Charvet, Claude L.

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  • Charvet, Claude L. (1)
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Pharmacological effects of monoterpene carveol on the neuromuscular system of nematodes and mammals

Stojković, Maja; Todorović, Zoran; Protić, Dragana; Stevanović, Strahinja; Medić, Dragana; Charvet, Claude L.; Marjanović, Djordje; Nedeljković Trailović, Jelena; Trailović, Saša M.

(Frontiers Media, 2024) 

TY  - JOUR
AU  - Stojković, Maja
AU  - Todorović, Zoran
AU  - Protić, Dragana
AU  - Stevanović, Strahinja
AU  - Medić, Dragana
AU  - Charvet, Claude L.
AU  - Marjanović, Djordje
AU  - Nedeljković Trailović, Jelena
AU  - Trailović, Saša M.
PY  - 2024
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/3564
AB  - The control of parasitic nematode infections relies mostly on anthelmintics. The potential pharmacotherapeutic application of phytochemicals, in order to overcome parasite resistance and enhance the effect of existing drugs, is becoming increasingly important. The antinematodal effects of carveol was tested on the free-living nematode Caenorhabditis elegans and the neuromuscular preparation of the parasitic nematode Ascaris suum. Carveol caused spastic and geraniol atonic paralysis in C. elegans. In A. suum carveol potentiated contractions induced by acetylcholine (ACh) and this effect was confirmed with two-electrode voltage-clamp electrophysiology on the A. suum nicotinic acetylcholine receptor expressed in Xenopus oocytes. However, potentiating effect of carveol on ACh-induced contractions was partially sensitive to atropine, indicates a dominant nicotine effect but also the involvement of some muscarinic structures. The effects of carveol on the neuromuscular system of mammals are also specific. In micromolar concentrations, carveol acts as a non-competitive ACh antagonist on ileum contractions. Unlike atropine, it does not change the EC50 of ACh but reduces the amplitude of contractions. Carveol caused an increase in Electrical Field Stimulation-evoked contractions of the isolated rat diaphragm, but at higher concentrations it caused an inhibition. Also, carveol neutralized the mecamylamine-induced tetanic fade, indicating a possibly different pre-and post-synaptic action at the neuromuscular junction.
PB  - Frontiers Media
T2  - Frontiers in Pharmacology
T1  - Pharmacological effects of monoterpene carveol on the neuromuscular system of nematodes and mammals
VL  - 15
DO  - 10.3389/fphar.2024.1326779
ER  - 
@article{
author = "Stojković, Maja and Todorović, Zoran and Protić, Dragana and Stevanović, Strahinja and Medić, Dragana and Charvet, Claude L. and Marjanović, Djordje and Nedeljković Trailović, Jelena and Trailović, Saša M.",
year = "2024",
abstract = "The control of parasitic nematode infections relies mostly on anthelmintics. The potential pharmacotherapeutic application of phytochemicals, in order to overcome parasite resistance and enhance the effect of existing drugs, is becoming increasingly important. The antinematodal effects of carveol was tested on the free-living nematode Caenorhabditis elegans and the neuromuscular preparation of the parasitic nematode Ascaris suum. Carveol caused spastic and geraniol atonic paralysis in C. elegans. In A. suum carveol potentiated contractions induced by acetylcholine (ACh) and this effect was confirmed with two-electrode voltage-clamp electrophysiology on the A. suum nicotinic acetylcholine receptor expressed in Xenopus oocytes. However, potentiating effect of carveol on ACh-induced contractions was partially sensitive to atropine, indicates a dominant nicotine effect but also the involvement of some muscarinic structures. The effects of carveol on the neuromuscular system of mammals are also specific. In micromolar concentrations, carveol acts as a non-competitive ACh antagonist on ileum contractions. Unlike atropine, it does not change the EC50 of ACh but reduces the amplitude of contractions. Carveol caused an increase in Electrical Field Stimulation-evoked contractions of the isolated rat diaphragm, but at higher concentrations it caused an inhibition. Also, carveol neutralized the mecamylamine-induced tetanic fade, indicating a possibly different pre-and post-synaptic action at the neuromuscular junction.",
publisher = "Frontiers Media",
journal = "Frontiers in Pharmacology",
title = "Pharmacological effects of monoterpene carveol on the neuromuscular system of nematodes and mammals",
volume = "15",
doi = "10.3389/fphar.2024.1326779"
}
Stojković, M., Todorović, Z., Protić, D., Stevanović, S., Medić, D., Charvet, C. L., Marjanović, D., Nedeljković Trailović, J.,& Trailović, S. M.. (2024). Pharmacological effects of monoterpene carveol on the neuromuscular system of nematodes and mammals. in Frontiers in Pharmacology
Frontiers Media., 15.
https://doi.org/10.3389/fphar.2024.1326779
Stojković M, Todorović Z, Protić D, Stevanović S, Medić D, Charvet CL, Marjanović D, Nedeljković Trailović J, Trailović SM. Pharmacological effects of monoterpene carveol on the neuromuscular system of nematodes and mammals. in Frontiers in Pharmacology. 2024;15.
doi:10.3389/fphar.2024.1326779 .
Stojković, Maja, Todorović, Zoran, Protić, Dragana, Stevanović, Strahinja, Medić, Dragana, Charvet, Claude L., Marjanović, Djordje, Nedeljković Trailović, Jelena, Trailović, Saša M., "Pharmacological effects of monoterpene carveol on the neuromuscular system of nematodes and mammals" in Frontiers in Pharmacology, 15 (2024),
https://doi.org/10.3389/fphar.2024.1326779 . .
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