TY  - JOUR
AU  - Nedić, Svetlana
AU  - Đurić, Miloje
AU  - Vakanjac, Slobodanka
AU  - Arsić, Sveta
AU  - Nedić, Sreten
AU  - Samardžija, Marko
AU  - Borozan, Sunčica
PY  - 2023
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2523
AB  - The aim of this study was to examine the biochemical components and the parameters of antioxidant protection in the
seminal plasma (SP) of boars, as well as their relationship with semen quality parameters. Thirty-six boars were included
in the study, whose ejaculates were divided into two groups: Group I (good quality semen, > 70% progressively motile
sperm, < 20% spermatozoa with abnormal morphology, n=16), and Group II (poor quality semen, < 70% progressively
motile sperm, > 20% spermatozoa with abnormal morphology, n=20). Significantly higher concentrations of ionized calcium (iCa), total cholesterol (TC), lactate-dehydrogenase (LDH) activity, as well as significantly higher values of antioxidant protection parameters: thiol groups (-SH), paraoxonase 1 (PON1), and total antioxidant capacity (TAC) ) were found
in the good quality semen, while higher phosphorus (P) concentrations and increased alkaline-phosphatase (ALP) activity
were found in the semen of poor quality. A negative correlation of total and progressive sperm motility with P and ALP
was found in all examined semen samples, while a positive correlation was found with PON1 and TAC. The percentage
of fast sperm cells positively correlated with iCa, chlorine (Cl), lactate, LDH and TAC, while a negative correlation was
found with P, magnesium (Mg) and the enzyme creatine-kinase (CK). The percentage of immobile sperm positively correlated with P and ALP, and negatively correlated with TC, CK, PON1 and TAC. Elevated values of PON1 and TAC in
SP and a positive correlation with sperm motility indicate the possible use of these parameters as sensitive biomarkers of
boar semen quality. To the best of our knowledge there are no published data on association between PON1 activity and
boar semen quality.
PB  - Springer
T2  - Veterinary Research Communications
T1  - Relationship between biochemical parameters and paraoxonase 1 activity of boar seminal plasma and semen quality
VL  - 47
SP  - 1243
EP  - 1253
DO  - 10.1007/s11259-022-10066-x
ER  - 

@article{
author = "Nedić, Svetlana and Đurić, Miloje and Vakanjac, Slobodanka and Arsić, Sveta and Nedić, Sreten and Samardžija, Marko and Borozan, Sunčica",
year = "2023",
abstract = "The aim of this study was to examine the biochemical components and the parameters of antioxidant protection in the
seminal plasma (SP) of boars, as well as their relationship with semen quality parameters. Thirty-six boars were included
in the study, whose ejaculates were divided into two groups: Group I (good quality semen, > 70% progressively motile
sperm, < 20% spermatozoa with abnormal morphology, n=16), and Group II (poor quality semen, < 70% progressively
motile sperm, > 20% spermatozoa with abnormal morphology, n=20). Significantly higher concentrations of ionized calcium (iCa), total cholesterol (TC), lactate-dehydrogenase (LDH) activity, as well as significantly higher values of antioxidant protection parameters: thiol groups (-SH), paraoxonase 1 (PON1), and total antioxidant capacity (TAC) ) were found
in the good quality semen, while higher phosphorus (P) concentrations and increased alkaline-phosphatase (ALP) activity
were found in the semen of poor quality. A negative correlation of total and progressive sperm motility with P and ALP
was found in all examined semen samples, while a positive correlation was found with PON1 and TAC. The percentage
of fast sperm cells positively correlated with iCa, chlorine (Cl), lactate, LDH and TAC, while a negative correlation was
found with P, magnesium (Mg) and the enzyme creatine-kinase (CK). The percentage of immobile sperm positively correlated with P and ALP, and negatively correlated with TC, CK, PON1 and TAC. Elevated values of PON1 and TAC in
SP and a positive correlation with sperm motility indicate the possible use of these parameters as sensitive biomarkers of
boar semen quality. To the best of our knowledge there are no published data on association between PON1 activity and
boar semen quality.",
publisher = "Springer",
journal = "Veterinary Research Communications",
title = "Relationship between biochemical parameters and paraoxonase 1 activity of boar seminal plasma and semen quality",
volume = "47",
pages = "1243-1253",
doi = "10.1007/s11259-022-10066-x"
}

Nedić, S., Đurić, M., Vakanjac, S., Arsić, S., Nedić, S., Samardžija, M.,& Borozan, S.. (2023). Relationship between biochemical parameters and paraoxonase 1 activity of boar seminal plasma and semen quality. in Veterinary Research Communications
Springer., 47, 1243-1253.
https://doi.org/10.1007/s11259-022-10066-x

Nedić S, Đurić M, Vakanjac S, Arsić S, Nedić S, Samardžija M, Borozan S. Relationship between biochemical parameters and paraoxonase 1 activity of boar seminal plasma and semen quality. in Veterinary Research Communications. 2023;47:1243-1253.
doi:10.1007/s11259-022-10066-x .

Nedić, Svetlana, Đurić, Miloje, Vakanjac, Slobodanka, Arsić, Sveta, Nedić, Sreten, Samardžija, Marko, Borozan, Sunčica, "Relationship between biochemical parameters and paraoxonase 1 activity of boar seminal plasma and semen quality" in Veterinary Research Communications, 47 (2023):1243-1253,
https://doi.org/10.1007/s11259-022-10066-x . .

TY  - JOUR
AU  - Samardžija, Marko
AU  - Lojkić, Martina
AU  - Maćešić, Nino
AU  - Valpotić, Hrvoje
AU  - Butković, Ivan
AU  - Šavorić, Juraj
AU  - Žura Žaja, Ivona
AU  - Leiner, Denis
AU  - Đuričić, Dražen
AU  - Marković, Franjo
AU  - Kočila, Predrag
AU  - Vidas, Željko
AU  - Gerenčer, Marijan
AU  - Kaštelan, Andrija
AU  - Milovanović, Aleksandar
AU  - Lazarević, Miodrag
AU  - Rukavina, Daniel
AU  - Valpotić, Ivica
PY  - 2020
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1967
AB  - Literally, reproductive immunology was born in bovine on-farm reproduction where seminal experiments intended for developing methods for embryo transfer in cattle were performed. Actually, these experiments led to two of major concepts and fundamental principles of reproductive immunology using the bovine species as a model for biomedical research, namely the concept of acquired immunological tolerance and the paradox of the semiallogeneic bovine foetus whereby such organism can develop within an immunologically competent host. Peter Medawar, a scientist who together with Frank Macfarlande Burnet shared the 1960 Nobel Prize in physiology or medicine for discovery of acquired immunological tolerance, while studying dizygotic cattle twins, thereby giving birth to reproductive immunology. Also, these findings significantly influenced development of organ transplants and showed that using farm animals as models for studying transplantation immunology had general relevance for mammalian biology and health including those of humans. However, the interest for further research of the fascinating maternal immune influences on pregnancy and perinatal outcomes and of the prevention and treatment of immunologically mediated reproductive disorders in viviparous mammals of veterinary relevance by veterinary immunologists and reproductive clinicians have been very scarce regarding the application of nonspecific immunomodulatory agents for prevention and treatment of subfertility and infertility in pigs and cattle, but still broadening knowledge in this area and hold great potential for improving such therapy in the future. The aim of the current overview is to provide up-to-date information and explaining/translating relevant immunology phenomena into veterinary practice for specialists and scientists/clinicians in reproduction of animals.
PB  - Taylor & Francis
T2  - Veterinary Quarterly
T1  - Reproductive immunology in viviparous mammals: evolutionary paradox of interactions among immune mechanisms and autologous or allogeneic gametes and semiallogeneic foetuses
VL  - 40
IS  - 1
SP  - 353
EP  - 383
DO  - 10.1080/01652176.2020.1852336
ER  - 

@article{
author = "Samardžija, Marko and Lojkić, Martina and Maćešić, Nino and Valpotić, Hrvoje and Butković, Ivan and Šavorić, Juraj and Žura Žaja, Ivona and Leiner, Denis and Đuričić, Dražen and Marković, Franjo and Kočila, Predrag and Vidas, Željko and Gerenčer, Marijan and Kaštelan, Andrija and Milovanović, Aleksandar and Lazarević, Miodrag and Rukavina, Daniel and Valpotić, Ivica",
year = "2020",
abstract = "Literally, reproductive immunology was born in bovine on-farm reproduction where seminal experiments intended for developing methods for embryo transfer in cattle were performed. Actually, these experiments led to two of major concepts and fundamental principles of reproductive immunology using the bovine species as a model for biomedical research, namely the concept of acquired immunological tolerance and the paradox of the semiallogeneic bovine foetus whereby such organism can develop within an immunologically competent host. Peter Medawar, a scientist who together with Frank Macfarlande Burnet shared the 1960 Nobel Prize in physiology or medicine for discovery of acquired immunological tolerance, while studying dizygotic cattle twins, thereby giving birth to reproductive immunology. Also, these findings significantly influenced development of organ transplants and showed that using farm animals as models for studying transplantation immunology had general relevance for mammalian biology and health including those of humans. However, the interest for further research of the fascinating maternal immune influences on pregnancy and perinatal outcomes and of the prevention and treatment of immunologically mediated reproductive disorders in viviparous mammals of veterinary relevance by veterinary immunologists and reproductive clinicians have been very scarce regarding the application of nonspecific immunomodulatory agents for prevention and treatment of subfertility and infertility in pigs and cattle, but still broadening knowledge in this area and hold great potential for improving such therapy in the future. The aim of the current overview is to provide up-to-date information and explaining/translating relevant immunology phenomena into veterinary practice for specialists and scientists/clinicians in reproduction of animals.",
publisher = "Taylor & Francis",
journal = "Veterinary Quarterly",
title = "Reproductive immunology in viviparous mammals: evolutionary paradox of interactions among immune mechanisms and autologous or allogeneic gametes and semiallogeneic foetuses",
volume = "40",
number = "1",
pages = "353-383",
doi = "10.1080/01652176.2020.1852336"
}

Samardžija, M., Lojkić, M., Maćešić, N., Valpotić, H., Butković, I., Šavorić, J., Žura Žaja, I., Leiner, D., Đuričić, D., Marković, F., Kočila, P., Vidas, Ž., Gerenčer, M., Kaštelan, A., Milovanović, A., Lazarević, M., Rukavina, D.,& Valpotić, I.. (2020). Reproductive immunology in viviparous mammals: evolutionary paradox of interactions among immune mechanisms and autologous or allogeneic gametes and semiallogeneic foetuses. in Veterinary Quarterly
Taylor & Francis., 40(1), 353-383.
https://doi.org/10.1080/01652176.2020.1852336

Samardžija M, Lojkić M, Maćešić N, Valpotić H, Butković I, Šavorić J, Žura Žaja I, Leiner D, Đuričić D, Marković F, Kočila P, Vidas Ž, Gerenčer M, Kaštelan A, Milovanović A, Lazarević M, Rukavina D, Valpotić I. Reproductive immunology in viviparous mammals: evolutionary paradox of interactions among immune mechanisms and autologous or allogeneic gametes and semiallogeneic foetuses. in Veterinary Quarterly. 2020;40(1):353-383.
doi:10.1080/01652176.2020.1852336 .

Samardžija, Marko, Lojkić, Martina, Maćešić, Nino, Valpotić, Hrvoje, Butković, Ivan, Šavorić, Juraj, Žura Žaja, Ivona, Leiner, Denis, Đuričić, Dražen, Marković, Franjo, Kočila, Predrag, Vidas, Željko, Gerenčer, Marijan, Kaštelan, Andrija, Milovanović, Aleksandar, Lazarević, Miodrag, Rukavina, Daniel, Valpotić, Ivica, "Reproductive immunology in viviparous mammals: evolutionary paradox of interactions among immune mechanisms and autologous or allogeneic gametes and semiallogeneic foetuses" in Veterinary Quarterly, 40, no. 1 (2020):353-383,
https://doi.org/10.1080/01652176.2020.1852336 . .

TY  - JOUR
AU  - Samardžija, Marko
AU  - Lojkić, Martina
AU  - Maćešić, Nino
AU  - Valpotić, Hrvoje
AU  - Butković, Ivan
AU  - Šavorić, Juraj
AU  - Žura Žaja, Ivona
AU  - Leiner, Denis
AU  - Đuričić, Dražen
AU  - Marković, Franjo
AU  - Kočila, Predrag
AU  - Vidas, Željko
AU  - Gerenčer, Marijan
AU  - Kaštelan, Andrija
AU  - Milovanović, Aleksandar
AU  - Lazarević, Miodrag
AU  - Rukavina, Daniel
AU  - Valpotić, Ivica
PY  - 2020
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2052
AB  - In the original manuscript the affiliations for the authors M. Gerencer, A. Kastelan, A. Milovanovic, M. Lazarevic, D. Rukavina, I. Valpotic are set incorrectly. This has now been corrected as shown below. M. Samardzijaa , M. Lojkica , N. Macesica , H. Valpoticb , I. Butkovica , J. Savorica , I. Zura  Zaja  c , D. Leinerd , D. Duri - cice , F. Markovicf , P. Kocilag , Z. Vidas  h , M. Gerencerl , A. Kastelani , A. Milovanovicj , M. Lazarevick , D. Rukavinai and I. Valpotic m a Clinic for Obstetrics and Reproduction of Animals, Veterinary Faculty University of Zagreb, Zagreb, Croatia; b Department for Animal Nutrition and Dietetics, Veterinary Faculty University of Zagreb, Zagreb, Croatia; c Department for Physiology and Radiobiology, Veterinary Faculty University of Zagreb, Zagreb, Croatia; d Department of Anatomy, Histology and Embriology, Veterinary Faculty University of Zagreb, Zagreb, Croatia; e Veterinary Practice, Durd - - evac, Croatia; f Belupo d.d. Danica, Koprivnica, Croatia; g Animal Feed Factory, Cakovec, Croatia; h Faculty of Medicine, Department of Urology, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; i Croatian Academy of Sciences and Arts, Croatian Academy of Sciences and Arts, Zagreb, Croatia; j Department of Reproduction, Veterinary Scientific Institute, Novi Sad, Serbia; k Department for Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Belgrade, Belgrade, Serbia; l Department of Cellular Immunology, Baxter Hyland Immuno, Vienna, Austria; mDepartment of Biology, Veterinary Faculty University of Zagreb, Zagreb, Croatia
PB  - Taylor & Francis
T2  - Veterinary Quarterly
T1  - Erratum: Samardžija, M.; Lojkić, M.; Maćešić, N.; Valpotić, H.; Butković, I.; Šavorić, J.; Žura Žaja, I.; Leiner, D.; Đuričić, D.; Marković, F.; Kočila, P.; Vidas, Ž.; Gerenčer, M.; Kaštelan, A.; Milovanović, A.; Lazarević, M.; Rukavina, D.; Valpotić, I. Reproductive Immunology in Viviparous Mammals: Evolutionary Paradox of Interactions among Immune Mechanisms and Autologous or Allogeneic Gametes and Semiallogeneic Foetuses. Veterinary Quarterly 2020, 40 (1), 353–383. https://doi.org/10.1080/01652176.2020.1852336.
VL  - 41
IS  - 1
SP  - 152
EP  - 152
DO  - 10.1080/01652176.2020.1852336
ER  - 

@article{
author = "Samardžija, Marko and Lojkić, Martina and Maćešić, Nino and Valpotić, Hrvoje and Butković, Ivan and Šavorić, Juraj and Žura Žaja, Ivona and Leiner, Denis and Đuričić, Dražen and Marković, Franjo and Kočila, Predrag and Vidas, Željko and Gerenčer, Marijan and Kaštelan, Andrija and Milovanović, Aleksandar and Lazarević, Miodrag and Rukavina, Daniel and Valpotić, Ivica",
year = "2020",
abstract = "In the original manuscript the affiliations for the authors M. Gerencer, A. Kastelan, A. Milovanovic, M. Lazarevic, D. Rukavina, I. Valpotic are set incorrectly. This has now been corrected as shown below. M. Samardzijaa , M. Lojkica , N. Macesica , H. Valpoticb , I. Butkovica , J. Savorica , I. Zura  Zaja  c , D. Leinerd , D. Duri - cice , F. Markovicf , P. Kocilag , Z. Vidas  h , M. Gerencerl , A. Kastelani , A. Milovanovicj , M. Lazarevick , D. Rukavinai and I. Valpotic m a Clinic for Obstetrics and Reproduction of Animals, Veterinary Faculty University of Zagreb, Zagreb, Croatia; b Department for Animal Nutrition and Dietetics, Veterinary Faculty University of Zagreb, Zagreb, Croatia; c Department for Physiology and Radiobiology, Veterinary Faculty University of Zagreb, Zagreb, Croatia; d Department of Anatomy, Histology and Embriology, Veterinary Faculty University of Zagreb, Zagreb, Croatia; e Veterinary Practice, Durd - - evac, Croatia; f Belupo d.d. Danica, Koprivnica, Croatia; g Animal Feed Factory, Cakovec, Croatia; h Faculty of Medicine, Department of Urology, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; i Croatian Academy of Sciences and Arts, Croatian Academy of Sciences and Arts, Zagreb, Croatia; j Department of Reproduction, Veterinary Scientific Institute, Novi Sad, Serbia; k Department for Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Belgrade, Belgrade, Serbia; l Department of Cellular Immunology, Baxter Hyland Immuno, Vienna, Austria; mDepartment of Biology, Veterinary Faculty University of Zagreb, Zagreb, Croatia",
publisher = "Taylor & Francis",
journal = "Veterinary Quarterly",
title = "Erratum: Samardžija, M.; Lojkić, M.; Maćešić, N.; Valpotić, H.; Butković, I.; Šavorić, J.; Žura Žaja, I.; Leiner, D.; Đuričić, D.; Marković, F.; Kočila, P.; Vidas, Ž.; Gerenčer, M.; Kaštelan, A.; Milovanović, A.; Lazarević, M.; Rukavina, D.; Valpotić, I. Reproductive Immunology in Viviparous Mammals: Evolutionary Paradox of Interactions among Immune Mechanisms and Autologous or Allogeneic Gametes and Semiallogeneic Foetuses. Veterinary Quarterly 2020, 40 (1), 353–383. https://doi.org/10.1080/01652176.2020.1852336.",
volume = "41",
number = "1",
pages = "152-152",
doi = "10.1080/01652176.2020.1852336"
}

Samardžija, M., Lojkić, M., Maćešić, N., Valpotić, H., Butković, I., Šavorić, J., Žura Žaja, I., Leiner, D., Đuričić, D., Marković, F., Kočila, P., Vidas, Ž., Gerenčer, M., Kaštelan, A., Milovanović, A., Lazarević, M., Rukavina, D.,& Valpotić, I.. (2020). Erratum: Samardžija, M.; Lojkić, M.; Maćešić, N.; Valpotić, H.; Butković, I.; Šavorić, J.; Žura Žaja, I.; Leiner, D.; Đuričić, D.; Marković, F.; Kočila, P.; Vidas, Ž.; Gerenčer, M.; Kaštelan, A.; Milovanović, A.; Lazarević, M.; Rukavina, D.; Valpotić, I. Reproductive Immunology in Viviparous Mammals: Evolutionary Paradox of Interactions among Immune Mechanisms and Autologous or Allogeneic Gametes and Semiallogeneic Foetuses. Veterinary Quarterly 2020, 40 (1), 353–383. https://doi.org/10.1080/01652176.2020.1852336.. in Veterinary Quarterly
Taylor & Francis., 41(1), 152-152.
https://doi.org/10.1080/01652176.2020.1852336

Samardžija M, Lojkić M, Maćešić N, Valpotić H, Butković I, Šavorić J, Žura Žaja I, Leiner D, Đuričić D, Marković F, Kočila P, Vidas Ž, Gerenčer M, Kaštelan A, Milovanović A, Lazarević M, Rukavina D, Valpotić I. Erratum: Samardžija, M.; Lojkić, M.; Maćešić, N.; Valpotić, H.; Butković, I.; Šavorić, J.; Žura Žaja, I.; Leiner, D.; Đuričić, D.; Marković, F.; Kočila, P.; Vidas, Ž.; Gerenčer, M.; Kaštelan, A.; Milovanović, A.; Lazarević, M.; Rukavina, D.; Valpotić, I. Reproductive Immunology in Viviparous Mammals: Evolutionary Paradox of Interactions among Immune Mechanisms and Autologous or Allogeneic Gametes and Semiallogeneic Foetuses. Veterinary Quarterly 2020, 40 (1), 353–383. https://doi.org/10.1080/01652176.2020.1852336.. in Veterinary Quarterly. 2020;41(1):152-152.
doi:10.1080/01652176.2020.1852336 .

Samardžija, Marko, Lojkić, Martina, Maćešić, Nino, Valpotić, Hrvoje, Butković, Ivan, Šavorić, Juraj, Žura Žaja, Ivona, Leiner, Denis, Đuričić, Dražen, Marković, Franjo, Kočila, Predrag, Vidas, Željko, Gerenčer, Marijan, Kaštelan, Andrija, Milovanović, Aleksandar, Lazarević, Miodrag, Rukavina, Daniel, Valpotić, Ivica, "Erratum: Samardžija, M.; Lojkić, M.; Maćešić, N.; Valpotić, H.; Butković, I.; Šavorić, J.; Žura Žaja, I.; Leiner, D.; Đuričić, D.; Marković, F.; Kočila, P.; Vidas, Ž.; Gerenčer, M.; Kaštelan, A.; Milovanović, A.; Lazarević, M.; Rukavina, D.; Valpotić, I. Reproductive Immunology in Viviparous Mammals: Evolutionary Paradox of Interactions among Immune Mechanisms and Autologous or Allogeneic Gametes and Semiallogeneic Foetuses. Veterinary Quarterly 2020, 40 (1), 353–383. https://doi.org/10.1080/01652176.2020.1852336." in Veterinary Quarterly, 41, no. 1 (2020):152-152,
https://doi.org/10.1080/01652176.2020.1852336 . .

TY  - JOUR
AU  - Genter, Alan
AU  - Capak, Hrvoje
AU  - Lipar, Marija
AU  - Samardžija, Marko
AU  - Harapin, Ivica
AU  - Bedrica, Ljiljana
AU  - Capak, Darko
PY  - 2014
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2186
AB  - The aim of this study was to evaluate three combinations of antibiotics applied perorally prior to laparotomy and gastrointestinal surgery and to select the most favorable combination. Research was performed on 24 female and male dogs divided into four groups. Following abdominal wall incision the caecum was compressed manually and 5 mL of saline solution was injected into it. Five mL of caecum contents was aspirated in a sterile syringe and only 0.1 mL was incubated into blood agar and homogenous agar. Bacterial colonies were counted and determined. Prior to surgery the control group (n=6) received no antibiotics. The group which received the combination of gentamicin and clindamycin (n=6) achieved the best reduction of E. coli whereas Enterococcus faecals was 100% destroyed. The group which received amoxicillin with clavulanic acid and metronidazole (n=6) acquired a reduction of bacteria Enterococcus faecalis, which could be sufficient for prophylaxis. The combination of gentamicin and erythromycin (n=6) failed to accomplish a reduction of the number of bacteria.
AB  - Cilj ovog istraživanja bio je da se procene tri kombinacije antibiotika primenjenih peroralno pre laparotomije i gastrointestinalne hirurgije i da se odredi najefi kasnija kombinacija. Istraživanje na psima je izvedeno na 24 mužjaka i ženke podeljene u četiri grupe. Nakon incizije abdominalnog zida slepo crevo je pritisnuto i ubrizgano je 5 mL fi ziološkog rastvora u njega. Pet mL sadržaja slepog creva je aspirirano u sterilne injekcione špriceve, od čega je samo 0,1 mL inkubiran na krvni i homogeni agar. Nakon toga su prebrojane i determinisane bakterijske kolonije. Pre hirurškog zahvata kontrolna grupa (n=6) nije primila antibiotik. U grupi koja je primila kombinaciju gentamicina i klindamicina (n=6) ostvareno je najveće smanjenje broja E. coli, dok je Enterococcus faecalis uništen u 100% efektu. U grupi koja je primila amoksicilin - klavulansku kiselinu i metronidazol (n=6) ostvareno je smanjenje broja bakterije Enterococcus faecalis, što bi moglo da bude dovoljno za profi laksu. Kombinacija gentamicina i eritromicina (n=6) nije ostvarila zadovoljavajuće rezultate.
T2  - Acta Veterinaria-Beograd
T1  - Antimicrobial prophylaxis in addition to premedication in gastrointestinal surgery
T1  - Antimikrobna premedikacija kao profilaksa pri izvođenju hirurških zahvata u abdomenu
VL  - 64
IS  - 1
SP  - 149
EP  - 155
DO  - 10.2478/acve-2014-0015
ER  - 

@article{
author = "Genter, Alan and Capak, Hrvoje and Lipar, Marija and Samardžija, Marko and Harapin, Ivica and Bedrica, Ljiljana and Capak, Darko",
year = "2014",
abstract = "The aim of this study was to evaluate three combinations of antibiotics applied perorally prior to laparotomy and gastrointestinal surgery and to select the most favorable combination. Research was performed on 24 female and male dogs divided into four groups. Following abdominal wall incision the caecum was compressed manually and 5 mL of saline solution was injected into it. Five mL of caecum contents was aspirated in a sterile syringe and only 0.1 mL was incubated into blood agar and homogenous agar. Bacterial colonies were counted and determined. Prior to surgery the control group (n=6) received no antibiotics. The group which received the combination of gentamicin and clindamycin (n=6) achieved the best reduction of E. coli whereas Enterococcus faecals was 100% destroyed. The group which received amoxicillin with clavulanic acid and metronidazole (n=6) acquired a reduction of bacteria Enterococcus faecalis, which could be sufficient for prophylaxis. The combination of gentamicin and erythromycin (n=6) failed to accomplish a reduction of the number of bacteria., Cilj ovog istraživanja bio je da se procene tri kombinacije antibiotika primenjenih peroralno pre laparotomije i gastrointestinalne hirurgije i da se odredi najefi kasnija kombinacija. Istraživanje na psima je izvedeno na 24 mužjaka i ženke podeljene u četiri grupe. Nakon incizije abdominalnog zida slepo crevo je pritisnuto i ubrizgano je 5 mL fi ziološkog rastvora u njega. Pet mL sadržaja slepog creva je aspirirano u sterilne injekcione špriceve, od čega je samo 0,1 mL inkubiran na krvni i homogeni agar. Nakon toga su prebrojane i determinisane bakterijske kolonije. Pre hirurškog zahvata kontrolna grupa (n=6) nije primila antibiotik. U grupi koja je primila kombinaciju gentamicina i klindamicina (n=6) ostvareno je najveće smanjenje broja E. coli, dok je Enterococcus faecalis uništen u 100% efektu. U grupi koja je primila amoksicilin - klavulansku kiselinu i metronidazol (n=6) ostvareno je smanjenje broja bakterije Enterococcus faecalis, što bi moglo da bude dovoljno za profi laksu. Kombinacija gentamicina i eritromicina (n=6) nije ostvarila zadovoljavajuće rezultate.",
journal = "Acta Veterinaria-Beograd",
title = "Antimicrobial prophylaxis in addition to premedication in gastrointestinal surgery, Antimikrobna premedikacija kao profilaksa pri izvođenju hirurških zahvata u abdomenu",
volume = "64",
number = "1",
pages = "149-155",
doi = "10.2478/acve-2014-0015"
}

Genter, A., Capak, H., Lipar, M., Samardžija, M., Harapin, I., Bedrica, L.,& Capak, D.. (2014). Antimicrobial prophylaxis in addition to premedication in gastrointestinal surgery. in Acta Veterinaria-Beograd, 64(1), 149-155.
https://doi.org/10.2478/acve-2014-0015

Genter A, Capak H, Lipar M, Samardžija M, Harapin I, Bedrica L, Capak D. Antimicrobial prophylaxis in addition to premedication in gastrointestinal surgery. in Acta Veterinaria-Beograd. 2014;64(1):149-155.
doi:10.2478/acve-2014-0015 .

Genter, Alan, Capak, Hrvoje, Lipar, Marija, Samardžija, Marko, Harapin, Ivica, Bedrica, Ljiljana, Capak, Darko, "Antimicrobial prophylaxis in addition to premedication in gastrointestinal surgery" in Acta Veterinaria-Beograd, 64, no. 1 (2014):149-155,
https://doi.org/10.2478/acve-2014-0015 . .