@article{
author = "Davitkov, Dajana and Nešić, Vladimir and Marinković, Darko and Davitkov, Darko and Lončar, Zoran and Delić, Aleksandar and Aničić, Milan",
year = "2023",
abstract = "The aging process is still not fully understood, although it has been studied for centuries. One
of the processes in the brain during aging is the accumulation of extracellular and intracellular
deposits of amyloid and lipofuscin. Deposits of various polyglucosan bodies (PGBs) are also
found in brain tissue. The accumulation of the Lafora bodies (LB), a type of PGBs, can cause
the Lafora disease (LD). Initial signs of the disease in humans are tonic-clonic seizures with
blindness and myoclonus seizures. Normally, all haematological and biochemical indices are
within the reference range in dogs with this disease. In this case, a 7-year-old Chihuahua dog with
tonic-clonic seizures was presented. According to history, neurological examination, and blood
test, toxic, metabolic, and infectious causes for the seizures were ruled out. The dog was started
on phenobarbital 2.5 mg/kg twice daily per os. Two years later, the dog died due to complications
caused by a duodenal foreign body. Postmortem examination revealed hyperaemic meninges
and an enlarged, oedematous brain with flattened gyri and narrowed sulci. Histopathological
examination revealed multifocal to diffuse, randomly distributed PGBs that were positive
on periodic acid-Schiff (PAS) staining. The diagnosis of LD in dogs is of great importance because
they are a good experimental model for neurological studies of neurodegenerative diseases
in humans.",
publisher = "University of Veterinary Sciences Brno, Czech Republic",
journal = "Acta Veterinaria Brno",
title = "Lafora disease in a Chihuahua dog: a case report",
volume = "92",
number = "4",
pages = "369-373",
doi = "10.2754/avb202392040369"
}
