TY  - JOUR
AU  - Popović-Bubujuk, Slavica
AU  - Đelić, Ninoslav
AU  - Muster, Adrian
AU  - Kataranovski, Dragan
AU  - Anđelković, Marko
PY  - 2018
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1661
AB  - Heavy metal cadmium (Cd), a well-known environmental hazard, exerts a number of toxic and genotoxic effects. Experimental animals, Albino Oxford (AO) and Dark August (DA) rat strains, were treated intraperitoneally with three different concentrations of cadmium chloride (CdCl2): 0.5, 1, and 2 mg CdCl2 per kg of body weight, while the control animals received equal volume of sterile phosphate buffered saline. In this investigation individuals of both sexes aged 3, 6 and 12 month were used. Frequency of micronuclei formation was evaluated in polychromatic erythrocytes (PCEs), 24h hours after treatment. The results showed that that cadmium-cloride (CdCl2) exibits the genotoxic effects causing an increase of the frequency of micronuclei depending on concentration, sex, age and strain.
PB  - Društvo genetičara Srbije, Beograd
T2  - Genetika
T1  - Influence of cadmium chloride on the frequency of micronuclei in da and AO rats
VL  - 50
IS  - 2
SP  - 705
EP  - 716
DO  - 10.2298/GENSR1802705P
ER  - 

@article{
author = "Popović-Bubujuk, Slavica and Đelić, Ninoslav and Muster, Adrian and Kataranovski, Dragan and Anđelković, Marko",
year = "2018",
abstract = "Heavy metal cadmium (Cd), a well-known environmental hazard, exerts a number of toxic and genotoxic effects. Experimental animals, Albino Oxford (AO) and Dark August (DA) rat strains, were treated intraperitoneally with three different concentrations of cadmium chloride (CdCl2): 0.5, 1, and 2 mg CdCl2 per kg of body weight, while the control animals received equal volume of sterile phosphate buffered saline. In this investigation individuals of both sexes aged 3, 6 and 12 month were used. Frequency of micronuclei formation was evaluated in polychromatic erythrocytes (PCEs), 24h hours after treatment. The results showed that that cadmium-cloride (CdCl2) exibits the genotoxic effects causing an increase of the frequency of micronuclei depending on concentration, sex, age and strain.",
publisher = "Društvo genetičara Srbije, Beograd",
journal = "Genetika",
title = "Influence of cadmium chloride on the frequency of micronuclei in da and AO rats",
volume = "50",
number = "2",
pages = "705-716",
doi = "10.2298/GENSR1802705P"
}

Popović-Bubujuk, S., Đelić, N., Muster, A., Kataranovski, D.,& Anđelković, M.. (2018). Influence of cadmium chloride on the frequency of micronuclei in da and AO rats. in Genetika
Društvo genetičara Srbije, Beograd., 50(2), 705-716.
https://doi.org/10.2298/GENSR1802705P

Popović-Bubujuk S, Đelić N, Muster A, Kataranovski D, Anđelković M. Influence of cadmium chloride on the frequency of micronuclei in da and AO rats. in Genetika. 2018;50(2):705-716.
doi:10.2298/GENSR1802705P .

Popović-Bubujuk, Slavica, Đelić, Ninoslav, Muster, Adrian, Kataranovski, Dragan, Anđelković, Marko, "Influence of cadmium chloride on the frequency of micronuclei in da and AO rats" in Genetika, 50, no. 2 (2018):705-716,
https://doi.org/10.2298/GENSR1802705P . .

TY  - JOUR
AU  - Popović-Bubujuk, Slavica
AU  - Muster, Adrian
AU  - Đelić, Ninoslav
AU  - Kataranovski, Dragan
AU  - Anđelković, Marko
PY  - 2014
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1097
AB  - Cadmium (Cd) is one of the most toxic industrial and metal in the environment which may cause severe genotoxic effects. The aim of the work was an evaluation of genotoxic effects of CdCl2 in genetically pure Albino Oxford (AO) rats, depending on sex, age and dosage. Experimental animals were treated intraperitoneally with three different concentrations of CdCl2: 0.5, 1, and 2 mg/kg of CdCl2, while the control animals received equal volume of sterile phosphate buffered saline. The individuals of both sexes were treated at the age of 3, 6 and 12 month. Frequency of micronuclei formation was evaluated in polychromatic erythrocytes (PCEs), 24h hours after the treatment. The results showed that CdCl2 caused a concentration-dependent increase of micronucleus frequency. The most significant differences were found between ages of 3/12 and 6/12 months at 0.5 and 1.0 mg CdCl2 concentrations. Namely, 3 month old males had higher frequency of MNi in comparison to 12 month old males, whereas in females it was the opposite. Likewise, 6 months old males exbibited greater sensistivity to CdCl2 in comparison to 12 month old rats, and in the females it was the opposite. Sex differences were further confirmed as slightly stronger genotoxic effects in 12 months old females treated with 0.5 and 1 mg/kg of CdCl2. Therefore, the genotoxic effects of cadmium in AO rats depend on concentration, age and sex.
PB  - Društvo genetičara Srbije, Beograd
T2  - Genetika
T1  - Induction of micronuclei by cadmium chloride in AO rats depends on age and sex
VL  - 46
IS  - 3
SP  - 1003
EP  - 1012
DO  - 10.2298/GENSR1403003P
ER  - 

@article{
author = "Popović-Bubujuk, Slavica and Muster, Adrian and Đelić, Ninoslav and Kataranovski, Dragan and Anđelković, Marko",
year = "2014",
abstract = "Cadmium (Cd) is one of the most toxic industrial and metal in the environment which may cause severe genotoxic effects. The aim of the work was an evaluation of genotoxic effects of CdCl2 in genetically pure Albino Oxford (AO) rats, depending on sex, age and dosage. Experimental animals were treated intraperitoneally with three different concentrations of CdCl2: 0.5, 1, and 2 mg/kg of CdCl2, while the control animals received equal volume of sterile phosphate buffered saline. The individuals of both sexes were treated at the age of 3, 6 and 12 month. Frequency of micronuclei formation was evaluated in polychromatic erythrocytes (PCEs), 24h hours after the treatment. The results showed that CdCl2 caused a concentration-dependent increase of micronucleus frequency. The most significant differences were found between ages of 3/12 and 6/12 months at 0.5 and 1.0 mg CdCl2 concentrations. Namely, 3 month old males had higher frequency of MNi in comparison to 12 month old males, whereas in females it was the opposite. Likewise, 6 months old males exbibited greater sensistivity to CdCl2 in comparison to 12 month old rats, and in the females it was the opposite. Sex differences were further confirmed as slightly stronger genotoxic effects in 12 months old females treated with 0.5 and 1 mg/kg of CdCl2. Therefore, the genotoxic effects of cadmium in AO rats depend on concentration, age and sex.",
publisher = "Društvo genetičara Srbije, Beograd",
journal = "Genetika",
title = "Induction of micronuclei by cadmium chloride in AO rats depends on age and sex",
volume = "46",
number = "3",
pages = "1003-1012",
doi = "10.2298/GENSR1403003P"
}

Popović-Bubujuk, S., Muster, A., Đelić, N., Kataranovski, D.,& Anđelković, M.. (2014). Induction of micronuclei by cadmium chloride in AO rats depends on age and sex. in Genetika
Društvo genetičara Srbije, Beograd., 46(3), 1003-1012.
https://doi.org/10.2298/GENSR1403003P

Popović-Bubujuk S, Muster A, Đelić N, Kataranovski D, Anđelković M. Induction of micronuclei by cadmium chloride in AO rats depends on age and sex. in Genetika. 2014;46(3):1003-1012.
doi:10.2298/GENSR1403003P .

Popović-Bubujuk, Slavica, Muster, Adrian, Đelić, Ninoslav, Kataranovski, Dragan, Anđelković, Marko, "Induction of micronuclei by cadmium chloride in AO rats depends on age and sex" in Genetika, 46, no. 3 (2014):1003-1012,
https://doi.org/10.2298/GENSR1403003P . .