Antonijević, Biljana

Link to this page

Authority KeyName Variants
orcid::0000-0002-3996-454X
  • Antonijević, Biljana (7)
Projects

Author's Bibliography

Assessment of fluoride intake from drinking water and toothpaste in 3-year-olds: Preliminary results in Belgrade, Republic of Serbia

Đukić-Ćosić, Danijela; Antonijević, Evica; Mandinić, Zoran; Ćurčić, Marijana; Ćupić Miladinović, Dejana; Antonijević, Biljana; Matović, Vesna

(Vojnomedicinska akademija - Institut za naučne informacije, Beograd, 2019)

TY  - JOUR
AU  - Đukić-Ćosić, Danijela
AU  - Antonijević, Evica
AU  - Mandinić, Zoran
AU  - Ćurčić, Marijana
AU  - Ćupić Miladinović, Dejana
AU  - Antonijević, Biljana
AU  - Matović, Vesna
PY  - 2019
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1711
AB  - Background/Aim. Fluoride has beneficial effect on dental caries prevention and enables high hardness of enamel. However, fluoride intake above optimal levels can have adverse effects on teeth and bones, especially in young children during the period of intense growth and teeth development. The aim of this study was to assess fluoride intake from water and toothpaste among 3-year-old children in Belgrade, Serbia, in the municipalities of Vračar and Novi Beograd. Methods. A questionnaire for the parents (n = 40) was used to provide information on the water consumption (tap and/or bottled water) and the brand of toothpaste used by children as well as the frequency of tooth brushing and the amount of toothpaste during brushing. Fluoride concentrations in water and toothpaste samples were determined electrochemically by using fluoride-selective electrode. Fluoride intake was estimated through a mathematical model commonly used by the U.S. Environmental Protection Agency. Results. The obtained results indicate no significant difference in daily fluoride intake through drinking water and toothpaste in 3-year-old children in Vračar (n = 19) compared to Novi Beograd (n = 21) (p > 0.05). However, all estimated fluoride levels (0.089-0.625 mg/day) are significantly lower than the optimal daily intake level for caries protection (0.7 mg/day for children up to 4 years, FNB-USA National Institute of Medicine) and two to six times lower than tolerable upper fluoride level for the children of same age (1.3 mg/day, FNB-USA National Institute of Medicine). Furthermore, calculated daily fluoride intake per kilogram body weight confirm very low fluoride intake by water and toothpaste in children of investigated municipalities in Belgrade, being significantly below the recommended an adequate intake (0.05 mg/kg/day, EFSA). Conclusion. This preliminary study has shown that daily fluoride intake in 3-year-olds is lower than tolerable upper fluoride level, even not sufficient for the prevention of dental caries.
AB  - Uvod/Cilj. Fluoridi imaju pozitivan efekat na prevenciju karijesa zuba kao i povećanje čvrstine zubnog emajla. Međutim, njihov unos iznad optimalnog može imati štetne efekte na zube i kosti, posebno kod male dece tokom intenzivnog rasta i razvoja zuba. Cilj ovog rada bio je da se proceni unos fluorida putem vode za piće i paste za zube kod dece uzrasta od tri godine u Beogradu, na teritoriji dve opštine, Vračar i Novi Beograd. Metode. Anketnim upitnicima (n = 40) za roditelje dobijeni su podaci o vrsti vode koju deca piju (česmenska i/ili flaširana), proizvodima koje koriste za čišćenje i negu zuba, učestalosti pranja zuba kao i količini paste za zube koja se koristi po jednom pranju. Sadržaj fluorida u vodi za piće i pastama za zube određen je elektrohemijski sa fluoridnom jonselektivnom elektrodom. Unos fluorida procenjen je korišćenjem matematičkog modela datog od strane Američke agencije za zaštitu životne sredine. Rezultati. Dobijeni rezultati pokazuju da nema statistički značajne razlike u dnevnom unosu fluorida putem vode za piće i paste za zube između dece uzrasta od tri godine na Vračaru i Novom Beogradu (p > 0,05). Međutim, sve procenjene vrednosti unosa fluorida (0,089-0,625 mg/dan) značajno su niže od optimalnog dnevnog unosa za prevenciju karijesa (0,7 mg/dan za decu uzrasta do 4 godine, FNB-Nacionalnog instituta medicine, SAD) i dva do šest puta niže od tolerišućeg gornjeg nivoa unosa fluorida za decu istog uzrasta (1,3 mg/dan, FNBNacionalnog instituta medicine, SAD). Štaviše, izračunati dnevni unosi fluorida izraženi po kilogramu telesne mase potvrđuju veoma nizak unos fluorida kod dece ispitivanih opština u Beogradu, čak značajno niže od preporučenog optimalnog unosa (0,05 mg/kg/dan, EFSA). Zaključak. Ovim preliminarnim istraživanjem pokazano je da je dnevni unos fluorida kod trogodišnjaka u Beogradu značajno niži od tolerišućeg gornjeg nivoa unosa fluorida, čak niži od optimalnog unosa za prevenciju karijesa.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Assessment of fluoride intake from drinking water and toothpaste in 3-year-olds: Preliminary results in Belgrade, Republic of Serbia
T1  - Procena unosa fluorida putem vode za piće i paste za zube kod dece uzrasta od tri godine - preliminarni rezultati u Beogradu, Republika Srbija
VL  - 76
IS  - 6
SP  - 607
EP  - 614
DO  - 10.2298/VSP170721136D
ER  - 
@article{
author = "Đukić-Ćosić, Danijela and Antonijević, Evica and Mandinić, Zoran and Ćurčić, Marijana and Ćupić Miladinović, Dejana and Antonijević, Biljana and Matović, Vesna",
year = "2019",
abstract = "Background/Aim. Fluoride has beneficial effect on dental caries prevention and enables high hardness of enamel. However, fluoride intake above optimal levels can have adverse effects on teeth and bones, especially in young children during the period of intense growth and teeth development. The aim of this study was to assess fluoride intake from water and toothpaste among 3-year-old children in Belgrade, Serbia, in the municipalities of Vračar and Novi Beograd. Methods. A questionnaire for the parents (n = 40) was used to provide information on the water consumption (tap and/or bottled water) and the brand of toothpaste used by children as well as the frequency of tooth brushing and the amount of toothpaste during brushing. Fluoride concentrations in water and toothpaste samples were determined electrochemically by using fluoride-selective electrode. Fluoride intake was estimated through a mathematical model commonly used by the U.S. Environmental Protection Agency. Results. The obtained results indicate no significant difference in daily fluoride intake through drinking water and toothpaste in 3-year-old children in Vračar (n = 19) compared to Novi Beograd (n = 21) (p > 0.05). However, all estimated fluoride levels (0.089-0.625 mg/day) are significantly lower than the optimal daily intake level for caries protection (0.7 mg/day for children up to 4 years, FNB-USA National Institute of Medicine) and two to six times lower than tolerable upper fluoride level for the children of same age (1.3 mg/day, FNB-USA National Institute of Medicine). Furthermore, calculated daily fluoride intake per kilogram body weight confirm very low fluoride intake by water and toothpaste in children of investigated municipalities in Belgrade, being significantly below the recommended an adequate intake (0.05 mg/kg/day, EFSA). Conclusion. This preliminary study has shown that daily fluoride intake in 3-year-olds is lower than tolerable upper fluoride level, even not sufficient for the prevention of dental caries., Uvod/Cilj. Fluoridi imaju pozitivan efekat na prevenciju karijesa zuba kao i povećanje čvrstine zubnog emajla. Međutim, njihov unos iznad optimalnog može imati štetne efekte na zube i kosti, posebno kod male dece tokom intenzivnog rasta i razvoja zuba. Cilj ovog rada bio je da se proceni unos fluorida putem vode za piće i paste za zube kod dece uzrasta od tri godine u Beogradu, na teritoriji dve opštine, Vračar i Novi Beograd. Metode. Anketnim upitnicima (n = 40) za roditelje dobijeni su podaci o vrsti vode koju deca piju (česmenska i/ili flaširana), proizvodima koje koriste za čišćenje i negu zuba, učestalosti pranja zuba kao i količini paste za zube koja se koristi po jednom pranju. Sadržaj fluorida u vodi za piće i pastama za zube određen je elektrohemijski sa fluoridnom jonselektivnom elektrodom. Unos fluorida procenjen je korišćenjem matematičkog modela datog od strane Američke agencije za zaštitu životne sredine. Rezultati. Dobijeni rezultati pokazuju da nema statistički značajne razlike u dnevnom unosu fluorida putem vode za piće i paste za zube između dece uzrasta od tri godine na Vračaru i Novom Beogradu (p > 0,05). Međutim, sve procenjene vrednosti unosa fluorida (0,089-0,625 mg/dan) značajno su niže od optimalnog dnevnog unosa za prevenciju karijesa (0,7 mg/dan za decu uzrasta do 4 godine, FNB-Nacionalnog instituta medicine, SAD) i dva do šest puta niže od tolerišućeg gornjeg nivoa unosa fluorida za decu istog uzrasta (1,3 mg/dan, FNBNacionalnog instituta medicine, SAD). Štaviše, izračunati dnevni unosi fluorida izraženi po kilogramu telesne mase potvrđuju veoma nizak unos fluorida kod dece ispitivanih opština u Beogradu, čak značajno niže od preporučenog optimalnog unosa (0,05 mg/kg/dan, EFSA). Zaključak. Ovim preliminarnim istraživanjem pokazano je da je dnevni unos fluorida kod trogodišnjaka u Beogradu značajno niži od tolerišućeg gornjeg nivoa unosa fluorida, čak niži od optimalnog unosa za prevenciju karijesa.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Assessment of fluoride intake from drinking water and toothpaste in 3-year-olds: Preliminary results in Belgrade, Republic of Serbia, Procena unosa fluorida putem vode za piće i paste za zube kod dece uzrasta od tri godine - preliminarni rezultati u Beogradu, Republika Srbija",
volume = "76",
number = "6",
pages = "607-614",
doi = "10.2298/VSP170721136D"
}
Đukić-Ćosić, D., Antonijević, E., Mandinić, Z., Ćurčić, M., Ćupić Miladinović, D., Antonijević, B.,& Matović, V.. (2019). Assessment of fluoride intake from drinking water and toothpaste in 3-year-olds: Preliminary results in Belgrade, Republic of Serbia. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 76(6), 607-614.
https://doi.org/10.2298/VSP170721136D
Đukić-Ćosić D, Antonijević E, Mandinić Z, Ćurčić M, Ćupić Miladinović D, Antonijević B, Matović V. Assessment of fluoride intake from drinking water and toothpaste in 3-year-olds: Preliminary results in Belgrade, Republic of Serbia. in Vojnosanitetski pregled. 2019;76(6):607-614.
doi:10.2298/VSP170721136D .
Đukić-Ćosić, Danijela, Antonijević, Evica, Mandinić, Zoran, Ćurčić, Marijana, Ćupić Miladinović, Dejana, Antonijević, Biljana, Matović, Vesna, "Assessment of fluoride intake from drinking water and toothpaste in 3-year-olds: Preliminary results in Belgrade, Republic of Serbia" in Vojnosanitetski pregled, 76, no. 6 (2019):607-614,
https://doi.org/10.2298/VSP170721136D . .

Dose-response modeling of reactivating potency of oximes K027 and K203 against a direct acetylcholinesterase inhibitor in rat erythrocytes

Antonijević, Evica; Musilek, Kamil; Kuca, Kamil; Đukić-Ćosić, Danijela; Curcić, Marijana; Ćupić Miladinović, Dejana; Bulat, Zorica; Antonijević, Biljana

(Pergamon-Elsevier Science Ltd, Oxford, 2018)

TY  - JOUR
AU  - Antonijević, Evica
AU  - Musilek, Kamil
AU  - Kuca, Kamil
AU  - Đukić-Ćosić, Danijela
AU  - Curcić, Marijana
AU  - Ćupić Miladinović, Dejana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
PY  - 2018
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1566
AB  - Inhibition of acethylcholinesterase (AChE) as a key molecular event induced by organophosphate (OP) pesticides and nerve agents presents a human health concern. In efficacy testing of experimental oximes, potential antidotes in OP poisoning, reactivation of OP-inhibited AChE is used as specific endpoint. However, according to our best knowledge, so far oximes have not been quantitatively evaluated by comprehensive benchmark dose (BMD) approach, that would improve both identification and quantification of the effect and allow more rigorous comparison of efficacies. Thus, we have examined in vivo dose-response relationship for two promising experimental oximes, K203 and K027, concerning reactivation of erythrocyte AChE inhibited by dichlorvos (DDVP). Groups of Wistar rats were treated with six different doses of oximes (i.m) immediately after DDVP challenge (s.c) and AChE was measured 60 min later. Dose-response modeling was done by PROAST software 65.5 (RIVM, The Nederlands). BMD-covariate method resulted in four-parameter model from both exponential and Hill model families as the best estimate of relationship between AChE activity and oxime dose, with potency parameter being oxime-dependent. Oxime K027 was shown to be 1.929-fold more potent considering that 58% increase in AChE activity was achived with the dose BMD58-K027 = 52 mu mol/kg in contrast to BMD58-K203 = 100 mu mol/kg.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Food and Chemical Toxicology
T1  - Dose-response modeling of reactivating potency of oximes K027 and K203 against a direct acetylcholinesterase inhibitor in rat erythrocytes
VL  - 121
SP  - 224
EP  - 230
DO  - 10.1016/j.fct.2018.08.065
ER  - 
@article{
author = "Antonijević, Evica and Musilek, Kamil and Kuca, Kamil and Đukić-Ćosić, Danijela and Curcić, Marijana and Ćupić Miladinović, Dejana and Bulat, Zorica and Antonijević, Biljana",
year = "2018",
abstract = "Inhibition of acethylcholinesterase (AChE) as a key molecular event induced by organophosphate (OP) pesticides and nerve agents presents a human health concern. In efficacy testing of experimental oximes, potential antidotes in OP poisoning, reactivation of OP-inhibited AChE is used as specific endpoint. However, according to our best knowledge, so far oximes have not been quantitatively evaluated by comprehensive benchmark dose (BMD) approach, that would improve both identification and quantification of the effect and allow more rigorous comparison of efficacies. Thus, we have examined in vivo dose-response relationship for two promising experimental oximes, K203 and K027, concerning reactivation of erythrocyte AChE inhibited by dichlorvos (DDVP). Groups of Wistar rats were treated with six different doses of oximes (i.m) immediately after DDVP challenge (s.c) and AChE was measured 60 min later. Dose-response modeling was done by PROAST software 65.5 (RIVM, The Nederlands). BMD-covariate method resulted in four-parameter model from both exponential and Hill model families as the best estimate of relationship between AChE activity and oxime dose, with potency parameter being oxime-dependent. Oxime K027 was shown to be 1.929-fold more potent considering that 58% increase in AChE activity was achived with the dose BMD58-K027 = 52 mu mol/kg in contrast to BMD58-K203 = 100 mu mol/kg.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Food and Chemical Toxicology",
title = "Dose-response modeling of reactivating potency of oximes K027 and K203 against a direct acetylcholinesterase inhibitor in rat erythrocytes",
volume = "121",
pages = "224-230",
doi = "10.1016/j.fct.2018.08.065"
}
Antonijević, E., Musilek, K., Kuca, K., Đukić-Ćosić, D., Curcić, M., Ćupić Miladinović, D., Bulat, Z.,& Antonijević, B.. (2018). Dose-response modeling of reactivating potency of oximes K027 and K203 against a direct acetylcholinesterase inhibitor in rat erythrocytes. in Food and Chemical Toxicology
Pergamon-Elsevier Science Ltd, Oxford., 121, 224-230.
https://doi.org/10.1016/j.fct.2018.08.065
Antonijević E, Musilek K, Kuca K, Đukić-Ćosić D, Curcić M, Ćupić Miladinović D, Bulat Z, Antonijević B. Dose-response modeling of reactivating potency of oximes K027 and K203 against a direct acetylcholinesterase inhibitor in rat erythrocytes. in Food and Chemical Toxicology. 2018;121:224-230.
doi:10.1016/j.fct.2018.08.065 .
Antonijević, Evica, Musilek, Kamil, Kuca, Kamil, Đukić-Ćosić, Danijela, Curcić, Marijana, Ćupić Miladinović, Dejana, Bulat, Zorica, Antonijević, Biljana, "Dose-response modeling of reactivating potency of oximes K027 and K203 against a direct acetylcholinesterase inhibitor in rat erythrocytes" in Food and Chemical Toxicology, 121 (2018):224-230,
https://doi.org/10.1016/j.fct.2018.08.065 . .
8
5
10

The influence of chlorpyrifos on the activity of butyryilcholinesterase and catalase, as well as concentration of malondialdehyde in plasma of Japanese quail

Ćupić Miladinović, Dejana; Borozan, Sunčica; Popović, Z.; Ćupić, Vitomir; Velev, Romel; Antonijević, Biljana

(Elsevier Ireland Ltd, Clare, 2015)

TY  - CONF
AU  - Ćupić Miladinović, Dejana
AU  - Borozan, Sunčica
AU  - Popović, Z.
AU  - Ćupić, Vitomir
AU  - Velev, Romel
AU  - Antonijević, Biljana
PY  - 2015
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1301
PB  - Elsevier Ireland Ltd, Clare
C3  - Toxicology Letters
T1  - The influence of chlorpyrifos on the activity of butyryilcholinesterase and catalase, as well as concentration of malondialdehyde in plasma of Japanese quail
VL  - 238
IS  - 2
SP  - S111
EP  - S111
DO  - 10.1016/j.toxlet.2015.08.360
ER  - 
@conference{
author = "Ćupić Miladinović, Dejana and Borozan, Sunčica and Popović, Z. and Ćupić, Vitomir and Velev, Romel and Antonijević, Biljana",
year = "2015",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "The influence of chlorpyrifos on the activity of butyryilcholinesterase and catalase, as well as concentration of malondialdehyde in plasma of Japanese quail",
volume = "238",
number = "2",
pages = "S111-S111",
doi = "10.1016/j.toxlet.2015.08.360"
}
Ćupić Miladinović, D., Borozan, S., Popović, Z., Ćupić, V., Velev, R.,& Antonijević, B.. (2015). The influence of chlorpyrifos on the activity of butyryilcholinesterase and catalase, as well as concentration of malondialdehyde in plasma of Japanese quail. in Toxicology Letters
Elsevier Ireland Ltd, Clare., 238(2), S111-S111.
https://doi.org/10.1016/j.toxlet.2015.08.360
Ćupić Miladinović D, Borozan S, Popović Z, Ćupić V, Velev R, Antonijević B. The influence of chlorpyrifos on the activity of butyryilcholinesterase and catalase, as well as concentration of malondialdehyde in plasma of Japanese quail. in Toxicology Letters. 2015;238(2):S111-S111.
doi:10.1016/j.toxlet.2015.08.360 .
Ćupić Miladinović, Dejana, Borozan, Sunčica, Popović, Z., Ćupić, Vitomir, Velev, Romel, Antonijević, Biljana, "The influence of chlorpyrifos on the activity of butyryilcholinesterase and catalase, as well as concentration of malondialdehyde in plasma of Japanese quail" in Toxicology Letters, 238, no. 2 (2015):S111-S111,
https://doi.org/10.1016/j.toxlet.2015.08.360 . .

Kliničke manifestacije i mehanizmi toksičnog delovanja hemijskih supstancija

Ćupić, Vitomir; Antonijević, Biljana; Matović, Vesna; Bulat, Zorica; Vasilev, Saša

(Banja Luka : PI Veterinary Institute Republic of Srpska „Dr. Vaso Butozan“, 2013)

TY  - JOUR
AU  - Ćupić, Vitomir
AU  - Antonijević, Biljana
AU  - Matović, Vesna
AU  - Bulat, Zorica
AU  - Vasilev, Saša
PY  - 2013
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2101
AB  - Kada određena supstacija uđe u organizam, njeno toksično delovanje se klinički
može manifestovati na razne načine, zavisno od vrste poremećaja prouzrokovanog
na nivou ćelije. Vezivanjem za određene endogene molekule, toksična jedinjenja
mogu prouzrokovati poremećaj genske ekspresije (neoplazija, teratogeneza),
poremećaj tekućih ili trenutnih aktivnosti ćelije (tremor, konvulzije, spazam,
aritmija), poremećaj integriteta ćelije (poremećaj sinteze proteina, poremećaj
funkcije ćelijske membrane, smrt ćelije) i poremećaj odnosa sa drugim ćelijama
(poremećaj u hemostazi – krvarenje).
Najteži poremećaji, koji nastaju usled vezivanja hemijskih supstancija sa
takozvanim „kritičnim proteinima” (DNK, RNK), klinički se mogu manifestovati
kao: mutageneza, karcinogeneza, teratogeneza i imunotoksičnost.
AB  - When chemical compound enter the body, its toxic effect may clinical to
demonstrate in different way, depend from kind of disturbance, what that
substance induced in the cell. Binding for endogenous molecules toxic substances can induced disturbance of gens expression (neoplasia, teratogenesis), disturbance
of curently activities of cell (tremor, convulsions, spasm, aritmia), disturbance of
integrity of cell (disturbance of sinthesis of proteins, disturbance of function of cell
membrane, death of cell) and disturbance of relation with other cells (disorders of
hemostasis – bleeding).
The most serious disturbances which may to begin because of binding chemical
substances for so-called “critical proteins” (DNA, RNA) clinical may to
demonstrate as: mutagenesis, carcinogenesis, teratogenesis and as immunotoxicity.
PB  - Banja Luka : PI Veterinary Institute Republic of Srpska „Dr. Vaso Butozan“
T2  - Veterinarski žurnal Republike Srpske
T1  - Kliničke manifestacije i mehanizmi toksičnog delovanja hemijskih supstancija
T1  - Clinical manifestations and toxic effect mechanisms of chemical substances
VL  - 13
IS  - 2
SP  - 117
EP  - 130
DO  - 10.7251/VJRS1302117C
ER  - 
@article{
author = "Ćupić, Vitomir and Antonijević, Biljana and Matović, Vesna and Bulat, Zorica and Vasilev, Saša",
year = "2013",
abstract = "Kada određena supstacija uđe u organizam, njeno toksično delovanje se klinički
može manifestovati na razne načine, zavisno od vrste poremećaja prouzrokovanog
na nivou ćelije. Vezivanjem za određene endogene molekule, toksična jedinjenja
mogu prouzrokovati poremećaj genske ekspresije (neoplazija, teratogeneza),
poremećaj tekućih ili trenutnih aktivnosti ćelije (tremor, konvulzije, spazam,
aritmija), poremećaj integriteta ćelije (poremećaj sinteze proteina, poremećaj
funkcije ćelijske membrane, smrt ćelije) i poremećaj odnosa sa drugim ćelijama
(poremećaj u hemostazi – krvarenje).
Najteži poremećaji, koji nastaju usled vezivanja hemijskih supstancija sa
takozvanim „kritičnim proteinima” (DNK, RNK), klinički se mogu manifestovati
kao: mutageneza, karcinogeneza, teratogeneza i imunotoksičnost., When chemical compound enter the body, its toxic effect may clinical to
demonstrate in different way, depend from kind of disturbance, what that
substance induced in the cell. Binding for endogenous molecules toxic substances can induced disturbance of gens expression (neoplasia, teratogenesis), disturbance
of curently activities of cell (tremor, convulsions, spasm, aritmia), disturbance of
integrity of cell (disturbance of sinthesis of proteins, disturbance of function of cell
membrane, death of cell) and disturbance of relation with other cells (disorders of
hemostasis – bleeding).
The most serious disturbances which may to begin because of binding chemical
substances for so-called “critical proteins” (DNA, RNA) clinical may to
demonstrate as: mutagenesis, carcinogenesis, teratogenesis and as immunotoxicity.",
publisher = "Banja Luka : PI Veterinary Institute Republic of Srpska „Dr. Vaso Butozan“",
journal = "Veterinarski žurnal Republike Srpske",
title = "Kliničke manifestacije i mehanizmi toksičnog delovanja hemijskih supstancija, Clinical manifestations and toxic effect mechanisms of chemical substances",
volume = "13",
number = "2",
pages = "117-130",
doi = "10.7251/VJRS1302117C"
}
Ćupić, V., Antonijević, B., Matović, V., Bulat, Z.,& Vasilev, S.. (2013). Kliničke manifestacije i mehanizmi toksičnog delovanja hemijskih supstancija. in Veterinarski žurnal Republike Srpske
Banja Luka : PI Veterinary Institute Republic of Srpska „Dr. Vaso Butozan“., 13(2), 117-130.
https://doi.org/10.7251/VJRS1302117C
Ćupić V, Antonijević B, Matović V, Bulat Z, Vasilev S. Kliničke manifestacije i mehanizmi toksičnog delovanja hemijskih supstancija. in Veterinarski žurnal Republike Srpske. 2013;13(2):117-130.
doi:10.7251/VJRS1302117C .
Ćupić, Vitomir, Antonijević, Biljana, Matović, Vesna, Bulat, Zorica, Vasilev, Saša, "Kliničke manifestacije i mehanizmi toksičnog delovanja hemijskih supstancija" in Veterinarski žurnal Republike Srpske, 13, no. 2 (2013):117-130,
https://doi.org/10.7251/VJRS1302117C . .

Protective effect of HI-6 and trimedoxime combination in mice acutely poisoned with tabun, dichlorvos or heptenophos

Antonijević, Biljana; Vučinić, Slavica; Ćupić, Vitomir

(Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd, 2012)

TY  - JOUR
AU  - Antonijević, Biljana
AU  - Vučinić, Slavica
AU  - Ćupić, Vitomir
PY  - 2012
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/871
AB  - The aim of this study was to compare the protective effect of two individual oximes (HI-6 and trimedoxime) with their combination in mice acutely poisoned with tabun, dichlorvos or heptenophos. Oxime HI-6 did not protect experimental animals against either dichlorvos, heptenophos or tabun. Trimedoxime was very effective against all three OPs. The ED-500 doses of trimedoxime necessary to protect 50% of animals after the simultaneous administration of OPs and oxime were 42.18, 14.97 and 32.08 μmol/kg in dichlorvos, heptenophos and tabun poisoning, respectively. Half-time of efficacy in the tabun protocol was approximately three and two times longer than in the protocol for heptenophos and dichlorvos, respectively indicating also that trimedoxime is very potent in counteracting tabun toxicity. Addition of trimedoxime significantly improved the protective effect of HI-6 in acute tabun poisoning. When dichlorvos or heptenophos were used, addition of trimedoxime generally improved the antidotal effect of HI-6, but still lower protection was obtained than in the case when trimedoxime alone was administered. The investigations of different oxime combinations have indicated that application of a mixture of two oximes represents a promising antidotal approach.
AB  - Cilj ovog rada je bio da se uporedi zaštitni efekat pojedinačnih oksima HI-6 i trimedoksima sa zaštitnim efektom njihove kombinacije u miševa akutno trovanih tabunom, dihlorvosom ili heptenofosom. Oksim HI-6 nije štitio eksperimentalne životinje od trovanja, ali je trimedoksim bio veoma efikasan u antagonitovanju toksičnih efekata sva tri organofosforna jedinjenja. ED-500 doze trimedoksima potrebne da zaštite 50% životinja pri istovremenoj primeni organofosfata i oksima iznosile su 42,18, 14,97 i 32,08 μmol/kg kod trovanja dihlorvosom, heptenofosom odnosno tabunom. Poluvreme efikasnosti trimedoksima u tretmanu sa tabunom bilo je dva odnosno tri puta duže od poluvremena izračunatih kod trovanja heptenofosom odnosno dihlorvosom. Dodatak trimedoksima doveo je do značajnog poboljšanja zaštitnog efekta HI-6 kod trovanja tabunom. Dodatak trimedoksima takođe je poboljšao zaštitni efekat HI-6 i kod ostala dva otrova, ali je zaštita i dalje bila najbolja kada je primenjen sam trimedoksim. Ispitivanja različitih kombinacija oksima ukazuju da je primena smeše dva oksima opravdani pristup u prevazilaženju problema nejednake efikasnosti oksima.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta Veterinaria-Beograd
T1  - Protective effect of HI-6 and trimedoxime combination in mice acutely poisoned with tabun, dichlorvos or heptenophos
T1  - Zaštitni efekat kombinacije HI-6 i trimedoksima u miševa akutno trovanih tabunom, dihlorvosom ili heptenofosom
VL  - 62
IS  - 2-3
SP  - 123
EP  - 135
DO  - 10.2298/AVB1203123A
ER  - 
@article{
author = "Antonijević, Biljana and Vučinić, Slavica and Ćupić, Vitomir",
year = "2012",
abstract = "The aim of this study was to compare the protective effect of two individual oximes (HI-6 and trimedoxime) with their combination in mice acutely poisoned with tabun, dichlorvos or heptenophos. Oxime HI-6 did not protect experimental animals against either dichlorvos, heptenophos or tabun. Trimedoxime was very effective against all three OPs. The ED-500 doses of trimedoxime necessary to protect 50% of animals after the simultaneous administration of OPs and oxime were 42.18, 14.97 and 32.08 μmol/kg in dichlorvos, heptenophos and tabun poisoning, respectively. Half-time of efficacy in the tabun protocol was approximately three and two times longer than in the protocol for heptenophos and dichlorvos, respectively indicating also that trimedoxime is very potent in counteracting tabun toxicity. Addition of trimedoxime significantly improved the protective effect of HI-6 in acute tabun poisoning. When dichlorvos or heptenophos were used, addition of trimedoxime generally improved the antidotal effect of HI-6, but still lower protection was obtained than in the case when trimedoxime alone was administered. The investigations of different oxime combinations have indicated that application of a mixture of two oximes represents a promising antidotal approach., Cilj ovog rada je bio da se uporedi zaštitni efekat pojedinačnih oksima HI-6 i trimedoksima sa zaštitnim efektom njihove kombinacije u miševa akutno trovanih tabunom, dihlorvosom ili heptenofosom. Oksim HI-6 nije štitio eksperimentalne životinje od trovanja, ali je trimedoksim bio veoma efikasan u antagonitovanju toksičnih efekata sva tri organofosforna jedinjenja. ED-500 doze trimedoksima potrebne da zaštite 50% životinja pri istovremenoj primeni organofosfata i oksima iznosile su 42,18, 14,97 i 32,08 μmol/kg kod trovanja dihlorvosom, heptenofosom odnosno tabunom. Poluvreme efikasnosti trimedoksima u tretmanu sa tabunom bilo je dva odnosno tri puta duže od poluvremena izračunatih kod trovanja heptenofosom odnosno dihlorvosom. Dodatak trimedoksima doveo je do značajnog poboljšanja zaštitnog efekta HI-6 kod trovanja tabunom. Dodatak trimedoksima takođe je poboljšao zaštitni efekat HI-6 i kod ostala dva otrova, ali je zaštita i dalje bila najbolja kada je primenjen sam trimedoksim. Ispitivanja različitih kombinacija oksima ukazuju da je primena smeše dva oksima opravdani pristup u prevazilaženju problema nejednake efikasnosti oksima.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta Veterinaria-Beograd",
title = "Protective effect of HI-6 and trimedoxime combination in mice acutely poisoned with tabun, dichlorvos or heptenophos, Zaštitni efekat kombinacije HI-6 i trimedoksima u miševa akutno trovanih tabunom, dihlorvosom ili heptenofosom",
volume = "62",
number = "2-3",
pages = "123-135",
doi = "10.2298/AVB1203123A"
}
Antonijević, B., Vučinić, S.,& Ćupić, V.. (2012). Protective effect of HI-6 and trimedoxime combination in mice acutely poisoned with tabun, dichlorvos or heptenophos. in Acta Veterinaria-Beograd
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 62(2-3), 123-135.
https://doi.org/10.2298/AVB1203123A
Antonijević B, Vučinić S, Ćupić V. Protective effect of HI-6 and trimedoxime combination in mice acutely poisoned with tabun, dichlorvos or heptenophos. in Acta Veterinaria-Beograd. 2012;62(2-3):123-135.
doi:10.2298/AVB1203123A .
Antonijević, Biljana, Vučinić, Slavica, Ćupić, Vitomir, "Protective effect of HI-6 and trimedoxime combination in mice acutely poisoned with tabun, dichlorvos or heptenophos" in Acta Veterinaria-Beograd, 62, no. 2-3 (2012):123-135,
https://doi.org/10.2298/AVB1203123A . .
3
2
2

Assessment of mercury intake associated with fish consumption in Serbia

Janković, Saša; Antonijević, Biljana; Ćurčić, Marijana; Radičević, Tatjana; Stefanović, Srđan; Nikolić, Dragica M.; Ćupić, Vitomir

(Institut za higijenu i tehnologiju mesa, Beograd, 2012)

TY  - JOUR
AU  - Janković, Saša
AU  - Antonijević, Biljana
AU  - Ćurčić, Marijana
AU  - Radičević, Tatjana
AU  - Stefanović, Srđan
AU  - Nikolić, Dragica M.
AU  - Ćupić, Vitomir
PY  - 2012
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/903
AB  - Nutritional benefits of fish can be attributed primarily to the content of high-quality proteins, vitamins, elements and omega-3 polyunsaturated fatty acids. On the other hand, fish and fishery products are susceptible to contamination by chemicals that have been recognized as ubiquitous environmental pollutants such as toxic elements and polychlorinated organic compounds. Fish consumption could be therefore considered as one of the major sources of human exposure to all above-mentioned environmental contaminants. This paper is focused on mercury (Hg) that enters the environment by both, natural means (such as volcanic activity, erosions and weathering, factors which contribute to the presence of Hg in water, soil and the atmosphere) and human activities - mining, fossil fuels combustion, industrial emissions, direct application of fertilizers and fungicides as well as disposal of solid waste. Total concentrations of Hg were measured in fish muscle and canned fish products available on Serbian market. Total of 651 samples were analyzed: 350 samples of marine fish (hake, mackerel, sprat, scorpanea, gilthead, salmon), 34 samples of freshwater fish (trout and carp) and 267 samples of canned fish products (tuna and sardines). Data were collected during 2011. For the purpose of intake assessment, we used the data obtained from the GEMS/Food Consumption Cluster Diets database. According to this source, estimated average weekly consumption of marine fish is 106.4 g/week, while freshwater fish and canned fish contribute to the consumption with 29.4 g and 18.2 g/week respectively. Mercury concentrations in marine fish were in the range of 0.005-0.208 μgg-1 (mean 0.040 μgg-1); in freshwater fish 0.005- 0.099 μgg-1 (mean 0.020 μgg-1) and in canned products they were in the range of 0.005-0.642 μgg-1 (mean 0.064 μgg-1). All analyzed samples contained mercury below the maximum level laid down by the European Union and Serbian regulation. The estimated weekly intake for total mercury, based on mean mercury value in fish and average body mass of 70 kg, was 0.095 μg/kg b.w./week. Based on FAO/WHO recommended safe limit and on obtained results, we can conclude that the intake of mercury in the case of consuming fish and canned fish products is lower than the safe limit.
AB  - Nutritivna korist od konzumacije ribe ogleda se, pre svega u sadržaju visoko vrednih proteina, vitamina, makro i mikroelemenata i omega-3 polinezasićenih masnih kiselina. Sa druge strane, riba i proizvodi od ribe su u značajnoj meri podložni hemijskoj kontaminaciji ubikvitarnim zagađivačima kao što su teški metal i polihlorovana organska jedinjenja. Zbog svega ovoga, konzumacija ribe se smatra jednim od najznačajnijih izvora izloženosti navedenim kontaminentima. U radu je ispitivana kontaminacija živom koja se u spoljašnjoj sredini može naći kao posledica prirodnih procesa (vulkanska aktivnost, erozija tla i klimatska dešavanja koja doprinose prisustvu žive u vodi, zemljištu i atmosferi), kao i aktivnosti čoveka - eksploatacija ruda, sagorevanje fosilnih goriva, emisija industrijskih gasova, direktna primena veštačkih đubriva i fungicida, kao i neadekvatno odlaganje čvrstog otpada. Sadržaj ukupne žive je određivan u svežoj i konzervisanoj ribi sa srpskog tržišta. Ispitan je 651 uzorak: 350 uzoraka morske ribe (oslić, skuša, sardela, škarpina, orada i losos), 34 uzorka slatkovodne ribe (šaran i pastrmka) i 267 uzoraka konzervisane ribe (tuna i sardela). Svi uzorci su analizirani tokom 2011. godine. Za procenu unosa korišćeni su podaci iz 'GEMS/Food Consumption Cluster Diets database'. Prema ovom izvoru, procenjena prosečna nedeljna konzumacija morske ribe iznosi 106,4 g, slatkovodne 29,4 g dok je ova vrednost za konzervisane proizvode od ribe 18,2 g. Sardžaj žive u morskoj ribi se kretao u opsegu od 0,005 do 0,208 μgg-1 (srednja vrednost 0,040 μgg-1); u slatkovodnoj ribi 0,005-0,099 μgg-1 (srednja vrednost 0,020 μgg-1), dok se u konzervisanim ribljim proizvodima sadržaj žive kretao od 0,005 do 0,642 μgg-1 (srednja vrednost 0,064 μgg-1). Nivo žive u svim ispitanim uzorcima je bio ispod maksimalno dozvoljenih vrednosti propisanih relevantnom legislativom EU kao i domaćim propisima. Procenjeni nedeljni unos žive baziran na srednjoj vrednosti žive u konzumiranoj ribi i prosečnoj telesnoj težini od 70 kg, bio je 0,095 μg/kg telesne mase nedeljno. Na osnovu preporuka FAO/WHO i dobijenih rezultata, može se zaključiti da je unos žive pri konzumaciji morske i slatkovodne ribe i konzervisanih ribljih proizvoda, niži od preporučenih graničnih vrednosti.
PB  - Institut za higijenu i tehnologiju mesa, Beograd
T2  - Tehnologija mesa
T1  - Assessment of mercury intake associated with fish consumption in Serbia
T1  - Procena unosa žive kroz konzumaciju ribe u Srbiji
VL  - 53
IS  - 1
SP  - 56
EP  - 61
DO  - 10.5937/tehmesa1201056J
ER  - 
@article{
author = "Janković, Saša and Antonijević, Biljana and Ćurčić, Marijana and Radičević, Tatjana and Stefanović, Srđan and Nikolić, Dragica M. and Ćupić, Vitomir",
year = "2012",
abstract = "Nutritional benefits of fish can be attributed primarily to the content of high-quality proteins, vitamins, elements and omega-3 polyunsaturated fatty acids. On the other hand, fish and fishery products are susceptible to contamination by chemicals that have been recognized as ubiquitous environmental pollutants such as toxic elements and polychlorinated organic compounds. Fish consumption could be therefore considered as one of the major sources of human exposure to all above-mentioned environmental contaminants. This paper is focused on mercury (Hg) that enters the environment by both, natural means (such as volcanic activity, erosions and weathering, factors which contribute to the presence of Hg in water, soil and the atmosphere) and human activities - mining, fossil fuels combustion, industrial emissions, direct application of fertilizers and fungicides as well as disposal of solid waste. Total concentrations of Hg were measured in fish muscle and canned fish products available on Serbian market. Total of 651 samples were analyzed: 350 samples of marine fish (hake, mackerel, sprat, scorpanea, gilthead, salmon), 34 samples of freshwater fish (trout and carp) and 267 samples of canned fish products (tuna and sardines). Data were collected during 2011. For the purpose of intake assessment, we used the data obtained from the GEMS/Food Consumption Cluster Diets database. According to this source, estimated average weekly consumption of marine fish is 106.4 g/week, while freshwater fish and canned fish contribute to the consumption with 29.4 g and 18.2 g/week respectively. Mercury concentrations in marine fish were in the range of 0.005-0.208 μgg-1 (mean 0.040 μgg-1); in freshwater fish 0.005- 0.099 μgg-1 (mean 0.020 μgg-1) and in canned products they were in the range of 0.005-0.642 μgg-1 (mean 0.064 μgg-1). All analyzed samples contained mercury below the maximum level laid down by the European Union and Serbian regulation. The estimated weekly intake for total mercury, based on mean mercury value in fish and average body mass of 70 kg, was 0.095 μg/kg b.w./week. Based on FAO/WHO recommended safe limit and on obtained results, we can conclude that the intake of mercury in the case of consuming fish and canned fish products is lower than the safe limit., Nutritivna korist od konzumacije ribe ogleda se, pre svega u sadržaju visoko vrednih proteina, vitamina, makro i mikroelemenata i omega-3 polinezasićenih masnih kiselina. Sa druge strane, riba i proizvodi od ribe su u značajnoj meri podložni hemijskoj kontaminaciji ubikvitarnim zagađivačima kao što su teški metal i polihlorovana organska jedinjenja. Zbog svega ovoga, konzumacija ribe se smatra jednim od najznačajnijih izvora izloženosti navedenim kontaminentima. U radu je ispitivana kontaminacija živom koja se u spoljašnjoj sredini može naći kao posledica prirodnih procesa (vulkanska aktivnost, erozija tla i klimatska dešavanja koja doprinose prisustvu žive u vodi, zemljištu i atmosferi), kao i aktivnosti čoveka - eksploatacija ruda, sagorevanje fosilnih goriva, emisija industrijskih gasova, direktna primena veštačkih đubriva i fungicida, kao i neadekvatno odlaganje čvrstog otpada. Sadržaj ukupne žive je određivan u svežoj i konzervisanoj ribi sa srpskog tržišta. Ispitan je 651 uzorak: 350 uzoraka morske ribe (oslić, skuša, sardela, škarpina, orada i losos), 34 uzorka slatkovodne ribe (šaran i pastrmka) i 267 uzoraka konzervisane ribe (tuna i sardela). Svi uzorci su analizirani tokom 2011. godine. Za procenu unosa korišćeni su podaci iz 'GEMS/Food Consumption Cluster Diets database'. Prema ovom izvoru, procenjena prosečna nedeljna konzumacija morske ribe iznosi 106,4 g, slatkovodne 29,4 g dok je ova vrednost za konzervisane proizvode od ribe 18,2 g. Sardžaj žive u morskoj ribi se kretao u opsegu od 0,005 do 0,208 μgg-1 (srednja vrednost 0,040 μgg-1); u slatkovodnoj ribi 0,005-0,099 μgg-1 (srednja vrednost 0,020 μgg-1), dok se u konzervisanim ribljim proizvodima sadržaj žive kretao od 0,005 do 0,642 μgg-1 (srednja vrednost 0,064 μgg-1). Nivo žive u svim ispitanim uzorcima je bio ispod maksimalno dozvoljenih vrednosti propisanih relevantnom legislativom EU kao i domaćim propisima. Procenjeni nedeljni unos žive baziran na srednjoj vrednosti žive u konzumiranoj ribi i prosečnoj telesnoj težini od 70 kg, bio je 0,095 μg/kg telesne mase nedeljno. Na osnovu preporuka FAO/WHO i dobijenih rezultata, može se zaključiti da je unos žive pri konzumaciji morske i slatkovodne ribe i konzervisanih ribljih proizvoda, niži od preporučenih graničnih vrednosti.",
publisher = "Institut za higijenu i tehnologiju mesa, Beograd",
journal = "Tehnologija mesa",
title = "Assessment of mercury intake associated with fish consumption in Serbia, Procena unosa žive kroz konzumaciju ribe u Srbiji",
volume = "53",
number = "1",
pages = "56-61",
doi = "10.5937/tehmesa1201056J"
}
Janković, S., Antonijević, B., Ćurčić, M., Radičević, T., Stefanović, S., Nikolić, D. M.,& Ćupić, V.. (2012). Assessment of mercury intake associated with fish consumption in Serbia. in Tehnologija mesa
Institut za higijenu i tehnologiju mesa, Beograd., 53(1), 56-61.
https://doi.org/10.5937/tehmesa1201056J
Janković S, Antonijević B, Ćurčić M, Radičević T, Stefanović S, Nikolić DM, Ćupić V. Assessment of mercury intake associated with fish consumption in Serbia. in Tehnologija mesa. 2012;53(1):56-61.
doi:10.5937/tehmesa1201056J .
Janković, Saša, Antonijević, Biljana, Ćurčić, Marijana, Radičević, Tatjana, Stefanović, Srđan, Nikolić, Dragica M., Ćupić, Vitomir, "Assessment of mercury intake associated with fish consumption in Serbia" in Tehnologija mesa, 53, no. 1 (2012):56-61,
https://doi.org/10.5937/tehmesa1201056J . .
8

The significance of rational use of drugs in veterinary medicine for food safety

Ćupić, Vitomir; Dobrić, Silva; Antonijević, Biljana; Čelebićanin, Sanja

(Institut za higijenu i tehnologiju mesa, Beograd, 2011)

TY  - JOUR
AU  - Ćupić, Vitomir
AU  - Dobrić, Silva
AU  - Antonijević, Biljana
AU  - Čelebićanin, Sanja
PY  - 2011
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/778
AB  - Rational use of drugs in veterinary medicine has manifold significance. By using each drug, only when it is really necessary (indicated), in right dose and route of administration, the potential damage of their use is reduced, efficiency increased, and the risk of microorganisms resistance development (in case of antimicrobials) significantly decreased. All of this becomes more important when these drugs are used in food producing animals. Simultaneously with the intensifying of cattle breeding and exceptional increase of animal productivity, the number of used drugs is unavoidably increased. There are almost no animals today in intensive as well as in extensive production/rearing system, which haven't received at least one drug during their life. In poultry, cattle and pig production, which are main sectors for production of food stuffs of animal origin, the use of drugs has increased and reached the limits which are considered alarming for health of people. On the first place are antibiotics, or antimicrobial drugs, which are used very often in therapy or prevention of bacteria diseases, and also, very often, as growth stimulator. In addition to antibiotics, many other drugs are used, with proven numerous harmful effects, even with carcinogenic and teratogenic features, whose residues in food intended for human consumption can very seriously endanger the health of people, as potential consumers of this kind of food. Therefore, the control of use of antimicrobial, and other drugs in livestock production is exceptionally significant.
AB  - Racionalna primena lekova u veterinarskoj medicini ima višestruk značaj. Korišćenjem lekova samo kada su stvarno neophodni (indikovani), u pravoj dozi i na pravi način, smanjuje se potencijalna šteta od njihovog korišćenja, a ujedno se povećava delotvornost, i smanjuje rizik od nastanka rezistentnosti mikroorganizama (odnosi se na antimikrobne lekove). Sve navedeno postaje još važnije kada se veterinarski lekovi koriste u lečenju farmskih životinja, odnosno životinja čiji se proizvodi koriste za ishranu ljudi. Istovremeno sa intenziviranjem stočarske proizvodnje i povećanjem produktivnosti životinja, povećava se i broj lekova koji se koriste. Danas ne postoji skoro nijedna životinja, u intenzivnom, kao i ekstenzivnom uzgoju, koja nije primila barem jedan lek tokom svog života. U živinarstvu, govedarstvu i svinjarstvu, kao glavnim sektorima gde se proizvode prehrambeni proizvodi životinjskog porekla, upotreba lekova je dostigla granice koje se mogu smatrati alarmantnim za zdravlje ljudi. Na prvom mestu su antibiotici, ili antimikrobni lekovi, koji se veoma često koriste u terapiji ili prevenciji bakterijskih bolesti, a ne tako retko i kao promotori rasta. Osim antibiotika, koriste se i mnogi drugi lekovi, koji imaju dokazano štetno dejstvo, pa čak i kancerogene ili teratogene osobine/svojstva. Njihove rezidue u proizvodima životinjskog porekla koji se koriste u ljudskoj ishrani, mogu veoma ozbiljno da ugroze zdravlje ljudi, koji su potencijalni konzumenti ove vrste hrane. Zbog toga je kontrola primene antimikrobnih lekova, kao i ostalih lekova u stočarstvu, od izuzetne važnosti.
PB  - Institut za higijenu i tehnologiju mesa, Beograd
T2  - Tehnologija mesa
T1  - The significance of rational use of drugs in veterinary medicine for food safety
T1  - Značaj racionalne primene lekova u veterinarskoj medicini za bezbednost hrane
VL  - 52
IS  - 1
SP  - 74
EP  - 79
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_778
ER  - 
@article{
author = "Ćupić, Vitomir and Dobrić, Silva and Antonijević, Biljana and Čelebićanin, Sanja",
year = "2011",
abstract = "Rational use of drugs in veterinary medicine has manifold significance. By using each drug, only when it is really necessary (indicated), in right dose and route of administration, the potential damage of their use is reduced, efficiency increased, and the risk of microorganisms resistance development (in case of antimicrobials) significantly decreased. All of this becomes more important when these drugs are used in food producing animals. Simultaneously with the intensifying of cattle breeding and exceptional increase of animal productivity, the number of used drugs is unavoidably increased. There are almost no animals today in intensive as well as in extensive production/rearing system, which haven't received at least one drug during their life. In poultry, cattle and pig production, which are main sectors for production of food stuffs of animal origin, the use of drugs has increased and reached the limits which are considered alarming for health of people. On the first place are antibiotics, or antimicrobial drugs, which are used very often in therapy or prevention of bacteria diseases, and also, very often, as growth stimulator. In addition to antibiotics, many other drugs are used, with proven numerous harmful effects, even with carcinogenic and teratogenic features, whose residues in food intended for human consumption can very seriously endanger the health of people, as potential consumers of this kind of food. Therefore, the control of use of antimicrobial, and other drugs in livestock production is exceptionally significant., Racionalna primena lekova u veterinarskoj medicini ima višestruk značaj. Korišćenjem lekova samo kada su stvarno neophodni (indikovani), u pravoj dozi i na pravi način, smanjuje se potencijalna šteta od njihovog korišćenja, a ujedno se povećava delotvornost, i smanjuje rizik od nastanka rezistentnosti mikroorganizama (odnosi se na antimikrobne lekove). Sve navedeno postaje još važnije kada se veterinarski lekovi koriste u lečenju farmskih životinja, odnosno životinja čiji se proizvodi koriste za ishranu ljudi. Istovremeno sa intenziviranjem stočarske proizvodnje i povećanjem produktivnosti životinja, povećava se i broj lekova koji se koriste. Danas ne postoji skoro nijedna životinja, u intenzivnom, kao i ekstenzivnom uzgoju, koja nije primila barem jedan lek tokom svog života. U živinarstvu, govedarstvu i svinjarstvu, kao glavnim sektorima gde se proizvode prehrambeni proizvodi životinjskog porekla, upotreba lekova je dostigla granice koje se mogu smatrati alarmantnim za zdravlje ljudi. Na prvom mestu su antibiotici, ili antimikrobni lekovi, koji se veoma često koriste u terapiji ili prevenciji bakterijskih bolesti, a ne tako retko i kao promotori rasta. Osim antibiotika, koriste se i mnogi drugi lekovi, koji imaju dokazano štetno dejstvo, pa čak i kancerogene ili teratogene osobine/svojstva. Njihove rezidue u proizvodima životinjskog porekla koji se koriste u ljudskoj ishrani, mogu veoma ozbiljno da ugroze zdravlje ljudi, koji su potencijalni konzumenti ove vrste hrane. Zbog toga je kontrola primene antimikrobnih lekova, kao i ostalih lekova u stočarstvu, od izuzetne važnosti.",
publisher = "Institut za higijenu i tehnologiju mesa, Beograd",
journal = "Tehnologija mesa",
title = "The significance of rational use of drugs in veterinary medicine for food safety, Značaj racionalne primene lekova u veterinarskoj medicini za bezbednost hrane",
volume = "52",
number = "1",
pages = "74-79",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_778"
}
Ćupić, V., Dobrić, S., Antonijević, B.,& Čelebićanin, S.. (2011). The significance of rational use of drugs in veterinary medicine for food safety. in Tehnologija mesa
Institut za higijenu i tehnologiju mesa, Beograd., 52(1), 74-79.
https://hdl.handle.net/21.15107/rcub_veterinar_778
Ćupić V, Dobrić S, Antonijević B, Čelebićanin S. The significance of rational use of drugs in veterinary medicine for food safety. in Tehnologija mesa. 2011;52(1):74-79.
https://hdl.handle.net/21.15107/rcub_veterinar_778 .
Ćupić, Vitomir, Dobrić, Silva, Antonijević, Biljana, Čelebićanin, Sanja, "The significance of rational use of drugs in veterinary medicine for food safety" in Tehnologija mesa, 52, no. 1 (2011):74-79,
https://hdl.handle.net/21.15107/rcub_veterinar_778 .