant
sows, breeds Landrace-Yorkshire, which were divided into nine
groups. The animals of the first three groups were administered
prostaglandin F2-alfa (Dinoprost), i.m. at a single dose of 2 ml,
at 112 days of gestation and once (after farrowing fifth pigletsecond group) oxytocin (Oxytokel), i.m., at a dose of 2 ml per
animal (eq. 20 units per animal) or twice (after farrowing fifth
and tenth piglet-third group) oxytocin, i.m., at a dose of 2 ml
per animal (eq. 20 units per animal) first time and then
1.5 ml per animal (eq. 15 units per animal) second time. All
of this was done at 113 days (groups IV, V, VI) and at
114 days of gestation (groups VII, VIII, IX).
RESULTS
The obtained results showed that average duration of farrowing was the shortest (4.56 h) in sows which is applied only
prostaglandin at 114 days of gestation, and the longest
(7.17 h) in sows treated with prostaglandin at 112 day of gestation with twofold application of oxytocin. The largest number
of newborn piglets (20, 47) have been reported in sows which
were treated with prostaglandin at 113th day of pregnancy in
combination with twofold application of oxytocin.
CONCLUSION
On the base of all results it may be concluded that the best
effect is achieved (duration of partus and number of newborn
piglet) when prostaglandin applied in combination of oxytocin
(twofold) at 113th day of pregnancy.",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Journal of Veterinary Pharmacology and Therapeutics",
title = "Effect of combined application of prostaglandins and oxytocin on the duration of parturition and number of newborn piglets of sows",
volume = "38",
pages = "151-151",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_1292"
}

Ćupić, V., Jović, S., Ristić, G., Vakanjac, S., Velev, R.,& Ćupić Miladinović, D.. (2015). Effect of combined application of prostaglandins and oxytocin on the duration of parturition and number of newborn piglets of sows. in Journal of Veterinary Pharmacology and Therapeutics
Wiley-Blackwell, Hoboken., 38, 151-151.
https://hdl.handle.net/21.15107/rcub_veterinar_1292

Ćupić V, Jović S, Ristić G, Vakanjac S, Velev R, Ćupić Miladinović D. Effect of combined application of prostaglandins and oxytocin on the duration of parturition and number of newborn piglets of sows. in Journal of Veterinary Pharmacology and Therapeutics. 2015;38:151-151.
https://hdl.handle.net/21.15107/rcub_veterinar_1292 .

Ćupić, Vitomir, Jović, Slavoljub, Ristić, Gordana, Vakanjac, Slobodanka, Velev, Romel, Ćupić Miladinović, Dejana, "Effect of combined application of prostaglandins and oxytocin on the duration of parturition and number of newborn piglets of sows" in Journal of Veterinary Pharmacology and Therapeutics, 38 (2015):151-151,
https://hdl.handle.net/21.15107/rcub_veterinar_1292 .

TY  - JOUR
AU  - Ćupić, Vitomir
AU  - Pejčić, Predrag
AU  - Trailović, Dragiša
AU  - Prokić, Branislav
AU  - Ivanović, Saša
AU  - Ćupić Miladinović, Dejana
PY  - 2015
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1229
AB  - In this work there was investigated the effect of two nonsteroidal antiinflammatory drugs (NSAIDs), acetylsalicylic acid or aspirin (nonselective cyclooxygenase inhibitor - COX1 i COX2) and meloxicam (selective cyclooxygenase inhibitor - COX2) on certain hematological parameters in rats. The objective of the work was to determine whether (and to which extent), these drugs, after multiple peroral application, influence erythrocyte number, concentration of hemoglobin, hematological indices (mean corpuscular value - MCV; mean concentration of hemoglobin in erythrocytes - MCH; mean corpuscular hemoglobin concentration - MCHC), hematocrit, number of platelets, leukocytes, neutrophilic leukocytes, lymphocytes and monocytes. The experiment was conducted in vivo conditions on 70 clinically healthy Wistar strain male rats, 10 to 12 weeks of age and body weight 250 to 300 g. The rats were divided into seven groups and they were daily perorally (by probe) given aspirin (ASCOPIR) at doses of 30, 40 and 80 mg/kg b.m. (I, II and III groups), or meloxicam (METACAM) at doses of 100, 125 and 250 μg/kg b.m. (IV, V and VI groups), for seven days. The seventh group was a control one and they were given only saline. The obtained results showed that: acetylsalicylic acid in maximum dose tested (80 mg/kg b.m.) statistically significantly reduced the number of platelets (p lt 0,05), the number of leukocytes (p lt 0,05), the number of lymphocytes (p lt 0,05) and the number of monocytes (p lt 0,05), while on the other side, meloxicam in maximum dose tested (250 μg/kg), statis­tically significantly reduced the mean corpuscular value (MCV), and increased the number of platelets (p lt 0,05), relative to the control value.
AB  - U ovom radu je ispitivan uticaj dva nesteroidna antiinflamatorna leka (NSAIL), acetilsalicilne kiseline ili aspirina (neselektivni inhibitor ciklooksigenaze - COX1 i COX2) i meloksikama (selektivnog inhibitora ciklooksigenaze - COX2) na određene hematološke parametre kod pacova. Cilj rada je bio da se utvrdi da li (i u kom stepenu) navedeni lekovi posle višekratne peroralne aplikacije, imaju uticaja na broj eritrocita, koncentraciju hemoglobina, hematološke indekse (prosečnu zapreminu eritrocita - MCV; prosečnu količinu hemoglobina u eritrocitima - MCH; prosečnu koncentraciju hemoglobina u eritrocitima - MCHC), hematokrit, broj trombocita, broj leukocita, neutrofilnih leukocita, limfocita i monocita. Ogled je izveden u in vivo uslovima na 70 kliničkih zdravih pacova, soja Wistar, muškog pola, starosti od 10 do 12 nedelja i telesne mase od 250 do 300 g. Pacovi su podeljeni u sedam grupa i njima je svakodnevno peroralno (uz pomoć sonde), u toku 7 dana primenjivan aspirin (ASCOPIR) u dozama od 30, 40 i 80 mg/kg t.m./ dnevno (I, II i III grupa), odnosno meloksikam (METACAM) u dozama od 100, 125 i 250 μg/kg t.m.(IV, V i VI grupa). Sedma grupa je služila kao kontrola i njoj je aplikovan samo fiziološki rastvor. Dobijeni rezultati pokazali su da je: acetilsalicilna kiselina u najvećoj testiranoj dozi (80 mg/kg t.m.), statistički značajno smanjila broj trombocita (p lt 0,05), broj leukocita (p lt 0,05), broj limfocita (p lt 0,05) i broj monocita (p lt 0,05), dok je meloksikam u najvećoj testiranoj dozi (250 μg/kg), statistički značajno smanjio zapreminu eritrocita (MCV), a povećao broj trombocita (p lt 0,05) u odnosu na kontrolnu vrednost.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Veterinarski Glasnik
T1  - The effect of acetylsalicylic acid and meloxicam on hematological parameters in rats
T1  - Uticaj acetilsalicilne kiseline i meloksikama na hematološke parametre kod pacova
VL  - 69
IS  - 5-6
SP  - 357
EP  - 375
DO  - 10.2298/VETGL1506357C
ER  - 

@article{
author = "Ćupić, Vitomir and Pejčić, Predrag and Trailović, Dragiša and Prokić, Branislav and Ivanović, Saša and Ćupić Miladinović, Dejana",
year = "2015",
abstract = "In this work there was investigated the effect of two nonsteroidal antiinflammatory drugs (NSAIDs), acetylsalicylic acid or aspirin (nonselective cyclooxygenase inhibitor - COX1 i COX2) and meloxicam (selective cyclooxygenase inhibitor - COX2) on certain hematological parameters in rats. The objective of the work was to determine whether (and to which extent), these drugs, after multiple peroral application, influence erythrocyte number, concentration of hemoglobin, hematological indices (mean corpuscular value - MCV; mean concentration of hemoglobin in erythrocytes - MCH; mean corpuscular hemoglobin concentration - MCHC), hematocrit, number of platelets, leukocytes, neutrophilic leukocytes, lymphocytes and monocytes. The experiment was conducted in vivo conditions on 70 clinically healthy Wistar strain male rats, 10 to 12 weeks of age and body weight 250 to 300 g. The rats were divided into seven groups and they were daily perorally (by probe) given aspirin (ASCOPIR) at doses of 30, 40 and 80 mg/kg b.m. (I, II and III groups), or meloxicam (METACAM) at doses of 100, 125 and 250 μg/kg b.m. (IV, V and VI groups), for seven days. The seventh group was a control one and they were given only saline. The obtained results showed that: acetylsalicylic acid in maximum dose tested (80 mg/kg b.m.) statistically significantly reduced the number of platelets (p lt 0,05), the number of leukocytes (p lt 0,05), the number of lymphocytes (p lt 0,05) and the number of monocytes (p lt 0,05), while on the other side, meloxicam in maximum dose tested (250 μg/kg), statis­tically significantly reduced the mean corpuscular value (MCV), and increased the number of platelets (p lt 0,05), relative to the control value., U ovom radu je ispitivan uticaj dva nesteroidna antiinflamatorna leka (NSAIL), acetilsalicilne kiseline ili aspirina (neselektivni inhibitor ciklooksigenaze - COX1 i COX2) i meloksikama (selektivnog inhibitora ciklooksigenaze - COX2) na određene hematološke parametre kod pacova. Cilj rada je bio da se utvrdi da li (i u kom stepenu) navedeni lekovi posle višekratne peroralne aplikacije, imaju uticaja na broj eritrocita, koncentraciju hemoglobina, hematološke indekse (prosečnu zapreminu eritrocita - MCV; prosečnu količinu hemoglobina u eritrocitima - MCH; prosečnu koncentraciju hemoglobina u eritrocitima - MCHC), hematokrit, broj trombocita, broj leukocita, neutrofilnih leukocita, limfocita i monocita. Ogled je izveden u in vivo uslovima na 70 kliničkih zdravih pacova, soja Wistar, muškog pola, starosti od 10 do 12 nedelja i telesne mase od 250 do 300 g. Pacovi su podeljeni u sedam grupa i njima je svakodnevno peroralno (uz pomoć sonde), u toku 7 dana primenjivan aspirin (ASCOPIR) u dozama od 30, 40 i 80 mg/kg t.m./ dnevno (I, II i III grupa), odnosno meloksikam (METACAM) u dozama od 100, 125 i 250 μg/kg t.m.(IV, V i VI grupa). Sedma grupa je služila kao kontrola i njoj je aplikovan samo fiziološki rastvor. Dobijeni rezultati pokazali su da je: acetilsalicilna kiselina u najvećoj testiranoj dozi (80 mg/kg t.m.), statistički značajno smanjila broj trombocita (p lt 0,05), broj leukocita (p lt 0,05), broj limfocita (p lt 0,05) i broj monocita (p lt 0,05), dok je meloksikam u najvećoj testiranoj dozi (250 μg/kg), statistički značajno smanjio zapreminu eritrocita (MCV), a povećao broj trombocita (p lt 0,05) u odnosu na kontrolnu vrednost.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Veterinarski Glasnik",
title = "The effect of acetylsalicylic acid and meloxicam on hematological parameters in rats, Uticaj acetilsalicilne kiseline i meloksikama na hematološke parametre kod pacova",
volume = "69",
number = "5-6",
pages = "357-375",
doi = "10.2298/VETGL1506357C"
}

Ćupić, V., Pejčić, P., Trailović, D., Prokić, B., Ivanović, S.,& Ćupić Miladinović, D.. (2015). The effect of acetylsalicylic acid and meloxicam on hematological parameters in rats. in Veterinarski Glasnik
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 69(5-6), 357-375.
https://doi.org/10.2298/VETGL1506357C

Ćupić V, Pejčić P, Trailović D, Prokić B, Ivanović S, Ćupić Miladinović D. The effect of acetylsalicylic acid and meloxicam on hematological parameters in rats. in Veterinarski Glasnik. 2015;69(5-6):357-375.
doi:10.2298/VETGL1506357C .

Ćupić, Vitomir, Pejčić, Predrag, Trailović, Dragiša, Prokić, Branislav, Ivanović, Saša, Ćupić Miladinović, Dejana, "The effect of acetylsalicylic acid and meloxicam on hematological parameters in rats" in Veterinarski Glasnik, 69, no. 5-6 (2015):357-375,
https://doi.org/10.2298/VETGL1506357C . .

TY  - JOUR
AU  - Jezdimirović, Milanka
AU  - Ćupić, Vitomir
AU  - Ivanović, Saša
AU  - Dimitrijević, Blagoje
AU  - Jezdimirović, Nemanja
PY  - 2015
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1172
AB  - According to the Law on medicines and medicinal devices, veterinary drugs must be of high quality, efficacy and safety to be suitable for use on animals. However, there are numerous factors which can alter the intensity of drugs and their established therapeutic efficacy and safety. These factors may depend on the patients themselves i.e. animals (species, age, sex, physiological state, impaired functions of organs involved in the elimination of drugs, diseases of other organ systems, nutrition, genetic disorders, individual varia­tions, tolerance etc.), veterinary surgeons (use of the drug which is not in accordance with the instructions - 'off-label use', improper selection of a drug or drug combination intended for a certain animal species or pathological condition, inadequate drug administration route, inadequate drug dosage and duration of therapy) and the drug itself (inappropriate formulation, bioavailability, instability of formulation, diminishing drug action due to external factors). Not following the instructions on using a drug and incorrect application may affect the rate and extent of the drug absorption. The route of the administration of a pharmaceutical product is defined in clinical trials, and depends on the physical and chemical properties of the active ingredient, characteristics of the pharmaceutical formulation and the anatomical and physiological characteristics of application sites which enable absorption. An adequate drug administration ensures a predictable level and rate of absorption from the application site, drug concentration at the sites of its action and pharmacological response or therapeutic efficacy. Concomitant use of multiple drugs in the same patient should be avoided because of possible interactions (antagonism or sinergism) which may decrease the activity of a drug and its effectiveness or increase them including appearance of drug toxicity. In addition, mixing drugs in an infusion system or a syringe should be avoided because the absence of visible interaction does not mean that the drugs applied are compatible.
AB  - Prema Zakonu o lekovima i medicinskim sredstvima veterinarski lekovi moraju da budu kvalitetni, dovoljno efikasni i bezbedni za primenu na životinjama. Međutim, brojni su faktori koji mogu da menjaju jačinu dejstva leka, ustanovljenu terapijsku efikasnost i bezbednost. Ovi faktori mogu da potiču od samog pacijenta - životinje (vrsta, uzrast, pol, fiziološko stanje, poremećena funkcija organa za eliminaciju lekova, oboljenja drugih organskih sistema, ishrana, genetski poremećaji, individualne varijacije, tolerancija itd.), veterinara (upotreba leka koja nije u skladu sa uputstvom - 'off label use', nepravilan izbor leka ili kombinacije lekova za vrstu životinje ili patološko stanje, neadekvatan način aplikacije leka, neodgovarajuća doza leka i dužina primene, inkompatibilnost i interakcija) i samog leka (neodgovarajuća formulacija, niska biološka raspoloživost, nestabilnost formulacija, slabljenje dejstva leka pod uticajem spoljašnjih faktora). Nepridržavanje preporučenog uputstva o načinu aplikacije leka, kao i nepravilna aplikacija može da utiče na brzinu i stepen apsorpcije leka. Sam način aplikacije gotovog leka definisan je tokom njegovog kliničkog ispitivanja, i zavisi od fizičko-hemijskih osobina lekovite supstance, karakteristika farmaceutske formulacije i anatomskih i fizioloških osobina mesta aplikacije koja obezbeđuju apsorpciju. Primena leka na preporučen način omogućava predvidljiv stepen i brzinu apsorpcije sa mesta primene, koncentraciju leka na mestu delovanja i farmakološki odgovor, odnosno terapijsku efikasnost. Treba da se izbegava istovremena primena više lekova kod istog pacijenta zbog moguće interakcije (antagonizam ili sinergizam) koja smanjuje aktivnost leka i njegovu efikasnost ili mu, pak, pojačava efekat uključujući i pojavu toksičnosti. Takođe, treba da se izbegava mešanje lekova u infuzionom sistemu ili brizgalici, jer odsustvo vidljivih reakcija ne znači da je mešavina lekova kompatibilna.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Veterinarski Glasnik
T1  - Factors that affect therapeutic efficacy and safety of drugs
T1  - Faktori koji utiču na terapijsku efikasnost i bezbednost lekova
VL  - 69
IS  - 5-6
SP  - 401
EP  - 415
DO  - 10.2298/VETGL1506401J
ER  - 

@article{
author = "Jezdimirović, Milanka and Ćupić, Vitomir and Ivanović, Saša and Dimitrijević, Blagoje and Jezdimirović, Nemanja",
year = "2015",
abstract = "According to the Law on medicines and medicinal devices, veterinary drugs must be of high quality, efficacy and safety to be suitable for use on animals. However, there are numerous factors which can alter the intensity of drugs and their established therapeutic efficacy and safety. These factors may depend on the patients themselves i.e. animals (species, age, sex, physiological state, impaired functions of organs involved in the elimination of drugs, diseases of other organ systems, nutrition, genetic disorders, individual varia­tions, tolerance etc.), veterinary surgeons (use of the drug which is not in accordance with the instructions - 'off-label use', improper selection of a drug or drug combination intended for a certain animal species or pathological condition, inadequate drug administration route, inadequate drug dosage and duration of therapy) and the drug itself (inappropriate formulation, bioavailability, instability of formulation, diminishing drug action due to external factors). Not following the instructions on using a drug and incorrect application may affect the rate and extent of the drug absorption. The route of the administration of a pharmaceutical product is defined in clinical trials, and depends on the physical and chemical properties of the active ingredient, characteristics of the pharmaceutical formulation and the anatomical and physiological characteristics of application sites which enable absorption. An adequate drug administration ensures a predictable level and rate of absorption from the application site, drug concentration at the sites of its action and pharmacological response or therapeutic efficacy. Concomitant use of multiple drugs in the same patient should be avoided because of possible interactions (antagonism or sinergism) which may decrease the activity of a drug and its effectiveness or increase them including appearance of drug toxicity. In addition, mixing drugs in an infusion system or a syringe should be avoided because the absence of visible interaction does not mean that the drugs applied are compatible., Prema Zakonu o lekovima i medicinskim sredstvima veterinarski lekovi moraju da budu kvalitetni, dovoljno efikasni i bezbedni za primenu na životinjama. Međutim, brojni su faktori koji mogu da menjaju jačinu dejstva leka, ustanovljenu terapijsku efikasnost i bezbednost. Ovi faktori mogu da potiču od samog pacijenta - životinje (vrsta, uzrast, pol, fiziološko stanje, poremećena funkcija organa za eliminaciju lekova, oboljenja drugih organskih sistema, ishrana, genetski poremećaji, individualne varijacije, tolerancija itd.), veterinara (upotreba leka koja nije u skladu sa uputstvom - 'off label use', nepravilan izbor leka ili kombinacije lekova za vrstu životinje ili patološko stanje, neadekvatan način aplikacije leka, neodgovarajuća doza leka i dužina primene, inkompatibilnost i interakcija) i samog leka (neodgovarajuća formulacija, niska biološka raspoloživost, nestabilnost formulacija, slabljenje dejstva leka pod uticajem spoljašnjih faktora). Nepridržavanje preporučenog uputstva o načinu aplikacije leka, kao i nepravilna aplikacija može da utiče na brzinu i stepen apsorpcije leka. Sam način aplikacije gotovog leka definisan je tokom njegovog kliničkog ispitivanja, i zavisi od fizičko-hemijskih osobina lekovite supstance, karakteristika farmaceutske formulacije i anatomskih i fizioloških osobina mesta aplikacije koja obezbeđuju apsorpciju. Primena leka na preporučen način omogućava predvidljiv stepen i brzinu apsorpcije sa mesta primene, koncentraciju leka na mestu delovanja i farmakološki odgovor, odnosno terapijsku efikasnost. Treba da se izbegava istovremena primena više lekova kod istog pacijenta zbog moguće interakcije (antagonizam ili sinergizam) koja smanjuje aktivnost leka i njegovu efikasnost ili mu, pak, pojačava efekat uključujući i pojavu toksičnosti. Takođe, treba da se izbegava mešanje lekova u infuzionom sistemu ili brizgalici, jer odsustvo vidljivih reakcija ne znači da je mešavina lekova kompatibilna.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Veterinarski Glasnik",
title = "Factors that affect therapeutic efficacy and safety of drugs, Faktori koji utiču na terapijsku efikasnost i bezbednost lekova",
volume = "69",
number = "5-6",
pages = "401-415",
doi = "10.2298/VETGL1506401J"
}

Jezdimirović, M., Ćupić, V., Ivanović, S., Dimitrijević, B.,& Jezdimirović, N.. (2015). Factors that affect therapeutic efficacy and safety of drugs. in Veterinarski Glasnik
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 69(5-6), 401-415.
https://doi.org/10.2298/VETGL1506401J

Jezdimirović M, Ćupić V, Ivanović S, Dimitrijević B, Jezdimirović N. Factors that affect therapeutic efficacy and safety of drugs. in Veterinarski Glasnik. 2015;69(5-6):401-415.
doi:10.2298/VETGL1506401J .

Jezdimirović, Milanka, Ćupić, Vitomir, Ivanović, Saša, Dimitrijević, Blagoje, Jezdimirović, Nemanja, "Factors that affect therapeutic efficacy and safety of drugs" in Veterinarski Glasnik, 69, no. 5-6 (2015):401-415,
https://doi.org/10.2298/VETGL1506401J . .

TY  - CONF
AU  - Velev, Romel
AU  - Krleska-Veleva, Nataša
AU  - Ćupić, Vitomir
AU  - Ćupić Miladinović, Dejana
PY  - 2015
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1291
AB  - INTRODUCTION
Animal medicines play an important role in the control and
prevention of disease but have the potential to cause harm if
not used properly. The use of veterinary medicines (VM) can
sometimes result in residues in foods taken from the treated
animals and can seriously endangered the health of people as
potential consumers. Therefore, the significance of control of
the VM in these animals is exceptionally high. These include
statutory controls on the authorisation, distribution and use of
such medicines. The aim of this paper is to show legal status
regarding distribution/dispensing and administration of VM in
Macedonia (RM) in order to identify legal weaknesses.
MATERIALS AND METHODS
National Law on VM (Article 47) provides legal basis for distribution of VM in categories. Following evaluation of scientific
data provided by the MAH, for each VM is granted a specific
distribution category by the Food and Veterinary Agency
(FVA) when it is for first time authorised. The data was collected from the web site of sector for Public Health in FVA and
was compared with Veterinary Medicines Regulations in other
countries.
RESULTS
All VM in the RM are assigned into one of six distribution categories. Only veterinary surgeons (VS) are entitled to prescribe
VM and they must be dispensed from registered premises. The
highest level of control is the VM intended for food production
animals which can be used only in veterinary premisses by the
VS or under their direct responsibility. This would include VM
containing controlled drugs and those intended for administration only following a diagnosis and clinical assessment of the
animal(s). VM which can be dispensed in veterinary pharmacies only by written prescription is intended for food production
animals but is not required a clinical assessment. VM intended
for non-food production animals may be supplied by any retailer without any restrictions, or provision of advice.CONCLUSIONS
Distribution categories provide controls on the supply of veterinary medicines to help ensure that appropriate advice is given
at the point of sale so that products can be used safely and
effectively. Also it is a practical tool for identification of different groups of VM for the veterinary practitioners as well as all
subjects involved in production, trade and distribution of VM.
The results obtained given an overall picture of trends in the
use of VM in RM and allows comparison of such trends in
other countries.
PB  - Wiley-Blackwell, Hoboken
C3  - Journal of Veterinary Pharmacology and Therapeutics
T1  - Legal status regarding distribution/dispensing and administration of veterinary medicines in Republic of Macedonia
VL  - 38
SP  - 151
EP  - 152
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_1291
ER  - 

@conference{
author = "Velev, Romel and Krleska-Veleva, Nataša and Ćupić, Vitomir and Ćupić Miladinović, Dejana",
year = "2015",
abstract = "INTRODUCTION
Animal medicines play an important role in the control and
prevention of disease but have the potential to cause harm if
not used properly. The use of veterinary medicines (VM) can
sometimes result in residues in foods taken from the treated
animals and can seriously endangered the health of people as
potential consumers. Therefore, the significance of control of
the VM in these animals is exceptionally high. These include
statutory controls on the authorisation, distribution and use of
such medicines. The aim of this paper is to show legal status
regarding distribution/dispensing and administration of VM in
Macedonia (RM) in order to identify legal weaknesses.
MATERIALS AND METHODS
National Law on VM (Article 47) provides legal basis for distribution of VM in categories. Following evaluation of scientific
data provided by the MAH, for each VM is granted a specific
distribution category by the Food and Veterinary Agency
(FVA) when it is for first time authorised. The data was collected from the web site of sector for Public Health in FVA and
was compared with Veterinary Medicines Regulations in other
countries.
RESULTS
All VM in the RM are assigned into one of six distribution categories. Only veterinary surgeons (VS) are entitled to prescribe
VM and they must be dispensed from registered premises. The
highest level of control is the VM intended for food production
animals which can be used only in veterinary premisses by the
VS or under their direct responsibility. This would include VM
containing controlled drugs and those intended for administration only following a diagnosis and clinical assessment of the
animal(s). VM which can be dispensed in veterinary pharmacies only by written prescription is intended for food production
animals but is not required a clinical assessment. VM intended
for non-food production animals may be supplied by any retailer without any restrictions, or provision of advice.CONCLUSIONS
Distribution categories provide controls on the supply of veterinary medicines to help ensure that appropriate advice is given
at the point of sale so that products can be used safely and
effectively. Also it is a practical tool for identification of different groups of VM for the veterinary practitioners as well as all
subjects involved in production, trade and distribution of VM.
The results obtained given an overall picture of trends in the
use of VM in RM and allows comparison of such trends in
other countries.",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Journal of Veterinary Pharmacology and Therapeutics",
title = "Legal status regarding distribution/dispensing and administration of veterinary medicines in Republic of Macedonia",
volume = "38",
pages = "151-152",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_1291"
}

Velev, R., Krleska-Veleva, N., Ćupić, V.,& Ćupić Miladinović, D.. (2015). Legal status regarding distribution/dispensing and administration of veterinary medicines in Republic of Macedonia. in Journal of Veterinary Pharmacology and Therapeutics
Wiley-Blackwell, Hoboken., 38, 151-152.
https://hdl.handle.net/21.15107/rcub_veterinar_1291

Velev R, Krleska-Veleva N, Ćupić V, Ćupić Miladinović D. Legal status regarding distribution/dispensing and administration of veterinary medicines in Republic of Macedonia. in Journal of Veterinary Pharmacology and Therapeutics. 2015;38:151-152.
https://hdl.handle.net/21.15107/rcub_veterinar_1291 .

Velev, Romel, Krleska-Veleva, Nataša, Ćupić, Vitomir, Ćupić Miladinović, Dejana, "Legal status regarding distribution/dispensing and administration of veterinary medicines in Republic of Macedonia" in Journal of Veterinary Pharmacology and Therapeutics, 38 (2015):151-152,
https://hdl.handle.net/21.15107/rcub_veterinar_1291 .

TY  - CONF
AU  - Ćupić Miladinović, Dejana
AU  - Borozan, Sunčica
AU  - Popović, Z.
AU  - Ćupić, Vitomir
AU  - Velev, Romel
AU  - Antonijević, Biljana
PY  - 2015
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1301
PB  - Elsevier Ireland Ltd, Clare
C3  - Toxicology Letters
T1  - The influence of chlorpyrifos on the activity of butyryilcholinesterase and catalase, as well as concentration of malondialdehyde in plasma of Japanese quail
VL  - 238
IS  - 2
SP  - S111
EP  - S111
DO  - 10.1016/j.toxlet.2015.08.360
ER  - 

@conference{
author = "Ćupić Miladinović, Dejana and Borozan, Sunčica and Popović, Z. and Ćupić, Vitomir and Velev, Romel and Antonijević, Biljana",
year = "2015",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "The influence of chlorpyrifos on the activity of butyryilcholinesterase and catalase, as well as concentration of malondialdehyde in plasma of Japanese quail",
volume = "238",
number = "2",
pages = "S111-S111",
doi = "10.1016/j.toxlet.2015.08.360"
}

Ćupić Miladinović, D., Borozan, S., Popović, Z., Ćupić, V., Velev, R.,& Antonijević, B.. (2015). The influence of chlorpyrifos on the activity of butyryilcholinesterase and catalase, as well as concentration of malondialdehyde in plasma of Japanese quail. in Toxicology Letters
Elsevier Ireland Ltd, Clare., 238(2), S111-S111.
https://doi.org/10.1016/j.toxlet.2015.08.360

Ćupić Miladinović D, Borozan S, Popović Z, Ćupić V, Velev R, Antonijević B. The influence of chlorpyrifos on the activity of butyryilcholinesterase and catalase, as well as concentration of malondialdehyde in plasma of Japanese quail. in Toxicology Letters. 2015;238(2):S111-S111.
doi:10.1016/j.toxlet.2015.08.360 .

Ćupić Miladinović, Dejana, Borozan, Sunčica, Popović, Z., Ćupić, Vitomir, Velev, Romel, Antonijević, Biljana, "The influence of chlorpyrifos on the activity of butyryilcholinesterase and catalase, as well as concentration of malondialdehyde in plasma of Japanese quail" in Toxicology Letters, 238, no. 2 (2015):S111-S111,
https://doi.org/10.1016/j.toxlet.2015.08.360 . .

TY  - JOUR
AU  - Cupara, Snežana
AU  - Ćupić, Vitomir
AU  - Milovanović, Olivera
AU  - Radovanović, Ana
AU  - Kipić, Mihailo
PY  - 2015
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1227
AB  - Classical homeopathy is a method belonging to complementary and alternative medicine and is used in treatment of both people and animals. In human medicine, classical homeopathy has a different status within the European Union, depending on legislation that applies in the member countries Veterinary homeopathy has currently being developed in three directions: scientific researches are being conducted, animals are being treated by homeopathy and education for homeopathic treatment of animals is being organised as well. European Council for Classical Homeopathy (ECCH) in 2007. published a report on homeopathic treatment of animals in Europe. The report encompassed a variety of issues related to homeopathic treatment in veterinary medicine in the countries of the European Union (EU) as well as ECCH members, wherein the situation in Serbia is also mentioned. The current veterinary homeopathy in Serbia is in the early development. Compared to the moment of publication of the report, there is a slight positive change, but there still lacks a standardized education and licencing system in this field.
AB  - Klasična homeopatija je metod koji pripada komplementarnoj i alternativnoj medicini (KAM) i koristi se za lečenje ljudi i životinja. U humanoj medicini klasična homeopatija ima različit status u različitim zemljama članicama Evropske unije, u zavisnosti od zakonske regulative koja važi u svakoj od zemalja. Veterinarska homeopatija se trenutno razvija u 3 pravca: sprovode se naučna istraživanja, homeopatski se leče životinje i organizuje edukacija za homeopatsko lečenje životinja. Evropski savet za klasičnu homeopatiju (European Councile of Classical Homeopathy, ECCH) je 2007. godine objavio izveštaj o homeopatskom lečenju životinja u Evropi. Izveštaj je obuhvatio različita pitanja u vezi sa homeopatskim lečenjem u veterinarskoj medicini u zemljama Evropske unije (EU) i članovima ECCH, pri čemu je navedena i situacija u Srbiji. Aktuelna veterinarska homeopatija u Srbiji je u ranom razvoju. U odnosu na trenutak objavljivanja izveštaja postoje blage pozitivne promene, ali još uvek nedostaje standardizovan način obrazovanja i licenciranja u veterinarskoj homeopatiji.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Veterinarski Glasnik
T1  - Homeopathy in human and veterinary medicine
T1  - Homeopatija u humanoj i veterinarskoj medicini
VL  - 69
IS  - 3-4
SP  - 283
EP  - 292
DO  - 10.2298/VETGL1504283C
ER  - 

@article{
author = "Cupara, Snežana and Ćupić, Vitomir and Milovanović, Olivera and Radovanović, Ana and Kipić, Mihailo",
year = "2015",
abstract = "Classical homeopathy is a method belonging to complementary and alternative medicine and is used in treatment of both people and animals. In human medicine, classical homeopathy has a different status within the European Union, depending on legislation that applies in the member countries Veterinary homeopathy has currently being developed in three directions: scientific researches are being conducted, animals are being treated by homeopathy and education for homeopathic treatment of animals is being organised as well. European Council for Classical Homeopathy (ECCH) in 2007. published a report on homeopathic treatment of animals in Europe. The report encompassed a variety of issues related to homeopathic treatment in veterinary medicine in the countries of the European Union (EU) as well as ECCH members, wherein the situation in Serbia is also mentioned. The current veterinary homeopathy in Serbia is in the early development. Compared to the moment of publication of the report, there is a slight positive change, but there still lacks a standardized education and licencing system in this field., Klasična homeopatija je metod koji pripada komplementarnoj i alternativnoj medicini (KAM) i koristi se za lečenje ljudi i životinja. U humanoj medicini klasična homeopatija ima različit status u različitim zemljama članicama Evropske unije, u zavisnosti od zakonske regulative koja važi u svakoj od zemalja. Veterinarska homeopatija se trenutno razvija u 3 pravca: sprovode se naučna istraživanja, homeopatski se leče životinje i organizuje edukacija za homeopatsko lečenje životinja. Evropski savet za klasičnu homeopatiju (European Councile of Classical Homeopathy, ECCH) je 2007. godine objavio izveštaj o homeopatskom lečenju životinja u Evropi. Izveštaj je obuhvatio različita pitanja u vezi sa homeopatskim lečenjem u veterinarskoj medicini u zemljama Evropske unije (EU) i članovima ECCH, pri čemu je navedena i situacija u Srbiji. Aktuelna veterinarska homeopatija u Srbiji je u ranom razvoju. U odnosu na trenutak objavljivanja izveštaja postoje blage pozitivne promene, ali još uvek nedostaje standardizovan način obrazovanja i licenciranja u veterinarskoj homeopatiji.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Veterinarski Glasnik",
title = "Homeopathy in human and veterinary medicine, Homeopatija u humanoj i veterinarskoj medicini",
volume = "69",
number = "3-4",
pages = "283-292",
doi = "10.2298/VETGL1504283C"
}

Cupara, S., Ćupić, V., Milovanović, O., Radovanović, A.,& Kipić, M.. (2015). Homeopathy in human and veterinary medicine. in Veterinarski Glasnik
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 69(3-4), 283-292.
https://doi.org/10.2298/VETGL1504283C

Cupara S, Ćupić V, Milovanović O, Radovanović A, Kipić M. Homeopathy in human and veterinary medicine. in Veterinarski Glasnik. 2015;69(3-4):283-292.
doi:10.2298/VETGL1504283C .

Cupara, Snežana, Ćupić, Vitomir, Milovanović, Olivera, Radovanović, Ana, Kipić, Mihailo, "Homeopathy in human and veterinary medicine" in Veterinarski Glasnik, 69, no. 3-4 (2015):283-292,
https://doi.org/10.2298/VETGL1504283C . .

TY  - JOUR
AU  - Ivković, Branka
AU  - Gojković-Bukarica, Ljiljana
AU  - Novaković, Radmila
AU  - Ćupić, Vitomir
AU  - Vladimirov, Sote
AU  - Živanović, Vladimir
AU  - Šćepanović, Radisav
PY  - 2014
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1134
AB  - By applying of aconitictest in in vivo experiments in rats under deep anesthesia, there was investigated the antiarrhythmic potential of newly synthetized fluorinated derivatives of propafenone. The animals were divided into four experimental groups. The first (aconitine group) was treated with aconitine at a dose of 60 μg/kg, which led to pronounced cardiac rhythm disorder in a short period of time. The appearance of ventricular extrasystole (VES) was taken as a parameter for ascertainment of cardiac rhytm disorder. The remaining three animal groups were taken for testing the potential of propafenone and propafenone fluorinated derivatives to stop the arrhythmia, and which was induced by i.v. aconitine injection (60 μg/kg). Propafenone, as well as 50F derivative, did not convert the disturbed cardiac rhythm (survival of animals was 0%). By applying 5PF derivative in a dose of 6 mg/kg, the animals survived with occasional establishment of sinus rhythm.
AB  - Primenom akonitinskog testa, u in vivo eksperimentima na pacovima u dubokoj anesteziji, ispitivan je antiaritmijski potencijal novosintetisanih fluoriranih derivata propafenona. Životinje su podeljene u četiri eksperimentalne grupe. Prva grupa (akonitinska grupa) je tretirana akonitinom u dozi od 60 μg/kg t.m., koja dovodi do vidnog poremećaja srčanog ritma u kratkom vremenskom periodu. Kao parameter za registrovanje poremećaja srčanog ritma uzetaje pojava ventrikularne ekstrasistole (VES). Ostale (tri) eksperimentalne grupe činile su životinje na kojima je ispitivan potencijal propafenona i fluoriranih derivata propafenona da zaustave aritmiju indukovanu i.v. injekcijom akonitina (60 μg/kg t.m.). Propafenon, kao i 50F derivat, nisu uspeli da konvertuju poremećen srčani ritam (preživljavanje životinja je 0 %). Prilikom aplikacije 5PF derivata u dozi od 6 mg/kg t.m. životinje su preživele, uz povremeno uspostavljanje sinusnog ritma.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Veterinarski Glasnik
T1  - Testing of newly synthesized propafenone derivatives antiarrhythmic activity in aconitic model of cardiac arrhythmia in rats
T1  - Issledovanie antiaritmičeskoj aktivnosti vnov' sintezirovannyh proizvodnyh propafenona pri modelirovanii akonitovoi aritmii serdca u krys
T1  - Ispitivanje antiaritmijske aktivnosti novosintetisanih derivata propafenona u akonitinskom modelu srčane aritmije kod pacova
VL  - 68
IS  - 5-6
SP  - 281
EP  - 290
DO  - 10.2298/VETGL1406281I
ER  - 

@article{
author = "Ivković, Branka and Gojković-Bukarica, Ljiljana and Novaković, Radmila and Ćupić, Vitomir and Vladimirov, Sote and Živanović, Vladimir and Šćepanović, Radisav",
year = "2014",
abstract = "By applying of aconitictest in in vivo experiments in rats under deep anesthesia, there was investigated the antiarrhythmic potential of newly synthetized fluorinated derivatives of propafenone. The animals were divided into four experimental groups. The first (aconitine group) was treated with aconitine at a dose of 60 μg/kg, which led to pronounced cardiac rhythm disorder in a short period of time. The appearance of ventricular extrasystole (VES) was taken as a parameter for ascertainment of cardiac rhytm disorder. The remaining three animal groups were taken for testing the potential of propafenone and propafenone fluorinated derivatives to stop the arrhythmia, and which was induced by i.v. aconitine injection (60 μg/kg). Propafenone, as well as 50F derivative, did not convert the disturbed cardiac rhythm (survival of animals was 0%). By applying 5PF derivative in a dose of 6 mg/kg, the animals survived with occasional establishment of sinus rhythm., Primenom akonitinskog testa, u in vivo eksperimentima na pacovima u dubokoj anesteziji, ispitivan je antiaritmijski potencijal novosintetisanih fluoriranih derivata propafenona. Životinje su podeljene u četiri eksperimentalne grupe. Prva grupa (akonitinska grupa) je tretirana akonitinom u dozi od 60 μg/kg t.m., koja dovodi do vidnog poremećaja srčanog ritma u kratkom vremenskom periodu. Kao parameter za registrovanje poremećaja srčanog ritma uzetaje pojava ventrikularne ekstrasistole (VES). Ostale (tri) eksperimentalne grupe činile su životinje na kojima je ispitivan potencijal propafenona i fluoriranih derivata propafenona da zaustave aritmiju indukovanu i.v. injekcijom akonitina (60 μg/kg t.m.). Propafenon, kao i 50F derivat, nisu uspeli da konvertuju poremećen srčani ritam (preživljavanje životinja je 0 %). Prilikom aplikacije 5PF derivata u dozi od 6 mg/kg t.m. životinje su preživele, uz povremeno uspostavljanje sinusnog ritma.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Veterinarski Glasnik",
title = "Testing of newly synthesized propafenone derivatives antiarrhythmic activity in aconitic model of cardiac arrhythmia in rats, Issledovanie antiaritmičeskoj aktivnosti vnov' sintezirovannyh proizvodnyh propafenona pri modelirovanii akonitovoi aritmii serdca u krys, Ispitivanje antiaritmijske aktivnosti novosintetisanih derivata propafenona u akonitinskom modelu srčane aritmije kod pacova",
volume = "68",
number = "5-6",
pages = "281-290",
doi = "10.2298/VETGL1406281I"
}

Ivković, B., Gojković-Bukarica, L., Novaković, R., Ćupić, V., Vladimirov, S., Živanović, V.,& Šćepanović, R.. (2014). Testing of newly synthesized propafenone derivatives antiarrhythmic activity in aconitic model of cardiac arrhythmia in rats. in Veterinarski Glasnik
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 68(5-6), 281-290.
https://doi.org/10.2298/VETGL1406281I

Ivković B, Gojković-Bukarica L, Novaković R, Ćupić V, Vladimirov S, Živanović V, Šćepanović R. Testing of newly synthesized propafenone derivatives antiarrhythmic activity in aconitic model of cardiac arrhythmia in rats. in Veterinarski Glasnik. 2014;68(5-6):281-290.
doi:10.2298/VETGL1406281I .

Ivković, Branka, Gojković-Bukarica, Ljiljana, Novaković, Radmila, Ćupić, Vitomir, Vladimirov, Sote, Živanović, Vladimir, Šćepanović, Radisav, "Testing of newly synthesized propafenone derivatives antiarrhythmic activity in aconitic model of cardiac arrhythmia in rats" in Veterinarski Glasnik, 68, no. 5-6 (2014):281-290,
https://doi.org/10.2298/VETGL1406281I . .

TY  - JOUR
AU  - Ivković, Branka
AU  - Gojković-Bukarica, Ljiljana
AU  - Vladimirov, Sote
AU  - Novaković, Radmila
AU  - Ćupić, Vitomir
AU  - Lešić, A.
AU  - Bumbaširević, Marko
AU  - Šćepanović, R.
PY  - 2013
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1071
AB  - The information on the inhibitory effect of propafenone in vascular smooth muscle is sparse. Propafenone acts through blockage of voltage-dependent cardiac Na+ channels, L-type Ca2+ channels, voltage-sensitive K+ (Kv) channels, as well as β-adrenergic receptors in the heart. The introduction of different chemical groups in the benzyl moiety of propafenone influences pharmacological properties of newly developed derivate of propafenone. Here we investigated the effect of new ortho-chloro derivate of propafenone (5OCl) on the vascular tone of precontracted rat aorta. 5OCl produced endothelium-independent relaxation of rat aorta. In order to test the involvement of different ion channels in 5OCl mechanism of action, antagonist of Na+, lidocaine, KV channels, 4-aminopyiridine (4-AP) and L-type Ca2+ channels, nifedipine were used. All tested antagonists of ion channels did not influence the relaxation of rat aorta induced by high a concentration of 5OCl (≥10 μM), but antagonized the relaxation induced by low concentrations of this propafenone derivate. Thus, 5OCl derivate has comparable potency and efficacy as propafenone. According to its interaction with lidocaine, 4-AP and nifedipine it seems that 5OCl partly shares the mechanism of action with propafenone. The mechanism of vasodilatation induced by high micromolar concentration of 5OCl is not defined and further investigations are necessary.
AB  - Informacije o efektima propafenona na vaskularne glatke mišiće su oskudne. Propafenon blokira voltažno-zavisne Na+ kanale, Ca2+ kanale L-tipa, voltažno-senzitivne K+ (Kv) kanale i β-adrenergičke receptore u srcu. Uvođenje različitih hemijskih grupa u benzilni deo molekula propafenona utiče na promenu njegovih farmakoloških osobina. U ovoj studiji je ispitivan uticaj novog orto-hloro derivata (5OCl) propafenona na vaskularni tonus prekontrahovane aorte pacova. Orto hlorni derivat (5OCl) je izazvao endotel-nezavisnu relaksaciju aortnih prstenova. Da bi se ispitala uloga različitih jonskih kanala u ovoj relaksaciji, korišćeni su lidokain, (antagonist Na+ kanala), 4-aminopiridin (antagonist Kv kanala) i nifedipin (antagonist Ca2+ kanala L-tipa). Testirani antagonisti jonskih kanala nisu uticali na relaksaciju aorte pacova izazvanu visokom koncentracijom 5OCl (≥10 μM), ali su zato antagonizovali relaksaciju aorte koncentracijama 5OCl koje su bile manje od 10 μM. Prema tome, 5OCl derivat ima sličnu jačinu i efikasnost kao propafenon. Prema njegovoj interakciji sa lidokainom, 4-AP i nifedipinom može se reći da je mehanizam dejstva 5OCl sličan propafenonu. Mehanizam vazodilatacije 5OCl derivata u koncentracijama većim od 10 μM nije definisan i za to su potrebna dalja istraživanja.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta Veterinaria-Beograd
T1  - The novel ortho-chloro derivate propafenone induced relaxation in isolated rat aorta
T1  - Relaksacija aorte pacova indukovana novosintetisanim orto-hlornim derivatom propafenona
VL  - 63
IS  - 4
SP  - 363
EP  - 371
DO  - 10.2298/AVB1304363I
ER  - 

@article{
author = "Ivković, Branka and Gojković-Bukarica, Ljiljana and Vladimirov, Sote and Novaković, Radmila and Ćupić, Vitomir and Lešić, A. and Bumbaširević, Marko and Šćepanović, R.",
year = "2013",
abstract = "The information on the inhibitory effect of propafenone in vascular smooth muscle is sparse. Propafenone acts through blockage of voltage-dependent cardiac Na+ channels, L-type Ca2+ channels, voltage-sensitive K+ (Kv) channels, as well as β-adrenergic receptors in the heart. The introduction of different chemical groups in the benzyl moiety of propafenone influences pharmacological properties of newly developed derivate of propafenone. Here we investigated the effect of new ortho-chloro derivate of propafenone (5OCl) on the vascular tone of precontracted rat aorta. 5OCl produced endothelium-independent relaxation of rat aorta. In order to test the involvement of different ion channels in 5OCl mechanism of action, antagonist of Na+, lidocaine, KV channels, 4-aminopyiridine (4-AP) and L-type Ca2+ channels, nifedipine were used. All tested antagonists of ion channels did not influence the relaxation of rat aorta induced by high a concentration of 5OCl (≥10 μM), but antagonized the relaxation induced by low concentrations of this propafenone derivate. Thus, 5OCl derivate has comparable potency and efficacy as propafenone. According to its interaction with lidocaine, 4-AP and nifedipine it seems that 5OCl partly shares the mechanism of action with propafenone. The mechanism of vasodilatation induced by high micromolar concentration of 5OCl is not defined and further investigations are necessary., Informacije o efektima propafenona na vaskularne glatke mišiće su oskudne. Propafenon blokira voltažno-zavisne Na+ kanale, Ca2+ kanale L-tipa, voltažno-senzitivne K+ (Kv) kanale i β-adrenergičke receptore u srcu. Uvođenje različitih hemijskih grupa u benzilni deo molekula propafenona utiče na promenu njegovih farmakoloških osobina. U ovoj studiji je ispitivan uticaj novog orto-hloro derivata (5OCl) propafenona na vaskularni tonus prekontrahovane aorte pacova. Orto hlorni derivat (5OCl) je izazvao endotel-nezavisnu relaksaciju aortnih prstenova. Da bi se ispitala uloga različitih jonskih kanala u ovoj relaksaciji, korišćeni su lidokain, (antagonist Na+ kanala), 4-aminopiridin (antagonist Kv kanala) i nifedipin (antagonist Ca2+ kanala L-tipa). Testirani antagonisti jonskih kanala nisu uticali na relaksaciju aorte pacova izazvanu visokom koncentracijom 5OCl (≥10 μM), ali su zato antagonizovali relaksaciju aorte koncentracijama 5OCl koje su bile manje od 10 μM. Prema tome, 5OCl derivat ima sličnu jačinu i efikasnost kao propafenon. Prema njegovoj interakciji sa lidokainom, 4-AP i nifedipinom može se reći da je mehanizam dejstva 5OCl sličan propafenonu. Mehanizam vazodilatacije 5OCl derivata u koncentracijama većim od 10 μM nije definisan i za to su potrebna dalja istraživanja.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta Veterinaria-Beograd",
title = "The novel ortho-chloro derivate propafenone induced relaxation in isolated rat aorta, Relaksacija aorte pacova indukovana novosintetisanim orto-hlornim derivatom propafenona",
volume = "63",
number = "4",
pages = "363-371",
doi = "10.2298/AVB1304363I"
}

Ivković, B., Gojković-Bukarica, L., Vladimirov, S., Novaković, R., Ćupić, V., Lešić, A., Bumbaširević, M.,& Šćepanović, R.. (2013). The novel ortho-chloro derivate propafenone induced relaxation in isolated rat aorta. in Acta Veterinaria-Beograd
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 63(4), 363-371.
https://doi.org/10.2298/AVB1304363I

Ivković B, Gojković-Bukarica L, Vladimirov S, Novaković R, Ćupić V, Lešić A, Bumbaširević M, Šćepanović R. The novel ortho-chloro derivate propafenone induced relaxation in isolated rat aorta. in Acta Veterinaria-Beograd. 2013;63(4):363-371.
doi:10.2298/AVB1304363I .

Ivković, Branka, Gojković-Bukarica, Ljiljana, Vladimirov, Sote, Novaković, Radmila, Ćupić, Vitomir, Lešić, A., Bumbaširević, Marko, Šćepanović, R., "The novel ortho-chloro derivate propafenone induced relaxation in isolated rat aorta" in Acta Veterinaria-Beograd, 63, no. 4 (2013):363-371,
https://doi.org/10.2298/AVB1304363I . .

TY  - JOUR
AU  - Smajlović, Ahmed
AU  - Muminović, Mehmed
AU  - Mujezinović, Indira
AU  - Ćupić, Vitomir
PY  - 2012
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/909
AB  - Aflatoxin M1 is a highly toxic 4-hydroxylated metabolite of aflatoxins B1 and B2. It is one of the most potent hepatocarcinogens, mutagens, teratogens and immunosuppressors. Feed is often contaminated with aflatoxigenic moulds and aflatoxins with a high possibility of contaminating milk and dairy products with aflatoxin M1. Samples of artificially contaminated milk were exposed to the effects of physical conditions (temperature of -18oC and for microwaves in a microwave oven), time (during the period from 1 to 12 months) and a combination of the above mentioned conditions. Following this, levels of aflatoxin M1 degradation were established by using the ELISA method. An insignificant decrease in concentration of toxin was observed which indicates that a temperature of -18°C does not significantly influence the concentration of aflatoxin M1 in the artificially contaminated milk. At the same time, treatment of milk with microwaves in a microwave oven showed an insignificant influence on the percentage of aflatoxin M1 absorbance.
AB  - Aflatoksin M1 je veoma toksičan metabolit aflatoksina B1 i B2. S obzirom na to da je jedan od najpotentnijih hepatokarcinogena, mutagena, teratogena i imunosupresora, a hrana za životinje često bude kontaminirana aflatoksinogenim gljivicama i aflatoksinima, moguća je i kontaminacija mlijeka i mliječnih proizvoda aflatoksinom M1. Vještački kontaminirano mlijeko aflatoksinom M1 je bilo podvrgnuto uticaju fizikalnih procesa (uticaj niske temperature od -18oC i izlaganja mikrotalasima u mikrotalasnoj rerni), te uticaju vremena držanja (od 1 do 12 mjeseci), kao i uticaju kombinacija navedenih postupaka, nakon čega je praćen nivo degradacije aflatoksina M1. Uzorci vještački kontaminiranog mlijeka, nakon pojedinačno provedenih postupaka su podvrgavani istraživanjima uz korištenje ELISA metode. Primjećeno je neznatno smanjenje koncentracije toksina, što ukazuje na to da vrijeme i temperatura od -18°C ne utiču znatnije na koncentraciju aflatoksina M1 u vještački kontaminiranom sirovom mlijeku, dok postupak tretiranja mlijeka mikrotalasima u mikrotalasnoj rerni nije značajnije uticao na postotak apsorbance aflatoksina M1.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Veterinarski Glasnik
T1  - Investigation of aflatoxin M1 degradation in milk
T1  - Istraživanje degradacije aflatoksina M1 u mlijeku
VL  - 66
IS  - 5-6
SP  - 387
EP  - 394
DO  - 10.2298/VETGL1206387S
ER  - 

@article{
author = "Smajlović, Ahmed and Muminović, Mehmed and Mujezinović, Indira and Ćupić, Vitomir",
year = "2012",
abstract = "Aflatoxin M1 is a highly toxic 4-hydroxylated metabolite of aflatoxins B1 and B2. It is one of the most potent hepatocarcinogens, mutagens, teratogens and immunosuppressors. Feed is often contaminated with aflatoxigenic moulds and aflatoxins with a high possibility of contaminating milk and dairy products with aflatoxin M1. Samples of artificially contaminated milk were exposed to the effects of physical conditions (temperature of -18oC and for microwaves in a microwave oven), time (during the period from 1 to 12 months) and a combination of the above mentioned conditions. Following this, levels of aflatoxin M1 degradation were established by using the ELISA method. An insignificant decrease in concentration of toxin was observed which indicates that a temperature of -18°C does not significantly influence the concentration of aflatoxin M1 in the artificially contaminated milk. At the same time, treatment of milk with microwaves in a microwave oven showed an insignificant influence on the percentage of aflatoxin M1 absorbance., Aflatoksin M1 je veoma toksičan metabolit aflatoksina B1 i B2. S obzirom na to da je jedan od najpotentnijih hepatokarcinogena, mutagena, teratogena i imunosupresora, a hrana za životinje često bude kontaminirana aflatoksinogenim gljivicama i aflatoksinima, moguća je i kontaminacija mlijeka i mliječnih proizvoda aflatoksinom M1. Vještački kontaminirano mlijeko aflatoksinom M1 je bilo podvrgnuto uticaju fizikalnih procesa (uticaj niske temperature od -18oC i izlaganja mikrotalasima u mikrotalasnoj rerni), te uticaju vremena držanja (od 1 do 12 mjeseci), kao i uticaju kombinacija navedenih postupaka, nakon čega je praćen nivo degradacije aflatoksina M1. Uzorci vještački kontaminiranog mlijeka, nakon pojedinačno provedenih postupaka su podvrgavani istraživanjima uz korištenje ELISA metode. Primjećeno je neznatno smanjenje koncentracije toksina, što ukazuje na to da vrijeme i temperatura od -18°C ne utiču znatnije na koncentraciju aflatoksina M1 u vještački kontaminiranom sirovom mlijeku, dok postupak tretiranja mlijeka mikrotalasima u mikrotalasnoj rerni nije značajnije uticao na postotak apsorbance aflatoksina M1.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Veterinarski Glasnik",
title = "Investigation of aflatoxin M1 degradation in milk, Istraživanje degradacije aflatoksina M1 u mlijeku",
volume = "66",
number = "5-6",
pages = "387-394",
doi = "10.2298/VETGL1206387S"
}

Smajlović, A., Muminović, M., Mujezinović, I.,& Ćupić, V.. (2012). Investigation of aflatoxin M1 degradation in milk. in Veterinarski Glasnik
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 66(5-6), 387-394.
https://doi.org/10.2298/VETGL1206387S

Smajlović A, Muminović M, Mujezinović I, Ćupić V. Investigation of aflatoxin M1 degradation in milk. in Veterinarski Glasnik. 2012;66(5-6):387-394.
doi:10.2298/VETGL1206387S .

Smajlović, Ahmed, Muminović, Mehmed, Mujezinović, Indira, Ćupić, Vitomir, "Investigation of aflatoxin M1 degradation in milk" in Veterinarski Glasnik, 66, no. 5-6 (2012):387-394,
https://doi.org/10.2298/VETGL1206387S . .

TY  - JOUR
AU  - Bulat, Zorica
AU  - Đukić-Ćosić, Danijela
AU  - Buha, Aleksandra
AU  - Ćupić, Vitomir
AU  - Pavlović, Zoran
AU  - Matović, Vesna
PY  - 2012
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/910
AB  - Cadmium (Cd) is today one of the most significant metal poisons, both in the area of professional as well as of eco toxicology. In the organism, cadmium has a harmful effect on the kidneys, liver, bones, testicles, etc., and, based on evidence in humans that it causes lung carcinoma, it has been placed in the first group of carcinogens. In spite of numerous data in literature on the harmful effects of cadmium, the interactions between cadmium and bioelements as a significant mechanism for cadmium toxicity have still not been sufficiently explained. Since the data so far point to a positive effect of supplementation with certain bioelements regarding toxicity and cadmium content in the organism, the objective of this work was to investigate the effect of increased simultaneous intake of magnesium, zinc and copper on urinary elimination of cadmium in rabbits exposed to cadmium. Rabbits were divided into two groups: Cd group - for a period of 28 days the animals received per os 10 mg Cd/kg b.m/day and Cd+(Mg+Zn+Cu) group - 10 mg Cd/kg b.m. + 40 mg Mg/kg b.m, 20 mg Zn/kg b.m. and 10 mg Cu/kg b.m/day. Daily urine was collected on days 0, 10, 15, 17, 19, 21, 23, 25, and 28 of the experiment. Following decomposition of urine samples with the help of concentrated HNO3 and HClO4 (4:1), the metal concentration was determined using the method of atomic absorption spectrophotometry. Supplementation with magnesium, zinc and copper did not result in significant changes in the elimination of cadmium through urine in animals poisoned with cadmium, in comparison with the animals that were administered only cadmium, while the concentration of all three applied bioelements in urine was significantly increased. It can be concluded that the simultaneous administration of increased doses of zinc, copper and magnesium does not have a positive effect on the elimination of cadmium in conditions when rabbits are poisoned with cadmium.
AB  - Kadmijum (Cd) je danas jedan od najznačajnijih metalnih otrova, kako u oblasti profesionalne tako i ekotoksikologije. U organizmu, Cd štetno deluje na bubrege, jetru, kosti, testise itd., a na osnovu dokaza da na ljudima izaziva karcinom pluća svrstan je i u I grupu karcinogena. I pored brojnih literaturnih podataka o štetnim efektima Cd, interakcije kadmijuma i bioelemenata kao značajnog mehanizma toksičnosti kadmijuma, još uvek nisu dovoljno razjašnjene. S obzirom na to da dosadašnji podaci ukazuju na pozitivan efekat suplementacije pojedinim bioelementima na toksičnost i sadržaj kadmijuma u organizmu, cilj ovog rada je bio da se ispita uticaj povećanog istovremenog unosa magnezijuma, cinka i bakra na urinarnu eliminaciju kadmijuma kod kunića izloženih kadmijumu. Kunići su bili podeljeni u dve grupe: I Cd grupa - životinje su 28 dana primale per os 10 mg Cd/kg t.m/dan i II grupa - Cd+ (Mg+Zn+Cu): 10 mg Cd/kg t.m. + 40 mg Mg/kg t.m, 20 mg Zn/kg t.m. i 10 mg Cu/kg t.m/dan. Dnevni urin je sakupljan 0, 10, 15, 17, 19, 21, 23, 25. i 28. dana eksperimenta. Nakon razaranja uzoraka urina uz pomoć koncentrovanih HNO3 i HClO4 (4:1), koncentracija metala je određena metodom atomske apsorpcione spektrofotometrije. Suplementacija magnezijumom, cinkom i bakrom nije dovela do značajne promene u eliminaciji kadmijuma urinom kod životinja trovanih kadmijumom u poređenju sa životinjama koje su primale samo kadmijum, dok je koncentracija sva tri primenjena bioelementa u urinu bila značajno povećana. Može se zaključiti da istovremeno davanje povećanih doza cinka, bakra i magnezijuma ne ispoljava pozitivan efekat na eliminaciju kadmijuma u uslovima trovanja kunića kadmijumom.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Veterinarski Glasnik
T1  - Investigations of effects of magnesium, zinc and copper on cadmium excretion in rabbits
T1  - Ispitivanje uticaja magnezijuma, cinka i bakra na izlučivanje kadmijuma kod kunića
VL  - 66
IS  - 5-6
SP  - 395
EP  - 406
DO  - 10.2298/VETGL1206395B
ER  - 

@article{
author = "Bulat, Zorica and Đukić-Ćosić, Danijela and Buha, Aleksandra and Ćupić, Vitomir and Pavlović, Zoran and Matović, Vesna",
year = "2012",
abstract = "Cadmium (Cd) is today one of the most significant metal poisons, both in the area of professional as well as of eco toxicology. In the organism, cadmium has a harmful effect on the kidneys, liver, bones, testicles, etc., and, based on evidence in humans that it causes lung carcinoma, it has been placed in the first group of carcinogens. In spite of numerous data in literature on the harmful effects of cadmium, the interactions between cadmium and bioelements as a significant mechanism for cadmium toxicity have still not been sufficiently explained. Since the data so far point to a positive effect of supplementation with certain bioelements regarding toxicity and cadmium content in the organism, the objective of this work was to investigate the effect of increased simultaneous intake of magnesium, zinc and copper on urinary elimination of cadmium in rabbits exposed to cadmium. Rabbits were divided into two groups: Cd group - for a period of 28 days the animals received per os 10 mg Cd/kg b.m/day and Cd+(Mg+Zn+Cu) group - 10 mg Cd/kg b.m. + 40 mg Mg/kg b.m, 20 mg Zn/kg b.m. and 10 mg Cu/kg b.m/day. Daily urine was collected on days 0, 10, 15, 17, 19, 21, 23, 25, and 28 of the experiment. Following decomposition of urine samples with the help of concentrated HNO3 and HClO4 (4:1), the metal concentration was determined using the method of atomic absorption spectrophotometry. Supplementation with magnesium, zinc and copper did not result in significant changes in the elimination of cadmium through urine in animals poisoned with cadmium, in comparison with the animals that were administered only cadmium, while the concentration of all three applied bioelements in urine was significantly increased. It can be concluded that the simultaneous administration of increased doses of zinc, copper and magnesium does not have a positive effect on the elimination of cadmium in conditions when rabbits are poisoned with cadmium., Kadmijum (Cd) je danas jedan od najznačajnijih metalnih otrova, kako u oblasti profesionalne tako i ekotoksikologije. U organizmu, Cd štetno deluje na bubrege, jetru, kosti, testise itd., a na osnovu dokaza da na ljudima izaziva karcinom pluća svrstan je i u I grupu karcinogena. I pored brojnih literaturnih podataka o štetnim efektima Cd, interakcije kadmijuma i bioelemenata kao značajnog mehanizma toksičnosti kadmijuma, još uvek nisu dovoljno razjašnjene. S obzirom na to da dosadašnji podaci ukazuju na pozitivan efekat suplementacije pojedinim bioelementima na toksičnost i sadržaj kadmijuma u organizmu, cilj ovog rada je bio da se ispita uticaj povećanog istovremenog unosa magnezijuma, cinka i bakra na urinarnu eliminaciju kadmijuma kod kunića izloženih kadmijumu. Kunići su bili podeljeni u dve grupe: I Cd grupa - životinje su 28 dana primale per os 10 mg Cd/kg t.m/dan i II grupa - Cd+ (Mg+Zn+Cu): 10 mg Cd/kg t.m. + 40 mg Mg/kg t.m, 20 mg Zn/kg t.m. i 10 mg Cu/kg t.m/dan. Dnevni urin je sakupljan 0, 10, 15, 17, 19, 21, 23, 25. i 28. dana eksperimenta. Nakon razaranja uzoraka urina uz pomoć koncentrovanih HNO3 i HClO4 (4:1), koncentracija metala je određena metodom atomske apsorpcione spektrofotometrije. Suplementacija magnezijumom, cinkom i bakrom nije dovela do značajne promene u eliminaciji kadmijuma urinom kod životinja trovanih kadmijumom u poređenju sa životinjama koje su primale samo kadmijum, dok je koncentracija sva tri primenjena bioelementa u urinu bila značajno povećana. Može se zaključiti da istovremeno davanje povećanih doza cinka, bakra i magnezijuma ne ispoljava pozitivan efekat na eliminaciju kadmijuma u uslovima trovanja kunića kadmijumom.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Veterinarski Glasnik",
title = "Investigations of effects of magnesium, zinc and copper on cadmium excretion in rabbits, Ispitivanje uticaja magnezijuma, cinka i bakra na izlučivanje kadmijuma kod kunića",
volume = "66",
number = "5-6",
pages = "395-406",
doi = "10.2298/VETGL1206395B"
}

Bulat, Z., Đukić-Ćosić, D., Buha, A., Ćupić, V., Pavlović, Z.,& Matović, V.. (2012). Investigations of effects of magnesium, zinc and copper on cadmium excretion in rabbits. in Veterinarski Glasnik
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 66(5-6), 395-406.
https://doi.org/10.2298/VETGL1206395B

Bulat Z, Đukić-Ćosić D, Buha A, Ćupić V, Pavlović Z, Matović V. Investigations of effects of magnesium, zinc and copper on cadmium excretion in rabbits. in Veterinarski Glasnik. 2012;66(5-6):395-406.
doi:10.2298/VETGL1206395B .

Bulat, Zorica, Đukić-Ćosić, Danijela, Buha, Aleksandra, Ćupić, Vitomir, Pavlović, Zoran, Matović, Vesna, "Investigations of effects of magnesium, zinc and copper on cadmium excretion in rabbits" in Veterinarski Glasnik, 66, no. 5-6 (2012):395-406,
https://doi.org/10.2298/VETGL1206395B . .

TY  - JOUR
AU  - Antonijević, Biljana
AU  - Vučinić, Slavica
AU  - Ćupić, Vitomir
PY  - 2012
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/871
AB  - The aim of this study was to compare the protective effect of two individual oximes (HI-6 and trimedoxime) with their combination in mice acutely poisoned with tabun, dichlorvos or heptenophos. Oxime HI-6 did not protect experimental animals against either dichlorvos, heptenophos or tabun. Trimedoxime was very effective against all three OPs. The ED-500 doses of trimedoxime necessary to protect 50% of animals after the simultaneous administration of OPs and oxime were 42.18, 14.97 and 32.08 μmol/kg in dichlorvos, heptenophos and tabun poisoning, respectively. Half-time of efficacy in the tabun protocol was approximately three and two times longer than in the protocol for heptenophos and dichlorvos, respectively indicating also that trimedoxime is very potent in counteracting tabun toxicity. Addition of trimedoxime significantly improved the protective effect of HI-6 in acute tabun poisoning. When dichlorvos or heptenophos were used, addition of trimedoxime generally improved the antidotal effect of HI-6, but still lower protection was obtained than in the case when trimedoxime alone was administered. The investigations of different oxime combinations have indicated that application of a mixture of two oximes represents a promising antidotal approach.
AB  - Cilj ovog rada je bio da se uporedi zaštitni efekat pojedinačnih oksima HI-6 i trimedoksima sa zaštitnim efektom njihove kombinacije u miševa akutno trovanih tabunom, dihlorvosom ili heptenofosom. Oksim HI-6 nije štitio eksperimentalne životinje od trovanja, ali je trimedoksim bio veoma efikasan u antagonitovanju toksičnih efekata sva tri organofosforna jedinjenja. ED-500 doze trimedoksima potrebne da zaštite 50% životinja pri istovremenoj primeni organofosfata i oksima iznosile su 42,18, 14,97 i 32,08 μmol/kg kod trovanja dihlorvosom, heptenofosom odnosno tabunom. Poluvreme efikasnosti trimedoksima u tretmanu sa tabunom bilo je dva odnosno tri puta duže od poluvremena izračunatih kod trovanja heptenofosom odnosno dihlorvosom. Dodatak trimedoksima doveo je do značajnog poboljšanja zaštitnog efekta HI-6 kod trovanja tabunom. Dodatak trimedoksima takođe je poboljšao zaštitni efekat HI-6 i kod ostala dva otrova, ali je zaštita i dalje bila najbolja kada je primenjen sam trimedoksim. Ispitivanja različitih kombinacija oksima ukazuju da je primena smeše dva oksima opravdani pristup u prevazilaženju problema nejednake efikasnosti oksima.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta Veterinaria-Beograd
T1  - Protective effect of HI-6 and trimedoxime combination in mice acutely poisoned with tabun, dichlorvos or heptenophos
T1  - Zaštitni efekat kombinacije HI-6 i trimedoksima u miševa akutno trovanih tabunom, dihlorvosom ili heptenofosom
VL  - 62
IS  - 2-3
SP  - 123
EP  - 135
DO  - 10.2298/AVB1203123A
ER  - 

@article{
author = "Antonijević, Biljana and Vučinić, Slavica and Ćupić, Vitomir",
year = "2012",
abstract = "The aim of this study was to compare the protective effect of two individual oximes (HI-6 and trimedoxime) with their combination in mice acutely poisoned with tabun, dichlorvos or heptenophos. Oxime HI-6 did not protect experimental animals against either dichlorvos, heptenophos or tabun. Trimedoxime was very effective against all three OPs. The ED-500 doses of trimedoxime necessary to protect 50% of animals after the simultaneous administration of OPs and oxime were 42.18, 14.97 and 32.08 μmol/kg in dichlorvos, heptenophos and tabun poisoning, respectively. Half-time of efficacy in the tabun protocol was approximately three and two times longer than in the protocol for heptenophos and dichlorvos, respectively indicating also that trimedoxime is very potent in counteracting tabun toxicity. Addition of trimedoxime significantly improved the protective effect of HI-6 in acute tabun poisoning. When dichlorvos or heptenophos were used, addition of trimedoxime generally improved the antidotal effect of HI-6, but still lower protection was obtained than in the case when trimedoxime alone was administered. The investigations of different oxime combinations have indicated that application of a mixture of two oximes represents a promising antidotal approach., Cilj ovog rada je bio da se uporedi zaštitni efekat pojedinačnih oksima HI-6 i trimedoksima sa zaštitnim efektom njihove kombinacije u miševa akutno trovanih tabunom, dihlorvosom ili heptenofosom. Oksim HI-6 nije štitio eksperimentalne životinje od trovanja, ali je trimedoksim bio veoma efikasan u antagonitovanju toksičnih efekata sva tri organofosforna jedinjenja. ED-500 doze trimedoksima potrebne da zaštite 50% životinja pri istovremenoj primeni organofosfata i oksima iznosile su 42,18, 14,97 i 32,08 μmol/kg kod trovanja dihlorvosom, heptenofosom odnosno tabunom. Poluvreme efikasnosti trimedoksima u tretmanu sa tabunom bilo je dva odnosno tri puta duže od poluvremena izračunatih kod trovanja heptenofosom odnosno dihlorvosom. Dodatak trimedoksima doveo je do značajnog poboljšanja zaštitnog efekta HI-6 kod trovanja tabunom. Dodatak trimedoksima takođe je poboljšao zaštitni efekat HI-6 i kod ostala dva otrova, ali je zaštita i dalje bila najbolja kada je primenjen sam trimedoksim. Ispitivanja različitih kombinacija oksima ukazuju da je primena smeše dva oksima opravdani pristup u prevazilaženju problema nejednake efikasnosti oksima.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta Veterinaria-Beograd",
title = "Protective effect of HI-6 and trimedoxime combination in mice acutely poisoned with tabun, dichlorvos or heptenophos, Zaštitni efekat kombinacije HI-6 i trimedoksima u miševa akutno trovanih tabunom, dihlorvosom ili heptenofosom",
volume = "62",
number = "2-3",
pages = "123-135",
doi = "10.2298/AVB1203123A"
}

Antonijević, B., Vučinić, S.,& Ćupić, V.. (2012). Protective effect of HI-6 and trimedoxime combination in mice acutely poisoned with tabun, dichlorvos or heptenophos. in Acta Veterinaria-Beograd
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 62(2-3), 123-135.
https://doi.org/10.2298/AVB1203123A

Antonijević B, Vučinić S, Ćupić V. Protective effect of HI-6 and trimedoxime combination in mice acutely poisoned with tabun, dichlorvos or heptenophos. in Acta Veterinaria-Beograd. 2012;62(2-3):123-135.
doi:10.2298/AVB1203123A .

Antonijević, Biljana, Vučinić, Slavica, Ćupić, Vitomir, "Protective effect of HI-6 and trimedoxime combination in mice acutely poisoned with tabun, dichlorvos or heptenophos" in Acta Veterinaria-Beograd, 62, no. 2-3 (2012):123-135,
https://doi.org/10.2298/AVB1203123A . .

TY  - JOUR
AU  - Janković, Saša
AU  - Antonijević, Biljana
AU  - Ćurčić, Marijana
AU  - Radičević, Tatjana
AU  - Stefanović, Srđan
AU  - Nikolić, Dragica M.
AU  - Ćupić, Vitomir
PY  - 2012
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/903
AB  - Nutritional benefits of fish can be attributed primarily to the content of high-quality proteins, vitamins, elements and omega-3 polyunsaturated fatty acids. On the other hand, fish and fishery products are susceptible to contamination by chemicals that have been recognized as ubiquitous environmental pollutants such as toxic elements and polychlorinated organic compounds. Fish consumption could be therefore considered as one of the major sources of human exposure to all above-mentioned environmental contaminants. This paper is focused on mercury (Hg) that enters the environment by both, natural means (such as volcanic activity, erosions and weathering, factors which contribute to the presence of Hg in water, soil and the atmosphere) and human activities - mining, fossil fuels combustion, industrial emissions, direct application of fertilizers and fungicides as well as disposal of solid waste. Total concentrations of Hg were measured in fish muscle and canned fish products available on Serbian market. Total of 651 samples were analyzed: 350 samples of marine fish (hake, mackerel, sprat, scorpanea, gilthead, salmon), 34 samples of freshwater fish (trout and carp) and 267 samples of canned fish products (tuna and sardines). Data were collected during 2011. For the purpose of intake assessment, we used the data obtained from the GEMS/Food Consumption Cluster Diets database. According to this source, estimated average weekly consumption of marine fish is 106.4 g/week, while freshwater fish and canned fish contribute to the consumption with 29.4 g and 18.2 g/week respectively. Mercury concentrations in marine fish were in the range of 0.005-0.208 μgg-1 (mean 0.040 μgg-1); in freshwater fish 0.005- 0.099 μgg-1 (mean 0.020 μgg-1) and in canned products they were in the range of 0.005-0.642 μgg-1 (mean 0.064 μgg-1). All analyzed samples contained mercury below the maximum level laid down by the European Union and Serbian regulation. The estimated weekly intake for total mercury, based on mean mercury value in fish and average body mass of 70 kg, was 0.095 μg/kg b.w./week. Based on FAO/WHO recommended safe limit and on obtained results, we can conclude that the intake of mercury in the case of consuming fish and canned fish products is lower than the safe limit.
AB  - Nutritivna korist od konzumacije ribe ogleda se, pre svega u sadržaju visoko vrednih proteina, vitamina, makro i mikroelemenata i omega-3 polinezasićenih masnih kiselina. Sa druge strane, riba i proizvodi od ribe su u značajnoj meri podložni hemijskoj kontaminaciji ubikvitarnim zagađivačima kao što su teški metal i polihlorovana organska jedinjenja. Zbog svega ovoga, konzumacija ribe se smatra jednim od najznačajnijih izvora izloženosti navedenim kontaminentima. U radu je ispitivana kontaminacija živom koja se u spoljašnjoj sredini može naći kao posledica prirodnih procesa (vulkanska aktivnost, erozija tla i klimatska dešavanja koja doprinose prisustvu žive u vodi, zemljištu i atmosferi), kao i aktivnosti čoveka - eksploatacija ruda, sagorevanje fosilnih goriva, emisija industrijskih gasova, direktna primena veštačkih đubriva i fungicida, kao i neadekvatno odlaganje čvrstog otpada. Sadržaj ukupne žive je određivan u svežoj i konzervisanoj ribi sa srpskog tržišta. Ispitan je 651 uzorak: 350 uzoraka morske ribe (oslić, skuša, sardela, škarpina, orada i losos), 34 uzorka slatkovodne ribe (šaran i pastrmka) i 267 uzoraka konzervisane ribe (tuna i sardela). Svi uzorci su analizirani tokom 2011. godine. Za procenu unosa korišćeni su podaci iz 'GEMS/Food Consumption Cluster Diets database'. Prema ovom izvoru, procenjena prosečna nedeljna konzumacija morske ribe iznosi 106,4 g, slatkovodne 29,4 g dok je ova vrednost za konzervisane proizvode od ribe 18,2 g. Sardžaj žive u morskoj ribi se kretao u opsegu od 0,005 do 0,208 μgg-1 (srednja vrednost 0,040 μgg-1); u slatkovodnoj ribi 0,005-0,099 μgg-1 (srednja vrednost 0,020 μgg-1), dok se u konzervisanim ribljim proizvodima sadržaj žive kretao od 0,005 do 0,642 μgg-1 (srednja vrednost 0,064 μgg-1). Nivo žive u svim ispitanim uzorcima je bio ispod maksimalno dozvoljenih vrednosti propisanih relevantnom legislativom EU kao i domaćim propisima. Procenjeni nedeljni unos žive baziran na srednjoj vrednosti žive u konzumiranoj ribi i prosečnoj telesnoj težini od 70 kg, bio je 0,095 μg/kg telesne mase nedeljno. Na osnovu preporuka FAO/WHO i dobijenih rezultata, može se zaključiti da je unos žive pri konzumaciji morske i slatkovodne ribe i konzervisanih ribljih proizvoda, niži od preporučenih graničnih vrednosti.
PB  - Institut za higijenu i tehnologiju mesa, Beograd
T2  - Tehnologija mesa
T1  - Assessment of mercury intake associated with fish consumption in Serbia
T1  - Procena unosa žive kroz konzumaciju ribe u Srbiji
VL  - 53
IS  - 1
SP  - 56
EP  - 61
DO  - 10.5937/tehmesa1201056J
ER  - 

@article{
author = "Janković, Saša and Antonijević, Biljana and Ćurčić, Marijana and Radičević, Tatjana and Stefanović, Srđan and Nikolić, Dragica M. and Ćupić, Vitomir",
year = "2012",
abstract = "Nutritional benefits of fish can be attributed primarily to the content of high-quality proteins, vitamins, elements and omega-3 polyunsaturated fatty acids. On the other hand, fish and fishery products are susceptible to contamination by chemicals that have been recognized as ubiquitous environmental pollutants such as toxic elements and polychlorinated organic compounds. Fish consumption could be therefore considered as one of the major sources of human exposure to all above-mentioned environmental contaminants. This paper is focused on mercury (Hg) that enters the environment by both, natural means (such as volcanic activity, erosions and weathering, factors which contribute to the presence of Hg in water, soil and the atmosphere) and human activities - mining, fossil fuels combustion, industrial emissions, direct application of fertilizers and fungicides as well as disposal of solid waste. Total concentrations of Hg were measured in fish muscle and canned fish products available on Serbian market. Total of 651 samples were analyzed: 350 samples of marine fish (hake, mackerel, sprat, scorpanea, gilthead, salmon), 34 samples of freshwater fish (trout and carp) and 267 samples of canned fish products (tuna and sardines). Data were collected during 2011. For the purpose of intake assessment, we used the data obtained from the GEMS/Food Consumption Cluster Diets database. According to this source, estimated average weekly consumption of marine fish is 106.4 g/week, while freshwater fish and canned fish contribute to the consumption with 29.4 g and 18.2 g/week respectively. Mercury concentrations in marine fish were in the range of 0.005-0.208 μgg-1 (mean 0.040 μgg-1); in freshwater fish 0.005- 0.099 μgg-1 (mean 0.020 μgg-1) and in canned products they were in the range of 0.005-0.642 μgg-1 (mean 0.064 μgg-1). All analyzed samples contained mercury below the maximum level laid down by the European Union and Serbian regulation. The estimated weekly intake for total mercury, based on mean mercury value in fish and average body mass of 70 kg, was 0.095 μg/kg b.w./week. Based on FAO/WHO recommended safe limit and on obtained results, we can conclude that the intake of mercury in the case of consuming fish and canned fish products is lower than the safe limit., Nutritivna korist od konzumacije ribe ogleda se, pre svega u sadržaju visoko vrednih proteina, vitamina, makro i mikroelemenata i omega-3 polinezasićenih masnih kiselina. Sa druge strane, riba i proizvodi od ribe su u značajnoj meri podložni hemijskoj kontaminaciji ubikvitarnim zagađivačima kao što su teški metal i polihlorovana organska jedinjenja. Zbog svega ovoga, konzumacija ribe se smatra jednim od najznačajnijih izvora izloženosti navedenim kontaminentima. U radu je ispitivana kontaminacija živom koja se u spoljašnjoj sredini može naći kao posledica prirodnih procesa (vulkanska aktivnost, erozija tla i klimatska dešavanja koja doprinose prisustvu žive u vodi, zemljištu i atmosferi), kao i aktivnosti čoveka - eksploatacija ruda, sagorevanje fosilnih goriva, emisija industrijskih gasova, direktna primena veštačkih đubriva i fungicida, kao i neadekvatno odlaganje čvrstog otpada. Sadržaj ukupne žive je određivan u svežoj i konzervisanoj ribi sa srpskog tržišta. Ispitan je 651 uzorak: 350 uzoraka morske ribe (oslić, skuša, sardela, škarpina, orada i losos), 34 uzorka slatkovodne ribe (šaran i pastrmka) i 267 uzoraka konzervisane ribe (tuna i sardela). Svi uzorci su analizirani tokom 2011. godine. Za procenu unosa korišćeni su podaci iz 'GEMS/Food Consumption Cluster Diets database'. Prema ovom izvoru, procenjena prosečna nedeljna konzumacija morske ribe iznosi 106,4 g, slatkovodne 29,4 g dok je ova vrednost za konzervisane proizvode od ribe 18,2 g. Sardžaj žive u morskoj ribi se kretao u opsegu od 0,005 do 0,208 μgg-1 (srednja vrednost 0,040 μgg-1); u slatkovodnoj ribi 0,005-0,099 μgg-1 (srednja vrednost 0,020 μgg-1), dok se u konzervisanim ribljim proizvodima sadržaj žive kretao od 0,005 do 0,642 μgg-1 (srednja vrednost 0,064 μgg-1). Nivo žive u svim ispitanim uzorcima je bio ispod maksimalno dozvoljenih vrednosti propisanih relevantnom legislativom EU kao i domaćim propisima. Procenjeni nedeljni unos žive baziran na srednjoj vrednosti žive u konzumiranoj ribi i prosečnoj telesnoj težini od 70 kg, bio je 0,095 μg/kg telesne mase nedeljno. Na osnovu preporuka FAO/WHO i dobijenih rezultata, može se zaključiti da je unos žive pri konzumaciji morske i slatkovodne ribe i konzervisanih ribljih proizvoda, niži od preporučenih graničnih vrednosti.",
publisher = "Institut za higijenu i tehnologiju mesa, Beograd",
journal = "Tehnologija mesa",
title = "Assessment of mercury intake associated with fish consumption in Serbia, Procena unosa žive kroz konzumaciju ribe u Srbiji",
volume = "53",
number = "1",
pages = "56-61",
doi = "10.5937/tehmesa1201056J"
}

Janković, S., Antonijević, B., Ćurčić, M., Radičević, T., Stefanović, S., Nikolić, D. M.,& Ćupić, V.. (2012). Assessment of mercury intake associated with fish consumption in Serbia. in Tehnologija mesa
Institut za higijenu i tehnologiju mesa, Beograd., 53(1), 56-61.
https://doi.org/10.5937/tehmesa1201056J

Janković S, Antonijević B, Ćurčić M, Radičević T, Stefanović S, Nikolić DM, Ćupić V. Assessment of mercury intake associated with fish consumption in Serbia. in Tehnologija mesa. 2012;53(1):56-61.
doi:10.5937/tehmesa1201056J .

Janković, Saša, Antonijević, Biljana, Ćurčić, Marijana, Radičević, Tatjana, Stefanović, Srđan, Nikolić, Dragica M., Ćupić, Vitomir, "Assessment of mercury intake associated with fish consumption in Serbia" in Tehnologija mesa, 53, no. 1 (2012):56-61,
https://doi.org/10.5937/tehmesa1201056J . .

TY  - JOUR
AU  - Ivković, B.
AU  - Vladimirov, Sote
AU  - Novaković, Radmila
AU  - Ćupić, Vitomir
AU  - Heinle, H.
AU  - Gojković-Bukarica, Ljiljana
PY  - 2012
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/861
AB  - Our aim was to define how different chemical properties of newly developed phenylpropiophenone derivates (PhPds) influenced their potency and efficacy to relax rat aorta. A contribution of ion channels in the PhPds and propafenone mechanism of vasodilatation was tested. PhPds were syntethysed by substitution in the benzyl moiety with -F, -CH3 or -CF3 groups on the ortho or para position. The vasodilatation by PhPds was examined on the rings of rat aorta precontracted with phenylephrine. In order to test involvement of voltage-gated Na+ and K+ channels and L-type Ca2+ channels in a mechanism of action of PhPds, we used their blockers: lidocaine, nifedipine and 4-aminopiridine, respectively. Aorta was more sensitive to 5-ortho-trifluoromethyl derivate than to propafenone and other PhPds. The 5-para-methyl derivate had lower potency and efficacy than propafenone and other PhPds. Lidocaine did not influenced relaxation induced by PhPds, but slightly inhibited the effect of propafenone. The 4-aminopiridine only inhibited relaxation induced by 5-para-methyl derivate. Nifedipine inhibited relaxation of the rat aorta induced by 5-ortho-trifluoromethyl derivate and by propafenone. Introduction of 5-ortho-trifluoromethyl and 5-para-methyl group in the benzyl moiety of propafenone molecule changed its potency, efficacy and mechanism of action in the rat aorta. The 4-aminopiridine- and nifedipine sensitive ion channels are involved in mechanism of action of 5-para-methyl and 5-ortho-trifluoromethyl derivate. The introduction of other tested groups in the benzyl moiety does not affect pharmacological properties of the PhPds in relation to propafenone.
PB  - Georg Thieme Verlag Kg, Stuttgart
T2  - Arzneimittelforschung-Drug Research
T1  - The Novel Phenylpropiophenone Derivates Induced Relaxation of Isolated Rat Aorta
VL  - 62
IS  - 7
SP  - 345
EP  - 350
DO  - 10.1055/s-0032-1312617
ER  - 

@article{
author = "Ivković, B. and Vladimirov, Sote and Novaković, Radmila and Ćupić, Vitomir and Heinle, H. and Gojković-Bukarica, Ljiljana",
year = "2012",
abstract = "Our aim was to define how different chemical properties of newly developed phenylpropiophenone derivates (PhPds) influenced their potency and efficacy to relax rat aorta. A contribution of ion channels in the PhPds and propafenone mechanism of vasodilatation was tested. PhPds were syntethysed by substitution in the benzyl moiety with -F, -CH3 or -CF3 groups on the ortho or para position. The vasodilatation by PhPds was examined on the rings of rat aorta precontracted with phenylephrine. In order to test involvement of voltage-gated Na+ and K+ channels and L-type Ca2+ channels in a mechanism of action of PhPds, we used their blockers: lidocaine, nifedipine and 4-aminopiridine, respectively. Aorta was more sensitive to 5-ortho-trifluoromethyl derivate than to propafenone and other PhPds. The 5-para-methyl derivate had lower potency and efficacy than propafenone and other PhPds. Lidocaine did not influenced relaxation induced by PhPds, but slightly inhibited the effect of propafenone. The 4-aminopiridine only inhibited relaxation induced by 5-para-methyl derivate. Nifedipine inhibited relaxation of the rat aorta induced by 5-ortho-trifluoromethyl derivate and by propafenone. Introduction of 5-ortho-trifluoromethyl and 5-para-methyl group in the benzyl moiety of propafenone molecule changed its potency, efficacy and mechanism of action in the rat aorta. The 4-aminopiridine- and nifedipine sensitive ion channels are involved in mechanism of action of 5-para-methyl and 5-ortho-trifluoromethyl derivate. The introduction of other tested groups in the benzyl moiety does not affect pharmacological properties of the PhPds in relation to propafenone.",
publisher = "Georg Thieme Verlag Kg, Stuttgart",
journal = "Arzneimittelforschung-Drug Research",
title = "The Novel Phenylpropiophenone Derivates Induced Relaxation of Isolated Rat Aorta",
volume = "62",
number = "7",
pages = "345-350",
doi = "10.1055/s-0032-1312617"
}

Ivković, B., Vladimirov, S., Novaković, R., Ćupić, V., Heinle, H.,& Gojković-Bukarica, L.. (2012). The Novel Phenylpropiophenone Derivates Induced Relaxation of Isolated Rat Aorta. in Arzneimittelforschung-Drug Research
Georg Thieme Verlag Kg, Stuttgart., 62(7), 345-350.
https://doi.org/10.1055/s-0032-1312617

Ivković B, Vladimirov S, Novaković R, Ćupić V, Heinle H, Gojković-Bukarica L. The Novel Phenylpropiophenone Derivates Induced Relaxation of Isolated Rat Aorta. in Arzneimittelforschung-Drug Research. 2012;62(7):345-350.
doi:10.1055/s-0032-1312617 .

Ivković, B., Vladimirov, Sote, Novaković, Radmila, Ćupić, Vitomir, Heinle, H., Gojković-Bukarica, Ljiljana, "The Novel Phenylpropiophenone Derivates Induced Relaxation of Isolated Rat Aorta" in Arzneimittelforschung-Drug Research, 62, no. 7 (2012):345-350,
https://doi.org/10.1055/s-0032-1312617 . .

TY  - CONF
AU  - Borozan, Sunčica
AU  - Ivanović, Saša
AU  - Micić, M.
AU  - Dimitrijević, B.
AU  - Zicari, M.
AU  - Katić-Radivojević, Sofija
AU  - Ćupić, Vitomir
PY  - 2011
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/762
PB  - Elsevier Ireland Ltd, Clare
C3  - Toxicology Letters
T1  - Paraoxonase activity, oxidative stress and toxic effects of diazinon in rats
VL  - 205
SP  - S219
EP  - S219
DO  - 10.1016/j.toxlet.2011.05.752
ER  - 

@conference{
author = "Borozan, Sunčica and Ivanović, Saša and Micić, M. and Dimitrijević, B. and Zicari, M. and Katić-Radivojević, Sofija and Ćupić, Vitomir",
year = "2011",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "Paraoxonase activity, oxidative stress and toxic effects of diazinon in rats",
volume = "205",
pages = "S219-S219",
doi = "10.1016/j.toxlet.2011.05.752"
}

Borozan, S., Ivanović, S., Micić, M., Dimitrijević, B., Zicari, M., Katić-Radivojević, S.,& Ćupić, V.. (2011). Paraoxonase activity, oxidative stress and toxic effects of diazinon in rats. in Toxicology Letters
Elsevier Ireland Ltd, Clare., 205, S219-S219.
https://doi.org/10.1016/j.toxlet.2011.05.752

Borozan S, Ivanović S, Micić M, Dimitrijević B, Zicari M, Katić-Radivojević S, Ćupić V. Paraoxonase activity, oxidative stress and toxic effects of diazinon in rats. in Toxicology Letters. 2011;205:S219-S219.
doi:10.1016/j.toxlet.2011.05.752 .

Borozan, Sunčica, Ivanović, Saša, Micić, M., Dimitrijević, B., Zicari, M., Katić-Radivojević, Sofija, Ćupić, Vitomir, "Paraoxonase activity, oxidative stress and toxic effects of diazinon in rats" in Toxicology Letters, 205 (2011):S219-S219,
https://doi.org/10.1016/j.toxlet.2011.05.752 . .