TY  - JOUR
AU  - Mujezinović, Indira
AU  - Smajlović, Ahmed
AU  - Zuko, A.
AU  - Dukić, B.
AU  - Ćupić, Vitomir
PY  - 2018
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1599
AB  - Extract of chestnut is a mixture of tannic and non-tannic components. The most common tannic components are the glycosides castalagin and vescalagin, which have a therapeutic effect. In conducted studies in vitro and in vivo, it was found that the tannin extract of chestnut has anti-diarrhoeal, astringent, antiviral, antimicrobial, antiprotozoal and anthelmintic properties. At the same time, it was found that the tannin extract of chestnut has anti-carcinogenic properties. Tannin interacts with the membrane structures of certain microorganisms, and thus decreases the permeability of the cell membrane. This antimicrobial activity is advantageous in terms of the action of antibiotics, because tannins only cause the inhibition of microflora growth but not its destruction. Ingested tannins at therapeutic concentrations (2-5%) cannot be absorbed and so cannot cause pharmacodynamic effects on the other organic systems. In the intestines, by means of hydrolysis, they are completely biotransformed into polyphenols (gallic, digallic and elastic acids) and glucose. In the urine, only the degradation products of tannin in the form of glucuronide can be identified. In therapeutic concentrations, tannins have an insignificant effect on the skin, while on mucous membranes they act astringently. At higher concentrations, tannins may lead to degradation of superficial, and even deeper layers of mucous membranes and granulation tissue. Given that they do not show teratogenic, mutagenic or carcinogenic effects, everything indicates that tannins should be more often and more extensively used as safe veterinary drugs.
PB  - Croatian Veterinary Institute
T2  - Veterinarska Stanica
T1  - Tannins from Sweet Chestnut (Castanea sativa)
T1  - Tanini pitomog kestena (Castanea sativa)
VL  - 49
IS  - 5
SP  - 371
EP  - 377
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_1599
ER  - 

@article{
author = "Mujezinović, Indira and Smajlović, Ahmed and Zuko, A. and Dukić, B. and Ćupić, Vitomir",
year = "2018",
abstract = "Extract of chestnut is a mixture of tannic and non-tannic components. The most common tannic components are the glycosides castalagin and vescalagin, which have a therapeutic effect. In conducted studies in vitro and in vivo, it was found that the tannin extract of chestnut has anti-diarrhoeal, astringent, antiviral, antimicrobial, antiprotozoal and anthelmintic properties. At the same time, it was found that the tannin extract of chestnut has anti-carcinogenic properties. Tannin interacts with the membrane structures of certain microorganisms, and thus decreases the permeability of the cell membrane. This antimicrobial activity is advantageous in terms of the action of antibiotics, because tannins only cause the inhibition of microflora growth but not its destruction. Ingested tannins at therapeutic concentrations (2-5%) cannot be absorbed and so cannot cause pharmacodynamic effects on the other organic systems. In the intestines, by means of hydrolysis, they are completely biotransformed into polyphenols (gallic, digallic and elastic acids) and glucose. In the urine, only the degradation products of tannin in the form of glucuronide can be identified. In therapeutic concentrations, tannins have an insignificant effect on the skin, while on mucous membranes they act astringently. At higher concentrations, tannins may lead to degradation of superficial, and even deeper layers of mucous membranes and granulation tissue. Given that they do not show teratogenic, mutagenic or carcinogenic effects, everything indicates that tannins should be more often and more extensively used as safe veterinary drugs.",
publisher = "Croatian Veterinary Institute",
journal = "Veterinarska Stanica",
title = "Tannins from Sweet Chestnut (Castanea sativa), Tanini pitomog kestena (Castanea sativa)",
volume = "49",
number = "5",
pages = "371-377",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_1599"
}

Mujezinović, I., Smajlović, A., Zuko, A., Dukić, B.,& Ćupić, V.. (2018). Tannins from Sweet Chestnut (Castanea sativa). in Veterinarska Stanica
Croatian Veterinary Institute., 49(5), 371-377.
https://hdl.handle.net/21.15107/rcub_veterinar_1599

Mujezinović I, Smajlović A, Zuko A, Dukić B, Ćupić V. Tannins from Sweet Chestnut (Castanea sativa). in Veterinarska Stanica. 2018;49(5):371-377.
https://hdl.handle.net/21.15107/rcub_veterinar_1599 .

Mujezinović, Indira, Smajlović, Ahmed, Zuko, A., Dukić, B., Ćupić, Vitomir, "Tannins from Sweet Chestnut (Castanea sativa)" in Veterinarska Stanica, 49, no. 5 (2018):371-377,
https://hdl.handle.net/21.15107/rcub_veterinar_1599 .

TY  - JOUR
AU  - Mujezinović, Indira
AU  - Smajlović, Ahmed
AU  - Ćupić, Vitomir
PY  - 2018
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1611
AB  - Introduction. Tetanus, also known as lockjaw, is a very dangerous, infectious, acute, usually afebrile disease characterised by muscle spasms. The causative agent of the disease is the bacterium Clostridium tetani. This pathogen produces a specifc neurotoxin, termed tetanus toxin, with two components: tetanospasmin and tetanolysin. Light chains of tetanospasmin cleavage synaptobrevin, which in turn prevent release of the inhibitory neurotransmitter GABA into the synaptic cleft. The α-motor neurons are, therefore, under no inhibitory control, as a result of which they undergo sustained excitatory discharge causing the characteristic motor spasms of tetanus. Materials and Methods. In this research, we attempted to normalise disorders caused by tetanus toxin by using haloperidol (at doses of 4, 5, 6, 7 and 8 mg/kg b.w.), alone and in combination with (-)-nuciferine (at a dose of 5 mg/kg b.w.) or aminooxyacetic acid (at a dose of 20 mg/kg b.w.). Experiments were conducted on albino mice. Experimental tetanus was induced by application of tetanus toxin. Results and Conclusions. Application of haloperidol (alone and in combination with (-)-nuciferine and aminooxyacetic acid) was carried out 24 h following the application of tetanus toxin. It was found that haloperidol, given alone in a dose of 4 mg/kg, prolonged the average survival time of mice with experimental tetanus by 24.35 h compared to the control animals. Additionally, the combination of haloperidol with (-)-nuciferine slightly, but non-signifcantly, extended survival time , while the combination of haloperidol with aminooxyacetic acid produced the best effect on extension of survival time (mice survived on average 27.74 h longer than control mice).
AB  - Uvod. Tetanus je veoma opasna, akutna, obično afebrilna bolest koju karakteriše mišićni spazam. Uzročnik obolenja je bakterija Clostridium tetani, koja proizvodi specifčan neurotoksin ili tetanus toksin. Toksin se sastoji od dve komponente: tetanospazmina i tetanolizina. Laki lanac tetanospazmina cepa sinaptobrevin, što za posledicu ima sprečavanje oslobađanje inhibitornog neurotransmitera GABA u sinaptički procep. Funkcija ekscitatornih neurotransmitera ostaje očuvana, te pod njihovim uticajem dolazi do grča skeletne muskulature. Materijali i metode. U ovom istraživanju pokušali smo normalizovati poremećaje uzrokovane tetanus toksinom koristeći haloperidol (u dozama od 4, 5, 6, 7 i 8 mg/ kg t.m.), samostalno i u kombinaciji sa (-)-nuciferinom (u dozi od 5 mg/kg t.m.) i aminooksirćetnom kiselinom (u dozi od 20 mg/kg t.m.). Kompletno istraživanje je sprovedeno na albino miševima. Eksperimentalni tetanus izazvan je aplikacijom tetanus toksina. Rezultati i zaključak. Primena haloperidola (samo i u kombinaciji sa (-)-nuciferinom i aminooksirćetnom kiselinom) vršena je 24 sata nakon aplikacije tetanus toksina. Haloperidol, aplikovan u dozi od 4 mg/kg t.m., produžio je vreme preživljavanja miševa s eksperimentalnim tetanusom za oko 24.35 sati u odnosu na kontrolnu grupu životinja, te smo ovu dozu smatrali jedino opravdanom za dalja istraživanja. Kombinacija haloperidola s (-)-nuciferinom neznatno produžava vreme preživljavanja, dok je kombinacija haloperidola sa aminooksirćetnom kiselinom imala nabolji efekt na produženje ovog perioda. Period preživljavanja je produžen oko 27.74 sata u odnosu na kontrolnu grupu životinja.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Veterinarski Glasnik
T1  - The effect of haloperidol, aminooxyacetic acid and (-)-nuciferine on prolonged survival time of mice with tetanus
T1  - Delovanje haloperidola, aminooksisirćetne kiseline i (-)-nuciferina na produženje preživljavanja miševa s tetanusom
VL  - 72
IS  - 2
SP  - 122
EP  - 128
DO  - 10.2298/VETGL171023005M
ER  - 

@article{
author = "Mujezinović, Indira and Smajlović, Ahmed and Ćupić, Vitomir",
year = "2018",
abstract = "Introduction. Tetanus, also known as lockjaw, is a very dangerous, infectious, acute, usually afebrile disease characterised by muscle spasms. The causative agent of the disease is the bacterium Clostridium tetani. This pathogen produces a specifc neurotoxin, termed tetanus toxin, with two components: tetanospasmin and tetanolysin. Light chains of tetanospasmin cleavage synaptobrevin, which in turn prevent release of the inhibitory neurotransmitter GABA into the synaptic cleft. The α-motor neurons are, therefore, under no inhibitory control, as a result of which they undergo sustained excitatory discharge causing the characteristic motor spasms of tetanus. Materials and Methods. In this research, we attempted to normalise disorders caused by tetanus toxin by using haloperidol (at doses of 4, 5, 6, 7 and 8 mg/kg b.w.), alone and in combination with (-)-nuciferine (at a dose of 5 mg/kg b.w.) or aminooxyacetic acid (at a dose of 20 mg/kg b.w.). Experiments were conducted on albino mice. Experimental tetanus was induced by application of tetanus toxin. Results and Conclusions. Application of haloperidol (alone and in combination with (-)-nuciferine and aminooxyacetic acid) was carried out 24 h following the application of tetanus toxin. It was found that haloperidol, given alone in a dose of 4 mg/kg, prolonged the average survival time of mice with experimental tetanus by 24.35 h compared to the control animals. Additionally, the combination of haloperidol with (-)-nuciferine slightly, but non-signifcantly, extended survival time , while the combination of haloperidol with aminooxyacetic acid produced the best effect on extension of survival time (mice survived on average 27.74 h longer than control mice)., Uvod. Tetanus je veoma opasna, akutna, obično afebrilna bolest koju karakteriše mišićni spazam. Uzročnik obolenja je bakterija Clostridium tetani, koja proizvodi specifčan neurotoksin ili tetanus toksin. Toksin se sastoji od dve komponente: tetanospazmina i tetanolizina. Laki lanac tetanospazmina cepa sinaptobrevin, što za posledicu ima sprečavanje oslobađanje inhibitornog neurotransmitera GABA u sinaptički procep. Funkcija ekscitatornih neurotransmitera ostaje očuvana, te pod njihovim uticajem dolazi do grča skeletne muskulature. Materijali i metode. U ovom istraživanju pokušali smo normalizovati poremećaje uzrokovane tetanus toksinom koristeći haloperidol (u dozama od 4, 5, 6, 7 i 8 mg/ kg t.m.), samostalno i u kombinaciji sa (-)-nuciferinom (u dozi od 5 mg/kg t.m.) i aminooksirćetnom kiselinom (u dozi od 20 mg/kg t.m.). Kompletno istraživanje je sprovedeno na albino miševima. Eksperimentalni tetanus izazvan je aplikacijom tetanus toksina. Rezultati i zaključak. Primena haloperidola (samo i u kombinaciji sa (-)-nuciferinom i aminooksirćetnom kiselinom) vršena je 24 sata nakon aplikacije tetanus toksina. Haloperidol, aplikovan u dozi od 4 mg/kg t.m., produžio je vreme preživljavanja miševa s eksperimentalnim tetanusom za oko 24.35 sati u odnosu na kontrolnu grupu životinja, te smo ovu dozu smatrali jedino opravdanom za dalja istraživanja. Kombinacija haloperidola s (-)-nuciferinom neznatno produžava vreme preživljavanja, dok je kombinacija haloperidola sa aminooksirćetnom kiselinom imala nabolji efekt na produženje ovog perioda. Period preživljavanja je produžen oko 27.74 sata u odnosu na kontrolnu grupu životinja.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Veterinarski Glasnik",
title = "The effect of haloperidol, aminooxyacetic acid and (-)-nuciferine on prolonged survival time of mice with tetanus, Delovanje haloperidola, aminooksisirćetne kiseline i (-)-nuciferina na produženje preživljavanja miševa s tetanusom",
volume = "72",
number = "2",
pages = "122-128",
doi = "10.2298/VETGL171023005M"
}

Mujezinović, I., Smajlović, A.,& Ćupić, V.. (2018). The effect of haloperidol, aminooxyacetic acid and (-)-nuciferine on prolonged survival time of mice with tetanus. in Veterinarski Glasnik
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 72(2), 122-128.
https://doi.org/10.2298/VETGL171023005M

Mujezinović I, Smajlović A, Ćupić V. The effect of haloperidol, aminooxyacetic acid and (-)-nuciferine on prolonged survival time of mice with tetanus. in Veterinarski Glasnik. 2018;72(2):122-128.
doi:10.2298/VETGL171023005M .

Mujezinović, Indira, Smajlović, Ahmed, Ćupić, Vitomir, "The effect of haloperidol, aminooxyacetic acid and (-)-nuciferine on prolonged survival time of mice with tetanus" in Veterinarski Glasnik, 72, no. 2 (2018):122-128,
https://doi.org/10.2298/VETGL171023005M . .

TY  - JOUR
AU  - Mujezinović, Indira
AU  - Smajlović, Ahmed
AU  - Zuko, A.
AU  - Dukić, B.
AU  - Ćupić, Vitomir
PY  - 2018
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1600
AB  - Thymol (2-isopropyl-5-methylphenol) is a natural compound from a group of monotherpentinic phenols. These phenols are present in the essential oils of many plants of the Labiateae family, which are used in the folk medicine for centuries. During this long-term period, it is established that thymol has, together with antiseptic and spasmolytic, also antihelmintic action. Thymol antimicrobial spectrum is wide because it acts on Gram-positive and Gramnegative bacteria, fungi and yeasts. As a natural alternative to antibiotics, unlike many traditional antibiotics with bactericidal action, thymol attacks bacterial organelles, especially respiratory chain enzymes, which are linked to mesosomes of the cell membranes, which leads to complete destruction of pathogenic aerobic bacteria results due to a blockage of the cellular respiration and death of the bacteria. During numerous in vitro and in vivo studies conducted with thymol, it has been proved that thymol has antibacterial, antifungal, anti-inflammatory, antiseptic, spasmolytic and anthelmintic effects. It has a wide spectrum of effects against both, Gram-positive and Gram-negative bacteria, yeasts and molds. Nowadays, thymol is used successfully both in human and in veterinary medicine. In veterinary practice, it is used with different species of animals in the treatment of respiratory diseases. Also, it is widely used in beekeeping as a good acaricide at very low concentrations. The exact mechanism of acaridical action of thymol is still not sufficiently known. General idea is that timol acaricidal action is mediated via GABA (A) receptor-R, leading to a neurotoxic effect on the octopaminergic nerves of ticks and insects. Most likely, the death of the ticks is the result of their choking. Thymol is rapidly absorbed from the gastrointestinal system, metabolized by oxidation and glucuronidation, and rapidly (in the first 24 hours of application) excreted via urine, and to a small extent in the unchanged and in large part in the form of glucuronides and /or conjugated sulphates. Additionally, it was found that thymol is quickly reabsorbed from the site of administration, promptly metabolized and rapidly excreted from the organism. Thymol is a natural and safe active substance for which MRL is not established, and it is listed in Annex II of the List of substances without withdrawal period. During the investigation of thymol residues in some bee products (honey and wax) it was found that treatments with this natural substance can be considered to be good alternatives for synthetic acaricides, especially because they do not represent a sanitary risk. Thymol has been evaluated 1992 by the Committee of Expert on Flavorings Substances of the Council of Europe. Thymol is listed among the substances that are permitted as flavouring agents. An upper limit for inclusion of thymol in food has been established at 50 mg/kg and in beverages at 10 mg/kg. During clinical trials of the various medicinal preparations containing thymol on bee-keeping communities, at the established therapeutic concentrations, no adverse effects have been observed. Thymol did not show any theratogenic, mutagenic or carcinogenic effects.
PB  - Croatian Veterinary Institute
T2  - Veterinarska Stanica
T1  - Importance of clinical applications of thymol
T1  - Značenje kliničke primjene timola
VL  - 49
IS  - 2
SP  - 123
EP  - 129
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_1600
ER  - 

@article{
author = "Mujezinović, Indira and Smajlović, Ahmed and Zuko, A. and Dukić, B. and Ćupić, Vitomir",
year = "2018",
abstract = "Thymol (2-isopropyl-5-methylphenol) is a natural compound from a group of monotherpentinic phenols. These phenols are present in the essential oils of many plants of the Labiateae family, which are used in the folk medicine for centuries. During this long-term period, it is established that thymol has, together with antiseptic and spasmolytic, also antihelmintic action. Thymol antimicrobial spectrum is wide because it acts on Gram-positive and Gramnegative bacteria, fungi and yeasts. As a natural alternative to antibiotics, unlike many traditional antibiotics with bactericidal action, thymol attacks bacterial organelles, especially respiratory chain enzymes, which are linked to mesosomes of the cell membranes, which leads to complete destruction of pathogenic aerobic bacteria results due to a blockage of the cellular respiration and death of the bacteria. During numerous in vitro and in vivo studies conducted with thymol, it has been proved that thymol has antibacterial, antifungal, anti-inflammatory, antiseptic, spasmolytic and anthelmintic effects. It has a wide spectrum of effects against both, Gram-positive and Gram-negative bacteria, yeasts and molds. Nowadays, thymol is used successfully both in human and in veterinary medicine. In veterinary practice, it is used with different species of animals in the treatment of respiratory diseases. Also, it is widely used in beekeeping as a good acaricide at very low concentrations. The exact mechanism of acaridical action of thymol is still not sufficiently known. General idea is that timol acaricidal action is mediated via GABA (A) receptor-R, leading to a neurotoxic effect on the octopaminergic nerves of ticks and insects. Most likely, the death of the ticks is the result of their choking. Thymol is rapidly absorbed from the gastrointestinal system, metabolized by oxidation and glucuronidation, and rapidly (in the first 24 hours of application) excreted via urine, and to a small extent in the unchanged and in large part in the form of glucuronides and /or conjugated sulphates. Additionally, it was found that thymol is quickly reabsorbed from the site of administration, promptly metabolized and rapidly excreted from the organism. Thymol is a natural and safe active substance for which MRL is not established, and it is listed in Annex II of the List of substances without withdrawal period. During the investigation of thymol residues in some bee products (honey and wax) it was found that treatments with this natural substance can be considered to be good alternatives for synthetic acaricides, especially because they do not represent a sanitary risk. Thymol has been evaluated 1992 by the Committee of Expert on Flavorings Substances of the Council of Europe. Thymol is listed among the substances that are permitted as flavouring agents. An upper limit for inclusion of thymol in food has been established at 50 mg/kg and in beverages at 10 mg/kg. During clinical trials of the various medicinal preparations containing thymol on bee-keeping communities, at the established therapeutic concentrations, no adverse effects have been observed. Thymol did not show any theratogenic, mutagenic or carcinogenic effects.",
publisher = "Croatian Veterinary Institute",
journal = "Veterinarska Stanica",
title = "Importance of clinical applications of thymol, Značenje kliničke primjene timola",
volume = "49",
number = "2",
pages = "123-129",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_1600"
}

Mujezinović, I., Smajlović, A., Zuko, A., Dukić, B.,& Ćupić, V.. (2018). Importance of clinical applications of thymol. in Veterinarska Stanica
Croatian Veterinary Institute., 49(2), 123-129.
https://hdl.handle.net/21.15107/rcub_veterinar_1600

Mujezinović I, Smajlović A, Zuko A, Dukić B, Ćupić V. Importance of clinical applications of thymol. in Veterinarska Stanica. 2018;49(2):123-129.
https://hdl.handle.net/21.15107/rcub_veterinar_1600 .

Mujezinović, Indira, Smajlović, Ahmed, Zuko, A., Dukić, B., Ćupić, Vitomir, "Importance of clinical applications of thymol" in Veterinarska Stanica, 49, no. 2 (2018):123-129,
https://hdl.handle.net/21.15107/rcub_veterinar_1600 .

TY  - JOUR
AU  - Smajlović, Ahmed
AU  - Muminović, Mehmed
AU  - Mujezinović, Indira
AU  - Ćupić, Vitomir
PY  - 2012
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/909
AB  - Aflatoxin M1 is a highly toxic 4-hydroxylated metabolite of aflatoxins B1 and B2. It is one of the most potent hepatocarcinogens, mutagens, teratogens and immunosuppressors. Feed is often contaminated with aflatoxigenic moulds and aflatoxins with a high possibility of contaminating milk and dairy products with aflatoxin M1. Samples of artificially contaminated milk were exposed to the effects of physical conditions (temperature of -18oC and for microwaves in a microwave oven), time (during the period from 1 to 12 months) and a combination of the above mentioned conditions. Following this, levels of aflatoxin M1 degradation were established by using the ELISA method. An insignificant decrease in concentration of toxin was observed which indicates that a temperature of -18°C does not significantly influence the concentration of aflatoxin M1 in the artificially contaminated milk. At the same time, treatment of milk with microwaves in a microwave oven showed an insignificant influence on the percentage of aflatoxin M1 absorbance.
AB  - Aflatoksin M1 je veoma toksičan metabolit aflatoksina B1 i B2. S obzirom na to da je jedan od najpotentnijih hepatokarcinogena, mutagena, teratogena i imunosupresora, a hrana za životinje često bude kontaminirana aflatoksinogenim gljivicama i aflatoksinima, moguća je i kontaminacija mlijeka i mliječnih proizvoda aflatoksinom M1. Vještački kontaminirano mlijeko aflatoksinom M1 je bilo podvrgnuto uticaju fizikalnih procesa (uticaj niske temperature od -18oC i izlaganja mikrotalasima u mikrotalasnoj rerni), te uticaju vremena držanja (od 1 do 12 mjeseci), kao i uticaju kombinacija navedenih postupaka, nakon čega je praćen nivo degradacije aflatoksina M1. Uzorci vještački kontaminiranog mlijeka, nakon pojedinačno provedenih postupaka su podvrgavani istraživanjima uz korištenje ELISA metode. Primjećeno je neznatno smanjenje koncentracije toksina, što ukazuje na to da vrijeme i temperatura od -18°C ne utiču znatnije na koncentraciju aflatoksina M1 u vještački kontaminiranom sirovom mlijeku, dok postupak tretiranja mlijeka mikrotalasima u mikrotalasnoj rerni nije značajnije uticao na postotak apsorbance aflatoksina M1.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Veterinarski Glasnik
T1  - Investigation of aflatoxin M1 degradation in milk
T1  - Istraživanje degradacije aflatoksina M1 u mlijeku
VL  - 66
IS  - 5-6
SP  - 387
EP  - 394
DO  - 10.2298/VETGL1206387S
ER  - 

@article{
author = "Smajlović, Ahmed and Muminović, Mehmed and Mujezinović, Indira and Ćupić, Vitomir",
year = "2012",
abstract = "Aflatoxin M1 is a highly toxic 4-hydroxylated metabolite of aflatoxins B1 and B2. It is one of the most potent hepatocarcinogens, mutagens, teratogens and immunosuppressors. Feed is often contaminated with aflatoxigenic moulds and aflatoxins with a high possibility of contaminating milk and dairy products with aflatoxin M1. Samples of artificially contaminated milk were exposed to the effects of physical conditions (temperature of -18oC and for microwaves in a microwave oven), time (during the period from 1 to 12 months) and a combination of the above mentioned conditions. Following this, levels of aflatoxin M1 degradation were established by using the ELISA method. An insignificant decrease in concentration of toxin was observed which indicates that a temperature of -18°C does not significantly influence the concentration of aflatoxin M1 in the artificially contaminated milk. At the same time, treatment of milk with microwaves in a microwave oven showed an insignificant influence on the percentage of aflatoxin M1 absorbance., Aflatoksin M1 je veoma toksičan metabolit aflatoksina B1 i B2. S obzirom na to da je jedan od najpotentnijih hepatokarcinogena, mutagena, teratogena i imunosupresora, a hrana za životinje često bude kontaminirana aflatoksinogenim gljivicama i aflatoksinima, moguća je i kontaminacija mlijeka i mliječnih proizvoda aflatoksinom M1. Vještački kontaminirano mlijeko aflatoksinom M1 je bilo podvrgnuto uticaju fizikalnih procesa (uticaj niske temperature od -18oC i izlaganja mikrotalasima u mikrotalasnoj rerni), te uticaju vremena držanja (od 1 do 12 mjeseci), kao i uticaju kombinacija navedenih postupaka, nakon čega je praćen nivo degradacije aflatoksina M1. Uzorci vještački kontaminiranog mlijeka, nakon pojedinačno provedenih postupaka su podvrgavani istraživanjima uz korištenje ELISA metode. Primjećeno je neznatno smanjenje koncentracije toksina, što ukazuje na to da vrijeme i temperatura od -18°C ne utiču znatnije na koncentraciju aflatoksina M1 u vještački kontaminiranom sirovom mlijeku, dok postupak tretiranja mlijeka mikrotalasima u mikrotalasnoj rerni nije značajnije uticao na postotak apsorbance aflatoksina M1.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Veterinarski Glasnik",
title = "Investigation of aflatoxin M1 degradation in milk, Istraživanje degradacije aflatoksina M1 u mlijeku",
volume = "66",
number = "5-6",
pages = "387-394",
doi = "10.2298/VETGL1206387S"
}

Smajlović, A., Muminović, M., Mujezinović, I.,& Ćupić, V.. (2012). Investigation of aflatoxin M1 degradation in milk. in Veterinarski Glasnik
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 66(5-6), 387-394.
https://doi.org/10.2298/VETGL1206387S

Smajlović A, Muminović M, Mujezinović I, Ćupić V. Investigation of aflatoxin M1 degradation in milk. in Veterinarski Glasnik. 2012;66(5-6):387-394.
doi:10.2298/VETGL1206387S .

Smajlović, Ahmed, Muminović, Mehmed, Mujezinović, Indira, Ćupić, Vitomir, "Investigation of aflatoxin M1 degradation in milk" in Veterinarski Glasnik, 66, no. 5-6 (2012):387-394,
https://doi.org/10.2298/VETGL1206387S . .

TY  - JOUR
AU  - Mujezinović, Indira
AU  - Ćupić, Vitomir
AU  - Smajlović, Ahmed
AU  - Muminović, Mehmed
PY  - 2011
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/790
AB  - Serotonin or 5-hydroxytryptamine (5-HT), is a monoamine neurotransmitter synthesised from L-tryptophan in serotonergic neurons and enterochromaffin cells of the gastrointestinal tract. This neurotransmitter is widely distributed in the animal and plant kingdom and regulates some central and peripheral functions through several types of specific serotonergic (5-HT) receptors. Since it is known that the effect of serotonin, especially in pathological conditions, is very important, we believe that determining the types of receptors for this substance would make it possible to use their agonist or antagonists, which would undoubtedly enhance the pharmacotherapy of functional disruption of the small intestine in broilers. Investigations were carried out on isolated smooth muscle strips of the circular and longitudinal layer of the broiler small intestine (strip dimension 3-4 mm x 2 cm). The muscle strips were placed in an isolated organ bath. The mechanical activity of the preparations was recorded via an isotonic force transducer coupled to a pen recorder. This was done following the addition of serotonin (nonselective 5-HT agonist), 8-OH-DPAT (selective 5-HT1A agonist) and spiroxatrin (selective 5-HT1A antagonist). The sensitivity of the tissues to acetylcholine was tested before starting the experiments. Using the obtained results, it can be concluded that 5HT1A type receptors are present in smooth muscles of the broiler small intestine, duodenum and ileum, especially in the longitudinal smooth muscle layer which reacted with contractions even to low serotonin concentration (10-6), but not in the jejunum.
AB  - Serotonin ili 5-hidroksitriptamin (5-HT) je monoaminski neurotransmiter kojeg iz L-triptofana sintetišu serotonergični neuroni i enterohrmofine ćelije gastrointestinalnog trakta. Ovaj neurotransmiter se nalazi kod velikog broja životinja i biljaka i reguliše neke centralne i periferne funkcije posredstvom nekoliko tipova specifičnih serotonergičnih (5- HT) receptora. Pošto je poznato da je efekat serotonina,posebno u patološkim uslovima, veoma značajan, mi mislimo da određivanje tipa receptora za ovu supstancu može učiniti mogućom upotrebu njenih agonista ili antagonista, što bi nedvosmisleno povećalo farmakoterapiju poremećaja funkcije tankog creva kod brojlera. Istraživanja su izvršena na izolovanim trakama glatkih mišića kružnog i uzdužnog sloja tankog creva brojlera (dimenzije trake 3-4 mm x 2 cm). Trake mišića su bile stavljane u kupatila za izolovane organe. Mehanička aktivnost preparata je registrovana pomoću izotoničnog transdjusera povezanog sa štampačem. Registrovanje je vršeno posle dodavanja serotonina (neselektivni 5-HT agonist), 8-OH-DPAT (selektivni agonist) i spiroksatrina (selektivni 5-HT1A antagonist). Osetljivost tkiva na acetilholin testirana je pre početka eksperimenta. Imajući u vidu dobijene rezultate može se zaključiti da su receptori 5HT1A tipa prisutni u glatkim mišićima tankog creva brojlera, duodenumu i ileumu, posebno u uzdužnom sloju glatkih mišića koji je reagovao kontrakcijama čak i na niske koncentracije serotonina (10-6), ali ne i u jejunumu.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Veterinarski Glasnik
T1  - Identification of serotonergic (5HT1A-type) receptors in broiler small intestine by application of serotonin and its agonists and antagonists
T1  - Utvrđivanje serotonergičnih receptora 5HT1A tipa u tankom crijevu brojlera primjenom serotonina i njegovih agonista i antagonista
VL  - 65
IS  - 1-2
SP  - 51
EP  - 59
DO  - 10.2298/VETGL1102051M
ER  - 

@article{
author = "Mujezinović, Indira and Ćupić, Vitomir and Smajlović, Ahmed and Muminović, Mehmed",
year = "2011",
abstract = "Serotonin or 5-hydroxytryptamine (5-HT), is a monoamine neurotransmitter synthesised from L-tryptophan in serotonergic neurons and enterochromaffin cells of the gastrointestinal tract. This neurotransmitter is widely distributed in the animal and plant kingdom and regulates some central and peripheral functions through several types of specific serotonergic (5-HT) receptors. Since it is known that the effect of serotonin, especially in pathological conditions, is very important, we believe that determining the types of receptors for this substance would make it possible to use their agonist or antagonists, which would undoubtedly enhance the pharmacotherapy of functional disruption of the small intestine in broilers. Investigations were carried out on isolated smooth muscle strips of the circular and longitudinal layer of the broiler small intestine (strip dimension 3-4 mm x 2 cm). The muscle strips were placed in an isolated organ bath. The mechanical activity of the preparations was recorded via an isotonic force transducer coupled to a pen recorder. This was done following the addition of serotonin (nonselective 5-HT agonist), 8-OH-DPAT (selective 5-HT1A agonist) and spiroxatrin (selective 5-HT1A antagonist). The sensitivity of the tissues to acetylcholine was tested before starting the experiments. Using the obtained results, it can be concluded that 5HT1A type receptors are present in smooth muscles of the broiler small intestine, duodenum and ileum, especially in the longitudinal smooth muscle layer which reacted with contractions even to low serotonin concentration (10-6), but not in the jejunum., Serotonin ili 5-hidroksitriptamin (5-HT) je monoaminski neurotransmiter kojeg iz L-triptofana sintetišu serotonergični neuroni i enterohrmofine ćelije gastrointestinalnog trakta. Ovaj neurotransmiter se nalazi kod velikog broja životinja i biljaka i reguliše neke centralne i periferne funkcije posredstvom nekoliko tipova specifičnih serotonergičnih (5- HT) receptora. Pošto je poznato da je efekat serotonina,posebno u patološkim uslovima, veoma značajan, mi mislimo da određivanje tipa receptora za ovu supstancu može učiniti mogućom upotrebu njenih agonista ili antagonista, što bi nedvosmisleno povećalo farmakoterapiju poremećaja funkcije tankog creva kod brojlera. Istraživanja su izvršena na izolovanim trakama glatkih mišića kružnog i uzdužnog sloja tankog creva brojlera (dimenzije trake 3-4 mm x 2 cm). Trake mišića su bile stavljane u kupatila za izolovane organe. Mehanička aktivnost preparata je registrovana pomoću izotoničnog transdjusera povezanog sa štampačem. Registrovanje je vršeno posle dodavanja serotonina (neselektivni 5-HT agonist), 8-OH-DPAT (selektivni agonist) i spiroksatrina (selektivni 5-HT1A antagonist). Osetljivost tkiva na acetilholin testirana je pre početka eksperimenta. Imajući u vidu dobijene rezultate može se zaključiti da su receptori 5HT1A tipa prisutni u glatkim mišićima tankog creva brojlera, duodenumu i ileumu, posebno u uzdužnom sloju glatkih mišića koji je reagovao kontrakcijama čak i na niske koncentracije serotonina (10-6), ali ne i u jejunumu.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Veterinarski Glasnik",
title = "Identification of serotonergic (5HT1A-type) receptors in broiler small intestine by application of serotonin and its agonists and antagonists, Utvrđivanje serotonergičnih receptora 5HT1A tipa u tankom crijevu brojlera primjenom serotonina i njegovih agonista i antagonista",
volume = "65",
number = "1-2",
pages = "51-59",
doi = "10.2298/VETGL1102051M"
}

Mujezinović, I., Ćupić, V., Smajlović, A.,& Muminović, M.. (2011). Identification of serotonergic (5HT1A-type) receptors in broiler small intestine by application of serotonin and its agonists and antagonists. in Veterinarski Glasnik
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 65(1-2), 51-59.
https://doi.org/10.2298/VETGL1102051M

Mujezinović I, Ćupić V, Smajlović A, Muminović M. Identification of serotonergic (5HT1A-type) receptors in broiler small intestine by application of serotonin and its agonists and antagonists. in Veterinarski Glasnik. 2011;65(1-2):51-59.
doi:10.2298/VETGL1102051M .

Mujezinović, Indira, Ćupić, Vitomir, Smajlović, Ahmed, Muminović, Mehmed, "Identification of serotonergic (5HT1A-type) receptors in broiler small intestine by application of serotonin and its agonists and antagonists" in Veterinarski Glasnik, 65, no. 1-2 (2011):51-59,
https://doi.org/10.2298/VETGL1102051M . .

TY  - JOUR
AU  - Smajlović, Ahmed
AU  - Mujezinović, Indira
AU  - Ćupić, Vitomir
AU  - Muminović, Mehmed
PY  - 2011
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/817
AB  - Nitrofurans are synthetic broad-spectrum antimicobial agents that are often used in commercial animal production because of their excellent antibacterial and pharmacokinetic properties. However, nitrofurans and their metabolites have been shown to have potentially carcinogenic and mutagenic characteristics which has led to a ban on the use of nitrofurans in preventive and therapeutic treatment of animals used for food production. Metabolites of nitrofurans that can be determined after their application are: a metabolite of furazolidone, furaltadone metabolite, a metabolite of nitrofurantoin and nitrofurazone metabolite. The presence of residues of nitrofuran antibiotics in meat, fish and shrimps, and milk and eggs originating from countries outside the European Union is monitored and recorded by the RASFF system of the European Union. Furthermore, since nitrofurans are used in some countries as prophylactic agents and growth promoters, it is necessary to carry out constant control of various types of food of animal origin, in order to reduce to the minimum potential carcinogenic and mutagenic effects of these supstances for the health of consumers. In Bosnia and Herzegovina, there is no permanent control of nitrofurans in food of animal origin. The provisions of the 'Regulation on the maximum allowable amounts of veterinary drugs and pesticides in products of animal origin', published in the Official Gazette of Bosnia and Herzegovina state the prohibiting of the use of certain veterinary drugs in animals intended for human consumption, including nitrofurans. The European Union has established the minimum required limit (MRLP) for performance which is 1 μg/kg of nitrofurans for edible tissues of animal origin. Taking all this into account, methods for nitrofurans detection should be accreditated and validated, both for screening and confirmatory methods, and further research into the presence of nitrofurans in food of animal origin in Bosnia and Herzegovina should be performed.
AB  - Nitrofurani su sintetski antimikrobici širokog spektra koji se često koriste u masovnoj animalnoj proizvodnji zbog svojih odličnih antibakterijskih i farmakokinetičkih svojstava. Međutim, nitrofurani i njihovi metaboliti su pokazali da imaju potencijalne kancerogene i mutagene karakteristike, zbog čega je zabranjena njihova upotreba u profilaksi i terapiji životinja koje se koriste za proizvodnju hrane. Metaboliti nitrofurana koji se mogu utvrditi nakon njihove aplikacije su: metabolit furazolidona, metabolit furaltadona, metabolit nitrofurantoina i metabolit nitrofurazona. Prisustvo rezidua nitrofurana u mesu, ribi i škampima, te mleku i jajima poreklom iz zemalja van Evropske unije se prati i beleži putem RASFF sistema Evropske unije. Pošto se nitrofurani još uvek koriste u nekim zemljama kao profilaktička sredstva i promotori rasta, potrebno je sprovoditi stalnu kontrolu različitih vrsta namirnica animalnog porekla. U Bosni i Hercegovini ne postoji stalna kontrola nitrofurana u namirnicama animalnog porekla. U odredbama 'Pravilnika o maksimalno dozvoljenim količinama veterinarskih lekova i pesticida u proizvodima životinjskog porekla' objavljenog u Službenom glasniku Bosne i Hercegovine se navodi zabrana primene određenih veterinarskih lekova kod životinja koje se koriste za proizvodnju hrane namenjene ishrani ljudi, među kojima se nalaze i nitrofurani. Evropska Unija je ustanovila i minimalnu potrebnu granicu performance (MRPL) metoda koja iznosi 1 μg/kg nitrofurana za jestiva tkiva životinjskog porekla. Uzevši sve ovo u obzir, trebalo bi izvršiti akreditaciju i validaciju metoda, kako 'screening' tako i konfirmativnih, te nakon toga ponovo sprovesti daljnja istraživanja prisustva nitrofurana u namirnicama animalnog porekla u Bosni i Hercegovini.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Veterinarski Glasnik
T1  - Nitrofurans' residues in food of animal origin
T1  - Rezidue nitrofurana u namirnicama animalnog porekla
VL  - 65
IS  - 3-4
SP  - 215
EP  - 222
DO  - 10.2298/VETGL1104215S
ER  - 

@article{
author = "Smajlović, Ahmed and Mujezinović, Indira and Ćupić, Vitomir and Muminović, Mehmed",
year = "2011",
abstract = "Nitrofurans are synthetic broad-spectrum antimicobial agents that are often used in commercial animal production because of their excellent antibacterial and pharmacokinetic properties. However, nitrofurans and their metabolites have been shown to have potentially carcinogenic and mutagenic characteristics which has led to a ban on the use of nitrofurans in preventive and therapeutic treatment of animals used for food production. Metabolites of nitrofurans that can be determined after their application are: a metabolite of furazolidone, furaltadone metabolite, a metabolite of nitrofurantoin and nitrofurazone metabolite. The presence of residues of nitrofuran antibiotics in meat, fish and shrimps, and milk and eggs originating from countries outside the European Union is monitored and recorded by the RASFF system of the European Union. Furthermore, since nitrofurans are used in some countries as prophylactic agents and growth promoters, it is necessary to carry out constant control of various types of food of animal origin, in order to reduce to the minimum potential carcinogenic and mutagenic effects of these supstances for the health of consumers. In Bosnia and Herzegovina, there is no permanent control of nitrofurans in food of animal origin. The provisions of the 'Regulation on the maximum allowable amounts of veterinary drugs and pesticides in products of animal origin', published in the Official Gazette of Bosnia and Herzegovina state the prohibiting of the use of certain veterinary drugs in animals intended for human consumption, including nitrofurans. The European Union has established the minimum required limit (MRLP) for performance which is 1 μg/kg of nitrofurans for edible tissues of animal origin. Taking all this into account, methods for nitrofurans detection should be accreditated and validated, both for screening and confirmatory methods, and further research into the presence of nitrofurans in food of animal origin in Bosnia and Herzegovina should be performed., Nitrofurani su sintetski antimikrobici širokog spektra koji se često koriste u masovnoj animalnoj proizvodnji zbog svojih odličnih antibakterijskih i farmakokinetičkih svojstava. Međutim, nitrofurani i njihovi metaboliti su pokazali da imaju potencijalne kancerogene i mutagene karakteristike, zbog čega je zabranjena njihova upotreba u profilaksi i terapiji životinja koje se koriste za proizvodnju hrane. Metaboliti nitrofurana koji se mogu utvrditi nakon njihove aplikacije su: metabolit furazolidona, metabolit furaltadona, metabolit nitrofurantoina i metabolit nitrofurazona. Prisustvo rezidua nitrofurana u mesu, ribi i škampima, te mleku i jajima poreklom iz zemalja van Evropske unije se prati i beleži putem RASFF sistema Evropske unije. Pošto se nitrofurani još uvek koriste u nekim zemljama kao profilaktička sredstva i promotori rasta, potrebno je sprovoditi stalnu kontrolu različitih vrsta namirnica animalnog porekla. U Bosni i Hercegovini ne postoji stalna kontrola nitrofurana u namirnicama animalnog porekla. U odredbama 'Pravilnika o maksimalno dozvoljenim količinama veterinarskih lekova i pesticida u proizvodima životinjskog porekla' objavljenog u Službenom glasniku Bosne i Hercegovine se navodi zabrana primene određenih veterinarskih lekova kod životinja koje se koriste za proizvodnju hrane namenjene ishrani ljudi, među kojima se nalaze i nitrofurani. Evropska Unija je ustanovila i minimalnu potrebnu granicu performance (MRPL) metoda koja iznosi 1 μg/kg nitrofurana za jestiva tkiva životinjskog porekla. Uzevši sve ovo u obzir, trebalo bi izvršiti akreditaciju i validaciju metoda, kako 'screening' tako i konfirmativnih, te nakon toga ponovo sprovesti daljnja istraživanja prisustva nitrofurana u namirnicama animalnog porekla u Bosni i Hercegovini.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Veterinarski Glasnik",
title = "Nitrofurans' residues in food of animal origin, Rezidue nitrofurana u namirnicama animalnog porekla",
volume = "65",
number = "3-4",
pages = "215-222",
doi = "10.2298/VETGL1104215S"
}

Smajlović, A., Mujezinović, I., Ćupić, V.,& Muminović, M.. (2011). Nitrofurans' residues in food of animal origin. in Veterinarski Glasnik
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 65(3-4), 215-222.
https://doi.org/10.2298/VETGL1104215S

Smajlović A, Mujezinović I, Ćupić V, Muminović M. Nitrofurans' residues in food of animal origin. in Veterinarski Glasnik. 2011;65(3-4):215-222.
doi:10.2298/VETGL1104215S .

Smajlović, Ahmed, Mujezinović, Indira, Ćupić, Vitomir, Muminović, Mehmed, "Nitrofurans' residues in food of animal origin" in Veterinarski Glasnik, 65, no. 3-4 (2011):215-222,
https://doi.org/10.2298/VETGL1104215S . .

TY  - JOUR
AU  - Mujezinović, Indira
AU  - Ćupić, Vitomir
AU  - Smajlović, Ahmed
AU  - Muminović, Mehmed
PY  - 2010
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/745
AB  - Histamine is a biologically active amine (biogenic amine) that has a broad spectra of physiologic and pathologic reactions in the organism. Its effects are shown through 4 types of specific receptors (H1, H2, H3 and H4). Histamine is one of the main causes of intestine disorders and the occurrence of diarrhea, both of which are very common in broilers. Whilst there is no information in scientific literature about the presence of histaminic receptors in smooth muscles of the small intestine wall of broilers (duodenum, jejunum and ileum), we tried to determine their presence, distribution and type in this kind of muscles. Investigations were carried out on isolated smooth muscles of the circular and longitudinal layer of the broiler small intestine (strip dimension 3-4 mm x 2 cm). The muscle strip was then placed in an isolated organ bath and the contractions obtained were registered with isometric transducers on a two-channel printer. This was done following the addition of histamine, betahistine (H1 agonist), and mepiramine (H1 antagonist). Muscle vitality was checked by adding acethylcholine chloride. Using the obtained results, it can be concluded that H1 types of histaminergic receptors are present in smooth muscles of the small intestine of broilers. .
AB  - Histamin je biološki aktivni amin (biogeni amin) koji ima širok spektar fizioloških i patoloških delovanja u organizmu. Svoje delovanje ispoljava preko četiri tipa specifičnih receptora (H1, H2, H3i H4). Histamin je jedan od glavnih uzroka poremećaja funkcije creva i nastanka proliva, koji su kod brojlera česti. Pošto u stručnoj literaturi nema podataka o zastupljenosti histaminskih receptora u glatkoj muskulaturi zida tankog creva (duodenuma, jejunuma i ileuma) brojlera, pokušali smo utvrditi njihovu zastupljenost, distribuciju i vrstu u ovoj muskulaturi. Ispitivanja su vršena na izoliranoj glatkoj muskulaturi cirkularnog i longitudinalnog sloja sva tri dela tankog creva brojlera (strip dimenzija 3-4 mm x 2 cm). Mišićni strip je postavljen u kupatilo za izolirane organe, a izazvane kontrakcije su registrovane na dvokanalnom pisaču izometrijskim transdjuserima, nakon dodavanja histamina, betahistina (H1 agonist) i mepiramina (H1 antagonist). Vitalnost glatke muskulature tankog creva brojlera smo proveravali dodavanjem acetilholina. Na osnovu dobijenih rezultata se može zaključiti da su histaminergični receptori H1 tipa zastupljeni u glatkoj muskulaturi sva tri segmenta tankog creva brojlera.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Veterinarski Glasnik
T1  - Identification of histaminic (H1-type) receptors in small intestine of broilers by application of histamine and some of its agonists and antagonists
T1  - Utvrđivanje histaminskih receptora h1 tipa u tankom crevu brojlera primenom histamina i nekih njegovih agonista i antagonista
VL  - 64
IS  - 3-4
SP  - 169
EP  - 176
DO  - 10.2298/VETGL1004169M
ER  - 

@article{
author = "Mujezinović, Indira and Ćupić, Vitomir and Smajlović, Ahmed and Muminović, Mehmed",
year = "2010",
abstract = "Histamine is a biologically active amine (biogenic amine) that has a broad spectra of physiologic and pathologic reactions in the organism. Its effects are shown through 4 types of specific receptors (H1, H2, H3 and H4). Histamine is one of the main causes of intestine disorders and the occurrence of diarrhea, both of which are very common in broilers. Whilst there is no information in scientific literature about the presence of histaminic receptors in smooth muscles of the small intestine wall of broilers (duodenum, jejunum and ileum), we tried to determine their presence, distribution and type in this kind of muscles. Investigations were carried out on isolated smooth muscles of the circular and longitudinal layer of the broiler small intestine (strip dimension 3-4 mm x 2 cm). The muscle strip was then placed in an isolated organ bath and the contractions obtained were registered with isometric transducers on a two-channel printer. This was done following the addition of histamine, betahistine (H1 agonist), and mepiramine (H1 antagonist). Muscle vitality was checked by adding acethylcholine chloride. Using the obtained results, it can be concluded that H1 types of histaminergic receptors are present in smooth muscles of the small intestine of broilers. ., Histamin je biološki aktivni amin (biogeni amin) koji ima širok spektar fizioloških i patoloških delovanja u organizmu. Svoje delovanje ispoljava preko četiri tipa specifičnih receptora (H1, H2, H3i H4). Histamin je jedan od glavnih uzroka poremećaja funkcije creva i nastanka proliva, koji su kod brojlera česti. Pošto u stručnoj literaturi nema podataka o zastupljenosti histaminskih receptora u glatkoj muskulaturi zida tankog creva (duodenuma, jejunuma i ileuma) brojlera, pokušali smo utvrditi njihovu zastupljenost, distribuciju i vrstu u ovoj muskulaturi. Ispitivanja su vršena na izoliranoj glatkoj muskulaturi cirkularnog i longitudinalnog sloja sva tri dela tankog creva brojlera (strip dimenzija 3-4 mm x 2 cm). Mišićni strip je postavljen u kupatilo za izolirane organe, a izazvane kontrakcije su registrovane na dvokanalnom pisaču izometrijskim transdjuserima, nakon dodavanja histamina, betahistina (H1 agonist) i mepiramina (H1 antagonist). Vitalnost glatke muskulature tankog creva brojlera smo proveravali dodavanjem acetilholina. Na osnovu dobijenih rezultata se može zaključiti da su histaminergični receptori H1 tipa zastupljeni u glatkoj muskulaturi sva tri segmenta tankog creva brojlera.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Veterinarski Glasnik",
title = "Identification of histaminic (H1-type) receptors in small intestine of broilers by application of histamine and some of its agonists and antagonists, Utvrđivanje histaminskih receptora h1 tipa u tankom crevu brojlera primenom histamina i nekih njegovih agonista i antagonista",
volume = "64",
number = "3-4",
pages = "169-176",
doi = "10.2298/VETGL1004169M"
}

Mujezinović, I., Ćupić, V., Smajlović, A.,& Muminović, M.. (2010). Identification of histaminic (H1-type) receptors in small intestine of broilers by application of histamine and some of its agonists and antagonists. in Veterinarski Glasnik
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 64(3-4), 169-176.
https://doi.org/10.2298/VETGL1004169M

Mujezinović I, Ćupić V, Smajlović A, Muminović M. Identification of histaminic (H1-type) receptors in small intestine of broilers by application of histamine and some of its agonists and antagonists. in Veterinarski Glasnik. 2010;64(3-4):169-176.
doi:10.2298/VETGL1004169M .

Mujezinović, Indira, Ćupić, Vitomir, Smajlović, Ahmed, Muminović, Mehmed, "Identification of histaminic (H1-type) receptors in small intestine of broilers by application of histamine and some of its agonists and antagonists" in Veterinarski Glasnik, 64, no. 3-4 (2010):169-176,
https://doi.org/10.2298/VETGL1004169M . .

TY  - CONF
AU  - Indira, M.
AU  - Ćupić, Vitomir
AU  - Smajlović, Ahmed
AU  - Muminović, Mehmed
AU  - Velev, Romel
PY  - 2009
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/596
PB  - Wiley-Blackwell Publishing, Inc, Malden
C3  - Journal of Veterinary Pharmacology and Therapeutics
T1  - Identification of histaminic (H1-type) receptors in broiler s small intestine by application of histamine and some of its agonists and antagonists
VL  - 32
SP  - 240
EP  - 241
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_596
ER  - 

@conference{
author = "Indira, M. and Ćupić, Vitomir and Smajlović, Ahmed and Muminović, Mehmed and Velev, Romel",
year = "2009",
publisher = "Wiley-Blackwell Publishing, Inc, Malden",
journal = "Journal of Veterinary Pharmacology and Therapeutics",
title = "Identification of histaminic (H1-type) receptors in broiler s small intestine by application of histamine and some of its agonists and antagonists",
volume = "32",
pages = "240-241",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_596"
}

Indira, M., Ćupić, V., Smajlović, A., Muminović, M.,& Velev, R.. (2009). Identification of histaminic (H1-type) receptors in broiler s small intestine by application of histamine and some of its agonists and antagonists. in Journal of Veterinary Pharmacology and Therapeutics
Wiley-Blackwell Publishing, Inc, Malden., 32, 240-241.
https://hdl.handle.net/21.15107/rcub_veterinar_596

Indira M, Ćupić V, Smajlović A, Muminović M, Velev R. Identification of histaminic (H1-type) receptors in broiler s small intestine by application of histamine and some of its agonists and antagonists. in Journal of Veterinary Pharmacology and Therapeutics. 2009;32:240-241.
https://hdl.handle.net/21.15107/rcub_veterinar_596 .

Indira, M., Ćupić, Vitomir, Smajlović, Ahmed, Muminović, Mehmed, Velev, Romel, "Identification of histaminic (H1-type) receptors in broiler s small intestine by application of histamine and some of its agonists and antagonists" in Journal of Veterinary Pharmacology and Therapeutics, 32 (2009):240-241,
https://hdl.handle.net/21.15107/rcub_veterinar_596 .