TY  - JOUR
AU  - Nešić, Ksenija
AU  - Resanović, Radmila
AU  - Nešić, Vladimir
AU  - Sinovec, Zlatan
PY  - 2008
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/562
AB  - Two trials, 31 and 29 days long, were conducted with the aim to pursue performance and health of pigs treated with different amounts of zearalenone and to investigate the feasibility of utilizing a modified clinoptilolite and esterified glucomannane in alleviating and/or preventing its harmful effects. Total of 64 pigs (32 each trial), 60 days old, divided into four groups, each containing 8 pigs were used. Both control groups (K) received feed without zearalenone, while experimental groups received feed supplemented with 3.84 mg/kg in the first trial and 5.12 mg/kg of zearalenone in the second trial. Pigs in the first experimental groups (O-I) were given feed with the toxin only. At the same time, a modified clinoptilolite (MC) in the amount of 0.2% was introduced in the contaminated feed of the second experimental groups (O-II) and an esterified glucomannane (EGM) in the amount of 0.1% in contaminated feed of the third experimental groups (O-III) of both experiments. Zearalenone exerted its negative effects on performance of pigs in concentrations used in the experiments, proportionally to the amount of toxin in the feed (weight gain was 19.86% lower in experiment I and 22.27% in experiment II, feed intake rate 5.89% lower in experiment I and 1.52% in experiment II, feed consumption ratio was higher for 14.82% in experiment I and 21.08% in experiment II). Addition of adsorbents only partially alleviated the harmful effects of zearalenone in the feed. Signs of intoxication in female pigs, known as the estrogenic syndrome, were manifested by inflammatory changes of the external genital organs (vulvovaginitis) and with histological findings of epithelial hyperplasia and submucous oedema. Also nonspecific symptoms could be seen - gastrointestinal disorders followed by diarrhea. Use of adsorbents as toxin binders mostly alleviated these negative effects.
AB  - Dva ogleda, u trajanju od 29 i 31 dan, izvedena su sa ciljem da se ispitaju proizvodni rezultati i zdravstveno stanje prasadi tretirane različitim dozama zearalenona i da se utvrdi mogućnost upotrebe modifikovanog klinoptilolita i esterifikovanog glukomanana u ublažavanju i/ili preveniranju njegovih štetnih efekata. Korišćeno je ukupno 64 prasadi (32 po ogledu), starosti 60 dana, podeljenih u četiri grupe, po 8 u svakoj. Prasad kontrolne grupe (K) u oba ogleda su hranjena smešom bez zearalenona, dok su prasad eksperimentalne grupe hranjena hranom koja je sadržavala 3.84 mg/kg u prvom, odnosno, 5.12 mg/kg hrane zearalenona u drugom ogledu. Prasad prve eksperimentalne grupe u oba ogleda su dobijala hranu samo sa toksinom. Istovremeno, modifikovani klinoptilolit (MC) u količini 0.2% dodat je u hranu za prasad obe druge eksperimentalne grupe (O-II), dok je u smeši obe treće eksperimentalne grupe (O-III) bio prisutan esterifikovani glukomanan (EGM) u količini od 0.1% Zearalenon ispoljava negativne efekte na proizvodne rezultate u koncentraciji upotrebljenoj u ispitivanjima, i to proporcionalno njegovoj količini u hrani (prirast je bio 19.86% slabiji u prvom i 22.27% u drugom ogledu, konzumacija niža za 5.89% u prvom i 1.52% u drugom eksperimentu, a konverzija hrane je bila viša za 14.82% u prvom i 21.08% u drugom ogledu), dok su dodavanjem adsorbenata delimično uklonjeni ovi štetni efekti. Simptomi intoksikacije, poznati kao estrogeni sindrom, klinički su se manifestovali vulvovaginitisom kod ženske prasadi, a histološkim ispitivanjem utvrđena je epitelijalna hiperplazija i submukozni edem. Takođe, javili su se i nespecifični simptomi u vidu gastrointestinalnih poremećaja, praćenih dijarejom. Upotreba adsorbenata za vezivanje toksina uspešno je ublažila negativne posledice prisustva zearalenona u hrani.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta Veterinaria-Beograd
T1  - Efficacy of mineral and organic adsorbent in alleviating harmful effects of zearalenone on pigs performance and health
T1  - Efikasnost mineralnog i organskog adsorbenta u ublažavanju negativnih efekata zearalenona na proizvodne rezultate i zdravstveno stanje prasadi
VL  - 58
IS  - 2-3
SP  - 211
EP  - 219
DO  - 10.2298/AVB0803211N
ER  - 

@article{
author = "Nešić, Ksenija and Resanović, Radmila and Nešić, Vladimir and Sinovec, Zlatan",
year = "2008",
abstract = "Two trials, 31 and 29 days long, were conducted with the aim to pursue performance and health of pigs treated with different amounts of zearalenone and to investigate the feasibility of utilizing a modified clinoptilolite and esterified glucomannane in alleviating and/or preventing its harmful effects. Total of 64 pigs (32 each trial), 60 days old, divided into four groups, each containing 8 pigs were used. Both control groups (K) received feed without zearalenone, while experimental groups received feed supplemented with 3.84 mg/kg in the first trial and 5.12 mg/kg of zearalenone in the second trial. Pigs in the first experimental groups (O-I) were given feed with the toxin only. At the same time, a modified clinoptilolite (MC) in the amount of 0.2% was introduced in the contaminated feed of the second experimental groups (O-II) and an esterified glucomannane (EGM) in the amount of 0.1% in contaminated feed of the third experimental groups (O-III) of both experiments. Zearalenone exerted its negative effects on performance of pigs in concentrations used in the experiments, proportionally to the amount of toxin in the feed (weight gain was 19.86% lower in experiment I and 22.27% in experiment II, feed intake rate 5.89% lower in experiment I and 1.52% in experiment II, feed consumption ratio was higher for 14.82% in experiment I and 21.08% in experiment II). Addition of adsorbents only partially alleviated the harmful effects of zearalenone in the feed. Signs of intoxication in female pigs, known as the estrogenic syndrome, were manifested by inflammatory changes of the external genital organs (vulvovaginitis) and with histological findings of epithelial hyperplasia and submucous oedema. Also nonspecific symptoms could be seen - gastrointestinal disorders followed by diarrhea. Use of adsorbents as toxin binders mostly alleviated these negative effects., Dva ogleda, u trajanju od 29 i 31 dan, izvedena su sa ciljem da se ispitaju proizvodni rezultati i zdravstveno stanje prasadi tretirane različitim dozama zearalenona i da se utvrdi mogućnost upotrebe modifikovanog klinoptilolita i esterifikovanog glukomanana u ublažavanju i/ili preveniranju njegovih štetnih efekata. Korišćeno je ukupno 64 prasadi (32 po ogledu), starosti 60 dana, podeljenih u četiri grupe, po 8 u svakoj. Prasad kontrolne grupe (K) u oba ogleda su hranjena smešom bez zearalenona, dok su prasad eksperimentalne grupe hranjena hranom koja je sadržavala 3.84 mg/kg u prvom, odnosno, 5.12 mg/kg hrane zearalenona u drugom ogledu. Prasad prve eksperimentalne grupe u oba ogleda su dobijala hranu samo sa toksinom. Istovremeno, modifikovani klinoptilolit (MC) u količini 0.2% dodat je u hranu za prasad obe druge eksperimentalne grupe (O-II), dok je u smeši obe treće eksperimentalne grupe (O-III) bio prisutan esterifikovani glukomanan (EGM) u količini od 0.1% Zearalenon ispoljava negativne efekte na proizvodne rezultate u koncentraciji upotrebljenoj u ispitivanjima, i to proporcionalno njegovoj količini u hrani (prirast je bio 19.86% slabiji u prvom i 22.27% u drugom ogledu, konzumacija niža za 5.89% u prvom i 1.52% u drugom eksperimentu, a konverzija hrane je bila viša za 14.82% u prvom i 21.08% u drugom ogledu), dok su dodavanjem adsorbenata delimično uklonjeni ovi štetni efekti. Simptomi intoksikacije, poznati kao estrogeni sindrom, klinički su se manifestovali vulvovaginitisom kod ženske prasadi, a histološkim ispitivanjem utvrđena je epitelijalna hiperplazija i submukozni edem. Takođe, javili su se i nespecifični simptomi u vidu gastrointestinalnih poremećaja, praćenih dijarejom. Upotreba adsorbenata za vezivanje toksina uspešno je ublažila negativne posledice prisustva zearalenona u hrani.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta Veterinaria-Beograd",
title = "Efficacy of mineral and organic adsorbent in alleviating harmful effects of zearalenone on pigs performance and health, Efikasnost mineralnog i organskog adsorbenta u ublažavanju negativnih efekata zearalenona na proizvodne rezultate i zdravstveno stanje prasadi",
volume = "58",
number = "2-3",
pages = "211-219",
doi = "10.2298/AVB0803211N"
}

Nešić, K., Resanović, R., Nešić, V.,& Sinovec, Z.. (2008). Efficacy of mineral and organic adsorbent in alleviating harmful effects of zearalenone on pigs performance and health. in Acta Veterinaria-Beograd
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 58(2-3), 211-219.
https://doi.org/10.2298/AVB0803211N

Nešić K, Resanović R, Nešić V, Sinovec Z. Efficacy of mineral and organic adsorbent in alleviating harmful effects of zearalenone on pigs performance and health. in Acta Veterinaria-Beograd. 2008;58(2-3):211-219.
doi:10.2298/AVB0803211N .

Nešić, Ksenija, Resanović, Radmila, Nešić, Vladimir, Sinovec, Zlatan, "Efficacy of mineral and organic adsorbent in alleviating harmful effects of zearalenone on pigs performance and health" in Acta Veterinaria-Beograd, 58, no. 2-3 (2008):211-219,
https://doi.org/10.2298/AVB0803211N . .

TY  - JOUR
AU  - Marković, Radmila
AU  - Jovanović, Ivan B.
AU  - Baltić, Milan Ž.
AU  - Šefer, Dragan
AU  - Petrujkić, Branko
AU  - Sinovec, Zlatan
PY  - 2008
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/550
AB  - The aim of this experiment was to determine the effects of broiler meal supplementation with different forms of selenium (as Na-selenite or selenized yeast) and different amounts of vitamin E on selenium and vitamin E status in broiler tissues. A total number of 240 broilers (Cobb 500) were divided in four experimental groups supplemented with Se and vitamin E for a period of 42 days: group SS+E20 - 0.3 mg/kg sodium selenite and 20 IU of vitamin E; group SY+E20 - 0.3 mg/kg selenized yeast and 20 IU of vitamin E; group SS+E100 - 0.3 mg/kg sodium selenite and 100 IU of vitamin E; group SY+E100 - 0.3 mg/kg selenized yeast and 100 IU of vitamin E. Blood plasma Se and MDA concentrations and Se dependent GSH-Px were determined on days 1, 21 and 42, where's content of Se and vitamin E in breast muscle and liver were measured on days 21 and 42 of the experiment. Highest blood plasma glutathione peroxidase (GSH-Px) activities were detected in groups SS+E20 and SS+E100. Supplementation with selenium enriched yeast did not result in a significant increase in plasma GSH-Px activity. Selenium and vitamin E concentrations in breast meat and liver were significantly higher in groups supplemented selenized yeast compared to those receiving Na-selenite. Selenium and vitamin E supplementation did not alter plasma MDA concentrations, but in tissues, selenized yeast provided a consistent, although not significant, reduction in MDA content. The increased dose of vitamin E supplemented in broiler meal was not justifiable on the basis of vitamin E tissue content and antioxidative effect.
AB  - Cilj ovog eksperimenta je bio da se utvrde efekti dodatka različitih formi selena u obrok (natrijum selenit ili selenizirani kvasac) i različitih količina vitamina E na status selena i vitamina E u tkivima brojlera. Ukupan broj od 240 brojlera (Cobb 500) je bio podeljen na četiri eksperimentalne grupe kojima je dodavan selen i vitamin E u obrok u periodu od 42 dana: grupa SS+E20 - 0,3 mg/kg Na-selenita i 20 IJ vitamina E; grupa SY+E20 - 0.3 mg/kg seleniziranog kvasca i 20 IJ vitamina E; grupa SS+E100 - 0,3 mg/kg Na-selenita i 100 IJ vitamina E; grupa SY+E100- 0,3 mg/kg seleniziranog kvasca i 100 IJ vitamina E. Koncentracija selena u krvnoj plazmi i MDA kao i selen zavisne GSH-PX je određivana 1., 21. i 42., dok su sadržaj selena i vitamina E u grudnoj muskulaturi i jetri određivani 21. i 42. dana eksperimenta. Najviše vrednosti aktivnosti glutation peroksidaze u krvnoj plazmi su utvrđene u grupama SS+E20 i SS+E100. Dodatak seleniziranog kvasca nije rezultirao značajnim povećanjem aktivnosti GSH-Px u krvnoj plazmi. Koncentracija selena i vitamina E u grudnoj muskulaturi i jetri je bila značajno viša u grupama kojima je dodat selenizirani kvasac u poređenju sa grupama koje su dobijale Na-selenit. Dodatak selena i vitamina E nije uticao na koncentraciju MDA u krvnoj plazmi, ali je u tkivima, selenizirani kvasac doveo do uočljivog ali ne značajnog smanjenja sadržaja MDA. Povećana doza vitamina E u obroku brojlera od 100 IJ vitamina E nije bila opravdana na osnovu sadržaja vitamina E i antioksidativnog dejstva.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta Veterinaria-Beograd
T1  - Effects of selenium supplementation as sodium selenite or selenized yeast and different amounts of vitamin E on selenium and vitamin E status of broilers
T1  - Uticaj dodavanja selena organskog i neorganskog porekla i različitih količina vitamina E na status selena i vitamina E brojlera
VL  - 58
IS  - 4
SP  - 369
EP  - 380
DO  - 10.2298/AVB0804369M
ER  - 

@article{
author = "Marković, Radmila and Jovanović, Ivan B. and Baltić, Milan Ž. and Šefer, Dragan and Petrujkić, Branko and Sinovec, Zlatan",
year = "2008",
abstract = "The aim of this experiment was to determine the effects of broiler meal supplementation with different forms of selenium (as Na-selenite or selenized yeast) and different amounts of vitamin E on selenium and vitamin E status in broiler tissues. A total number of 240 broilers (Cobb 500) were divided in four experimental groups supplemented with Se and vitamin E for a period of 42 days: group SS+E20 - 0.3 mg/kg sodium selenite and 20 IU of vitamin E; group SY+E20 - 0.3 mg/kg selenized yeast and 20 IU of vitamin E; group SS+E100 - 0.3 mg/kg sodium selenite and 100 IU of vitamin E; group SY+E100 - 0.3 mg/kg selenized yeast and 100 IU of vitamin E. Blood plasma Se and MDA concentrations and Se dependent GSH-Px were determined on days 1, 21 and 42, where's content of Se and vitamin E in breast muscle and liver were measured on days 21 and 42 of the experiment. Highest blood plasma glutathione peroxidase (GSH-Px) activities were detected in groups SS+E20 and SS+E100. Supplementation with selenium enriched yeast did not result in a significant increase in plasma GSH-Px activity. Selenium and vitamin E concentrations in breast meat and liver were significantly higher in groups supplemented selenized yeast compared to those receiving Na-selenite. Selenium and vitamin E supplementation did not alter plasma MDA concentrations, but in tissues, selenized yeast provided a consistent, although not significant, reduction in MDA content. The increased dose of vitamin E supplemented in broiler meal was not justifiable on the basis of vitamin E tissue content and antioxidative effect., Cilj ovog eksperimenta je bio da se utvrde efekti dodatka različitih formi selena u obrok (natrijum selenit ili selenizirani kvasac) i različitih količina vitamina E na status selena i vitamina E u tkivima brojlera. Ukupan broj od 240 brojlera (Cobb 500) je bio podeljen na četiri eksperimentalne grupe kojima je dodavan selen i vitamin E u obrok u periodu od 42 dana: grupa SS+E20 - 0,3 mg/kg Na-selenita i 20 IJ vitamina E; grupa SY+E20 - 0.3 mg/kg seleniziranog kvasca i 20 IJ vitamina E; grupa SS+E100 - 0,3 mg/kg Na-selenita i 100 IJ vitamina E; grupa SY+E100- 0,3 mg/kg seleniziranog kvasca i 100 IJ vitamina E. Koncentracija selena u krvnoj plazmi i MDA kao i selen zavisne GSH-PX je određivana 1., 21. i 42., dok su sadržaj selena i vitamina E u grudnoj muskulaturi i jetri određivani 21. i 42. dana eksperimenta. Najviše vrednosti aktivnosti glutation peroksidaze u krvnoj plazmi su utvrđene u grupama SS+E20 i SS+E100. Dodatak seleniziranog kvasca nije rezultirao značajnim povećanjem aktivnosti GSH-Px u krvnoj plazmi. Koncentracija selena i vitamina E u grudnoj muskulaturi i jetri je bila značajno viša u grupama kojima je dodat selenizirani kvasac u poređenju sa grupama koje su dobijale Na-selenit. Dodatak selena i vitamina E nije uticao na koncentraciju MDA u krvnoj plazmi, ali je u tkivima, selenizirani kvasac doveo do uočljivog ali ne značajnog smanjenja sadržaja MDA. Povećana doza vitamina E u obroku brojlera od 100 IJ vitamina E nije bila opravdana na osnovu sadržaja vitamina E i antioksidativnog dejstva.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta Veterinaria-Beograd",
title = "Effects of selenium supplementation as sodium selenite or selenized yeast and different amounts of vitamin E on selenium and vitamin E status of broilers, Uticaj dodavanja selena organskog i neorganskog porekla i različitih količina vitamina E na status selena i vitamina E brojlera",
volume = "58",
number = "4",
pages = "369-380",
doi = "10.2298/AVB0804369M"
}

Marković, R., Jovanović, I. B., Baltić, M. Ž., Šefer, D., Petrujkić, B.,& Sinovec, Z.. (2008). Effects of selenium supplementation as sodium selenite or selenized yeast and different amounts of vitamin E on selenium and vitamin E status of broilers. in Acta Veterinaria-Beograd
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 58(4), 369-380.
https://doi.org/10.2298/AVB0804369M

Marković R, Jovanović IB, Baltić MŽ, Šefer D, Petrujkić B, Sinovec Z. Effects of selenium supplementation as sodium selenite or selenized yeast and different amounts of vitamin E on selenium and vitamin E status of broilers. in Acta Veterinaria-Beograd. 2008;58(4):369-380.
doi:10.2298/AVB0804369M .

Marković, Radmila, Jovanović, Ivan B., Baltić, Milan Ž., Šefer, Dragan, Petrujkić, Branko, Sinovec, Zlatan, "Effects of selenium supplementation as sodium selenite or selenized yeast and different amounts of vitamin E on selenium and vitamin E status of broilers" in Acta Veterinaria-Beograd, 58, no. 4 (2008):369-380,
https://doi.org/10.2298/AVB0804369M . .

TY  - JOUR
AU  - Tokić, Vesna
AU  - Lazarević, Miodrag
AU  - Sinovec, Zlatan
AU  - Baltić, Milan Ž.
AU  - Jokić, Živan
PY  - 2007
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/481
AB  - The objective of these investigations was to examine the influence of prebiotics based on mannan-oligosaccharides and polysaccharide complexes of micro elements (Fe, Cu, Zn, Mn) on production results and abattoir parameters for broilers of the hybrid Arbor Acres. The experiment was performed on 186 chicken divided into three equal groups, it lasted 42 days and was divided into 3 phases. The first phase lasted 21 days, the second 14, and the third seven days. The complete mix for initial fattening of broilers was used from days 1-21, and complete fodder mixes for closing fattening from days 21-35, and on days 35-42 of the experiment. Feeding was ad libitum and the broilers were maintained in a floor system. Broilers fed mixes of standard raw material composition and the usual nutritive values achieved an average daily growth of 49.10 g at an average daily feed consumption of 115.55 g and with food conversion of 2.35, while the yield was 71.90%. The addition of prebiotics based on mannan-oligosaccharides resulted in an increased average daily growth by 14.95% with a lower feed consumption by 2.67% and better conversion by 15.32%, while the yield was approximately the same as in the control group. The use of mixes to which polysaccharide complexes of micro elements have been added (Fe, Cu, Zn, Mn) resulted in a higher daily growth by 11.43%, with a lower feed consumption by 4.28% and better conversion by 14%. The yield was approximately the same in this group as in the controls. The results realized in these investigations, throughout the experimental period, indicate that the use of the examined additives significantly affected the growth and body mass of chicks and that it is nutritionally and economically justified.
AB  - Cilj ovih istraživanja je bio da se ispita uticaj prebiotika na bazi manan-oligosaharida i polisaharidnih kompleksa mikro elemenata (Fe, Cu, Zn, Mn) na proizvodne rezultate i klanične parametre kod brojlerskih pilića hibrida Arbor Acres. Ogled je izveden na 186 pilića razvrstanih u tri jednake grupe, trajao je 42 dana i bio podeljen u 3 faze. Prva faza trajala je 21, druga 14, a treća 7 dana. Potpuna smeša za početni tov pilića korišćena je od 1-21 dana, a potpune krmne smeše za završni tov od 21-35 dana, odnosno 35-42 dana ogleda. Ishrana je bila po volji, a pilići su bili u uslovima podnog sistema držanja. Brojleri hranjeni smešama standardnog sirovinskog sastava i uobičajene hranljive vrednosti, ostvarili su prosečan dnevni prirast od 49,10 g pri prosečnoj dnevnoj konzumaciji hrane od 115,55 g i uz konverziju hrane od 2,35 dok je randman bio 71,90%. Dodavanje prebiotika na bazi manan-oligosaharida dovelo je do povećanja prosečnog dnevnog prirasta za 14,95% pri manjoj konzumaciji hrane za 2,67% i boljoj konverziji za 15,32%, dok je randman bio približno isti kao u kontrolnoj grupi. Korišćenjem smeša u koje su dodavani polisaharidni kompleksi mikroelemenata (Fe, Cu, Zn, Mn) postignuti su veći dnevni prirasti za 11,43%, pri manjoj konzumaciji hrane za 4,28% i boljoj konverziji za 14%. Randman je i u ovoj grupi bio približno isti kao u kontrolnoj. Rezultati ostvareni u ovim istraživanjima, u toku celog oglednog perioda, ukazuju da je upotreba ispitivanih aditiva značajno uticala na prirast i telesnu masu pilića i da ima nutritivno i ekonomsko opravdanje.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Veterinarski Glasnik
T1  - The influence of different feed additives in broiler diets on productivity and meat yield
T1  - Uticaj različitih aditiva u ishrani brojlera na proizvodne rezultate i klanične parametre
VL  - 61
IS  - 5-6
SP  - 261
EP  - 278
DO  - 10.2298/VETGL0706261T
ER  - 

@article{
author = "Tokić, Vesna and Lazarević, Miodrag and Sinovec, Zlatan and Baltić, Milan Ž. and Jokić, Živan",
year = "2007",
abstract = "The objective of these investigations was to examine the influence of prebiotics based on mannan-oligosaccharides and polysaccharide complexes of micro elements (Fe, Cu, Zn, Mn) on production results and abattoir parameters for broilers of the hybrid Arbor Acres. The experiment was performed on 186 chicken divided into three equal groups, it lasted 42 days and was divided into 3 phases. The first phase lasted 21 days, the second 14, and the third seven days. The complete mix for initial fattening of broilers was used from days 1-21, and complete fodder mixes for closing fattening from days 21-35, and on days 35-42 of the experiment. Feeding was ad libitum and the broilers were maintained in a floor system. Broilers fed mixes of standard raw material composition and the usual nutritive values achieved an average daily growth of 49.10 g at an average daily feed consumption of 115.55 g and with food conversion of 2.35, while the yield was 71.90%. The addition of prebiotics based on mannan-oligosaccharides resulted in an increased average daily growth by 14.95% with a lower feed consumption by 2.67% and better conversion by 15.32%, while the yield was approximately the same as in the control group. The use of mixes to which polysaccharide complexes of micro elements have been added (Fe, Cu, Zn, Mn) resulted in a higher daily growth by 11.43%, with a lower feed consumption by 4.28% and better conversion by 14%. The yield was approximately the same in this group as in the controls. The results realized in these investigations, throughout the experimental period, indicate that the use of the examined additives significantly affected the growth and body mass of chicks and that it is nutritionally and economically justified., Cilj ovih istraživanja je bio da se ispita uticaj prebiotika na bazi manan-oligosaharida i polisaharidnih kompleksa mikro elemenata (Fe, Cu, Zn, Mn) na proizvodne rezultate i klanične parametre kod brojlerskih pilića hibrida Arbor Acres. Ogled je izveden na 186 pilića razvrstanih u tri jednake grupe, trajao je 42 dana i bio podeljen u 3 faze. Prva faza trajala je 21, druga 14, a treća 7 dana. Potpuna smeša za početni tov pilića korišćena je od 1-21 dana, a potpune krmne smeše za završni tov od 21-35 dana, odnosno 35-42 dana ogleda. Ishrana je bila po volji, a pilići su bili u uslovima podnog sistema držanja. Brojleri hranjeni smešama standardnog sirovinskog sastava i uobičajene hranljive vrednosti, ostvarili su prosečan dnevni prirast od 49,10 g pri prosečnoj dnevnoj konzumaciji hrane od 115,55 g i uz konverziju hrane od 2,35 dok je randman bio 71,90%. Dodavanje prebiotika na bazi manan-oligosaharida dovelo je do povećanja prosečnog dnevnog prirasta za 14,95% pri manjoj konzumaciji hrane za 2,67% i boljoj konverziji za 15,32%, dok je randman bio približno isti kao u kontrolnoj grupi. Korišćenjem smeša u koje su dodavani polisaharidni kompleksi mikroelemenata (Fe, Cu, Zn, Mn) postignuti su veći dnevni prirasti za 11,43%, pri manjoj konzumaciji hrane za 4,28% i boljoj konverziji za 14%. Randman je i u ovoj grupi bio približno isti kao u kontrolnoj. Rezultati ostvareni u ovim istraživanjima, u toku celog oglednog perioda, ukazuju da je upotreba ispitivanih aditiva značajno uticala na prirast i telesnu masu pilića i da ima nutritivno i ekonomsko opravdanje.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Veterinarski Glasnik",
title = "The influence of different feed additives in broiler diets on productivity and meat yield, Uticaj različitih aditiva u ishrani brojlera na proizvodne rezultate i klanične parametre",
volume = "61",
number = "5-6",
pages = "261-278",
doi = "10.2298/VETGL0706261T"
}

Tokić, V., Lazarević, M., Sinovec, Z., Baltić, M. Ž.,& Jokić, Ž.. (2007). The influence of different feed additives in broiler diets on productivity and meat yield. in Veterinarski Glasnik
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 61(5-6), 261-278.
https://doi.org/10.2298/VETGL0706261T

Tokić V, Lazarević M, Sinovec Z, Baltić MŽ, Jokić Ž. The influence of different feed additives in broiler diets on productivity and meat yield. in Veterinarski Glasnik. 2007;61(5-6):261-278.
doi:10.2298/VETGL0706261T .

Tokić, Vesna, Lazarević, Miodrag, Sinovec, Zlatan, Baltić, Milan Ž., Jokić, Živan, "The influence of different feed additives in broiler diets on productivity and meat yield" in Veterinarski Glasnik, 61, no. 5-6 (2007):261-278,
https://doi.org/10.2298/VETGL0706261T . .

TY  - JOUR
AU  - Tokić, Vesna
AU  - Lazarević, Miodrag
AU  - Sinovec, Zlatan
AU  - Tokić, A.
PY  - 2007
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/459
AB  - Our investigations were conducted in order to determine the influence of mannan-oligosaccharide (MOS) based prebiotics and polysaccharide microelement complexes on the performance and immune response of Arbor Acre broiler chickens. Total of 186 chickens was included in the study which lasted 42 days. Birds were fed ad libitum three different complete food mixtures (from days 1- 21, 21 - 35 and 35-42) according to the standard fattening procedure. Mixtures for chickens from the first group were supplemented with mannanoligosaccharide based prebiotics and for the birds from the second group with polysaccharide microelement (Fe, Cu, ZN and Mn) complexes. Broilers in the control group had daily weight gain of 49.1 g, daily food consumption of 115.5 g and a feed : gain ratio 2.35. In the group of broilers feed mixtures supplemented with mannan-oligosaccharides, the daily weight gain was higher (+ 14.95%), daily food consumption was lower (- 2.67) and feed : gain ratio was smaller (-15.32%) when compared to the control group. In the group of broilers fed mixtures with polysaccharide microelement complexes, the daily weight gain was also higher (+ 11.43%), daily food consumption was lower (- 4.28) and feed: gain ratio was smaller (-14.0%) when compared to the control group. Following revaccination against NCD, broilers fed MOS based prebiotics had significantly higher titers of antibodies than observed in the other two groups. The highest degree of cutaneous hypersensitivity to PHA was recorded in the group of broilers fed mixtures with polysaccharide microelement complexes.
AB  - Cilj ovih istraživanja je bio da se ispita uticaj prebiotika na bazi mananoligosaharida i polisaharidnih kompleksa mikroelemenata (Fe, Cu, Zn i Mn) na proizvodne rezultate i imunski odgovor brojlera hibrida "Arbor Acres". Ogled je izveden na 186 pilića podeljenih u 3 grupe i trajao je 42 dana. Brojleri su bili hranjeni ad libitum sa tri potpune krmne smeše za tov (1-21 dan, 21-35 i 35-42) u skladu sa potrebama soja. Brojleri hranjeni smešama standardnog sirovinskog sastava i uobičajene hranljive vrednosti (kontrolna grupa) ostvarili su prosečan dnevni prirast od 49,1 g, pri dnevnoj konzumaciji hrane od 115,5 g i konverziju hrane od 2,35. Dodavanje mananoligosaharida potpunim smešama za ishranu tovnih pilića dovodi do povećanja prosečnog dnevnog prirasta za 14,95% pri manjoj konzumaciji hrane za 2,67% i boljoj konverziji hrane za 15,32%. Korišćenjem smeša u koje su dodavani polisaharidni kompleksi mikroelemenata postignuti su veći dnevni prirasti za 11,43%, pri manjoj konzumaciji hrane za 4,28% i boljoj konverziji hrane za 14,0%. Nakon sprovedenog postupka revakcinacije, brojleri hranjeni smešom sa dodatkom manan oligosaharida imali su značajno veći titar antitela na virus NCD u odnosu na kontrolnu grupu i grupu kojoj su dodavani organski vezani mikroelementi. Najveći stepen kožne reaktivnosti na PHA, kao indikator celularne imunološ ke reaktivnosti registrovan je u grupi brojlera hranjenih smešama u koje su dodavani polisaharidni kompleksi mikroelemenata.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta Veterinaria-Beograd
T1  - The influence of different feed additives to performances and immune response in broiler chicken
T1  - Uticaj različitih aditiva u ishrani brojlera na proizvodne rezultate i imunski odgovor
VL  - 57
IS  - 2-3
SP  - 217
EP  - 229
DO  - 10.2298/AVB0703217T
ER  - 

@article{
author = "Tokić, Vesna and Lazarević, Miodrag and Sinovec, Zlatan and Tokić, A.",
year = "2007",
abstract = "Our investigations were conducted in order to determine the influence of mannan-oligosaccharide (MOS) based prebiotics and polysaccharide microelement complexes on the performance and immune response of Arbor Acre broiler chickens. Total of 186 chickens was included in the study which lasted 42 days. Birds were fed ad libitum three different complete food mixtures (from days 1- 21, 21 - 35 and 35-42) according to the standard fattening procedure. Mixtures for chickens from the first group were supplemented with mannanoligosaccharide based prebiotics and for the birds from the second group with polysaccharide microelement (Fe, Cu, ZN and Mn) complexes. Broilers in the control group had daily weight gain of 49.1 g, daily food consumption of 115.5 g and a feed : gain ratio 2.35. In the group of broilers feed mixtures supplemented with mannan-oligosaccharides, the daily weight gain was higher (+ 14.95%), daily food consumption was lower (- 2.67) and feed : gain ratio was smaller (-15.32%) when compared to the control group. In the group of broilers fed mixtures with polysaccharide microelement complexes, the daily weight gain was also higher (+ 11.43%), daily food consumption was lower (- 4.28) and feed: gain ratio was smaller (-14.0%) when compared to the control group. Following revaccination against NCD, broilers fed MOS based prebiotics had significantly higher titers of antibodies than observed in the other two groups. The highest degree of cutaneous hypersensitivity to PHA was recorded in the group of broilers fed mixtures with polysaccharide microelement complexes., Cilj ovih istraživanja je bio da se ispita uticaj prebiotika na bazi mananoligosaharida i polisaharidnih kompleksa mikroelemenata (Fe, Cu, Zn i Mn) na proizvodne rezultate i imunski odgovor brojlera hibrida "Arbor Acres". Ogled je izveden na 186 pilića podeljenih u 3 grupe i trajao je 42 dana. Brojleri su bili hranjeni ad libitum sa tri potpune krmne smeše za tov (1-21 dan, 21-35 i 35-42) u skladu sa potrebama soja. Brojleri hranjeni smešama standardnog sirovinskog sastava i uobičajene hranljive vrednosti (kontrolna grupa) ostvarili su prosečan dnevni prirast od 49,1 g, pri dnevnoj konzumaciji hrane od 115,5 g i konverziju hrane od 2,35. Dodavanje mananoligosaharida potpunim smešama za ishranu tovnih pilića dovodi do povećanja prosečnog dnevnog prirasta za 14,95% pri manjoj konzumaciji hrane za 2,67% i boljoj konverziji hrane za 15,32%. Korišćenjem smeša u koje su dodavani polisaharidni kompleksi mikroelemenata postignuti su veći dnevni prirasti za 11,43%, pri manjoj konzumaciji hrane za 4,28% i boljoj konverziji hrane za 14,0%. Nakon sprovedenog postupka revakcinacije, brojleri hranjeni smešom sa dodatkom manan oligosaharida imali su značajno veći titar antitela na virus NCD u odnosu na kontrolnu grupu i grupu kojoj su dodavani organski vezani mikroelementi. Najveći stepen kožne reaktivnosti na PHA, kao indikator celularne imunološ ke reaktivnosti registrovan je u grupi brojlera hranjenih smešama u koje su dodavani polisaharidni kompleksi mikroelemenata.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta Veterinaria-Beograd",
title = "The influence of different feed additives to performances and immune response in broiler chicken, Uticaj različitih aditiva u ishrani brojlera na proizvodne rezultate i imunski odgovor",
volume = "57",
number = "2-3",
pages = "217-229",
doi = "10.2298/AVB0703217T"
}

Tokić, V., Lazarević, M., Sinovec, Z.,& Tokić, A.. (2007). The influence of different feed additives to performances and immune response in broiler chicken. in Acta Veterinaria-Beograd
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 57(2-3), 217-229.
https://doi.org/10.2298/AVB0703217T

Tokić V, Lazarević M, Sinovec Z, Tokić A. The influence of different feed additives to performances and immune response in broiler chicken. in Acta Veterinaria-Beograd. 2007;57(2-3):217-229.
doi:10.2298/AVB0703217T .

Tokić, Vesna, Lazarević, Miodrag, Sinovec, Zlatan, Tokić, A., "The influence of different feed additives to performances and immune response in broiler chicken" in Acta Veterinaria-Beograd, 57, no. 2-3 (2007):217-229,
https://doi.org/10.2298/AVB0703217T . .

TY  - CONF
AU  - Resanović, Radmila
AU  - Sinovec, Zlatan
PY  - 2006
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/400
AB  - The forty-two days long experiment was conducted on a total of 1000 Arbor Acres broilers, divided into two groups. Both groups of broilers were fed with a commercial feed mixture which consisted of standard feedstuffs and contained enough nutrients regarding the requirements. During the first three weeks of the trial, com naturally contaminated with AFB) 0.0445 ppm per kg dry matter was used in the amount of 20% in the experimental group, while AFB1 free com was given to birds in the control group. After the period of toxin administration until the end of the trial, broilers from both groups were normally fed another 5 weeks with uncontaminated feed. In the first phase of the trial, broilers in the control groups had an average daily gain (ADG) of 31 g, average daily feed intake (ADFI) of 45 g and a feed:gain ratio (FCR) of 1.42. In the same time, experimental broilers achieved an ADG of 25 g, ADFI of 35 g and a FCR of 1.39. During the whole period of the trial, control and experimental broilers achieved 49.12 g, 95.24 g and 1.94 and 39.71 g, 86.90 g and 2.19, respectively. For the experimental group, the end of the trial was delayed due to lower performances till weighing standard body weight. The trial lasted two weeks longer but overall performances were unsatisfying (ADG 37 g, ADFI 121 g and FCR 3.27). After the period of using contaminated feed, the liver of treated broilers was enlarged, dark yellow colored and tender in consistence. In some cases punctoforme and maculose extravasations could be seen. In all liver samples residues of AFB1 were detected in amounts of 0.63±0.12 ppb. AFB1 had negative effects on performances of broilers even in small amounts. The removal of contaminated feed could alleviate its adverse effects only to a certain extent.
C3  - Mycotoxin Research
T1  - Effects of limited feeding of aflatoxin B1 contaminated feed on the performance of broilers
VL  - 22
IS  - 3
SP  - 183
EP  - 188
DO  - 10.1007/BF02959274
ER  - 

@conference{
author = "Resanović, Radmila and Sinovec, Zlatan",
year = "2006",
abstract = "The forty-two days long experiment was conducted on a total of 1000 Arbor Acres broilers, divided into two groups. Both groups of broilers were fed with a commercial feed mixture which consisted of standard feedstuffs and contained enough nutrients regarding the requirements. During the first three weeks of the trial, com naturally contaminated with AFB) 0.0445 ppm per kg dry matter was used in the amount of 20% in the experimental group, while AFB1 free com was given to birds in the control group. After the period of toxin administration until the end of the trial, broilers from both groups were normally fed another 5 weeks with uncontaminated feed. In the first phase of the trial, broilers in the control groups had an average daily gain (ADG) of 31 g, average daily feed intake (ADFI) of 45 g and a feed:gain ratio (FCR) of 1.42. In the same time, experimental broilers achieved an ADG of 25 g, ADFI of 35 g and a FCR of 1.39. During the whole period of the trial, control and experimental broilers achieved 49.12 g, 95.24 g and 1.94 and 39.71 g, 86.90 g and 2.19, respectively. For the experimental group, the end of the trial was delayed due to lower performances till weighing standard body weight. The trial lasted two weeks longer but overall performances were unsatisfying (ADG 37 g, ADFI 121 g and FCR 3.27). After the period of using contaminated feed, the liver of treated broilers was enlarged, dark yellow colored and tender in consistence. In some cases punctoforme and maculose extravasations could be seen. In all liver samples residues of AFB1 were detected in amounts of 0.63±0.12 ppb. AFB1 had negative effects on performances of broilers even in small amounts. The removal of contaminated feed could alleviate its adverse effects only to a certain extent.",
journal = "Mycotoxin Research",
title = "Effects of limited feeding of aflatoxin B1 contaminated feed on the performance of broilers",
volume = "22",
number = "3",
pages = "183-188",
doi = "10.1007/BF02959274"
}

Resanović, R.,& Sinovec, Z.. (2006). Effects of limited feeding of aflatoxin B1 contaminated feed on the performance of broilers. in Mycotoxin Research, 22(3), 183-188.
https://doi.org/10.1007/BF02959274

Resanović R, Sinovec Z. Effects of limited feeding of aflatoxin B1 contaminated feed on the performance of broilers. in Mycotoxin Research. 2006;22(3):183-188.
doi:10.1007/BF02959274 .

Resanović, Radmila, Sinovec, Zlatan, "Effects of limited feeding of aflatoxin B1 contaminated feed on the performance of broilers" in Mycotoxin Research, 22, no. 3 (2006):183-188,
https://doi.org/10.1007/BF02959274 . .

TY  - JOUR
AU  - Nedeljković-Trailović, Jelena
AU  - Bočarov-Stančić, Aleksandra
AU  - Sinovec, Zlatan
PY  - 2005
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/365
AB  - The three-week long trial was performed on day-old Hybro broilers divided into four groups. After 14 days long preexperimental period, the experimental groups were offered feed contaminated with 0.5, 1.0 and 1.5 ppm OA during 7 respectively. At the end of the trial blood and kidney samples were taken for investigations. In broilers feed with 1.5 ppm of OA histopathological examination of the kidney tissue revealed changes located in proximal tubules. Some cells were dim and swollen. These changes produced particular or total reduction in tubular lumen of kidney. Acute tubular necrosis existed in some of tubulocites in form of small foci. Fragmentation of necrotic mass and presence of fresh red blood cells were also detected. The LDH activity was significantly greater in broilers of experimental groups compared with control group. All presented data indicated that intensity of pathohistological alterations and LDH activity depends upon dietary OTA level. Positive correlation between pathohistological changes and increased LDH activity caused by OTA was noticed. Thus, LDH activity measure could be used as early diagnostic tool in measuring changes caused by OTA.
AB  - Ogled je izveden na Hybro-brojlerima podeljenim u četiri grupe i trajao je 21 dan. Nakon četrnaestodnevnog pripremnog perioda ogledne grupe su hranjene hranom kontaminiranom ohratoksinom A u količini od 0.5; 1.0 i 1.5 ppm tokom 7 dana. Na kraju ogleda uzeti su uzorci krvi i tkiva za ispitivanja. Kod životinja koje su 7 dana dobijale količinu od 1.5 ppm OA patohistološkim pregledom bubrega uočava se da su promenama uglavnom zahvaćeni prokimalni bubrežni tubuli. Pojedine epitelne ćelije su mutne i nabubrele, što je dovelo do delimičnog ili potpunog suženja lumena bubrežnih tubula. Kod manjeg broja bubrežnih tubula zapaža se akutna tubularna nekroza u vidu sitnih ognjišta. Česta je pojava fragmentacije nekrotične mase, kao i nalaz svežih eritrocita. Aktivnost enzima LDH na kraju ogleda bila je signifikantno viša kod brojlera svih oglednih grupa u odnosu na kontrolnu grupu. Sve navedene činjenice ukazuju da intenzitet patohistoloških promena u bubregu zavisi od koncentracije ohratoksina A u hrani, pri čemu aktivnost enzima LDH može da posluži kao koristan parametar za procenjivanje stepena alteracija bubrega.
PB  - Matica srpska, Novi Sad
T2  - Zbornik Matice srpske za prirodne nauke
T1  - Pathohistological changes in kidney and LDH activity in broiler treated with different doses of ochratoxin A
T1  - Patohistološke promene u bubrezima brojlera i aktivnost laktat dehidrogenaze tretiranih različitim količinama ohratoksina A
IS  - 108
SP  - 103
EP  - 108
DO  - 10.2298/ZMSPN0508103N
ER  - 

@article{
author = "Nedeljković-Trailović, Jelena and Bočarov-Stančić, Aleksandra and Sinovec, Zlatan",
year = "2005",
abstract = "The three-week long trial was performed on day-old Hybro broilers divided into four groups. After 14 days long preexperimental period, the experimental groups were offered feed contaminated with 0.5, 1.0 and 1.5 ppm OA during 7 respectively. At the end of the trial blood and kidney samples were taken for investigations. In broilers feed with 1.5 ppm of OA histopathological examination of the kidney tissue revealed changes located in proximal tubules. Some cells were dim and swollen. These changes produced particular or total reduction in tubular lumen of kidney. Acute tubular necrosis existed in some of tubulocites in form of small foci. Fragmentation of necrotic mass and presence of fresh red blood cells were also detected. The LDH activity was significantly greater in broilers of experimental groups compared with control group. All presented data indicated that intensity of pathohistological alterations and LDH activity depends upon dietary OTA level. Positive correlation between pathohistological changes and increased LDH activity caused by OTA was noticed. Thus, LDH activity measure could be used as early diagnostic tool in measuring changes caused by OTA., Ogled je izveden na Hybro-brojlerima podeljenim u četiri grupe i trajao je 21 dan. Nakon četrnaestodnevnog pripremnog perioda ogledne grupe su hranjene hranom kontaminiranom ohratoksinom A u količini od 0.5; 1.0 i 1.5 ppm tokom 7 dana. Na kraju ogleda uzeti su uzorci krvi i tkiva za ispitivanja. Kod životinja koje su 7 dana dobijale količinu od 1.5 ppm OA patohistološkim pregledom bubrega uočava se da su promenama uglavnom zahvaćeni prokimalni bubrežni tubuli. Pojedine epitelne ćelije su mutne i nabubrele, što je dovelo do delimičnog ili potpunog suženja lumena bubrežnih tubula. Kod manjeg broja bubrežnih tubula zapaža se akutna tubularna nekroza u vidu sitnih ognjišta. Česta je pojava fragmentacije nekrotične mase, kao i nalaz svežih eritrocita. Aktivnost enzima LDH na kraju ogleda bila je signifikantno viša kod brojlera svih oglednih grupa u odnosu na kontrolnu grupu. Sve navedene činjenice ukazuju da intenzitet patohistoloških promena u bubregu zavisi od koncentracije ohratoksina A u hrani, pri čemu aktivnost enzima LDH može da posluži kao koristan parametar za procenjivanje stepena alteracija bubrega.",
publisher = "Matica srpska, Novi Sad",
journal = "Zbornik Matice srpske za prirodne nauke",
title = "Pathohistological changes in kidney and LDH activity in broiler treated with different doses of ochratoxin A, Patohistološke promene u bubrezima brojlera i aktivnost laktat dehidrogenaze tretiranih različitim količinama ohratoksina A",
number = "108",
pages = "103-108",
doi = "10.2298/ZMSPN0508103N"
}

Nedeljković-Trailović, J., Bočarov-Stančić, A.,& Sinovec, Z.. (2005). Pathohistological changes in kidney and LDH activity in broiler treated with different doses of ochratoxin A. in Zbornik Matice srpske za prirodne nauke
Matica srpska, Novi Sad.(108), 103-108.
https://doi.org/10.2298/ZMSPN0508103N

Nedeljković-Trailović J, Bočarov-Stančić A, Sinovec Z. Pathohistological changes in kidney and LDH activity in broiler treated with different doses of ochratoxin A. in Zbornik Matice srpske za prirodne nauke. 2005;(108):103-108.
doi:10.2298/ZMSPN0508103N .

Nedeljković-Trailović, Jelena, Bočarov-Stančić, Aleksandra, Sinovec, Zlatan, "Pathohistological changes in kidney and LDH activity in broiler treated with different doses of ochratoxin A" in Zbornik Matice srpske za prirodne nauke, no. 108 (2005):103-108,
https://doi.org/10.2298/ZMSPN0508103N . .

TY  - JOUR
AU  - Sinovec, Zlatan
AU  - Resanović, Radmila
PY  - 2005
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/349
AB  - Mikotoksini su toksične supstance koje mogu biti prisutne u velikom broju hraniva i namirnica. Mikotoksini ispoljavaju veoma širok spektar negativnih efekata koji se, pored patomorfoloških alteracija na različitim organima ispoljavaju i kao imunomodulatorni, teratogeni, mutageni i karcinogeni efekti. Za supstance takvog tipa ne postoje granice ispod kojih ne ispoljavaju svoje negativne efekte, pa se može zaključiti da se ne mogu odrediti ni dnevne tolerantne količine. Usaglašavanje unutar EU, ali i dragih zemalja, neophodno je kako bi se osiguralo jedinstveno tržište uz trajan princip proporcionalnosti. Generalno, maksimalno dozvoljene količine kontaminenata zasnovane su na kompromisu između zaštite konzumenata i ublažavanja ograničavanja trgovine. Ranim, odnosno pravovremenim utvrđivanjem prisustva mikotoksina u hrani i posledičnim isključivanjem kontaminirane hrane iz upotrebe mogu da se ublaže negativni efekti (Sinovec i sar., 2000). Zato, u proizvodnim uslovima mora da se praktikuje stalni i višestepeni monitoring higijenske ispravnosti hrane u cilju brzog i efikasnog reagovanja, kao za sada jedinog načina uspešne prevencije štetnih efekata mikotoksina. Kontrola gotovih proizvoda i provera saobraznosti neophodno je povezana sa uspostavljanjem sistema akreditovanih (reference) laboratorija, koji se zasniva na zvaničnom potvrđivanju (Stašić, 1993) da je laboratorija kompetentna za specifična ispitivanja ili specifične vrste ispitivanja (Đorđević, 1993). Akreditacijom nacionalnih referentnih laboratorija kroz Sistem akreditovanih laboratorija ušli bismo u Evropsku asocijaciju akreditovanih laboratorija, odnosno priključili bismo se zemljama sa razvijenim stočarstvom. Opremljenost laboratorija, čak i onih koje bi po svojoj nomenklaturi to morale da budu, je na vrlo niskom nivou. U našoj zemlji postoji opravdana potreba za intervencijom države u formiranju referentnih laboratorija u smislu kadrovske i tehničke opremljenosti kao preduslova za permanentniju i rigorozniju kontrolu kvaliteta hrane (Ševković i sar., 1995).
PB  - Institut za higijenu i tehnologiju mesa, Beograd
T2  - Tehnologija mesa
T1  - Mycotoxins in feeds: Risk in human health
T1  - Mikotoksini u hrani za životinje - rizik po zdravlje ljudi
VL  - 46
IS  - 1-2
SP  - 39
EP  - 44
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_349
ER  - 

@article{
author = "Sinovec, Zlatan and Resanović, Radmila",
year = "2005",
abstract = "Mikotoksini su toksične supstance koje mogu biti prisutne u velikom broju hraniva i namirnica. Mikotoksini ispoljavaju veoma širok spektar negativnih efekata koji se, pored patomorfoloških alteracija na različitim organima ispoljavaju i kao imunomodulatorni, teratogeni, mutageni i karcinogeni efekti. Za supstance takvog tipa ne postoje granice ispod kojih ne ispoljavaju svoje negativne efekte, pa se može zaključiti da se ne mogu odrediti ni dnevne tolerantne količine. Usaglašavanje unutar EU, ali i dragih zemalja, neophodno je kako bi se osiguralo jedinstveno tržište uz trajan princip proporcionalnosti. Generalno, maksimalno dozvoljene količine kontaminenata zasnovane su na kompromisu između zaštite konzumenata i ublažavanja ograničavanja trgovine. Ranim, odnosno pravovremenim utvrđivanjem prisustva mikotoksina u hrani i posledičnim isključivanjem kontaminirane hrane iz upotrebe mogu da se ublaže negativni efekti (Sinovec i sar., 2000). Zato, u proizvodnim uslovima mora da se praktikuje stalni i višestepeni monitoring higijenske ispravnosti hrane u cilju brzog i efikasnog reagovanja, kao za sada jedinog načina uspešne prevencije štetnih efekata mikotoksina. Kontrola gotovih proizvoda i provera saobraznosti neophodno je povezana sa uspostavljanjem sistema akreditovanih (reference) laboratorija, koji se zasniva na zvaničnom potvrđivanju (Stašić, 1993) da je laboratorija kompetentna za specifična ispitivanja ili specifične vrste ispitivanja (Đorđević, 1993). Akreditacijom nacionalnih referentnih laboratorija kroz Sistem akreditovanih laboratorija ušli bismo u Evropsku asocijaciju akreditovanih laboratorija, odnosno priključili bismo se zemljama sa razvijenim stočarstvom. Opremljenost laboratorija, čak i onih koje bi po svojoj nomenklaturi to morale da budu, je na vrlo niskom nivou. U našoj zemlji postoji opravdana potreba za intervencijom države u formiranju referentnih laboratorija u smislu kadrovske i tehničke opremljenosti kao preduslova za permanentniju i rigorozniju kontrolu kvaliteta hrane (Ševković i sar., 1995).",
publisher = "Institut za higijenu i tehnologiju mesa, Beograd",
journal = "Tehnologija mesa",
title = "Mycotoxins in feeds: Risk in human health, Mikotoksini u hrani za životinje - rizik po zdravlje ljudi",
volume = "46",
number = "1-2",
pages = "39-44",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_349"
}

Sinovec, Z.,& Resanović, R.. (2005). Mycotoxins in feeds: Risk in human health. in Tehnologija mesa
Institut za higijenu i tehnologiju mesa, Beograd., 46(1-2), 39-44.
https://hdl.handle.net/21.15107/rcub_veterinar_349

Sinovec Z, Resanović R. Mycotoxins in feeds: Risk in human health. in Tehnologija mesa. 2005;46(1-2):39-44.
https://hdl.handle.net/21.15107/rcub_veterinar_349 .

Sinovec, Zlatan, Resanović, Radmila, "Mycotoxins in feeds: Risk in human health" in Tehnologija mesa, 46, no. 1-2 (2005):39-44,
https://hdl.handle.net/21.15107/rcub_veterinar_349 .

TY  - JOUR
AU  - Sinovec, Zlatan
AU  - Resanović, Radmila
PY  - 2005
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/360
AB  - Mikotoksini predstavljaju stalnu opasnost u uzgoju životinja jer su prisutni u hranivima i negativno utiču na zdravstveno stanje i proizvodne rezultate čak i u malim količinama. Poremećaji proizvodnih rezultata životinja su vrlo česti, a slabija konverzija hrane, kao i slabiji parametri proizvodnje generalno se vezuju za korišćenje hrane kontaminirane mikotoksinima. S obzirom da je glavni put unošenja mikotoksina ingestija kontaminirane hrane optimalno rešenje je prevencija kontaminacije sprečavanjem ili redukcijom rasta toksin-produkujućih plesni na hranivima. Sa druge strane, u slučajevima kada se posumnja ili identifikuje prisustvo mikotoksina u hranivima i/ili hrani eliminacija se može izvršiti mehaničkom separacijom, hemijskom ekstrakcijom i dekontaminacijom ili detoksifikacijom korišćenjem fizičke hemijske ili biološke metode. Efikasni metodi za dekontaminaciju hrane veoma su skupi i nepraktični, posebno ako se radi o velikoj količini hrane. Zato mogućnost izbora predstavlja korišćenje adsorbenata u cilju ublažavanja negativnih efekata mikotoksina na proizvodne rezultate životinja. Adsorbenti imaju mogućnost da vežu mikotoksine tokom pasaže hrane kroz digestivni trakt odnosno da smanje resorpciju mikotoksina prisutnih u hrani. Istraživanja izvedena poslednjih godina, kao i rezultati sopstvene laboratorije, ukazuju da je stepen kontaminacije hrane veoma visok sa tendencijom rasta, što ukazuje na činjenicu da će mikotoksini još dugo biti jedan od primarnih problema u ishrani životinja. Dosadašnja iskustva, eksperimentalna i praktična, ukazuju da korišćenje adsorbenata može da ublaži i/ili prevenira negativne efekte mikotoksina. Adsorpcioni kapacitet modifikovanog klinoptilolita, dobijenog tehnološkom preradom zeolita, značajno raste modifikacijom molekulske strukture i polarnosti.
PB  - Matica srpska, Novi Sad
T2  - Zbornik Matice srpske za prirodne nauke
T1  - Prevention and control of mycotoxicoses using modified clinoptilolite
T1  - Prevencija i kontrola mikotoksikoza korišćenjem modifikovanog klinoptilolita
IS  - 108
SP  - 147
EP  - 155
DO  - 10.2298/ZMSPN0508147S
ER  - 

@article{
author = "Sinovec, Zlatan and Resanović, Radmila",
year = "2005",
abstract = "Mikotoksini predstavljaju stalnu opasnost u uzgoju životinja jer su prisutni u hranivima i negativno utiču na zdravstveno stanje i proizvodne rezultate čak i u malim količinama. Poremećaji proizvodnih rezultata životinja su vrlo česti, a slabija konverzija hrane, kao i slabiji parametri proizvodnje generalno se vezuju za korišćenje hrane kontaminirane mikotoksinima. S obzirom da je glavni put unošenja mikotoksina ingestija kontaminirane hrane optimalno rešenje je prevencija kontaminacije sprečavanjem ili redukcijom rasta toksin-produkujućih plesni na hranivima. Sa druge strane, u slučajevima kada se posumnja ili identifikuje prisustvo mikotoksina u hranivima i/ili hrani eliminacija se može izvršiti mehaničkom separacijom, hemijskom ekstrakcijom i dekontaminacijom ili detoksifikacijom korišćenjem fizičke hemijske ili biološke metode. Efikasni metodi za dekontaminaciju hrane veoma su skupi i nepraktični, posebno ako se radi o velikoj količini hrane. Zato mogućnost izbora predstavlja korišćenje adsorbenata u cilju ublažavanja negativnih efekata mikotoksina na proizvodne rezultate životinja. Adsorbenti imaju mogućnost da vežu mikotoksine tokom pasaže hrane kroz digestivni trakt odnosno da smanje resorpciju mikotoksina prisutnih u hrani. Istraživanja izvedena poslednjih godina, kao i rezultati sopstvene laboratorije, ukazuju da je stepen kontaminacije hrane veoma visok sa tendencijom rasta, što ukazuje na činjenicu da će mikotoksini još dugo biti jedan od primarnih problema u ishrani životinja. Dosadašnja iskustva, eksperimentalna i praktična, ukazuju da korišćenje adsorbenata može da ublaži i/ili prevenira negativne efekte mikotoksina. Adsorpcioni kapacitet modifikovanog klinoptilolita, dobijenog tehnološkom preradom zeolita, značajno raste modifikacijom molekulske strukture i polarnosti.",
publisher = "Matica srpska, Novi Sad",
journal = "Zbornik Matice srpske za prirodne nauke",
title = "Prevention and control of mycotoxicoses using modified clinoptilolite, Prevencija i kontrola mikotoksikoza korišćenjem modifikovanog klinoptilolita",
number = "108",
pages = "147-155",
doi = "10.2298/ZMSPN0508147S"
}

Sinovec, Z.,& Resanović, R.. (2005). Prevention and control of mycotoxicoses using modified clinoptilolite. in Zbornik Matice srpske za prirodne nauke
Matica srpska, Novi Sad.(108), 147-155.
https://doi.org/10.2298/ZMSPN0508147S

Sinovec Z, Resanović R. Prevention and control of mycotoxicoses using modified clinoptilolite. in Zbornik Matice srpske za prirodne nauke. 2005;(108):147-155.
doi:10.2298/ZMSPN0508147S .

Sinovec, Zlatan, Resanović, Radmila, "Prevention and control of mycotoxicoses using modified clinoptilolite" in Zbornik Matice srpske za prirodne nauke, no. 108 (2005):147-155,
https://doi.org/10.2298/ZMSPN0508147S . .

TY  - JOUR
AU  - Marković, Radmila
AU  - Jovanović, Nebojša D.
AU  - Šefer, Dragan
AU  - Sinovec, Zlatan
PY  - 2005
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/362
AB  - During ten-year period (1995-2004), a total of 756 analyses of pig and poultry feed was performed. Standard methods were used for microbiological determination. Qualitative and quantitative analyze of mycotoxins was performed by TLC technique. Feed for young categories contained from 100 to 3,400,000 CFU/g of feed. In 35.71% of all samples the detected amount was above acceptable levels. Feed for adult categories contained from 800 to 8,000,000 CFU/g of feed. In only 7.54% of samples this amount was over the tolerable level. Species determination revealed great heterogeneity, with the most common findings of Penicillium spp. (28.38%), Aspregillus spp. (26.37%) Mucor spp. (24.67%), Fusarium spp. (11.33%) and Rhizopus spp. (9.22%). The amount and type of mycotoxin varied depending on the feed category as well as on year of detection, implicating a strong influence of climatic factors and average humidity of the specified year. In a total of 320 analyzed feeds for pigs and poultry the characteristic finding was a combined contamination with two or three mycotoxins. In 161 samples of feed for young animals the presence of AFB1, F-2 and OTA was detected in 36, 161 and 161 samples respectively, while in 33, 83 and 71 samples the detected amounts were above tolerable levels. In 159 samples of feed for adult animals the presence of AFB1, F-2 and OTA was detected in 32, 159 and 159 samples, respectively while in 31, 65 and 99 samples the detected amounts were above tolerable levels.
AB  - Tokom desetogodišnjeg perioda (1995-2004) izvršeno je ukupno 756 analiza uzoraka stočne hrane namenjenih za ishranu živine i svinja. Za mikrobiološku analizu uzoraka korišćene su standardne metode, a kvalitativno i kvantitativno ispitivanje navedenih mikotoksina izvršeno je TLC metodom. Smeše za mlade životinje sadržale su od 100 do 3.400.000 plesni/gr, pri čemu je čak 35.71% ispitivanih uzoraka sadržalo nedozvoljen broj plesni. Smeše za odrasle životinje sadržale su od 800 do 8.000.000 plesni/gr, pri čemu je svega 7.54% ispitivanih uzoraka sadržalo nedozvoljen broj plesni. Vrste izolovanih rodova plesni pokazuju veliku heterogenost, a najčešće su detektovane Penicilium spp. (28.38%), Aspergillus spp. (26.37%), Mucor spp. (24.67%), Fusarium spp. (11.33%) i Rhisopus spp. (9.22%). Količina i vrsta mikotoksina varira u odnosu na vrstu smeše, kao i u odnosu na pojedine godine, što može da se dovede u direktnu vezu sa klimatskim faktorima, odnosno sa godišnjom vlažnošću. Ispitano je ukupno 320 smeša za ishranu svinja i živine, a karakteristično je da je velik broj smeša bio kontaminiran sa dva, odnosno tri mikotoksina. Od ukupno 161 uzorka hrane za mlade životinje prisustvo AFB1 F-2 i OTA utvrđeno je u 36, 161 i 161 uzorku, od čega je, istim redom, 33, 83 i 71 uzorak sadržao navedene mikotoksine iznad dozvoljene granice. Od ukupno 159 uzoraka hrane za odrasle životinje prisustvo AFB1, F-2 i OTA utvrđeno je u 32, 159 i 159 uzoraka, od čega je, istim redom, 31, 65 i 99 uzoraka sadržalo navedene mikotoksine iznad dozvoljene granice.
PB  - Matica srpska, Novi Sad
T2  - Zbornik Matice srpske za prirodne nauke
T1  - Mould and mycotoxin contamination of pig and poultry feed
T1  - Kontaminacija smeša za ishranu svinja i živine plesnima i mikotoksinima
IS  - 109
SP  - 89
EP  - 95
DO  - 10.2298/ZMSPN0519089M
ER  - 

@article{
author = "Marković, Radmila and Jovanović, Nebojša D. and Šefer, Dragan and Sinovec, Zlatan",
year = "2005",
abstract = "During ten-year period (1995-2004), a total of 756 analyses of pig and poultry feed was performed. Standard methods were used for microbiological determination. Qualitative and quantitative analyze of mycotoxins was performed by TLC technique. Feed for young categories contained from 100 to 3,400,000 CFU/g of feed. In 35.71% of all samples the detected amount was above acceptable levels. Feed for adult categories contained from 800 to 8,000,000 CFU/g of feed. In only 7.54% of samples this amount was over the tolerable level. Species determination revealed great heterogeneity, with the most common findings of Penicillium spp. (28.38%), Aspregillus spp. (26.37%) Mucor spp. (24.67%), Fusarium spp. (11.33%) and Rhizopus spp. (9.22%). The amount and type of mycotoxin varied depending on the feed category as well as on year of detection, implicating a strong influence of climatic factors and average humidity of the specified year. In a total of 320 analyzed feeds for pigs and poultry the characteristic finding was a combined contamination with two or three mycotoxins. In 161 samples of feed for young animals the presence of AFB1, F-2 and OTA was detected in 36, 161 and 161 samples respectively, while in 33, 83 and 71 samples the detected amounts were above tolerable levels. In 159 samples of feed for adult animals the presence of AFB1, F-2 and OTA was detected in 32, 159 and 159 samples, respectively while in 31, 65 and 99 samples the detected amounts were above tolerable levels., Tokom desetogodišnjeg perioda (1995-2004) izvršeno je ukupno 756 analiza uzoraka stočne hrane namenjenih za ishranu živine i svinja. Za mikrobiološku analizu uzoraka korišćene su standardne metode, a kvalitativno i kvantitativno ispitivanje navedenih mikotoksina izvršeno je TLC metodom. Smeše za mlade životinje sadržale su od 100 do 3.400.000 plesni/gr, pri čemu je čak 35.71% ispitivanih uzoraka sadržalo nedozvoljen broj plesni. Smeše za odrasle životinje sadržale su od 800 do 8.000.000 plesni/gr, pri čemu je svega 7.54% ispitivanih uzoraka sadržalo nedozvoljen broj plesni. Vrste izolovanih rodova plesni pokazuju veliku heterogenost, a najčešće su detektovane Penicilium spp. (28.38%), Aspergillus spp. (26.37%), Mucor spp. (24.67%), Fusarium spp. (11.33%) i Rhisopus spp. (9.22%). Količina i vrsta mikotoksina varira u odnosu na vrstu smeše, kao i u odnosu na pojedine godine, što može da se dovede u direktnu vezu sa klimatskim faktorima, odnosno sa godišnjom vlažnošću. Ispitano je ukupno 320 smeša za ishranu svinja i živine, a karakteristično je da je velik broj smeša bio kontaminiran sa dva, odnosno tri mikotoksina. Od ukupno 161 uzorka hrane za mlade životinje prisustvo AFB1 F-2 i OTA utvrđeno je u 36, 161 i 161 uzorku, od čega je, istim redom, 33, 83 i 71 uzorak sadržao navedene mikotoksine iznad dozvoljene granice. Od ukupno 159 uzoraka hrane za odrasle životinje prisustvo AFB1, F-2 i OTA utvrđeno je u 32, 159 i 159 uzoraka, od čega je, istim redom, 31, 65 i 99 uzoraka sadržalo navedene mikotoksine iznad dozvoljene granice.",
publisher = "Matica srpska, Novi Sad",
journal = "Zbornik Matice srpske za prirodne nauke",
title = "Mould and mycotoxin contamination of pig and poultry feed, Kontaminacija smeša za ishranu svinja i živine plesnima i mikotoksinima",
number = "109",
pages = "89-95",
doi = "10.2298/ZMSPN0519089M"
}

Marković, R., Jovanović, N. D., Šefer, D.,& Sinovec, Z.. (2005). Mould and mycotoxin contamination of pig and poultry feed. in Zbornik Matice srpske za prirodne nauke
Matica srpska, Novi Sad.(109), 89-95.
https://doi.org/10.2298/ZMSPN0519089M

Marković R, Jovanović ND, Šefer D, Sinovec Z. Mould and mycotoxin contamination of pig and poultry feed. in Zbornik Matice srpske za prirodne nauke. 2005;(109):89-95.
doi:10.2298/ZMSPN0519089M .

Marković, Radmila, Jovanović, Nebojša D., Šefer, Dragan, Sinovec, Zlatan, "Mould and mycotoxin contamination of pig and poultry feed" in Zbornik Matice srpske za prirodne nauke, no. 109 (2005):89-95,
https://doi.org/10.2298/ZMSPN0519089M . .

TY  - CONF
AU  - Sinovec, Zlatan
AU  - Marković, Radmila
PY  - 2005
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/363
PB  - Institut za stočarstvo, Beograd
C3  - Biotechnology in Animal Husbandry
T1  - Use of pre-biotics in poultry nutrition
T1  - Upotreba prebiotika u ishrani živine
VL  - 21
IS  - 5-6
SP  - 235
EP  - 239
DO  - 10.2298/BAH0506235S
ER  - 

@conference{
author = "Sinovec, Zlatan and Marković, Radmila",
year = "2005",
publisher = "Institut za stočarstvo, Beograd",
journal = "Biotechnology in Animal Husbandry",
title = "Use of pre-biotics in poultry nutrition, Upotreba prebiotika u ishrani živine",
volume = "21",
number = "5-6",
pages = "235-239",
doi = "10.2298/BAH0506235S"
}

Sinovec, Z.,& Marković, R.. (2005). Use of pre-biotics in poultry nutrition. in Biotechnology in Animal Husbandry
Institut za stočarstvo, Beograd., 21(5-6), 235-239.
https://doi.org/10.2298/BAH0506235S

Sinovec Z, Marković R. Use of pre-biotics in poultry nutrition. in Biotechnology in Animal Husbandry. 2005;21(5-6):235-239.
doi:10.2298/BAH0506235S .

Sinovec, Zlatan, Marković, Radmila, "Use of pre-biotics in poultry nutrition" in Biotechnology in Animal Husbandry, 21, no. 5-6 (2005):235-239,
https://doi.org/10.2298/BAH0506235S . .

TY  - JOUR
AU  - Sinovec, Zlatan
AU  - Šefer, Dragan
AU  - Jokić, Živan
PY  - 2005
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/321
AB  - All mineral matter, essential or non-essential, can have a significant influence on production results and the health of animals, if large quantities of them are present in a feed ration. A maximally tolerant content depends on the animal specie and category. Many factors, such as physiological status (growth, lactation, etc.), nutritive status, content and ratio of nutritive matter in the ration, duration of exposure, and the biological level of utilization of elements, also affect the maximally tolerant content of mineral matter in feed. The content of certain mineral matter in plant feed significantly depends on the soil factor, as well as the content and level of utilization of mineral matter from the soil. Mn, Se and Mo can be present in plant feed in such quantities as to induce toxicosis. Industrial contaminants, Cd, Pb or F, can contaminate plants, in particular their leaves, in quantities which lead to the appearance of clinical signs of conventional toxicosis. Moreover, natural water can contain large quantities of S, F, Na, Mg, or Fe, and certain mineral matter can get into water through industrial waste. In addition to the above, it is possible to cause unwanted effects through the frequent, but primarily unprofessional use of mineral additives, since it is extremely important, besides meeting the mineral requirements of each individual element, to secure a ratio among the mineral matter themselves as well as with other nutritive matter. Mineral matter present in food are in mutual interference, and these relations can be synergistic or antagonistic. The sufficiency of a large number of mineral matter has a negative effect on the utilization of other matter (conditional and/or border deficiency), while certain elements cause the clinical appearance of toxic effects. The accidental intake of large quantities of certain mineral matter is revealed as clinical signs of acute toxicosis, which is very different from chronic effects caused by the intake of increased quantities of mineral matter over a longer time period.
AB  - Sve mineralne materije, esencijalne ili neesencijalne, mogu značajno da utiču na proizvodne rezultate i zdravstevno stanje životinja ukoliko su u obroku prisutne u velikim količinama. Maksimalno tolerantan sadržaj zavisi se od vrste i kategorije životinja, a mnogi faktori, kao što su fiziološki status (rast, laktacija, itd), nuthtivni status, sadržaj i odnos hranljivih materija u obroku, trajanje ekspozicije i bioiskoristivost elementa, utiču na maksimalno tolerantan sadržaj mineralnih materija u hrani. Sadržaj pojedinih mineralnih materija u biljnim hranivima značajno zavisi od faktora tla, kao i sadržaja i iskoristivosti mineralnih materija iz tla. Mn, Se i Mo mogu da budu prisutni u hranivima biljnog porekla u takvim količinama da izazovu trovanja. Industrijski kontaminenti, Cd, Pb Hi F, mogu da kontaminiraju biljke, posebno lišće, u količinama koje dovode do ispoljavanja kliničkih znaka klasičnog trovanja. Osim toga, prirodno voda može da sadrži velike količine S, F, Na, Mg ili Fe, a pojedine mineralne materije mogu da dospeju u vodu preko industrijskog otpada. Pored navedenog, čestom, a pre svega nestručnom, upotrebom mineralnih dodataka postoji mogućnost izazivanja neželjenih efekata s obzirom na to daje, pored zadovoljenja minimalnih potreba svakog pojedinačnog elementa, neobično važan i odnos mineralnih materija međusobno, kao i sa drugim hranljivim materijama. Mineralne materije prisutne u hrani interferiraju međusobno, a odnosi mogu da budu sinergistički ili antagonistički. Suficit većeg broja mineralnih materija negativno utiče na iskorišćavanje drugih (uslovni i/ili granični deficiti), dok određeni elementi izazivaju kliničko ispoljavanje toksičnih efekata. Akcidentalno unošenje velikih količina pojedinih mineralnih materija ispoljavaju se kliničkim znacima akutne toksikoze, što se veoma razlikuje od hroničnih efekata izazvanih unošenjem povećanih količina mineralnih materija tokom dužeg perioda.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Veterinarski Glasnik
T1  - Role of minerals in animal health disorders
T1  - Uloga mineralnih materija u poremećaju zdravlja životinja
VL  - 59
IS  - 1-2
SP  - 155
EP  - 165
DO  - 10.2298/VETGL0502155S
ER  - 

@article{
author = "Sinovec, Zlatan and Šefer, Dragan and Jokić, Živan",
year = "2005",
abstract = "All mineral matter, essential or non-essential, can have a significant influence on production results and the health of animals, if large quantities of them are present in a feed ration. A maximally tolerant content depends on the animal specie and category. Many factors, such as physiological status (growth, lactation, etc.), nutritive status, content and ratio of nutritive matter in the ration, duration of exposure, and the biological level of utilization of elements, also affect the maximally tolerant content of mineral matter in feed. The content of certain mineral matter in plant feed significantly depends on the soil factor, as well as the content and level of utilization of mineral matter from the soil. Mn, Se and Mo can be present in plant feed in such quantities as to induce toxicosis. Industrial contaminants, Cd, Pb or F, can contaminate plants, in particular their leaves, in quantities which lead to the appearance of clinical signs of conventional toxicosis. Moreover, natural water can contain large quantities of S, F, Na, Mg, or Fe, and certain mineral matter can get into water through industrial waste. In addition to the above, it is possible to cause unwanted effects through the frequent, but primarily unprofessional use of mineral additives, since it is extremely important, besides meeting the mineral requirements of each individual element, to secure a ratio among the mineral matter themselves as well as with other nutritive matter. Mineral matter present in food are in mutual interference, and these relations can be synergistic or antagonistic. The sufficiency of a large number of mineral matter has a negative effect on the utilization of other matter (conditional and/or border deficiency), while certain elements cause the clinical appearance of toxic effects. The accidental intake of large quantities of certain mineral matter is revealed as clinical signs of acute toxicosis, which is very different from chronic effects caused by the intake of increased quantities of mineral matter over a longer time period., Sve mineralne materije, esencijalne ili neesencijalne, mogu značajno da utiču na proizvodne rezultate i zdravstevno stanje životinja ukoliko su u obroku prisutne u velikim količinama. Maksimalno tolerantan sadržaj zavisi se od vrste i kategorije životinja, a mnogi faktori, kao što su fiziološki status (rast, laktacija, itd), nuthtivni status, sadržaj i odnos hranljivih materija u obroku, trajanje ekspozicije i bioiskoristivost elementa, utiču na maksimalno tolerantan sadržaj mineralnih materija u hrani. Sadržaj pojedinih mineralnih materija u biljnim hranivima značajno zavisi od faktora tla, kao i sadržaja i iskoristivosti mineralnih materija iz tla. Mn, Se i Mo mogu da budu prisutni u hranivima biljnog porekla u takvim količinama da izazovu trovanja. Industrijski kontaminenti, Cd, Pb Hi F, mogu da kontaminiraju biljke, posebno lišće, u količinama koje dovode do ispoljavanja kliničkih znaka klasičnog trovanja. Osim toga, prirodno voda može da sadrži velike količine S, F, Na, Mg ili Fe, a pojedine mineralne materije mogu da dospeju u vodu preko industrijskog otpada. Pored navedenog, čestom, a pre svega nestručnom, upotrebom mineralnih dodataka postoji mogućnost izazivanja neželjenih efekata s obzirom na to daje, pored zadovoljenja minimalnih potreba svakog pojedinačnog elementa, neobično važan i odnos mineralnih materija međusobno, kao i sa drugim hranljivim materijama. Mineralne materije prisutne u hrani interferiraju međusobno, a odnosi mogu da budu sinergistički ili antagonistički. Suficit većeg broja mineralnih materija negativno utiče na iskorišćavanje drugih (uslovni i/ili granični deficiti), dok određeni elementi izazivaju kliničko ispoljavanje toksičnih efekata. Akcidentalno unošenje velikih količina pojedinih mineralnih materija ispoljavaju se kliničkim znacima akutne toksikoze, što se veoma razlikuje od hroničnih efekata izazvanih unošenjem povećanih količina mineralnih materija tokom dužeg perioda.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Veterinarski Glasnik",
title = "Role of minerals in animal health disorders, Uloga mineralnih materija u poremećaju zdravlja životinja",
volume = "59",
number = "1-2",
pages = "155-165",
doi = "10.2298/VETGL0502155S"
}

Sinovec, Z., Šefer, D.,& Jokić, Ž.. (2005). Role of minerals in animal health disorders. in Veterinarski Glasnik
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 59(1-2), 155-165.
https://doi.org/10.2298/VETGL0502155S

Sinovec Z, Šefer D, Jokić Ž. Role of minerals in animal health disorders. in Veterinarski Glasnik. 2005;59(1-2):155-165.
doi:10.2298/VETGL0502155S .

Sinovec, Zlatan, Šefer, Dragan, Jokić, Živan, "Role of minerals in animal health disorders" in Veterinarski Glasnik, 59, no. 1-2 (2005):155-165,
https://doi.org/10.2298/VETGL0502155S . .

TY  - JOUR
AU  - Nedeljković-Trailović, Jelena
AU  - Jovanović, Nebojša
AU  - Sinovec, Zlatan
PY  - 2004
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/265
AB  - The present study was designed to examine the harmful effects of low level ochratoxin A (OTA) for different period and different dietary OTA levels for same period of ingestion as well as to assess the resting period necessary to revoke any adverse effects of OTA. The trial was performed on 72 day-old chickens with 12 broilers in each group. The experimental groups were offered feed contaminated with 0.5 ppm OA during 7, 14 or 21 days in the first evaluation, and feed contaminated with 0.5, 1.0 or 1.5 ppm OTA for 7 days in the second evaluation. The control group (K) received feed free of toxin. Broilers in the control groups had an average daily gain of 43.5 g and a feed: gain ratio of 1.97 kg. OTA expressed a negative effect on performance proportion to the time of exposure and to the amount of dietary toxin showing prolong and cumulative effects. Early detection of OTA and exclusion of contaminated feed could partially prevent its adverse effects, but not less than three weeks of recovery is needed to nullify the damage.
AB  - Cilj rada je bio da se utvrde količine OTA u hrani koje izazivaju neželjene efekte sa aspekta doze i dužine ekspozicije, kao i da se utvrdi vreme odmora nakon zamene kontaminirane hrane potrebno za povlačenje tih efekata. U prvom ogledu su brojleri nakon dve nedelje pripreme dobijali 0,5 ppm OTA tokom 7 14 ili 21 dan. U drugom ogledu brojleri su dobijali 0,5, 1,0 ili 1,5 ppm OTA tokom 7 dana. Kontrolna grupa (K) je dobijala hranu bez toksina. Brojleri kontrolne grupe su postigli dnevni prirast od 43.5 g uz konverziju hrane od 1.97 kg. Ohratoksin je ispoljio negativne efekte na proizvodne rezultate proporcionalno dužini unošenja i količini u hrani, ispoljavajući protrahirano i kumulativno dejstvo. Rana detekcija prisustva OTA u hrani i isključivanje kontaminirane hrane može delimično da prevenira štetne efekte, ali je neophodan odmor od bar tri nedelje da se oni ublaže.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta Veterinaria-Beograd
T1  - Effects of exposure time and dietary ochratoxin A level on broiler performance
T1  - Efekti dužine ekspozicije i sadržaja ohratoksina A u hrani na proizvodne rezultate brojlera
VL  - 54
IS  - 5-6
SP  - 419
EP  - 426
DO  - 10.2298/AVB0406419N
ER  - 

@article{
author = "Nedeljković-Trailović, Jelena and Jovanović, Nebojša and Sinovec, Zlatan",
year = "2004",
abstract = "The present study was designed to examine the harmful effects of low level ochratoxin A (OTA) for different period and different dietary OTA levels for same period of ingestion as well as to assess the resting period necessary to revoke any adverse effects of OTA. The trial was performed on 72 day-old chickens with 12 broilers in each group. The experimental groups were offered feed contaminated with 0.5 ppm OA during 7, 14 or 21 days in the first evaluation, and feed contaminated with 0.5, 1.0 or 1.5 ppm OTA for 7 days in the second evaluation. The control group (K) received feed free of toxin. Broilers in the control groups had an average daily gain of 43.5 g and a feed: gain ratio of 1.97 kg. OTA expressed a negative effect on performance proportion to the time of exposure and to the amount of dietary toxin showing prolong and cumulative effects. Early detection of OTA and exclusion of contaminated feed could partially prevent its adverse effects, but not less than three weeks of recovery is needed to nullify the damage., Cilj rada je bio da se utvrde količine OTA u hrani koje izazivaju neželjene efekte sa aspekta doze i dužine ekspozicije, kao i da se utvrdi vreme odmora nakon zamene kontaminirane hrane potrebno za povlačenje tih efekata. U prvom ogledu su brojleri nakon dve nedelje pripreme dobijali 0,5 ppm OTA tokom 7 14 ili 21 dan. U drugom ogledu brojleri su dobijali 0,5, 1,0 ili 1,5 ppm OTA tokom 7 dana. Kontrolna grupa (K) je dobijala hranu bez toksina. Brojleri kontrolne grupe su postigli dnevni prirast od 43.5 g uz konverziju hrane od 1.97 kg. Ohratoksin je ispoljio negativne efekte na proizvodne rezultate proporcionalno dužini unošenja i količini u hrani, ispoljavajući protrahirano i kumulativno dejstvo. Rana detekcija prisustva OTA u hrani i isključivanje kontaminirane hrane može delimično da prevenira štetne efekte, ali je neophodan odmor od bar tri nedelje da se oni ublaže.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta Veterinaria-Beograd",
title = "Effects of exposure time and dietary ochratoxin A level on broiler performance, Efekti dužine ekspozicije i sadržaja ohratoksina A u hrani na proizvodne rezultate brojlera",
volume = "54",
number = "5-6",
pages = "419-426",
doi = "10.2298/AVB0406419N"
}

Nedeljković-Trailović, J., Jovanović, N.,& Sinovec, Z.. (2004). Effects of exposure time and dietary ochratoxin A level on broiler performance. in Acta Veterinaria-Beograd
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 54(5-6), 419-426.
https://doi.org/10.2298/AVB0406419N

Nedeljković-Trailović J, Jovanović N, Sinovec Z. Effects of exposure time and dietary ochratoxin A level on broiler performance. in Acta Veterinaria-Beograd. 2004;54(5-6):419-426.
doi:10.2298/AVB0406419N .

Nedeljković-Trailović, Jelena, Jovanović, Nebojša, Sinovec, Zlatan, "Effects of exposure time and dietary ochratoxin A level on broiler performance" in Acta Veterinaria-Beograd, 54, no. 5-6 (2004):419-426,
https://doi.org/10.2298/AVB0406419N . .

TY  - JOUR
AU  - Šefer, Dragan
AU  - Jakić-Dimić, Dobrila
AU  - Jokić, Živan
AU  - Sinovec, Zlatan
PY  - 2004
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/293
AB  - Animals need microelements in small quantities which participate in almost all physiological and biochemical processes. Microelement resorption does not depend only on their content in feed, but also on the age of the animal, the electrochemical reaction in the intestines and the form of the microelement itself. The choice of the source is based on the microelement content in solid state, its solubility in the organism, availability and utilization. Oxides, chlorides and carbonates are poorly soluble, and chlorides are hygroscopic, and carbonates oxidize rapidly. Sulphates are durable salts easy to purify, and sulphate ions are easily excreted from the organism. In addition to nonorganic forms of mineral matter, so-called chelated forms are today increasinlgy being used, in fact, organically bound microelements. Minerals bound to an amino acid or peptide are better protected during their passage through the stomach, and the resorption of a chelated form of copper is considerably higher than resorption from sulphates. The resorption of organically bound microelements does not proceed in the conventional manner (carrier/diffusion), so that there is no direct homeostatic control at the level of enterocytes, and retention and the biological half-life of a chelated form are bigger than those of an anorganic form.
AB  - Životinjama su mikroelementi potrebni u malim količinama i učestvuju u skoro svim fiziološkim i biohemijskim procesima. Resorpcija mikroelemenata ne zavisi samo od sadržaja u hrani, nego i od doba životinje, elektrohemijske reakcije u crevima i oblika u kome se mikroelement nalazi. Izbor izvora zasniva se na sadržaju mikroelementa u čistom stanju, rastvorljivosti u organizmu, dostupnosti i iskoristivosti. Oksidi, hloridi i karbonati slabo rastvorljivi, a pored toga hloridi su higroskopni, a karbonati brzo oksidišu. Sulfati su postojane soli, lake za prečišćavanje, a sulfatni jon se lako izlučuje iz organizma. Pored neorganskih formi mineralnih materija, danas se sve više koriste, takozvani "helatni" oblici, odnosno organski vezani mikroelementi. Minerali vezani sa amino-kiselinom ili peptidom bolje su zaštićeni za vreme pasaže kroz želudac, a resorpcija helatne forme bakra je znatno veća od resorpcije iz sulfata. Resorpcija organski vezanih mikroelemenata se ne odvija konvencionalno (nosač/dufuzija), pa direktna homeostatska kontrola na nivou enterocita ne postoji, a retencija i biološ ki poluživot helatnog oblika su veći kod anorganske forme.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Veterinarski Glasnik
T1  - Chelated forms of microelements as swine feed additives
T1  - Helatni oblici mikroelemenata kao dodatak hrani za svinje
VL  - 58
IS  - 3-4
SP  - 469
EP  - 479
UR  - https://hdl.handle.net/21.15107/rcub_agrospace_800
ER  - 

@article{
author = "Šefer, Dragan and Jakić-Dimić, Dobrila and Jokić, Živan and Sinovec, Zlatan",
year = "2004",
abstract = "Animals need microelements in small quantities which participate in almost all physiological and biochemical processes. Microelement resorption does not depend only on their content in feed, but also on the age of the animal, the electrochemical reaction in the intestines and the form of the microelement itself. The choice of the source is based on the microelement content in solid state, its solubility in the organism, availability and utilization. Oxides, chlorides and carbonates are poorly soluble, and chlorides are hygroscopic, and carbonates oxidize rapidly. Sulphates are durable salts easy to purify, and sulphate ions are easily excreted from the organism. In addition to nonorganic forms of mineral matter, so-called chelated forms are today increasinlgy being used, in fact, organically bound microelements. Minerals bound to an amino acid or peptide are better protected during their passage through the stomach, and the resorption of a chelated form of copper is considerably higher than resorption from sulphates. The resorption of organically bound microelements does not proceed in the conventional manner (carrier/diffusion), so that there is no direct homeostatic control at the level of enterocytes, and retention and the biological half-life of a chelated form are bigger than those of an anorganic form., Životinjama su mikroelementi potrebni u malim količinama i učestvuju u skoro svim fiziološkim i biohemijskim procesima. Resorpcija mikroelemenata ne zavisi samo od sadržaja u hrani, nego i od doba životinje, elektrohemijske reakcije u crevima i oblika u kome se mikroelement nalazi. Izbor izvora zasniva se na sadržaju mikroelementa u čistom stanju, rastvorljivosti u organizmu, dostupnosti i iskoristivosti. Oksidi, hloridi i karbonati slabo rastvorljivi, a pored toga hloridi su higroskopni, a karbonati brzo oksidišu. Sulfati su postojane soli, lake za prečišćavanje, a sulfatni jon se lako izlučuje iz organizma. Pored neorganskih formi mineralnih materija, danas se sve više koriste, takozvani "helatni" oblici, odnosno organski vezani mikroelementi. Minerali vezani sa amino-kiselinom ili peptidom bolje su zaštićeni za vreme pasaže kroz želudac, a resorpcija helatne forme bakra je znatno veća od resorpcije iz sulfata. Resorpcija organski vezanih mikroelemenata se ne odvija konvencionalno (nosač/dufuzija), pa direktna homeostatska kontrola na nivou enterocita ne postoji, a retencija i biološ ki poluživot helatnog oblika su veći kod anorganske forme.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Veterinarski Glasnik",
title = "Chelated forms of microelements as swine feed additives, Helatni oblici mikroelemenata kao dodatak hrani za svinje",
volume = "58",
number = "3-4",
pages = "469-479",
url = "https://hdl.handle.net/21.15107/rcub_agrospace_800"
}

Šefer, D., Jakić-Dimić, D., Jokić, Ž.,& Sinovec, Z.. (2004). Chelated forms of microelements as swine feed additives. in Veterinarski Glasnik
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 58(3-4), 469-479.
https://hdl.handle.net/21.15107/rcub_agrospace_800

Šefer D, Jakić-Dimić D, Jokić Ž, Sinovec Z. Chelated forms of microelements as swine feed additives. in Veterinarski Glasnik. 2004;58(3-4):469-479.
https://hdl.handle.net/21.15107/rcub_agrospace_800 .

Šefer, Dragan, Jakić-Dimić, Dobrila, Jokić, Živan, Sinovec, Zlatan, "Chelated forms of microelements as swine feed additives" in Veterinarski Glasnik, 58, no. 3-4 (2004):469-479,
https://hdl.handle.net/21.15107/rcub_agrospace_800 .

TY  - JOUR
AU  - Sinovec, Zlatan
AU  - Šefer, Dragan
PY  - 2004
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/289
AB  - Development of biotechnology contributes to the appearance of natural alternatives that meet the high demands of the animal itself, the consumer lobby, new legislatives, and the movement for environment protection. In the area of alternative solutions, the most often mentioned are enzymes. The goals of using enzymes are enhancement of endogenous enzymes activity removing antinutrients from some feedstuffs, increasing energy and nutritive value due to increasing bioaviability of nutrients to resorption, as well as decreasing the output of indigestible nutrients in the environments. The innovative solutions and flexible alternatives of using enzymes are the choice option for gaining optimal performances and satisfactory health of intensively managed pigs. Besides those mentioned, this solution is based on natural mechanisms as a basis for the production of healthy and safe food for human nutrition. The use of enzymes in swine nutrition has to find its place primarily in the feed mill factory, but it has to be based on a high professional approach to choosing different kinds of enzymes related to target substrates.
AB  - Razvoj biotehnologije doprineo je pojavi prirodnih alternativa koje ispunjavaju i zadovoljavaju visoko postavljene zahteve samog organizma potrošačkog lobija, novih zakonskih regulativa i pokreta za zaštitu životne sredine. U nizu alternativnih rešenja najčešće se pominju enzimi. Cilj dodavanja enzima je dopuna aktivnosti endogenih enzima svinja, otklanjanje antinutritivnih materija iz pojedinih hraniva (_-glukani, fitati), povećanje energetske i hranljive vrednost hraniva na osnovu veće dostupnosti pojedinih hranljivih materija za resorpciju, kao i smanjivanje izlučivanja neiskorišćenih hranljivih materija u spoljašnju sredinu. Primena enzima sa svojim inovativnim rešenjima i fleksibilnim alternativnima predstavlja mogućnost izbora postizanja optimalnih proizvodnih rezultata i zadovoljavajućeg zdravstvenog stanja u intezivnom uzgoju svinja koji se, u ovom slučaju, zasniva na prirodnim mehanizmima kao osnovi za proizvodnju zdrave i bezbedne hrane za ljude. Korišćenje enzima mora da nađe svoje mesto prvenstveno u pogonima za proizvodnju hrane za životinje, ali mora da se zasniva na visokom stručnom i profesionalnom pristupu pri izboru vrsta enzima u odnosu na ciljni supstrat.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Veterinarski Glasnik
T1  - Using enzymes in swine nutrition
T1  - Primena enzima u ishrani svinja
VL  - 58
IS  - 3-4
SP  - 455
EP  - 468
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_289
ER  - 

@article{
author = "Sinovec, Zlatan and Šefer, Dragan",
year = "2004",
abstract = "Development of biotechnology contributes to the appearance of natural alternatives that meet the high demands of the animal itself, the consumer lobby, new legislatives, and the movement for environment protection. In the area of alternative solutions, the most often mentioned are enzymes. The goals of using enzymes are enhancement of endogenous enzymes activity removing antinutrients from some feedstuffs, increasing energy and nutritive value due to increasing bioaviability of nutrients to resorption, as well as decreasing the output of indigestible nutrients in the environments. The innovative solutions and flexible alternatives of using enzymes are the choice option for gaining optimal performances and satisfactory health of intensively managed pigs. Besides those mentioned, this solution is based on natural mechanisms as a basis for the production of healthy and safe food for human nutrition. The use of enzymes in swine nutrition has to find its place primarily in the feed mill factory, but it has to be based on a high professional approach to choosing different kinds of enzymes related to target substrates., Razvoj biotehnologije doprineo je pojavi prirodnih alternativa koje ispunjavaju i zadovoljavaju visoko postavljene zahteve samog organizma potrošačkog lobija, novih zakonskih regulativa i pokreta za zaštitu životne sredine. U nizu alternativnih rešenja najčešće se pominju enzimi. Cilj dodavanja enzima je dopuna aktivnosti endogenih enzima svinja, otklanjanje antinutritivnih materija iz pojedinih hraniva (_-glukani, fitati), povećanje energetske i hranljive vrednost hraniva na osnovu veće dostupnosti pojedinih hranljivih materija za resorpciju, kao i smanjivanje izlučivanja neiskorišćenih hranljivih materija u spoljašnju sredinu. Primena enzima sa svojim inovativnim rešenjima i fleksibilnim alternativnima predstavlja mogućnost izbora postizanja optimalnih proizvodnih rezultata i zadovoljavajućeg zdravstvenog stanja u intezivnom uzgoju svinja koji se, u ovom slučaju, zasniva na prirodnim mehanizmima kao osnovi za proizvodnju zdrave i bezbedne hrane za ljude. Korišćenje enzima mora da nađe svoje mesto prvenstveno u pogonima za proizvodnju hrane za životinje, ali mora da se zasniva na visokom stručnom i profesionalnom pristupu pri izboru vrsta enzima u odnosu na ciljni supstrat.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Veterinarski Glasnik",
title = "Using enzymes in swine nutrition, Primena enzima u ishrani svinja",
volume = "58",
number = "3-4",
pages = "455-468",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_289"
}

Sinovec, Z.,& Šefer, D.. (2004). Using enzymes in swine nutrition. in Veterinarski Glasnik
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 58(3-4), 455-468.
https://hdl.handle.net/21.15107/rcub_veterinar_289

Sinovec Z, Šefer D. Using enzymes in swine nutrition. in Veterinarski Glasnik. 2004;58(3-4):455-468.
https://hdl.handle.net/21.15107/rcub_veterinar_289 .

Sinovec, Zlatan, Šefer, Dragan, "Using enzymes in swine nutrition" in Veterinarski Glasnik, 58, no. 3-4 (2004):455-468,
https://hdl.handle.net/21.15107/rcub_veterinar_289 .

TY  - JOUR
AU  - Šefer, Dragan
AU  - Knežević, Milijana
AU  - Sinovec, Snežana M.
AU  - Sinovec, Zlatan
PY  - 2003
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/233
AB  - The 42-day long trial was performed on a total of 48 Hybro broilers divided into four groups. After a 14 day pre-experimental period, the experimental groups were treated daily with T-2 toxin at 0.02 mg/kg BW for 7, 14 or 21 days respectively and a mixture of ethanol and physiological saline was administered to the control group of birds. Liver samples were taken after the period of toxin administration and the remaining birds from the control and experimental groups were normally fed and watered without toxin application until the end of the trial when liver samples were taken again. Histogenetic development of dystrophic and dyscyclic changes were found in the livers of the treated broilers. Morphological alterations of the liver were diverse in character, intensity and spread depending on the duration of exposure of broilers to the adverse effects of T-2 toxin, as well as the total quantity of toxin applied. The degree of the reparation varied depending on the duration of exposure to toxin, as well as the resting period. Evident reversible processes were found after short term exposure followed by a long resting period, while regeneration processes were not pronounced after chronic poisoning followed by a short resting period.
AB  - Ogled je izveden na 48 Hybro brojlera podeljenih u četiri grupe Eksperimentalne grupe su svakodnevno tretirane T-2 toksinom u količini od 0.02 mg/kg TM tokom 7, 14 ili 21 dana, dok je brojlerima kontrolne grupe aplikovana smeša etanola i fiziološkog rastvora. Uzorci jetre za patohistološka ispitivanja uzeti su nakon završetka tretmana, a preostali brojleri su hranjeni i pojeni bez aplikacije toksina do 42. dana kada su uzorci jetre ponovo uzeti. U jetri tretiranih brojlera utvrđen je histogenetski razvoj distrofičnih i discikličnih promena. Morfološke alteracije jetre razlikovale su se po karakteru, intenzitetu i raširenosti u zavisnosti od dužine ekspozicije brojlera, kao i od ukupne količine aplikovanog toksina. Stepen sanacionih procesa zavisio je od dužine ekspozicije brojlera, kao i od vremena oporavka. Reparacioni procesi su izraženi nakon kratkotrajnog delovanja T-2 toksina praćenog dugim periodom oporavka, dok se nakon hroničnog trovanja i kratkog vremena oporavka ne uočavaju regeneracioni procesi.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta Veterinaria-Beograd
T1  - Pathomorphological alterations and degree of reparatory processes in the liver of broilers treated with t-2 toxin
T1  - Patohistološke promene i stepen sanacionih procesa u jetri brojlera tretiranih T-2 toksinom
VL  - 53
IS  - 1
SP  - 27
EP  - 34
DO  - 10.2298/AVB0301027S
ER  - 

@article{
author = "Šefer, Dragan and Knežević, Milijana and Sinovec, Snežana M. and Sinovec, Zlatan",
year = "2003",
abstract = "The 42-day long trial was performed on a total of 48 Hybro broilers divided into four groups. After a 14 day pre-experimental period, the experimental groups were treated daily with T-2 toxin at 0.02 mg/kg BW for 7, 14 or 21 days respectively and a mixture of ethanol and physiological saline was administered to the control group of birds. Liver samples were taken after the period of toxin administration and the remaining birds from the control and experimental groups were normally fed and watered without toxin application until the end of the trial when liver samples were taken again. Histogenetic development of dystrophic and dyscyclic changes were found in the livers of the treated broilers. Morphological alterations of the liver were diverse in character, intensity and spread depending on the duration of exposure of broilers to the adverse effects of T-2 toxin, as well as the total quantity of toxin applied. The degree of the reparation varied depending on the duration of exposure to toxin, as well as the resting period. Evident reversible processes were found after short term exposure followed by a long resting period, while regeneration processes were not pronounced after chronic poisoning followed by a short resting period., Ogled je izveden na 48 Hybro brojlera podeljenih u četiri grupe Eksperimentalne grupe su svakodnevno tretirane T-2 toksinom u količini od 0.02 mg/kg TM tokom 7, 14 ili 21 dana, dok je brojlerima kontrolne grupe aplikovana smeša etanola i fiziološkog rastvora. Uzorci jetre za patohistološka ispitivanja uzeti su nakon završetka tretmana, a preostali brojleri su hranjeni i pojeni bez aplikacije toksina do 42. dana kada su uzorci jetre ponovo uzeti. U jetri tretiranih brojlera utvrđen je histogenetski razvoj distrofičnih i discikličnih promena. Morfološke alteracije jetre razlikovale su se po karakteru, intenzitetu i raširenosti u zavisnosti od dužine ekspozicije brojlera, kao i od ukupne količine aplikovanog toksina. Stepen sanacionih procesa zavisio je od dužine ekspozicije brojlera, kao i od vremena oporavka. Reparacioni procesi su izraženi nakon kratkotrajnog delovanja T-2 toksina praćenog dugim periodom oporavka, dok se nakon hroničnog trovanja i kratkog vremena oporavka ne uočavaju regeneracioni procesi.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta Veterinaria-Beograd",
title = "Pathomorphological alterations and degree of reparatory processes in the liver of broilers treated with t-2 toxin, Patohistološke promene i stepen sanacionih procesa u jetri brojlera tretiranih T-2 toksinom",
volume = "53",
number = "1",
pages = "27-34",
doi = "10.2298/AVB0301027S"
}

Šefer, D., Knežević, M., Sinovec, S. M.,& Sinovec, Z.. (2003). Pathomorphological alterations and degree of reparatory processes in the liver of broilers treated with t-2 toxin. in Acta Veterinaria-Beograd
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 53(1), 27-34.
https://doi.org/10.2298/AVB0301027S

Šefer D, Knežević M, Sinovec SM, Sinovec Z. Pathomorphological alterations and degree of reparatory processes in the liver of broilers treated with t-2 toxin. in Acta Veterinaria-Beograd. 2003;53(1):27-34.
doi:10.2298/AVB0301027S .

Šefer, Dragan, Knežević, Milijana, Sinovec, Snežana M., Sinovec, Zlatan, "Pathomorphological alterations and degree of reparatory processes in the liver of broilers treated with t-2 toxin" in Acta Veterinaria-Beograd, 53, no. 1 (2003):27-34,
https://doi.org/10.2298/AVB0301027S . .

TY  - JOUR
AU  - Sinovec, Zlatan
AU  - Jokić, Živan
AU  - Šefer, Dragan
PY  - 2002
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/191
AB  - To attain better feed utilization, longer preservation, easier manipultion and higher production and better quality of food of animal orgin as the final goal, besides raw materials, feed mixes contain numerous pronutrients (additives), added to perform different effects, in a narrower sense, the term pronutrient implies heterogenous substances, which have no diverse effects and have to be efficient in the manner of use. Basically, all pronutrients have to reach the goal of keeping optimal animal health status and to increase production of food of animal origin without adverse and negative effects. The development of biotechnology had a great part in the appearance of natural alternatives which are able to fulfil and satisfy the high demands of highly productive animals, as well as those of the consumer lobby and environmental protection movements. Growth promoters based upon physiological mechanisms and production potential of the animal have an unquestionable adventage, not only because of the lack of residues in food of animal origin; but also because of their ecological safety and decrease of envirnomental pollution by undigested materials. Demand continues to grow for "all natural", non-pharmaceutical feed additives with growth enhancing effects in food animals. Special attention is paid to minerals (anorganic and organic sources), growth stimulators (antibiotics, probiotics prebiotics), substances for better feed utilization (enzymes, acidifers) adsorbents.
AB  - Da bi se postiglo bolje iskorišćavanje hrane, duža održivost, laka manipulacija, a u krajnjem ishodu povećanje proizvodnje i poboljšanje kvaliteta namirnica animalnog porekla, pored osnovnih hraniva u smešu se dodaje veliki broj pronutritivnih materija (aditiva) koji imaju različite namene. Pronutritivne materije, u užem smislu, obuhvataju raznovrsne materije koje ne smeju da budu škodljive, a moraju da ispolje efikasnost u smislu namene. U osnovu sve pronutritivne materije imaju za cilj očuvanje zdravlja životinja uz povećanje proizvodnje namirnica animalnog porekla bez štetnih i negativnih efekata. Razvoj biotehnologije doprineo je pojavi prirodnih alternativa koje ispunjavaju i zadovoljavaju visoko postavljene zahteve samog organizma, potrošač- kog lobija i pokreta za zaštitu životne okoline. Prednost je na strani sredstava koja stimulišu rast korišćenjem fizioloških potencijala i mehanizama životinja, a značajan aspekt ima, ne samo prisustvo rezidua u namirnicama animalnog porekla, već i aspekt ekologije s obzirom i na eventualno zagađenje životne sredine izlučivanjem nesvarenih materija. Zahtevi za "prirodnom" hranom bez lekovitih dodataka koji stimulišu rast životinja rastu. Posebnu pažnju privlače mineralne materije (neorganski i organski izvori), stimulatori rasta (antibiotici probiotici, prebiotici), sredstva za bolje iskorišćavanje hrane (enzimi zakišeljivači), adsorbenti.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Veterinarski Glasnik
T1  - Additives in Swine Nutrition
T1  - Dodaci hrani za svinje
VL  - 56
IS  - 1-2
SP  - 73
EP  - 82
DO  - 10.2298/VETGL0202073S
ER  - 

@article{
author = "Sinovec, Zlatan and Jokić, Živan and Šefer, Dragan",
year = "2002",
abstract = "To attain better feed utilization, longer preservation, easier manipultion and higher production and better quality of food of animal orgin as the final goal, besides raw materials, feed mixes contain numerous pronutrients (additives), added to perform different effects, in a narrower sense, the term pronutrient implies heterogenous substances, which have no diverse effects and have to be efficient in the manner of use. Basically, all pronutrients have to reach the goal of keeping optimal animal health status and to increase production of food of animal origin without adverse and negative effects. The development of biotechnology had a great part in the appearance of natural alternatives which are able to fulfil and satisfy the high demands of highly productive animals, as well as those of the consumer lobby and environmental protection movements. Growth promoters based upon physiological mechanisms and production potential of the animal have an unquestionable adventage, not only because of the lack of residues in food of animal origin; but also because of their ecological safety and decrease of envirnomental pollution by undigested materials. Demand continues to grow for "all natural", non-pharmaceutical feed additives with growth enhancing effects in food animals. Special attention is paid to minerals (anorganic and organic sources), growth stimulators (antibiotics, probiotics prebiotics), substances for better feed utilization (enzymes, acidifers) adsorbents., Da bi se postiglo bolje iskorišćavanje hrane, duža održivost, laka manipulacija, a u krajnjem ishodu povećanje proizvodnje i poboljšanje kvaliteta namirnica animalnog porekla, pored osnovnih hraniva u smešu se dodaje veliki broj pronutritivnih materija (aditiva) koji imaju različite namene. Pronutritivne materije, u užem smislu, obuhvataju raznovrsne materije koje ne smeju da budu škodljive, a moraju da ispolje efikasnost u smislu namene. U osnovu sve pronutritivne materije imaju za cilj očuvanje zdravlja životinja uz povećanje proizvodnje namirnica animalnog porekla bez štetnih i negativnih efekata. Razvoj biotehnologije doprineo je pojavi prirodnih alternativa koje ispunjavaju i zadovoljavaju visoko postavljene zahteve samog organizma, potrošač- kog lobija i pokreta za zaštitu životne okoline. Prednost je na strani sredstava koja stimulišu rast korišćenjem fizioloških potencijala i mehanizama životinja, a značajan aspekt ima, ne samo prisustvo rezidua u namirnicama animalnog porekla, već i aspekt ekologije s obzirom i na eventualno zagađenje životne sredine izlučivanjem nesvarenih materija. Zahtevi za "prirodnom" hranom bez lekovitih dodataka koji stimulišu rast životinja rastu. Posebnu pažnju privlače mineralne materije (neorganski i organski izvori), stimulatori rasta (antibiotici probiotici, prebiotici), sredstva za bolje iskorišćavanje hrane (enzimi zakišeljivači), adsorbenti.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Veterinarski Glasnik",
title = "Additives in Swine Nutrition, Dodaci hrani za svinje",
volume = "56",
number = "1-2",
pages = "73-82",
doi = "10.2298/VETGL0202073S"
}

Sinovec, Z., Jokić, Ž.,& Šefer, D.. (2002). Additives in Swine Nutrition. in Veterinarski Glasnik
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 56(1-2), 73-82.
https://doi.org/10.2298/VETGL0202073S

Sinovec Z, Jokić Ž, Šefer D. Additives in Swine Nutrition. in Veterinarski Glasnik. 2002;56(1-2):73-82.
doi:10.2298/VETGL0202073S .

Sinovec, Zlatan, Jokić, Živan, Šefer, Dragan, "Additives in Swine Nutrition" in Veterinarski Glasnik, 56, no. 1-2 (2002):73-82,
https://doi.org/10.2298/VETGL0202073S . .

TY  - JOUR
AU  - Sinovec, Zlatan
AU  - Lazarević, Miodrag
PY  - 2002
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/209
AB  - In order to investigate the influence of carbo-hydrate protected oligoelements in broiler food on their productivity and health status, a control grouped based experiment was conducted. A total of 120 one-day old broiler "Arbor Acres" chickens was used and divided in two groups during fattening period of 42 days. During the experiment, chickens were fed three complete mixtures with standard composition. First mixture was used during the first three weeks, second during days 21-35 and third during 35-42 day of experiment. Control group of chickens was fed mixtures containing oligoelements (Fe, Cu, Zn and Mn) in the form of sulphates while in mixtures for experimental group, 30% of inorganic oligoelements was substituted with carbo-hydrate protected oligoelements. Broilers fed mixtures containing inorganic forms of oligoelements and usual energetic level had average daily gain of 50.68 g with daily food consumption of 115.5 g and feed conversion of 2.28. Usage of mixtures with carbo-hydrate protected oligoelements resulted in significantly higher average daily gain (12,78 %), lower daily consumption (5.81 %) and better feed conversion rate (16.7 %).
AB  - U cilju izučavanja uticaja mikroelemenata vezanih za ugljene - hidrate u smešama za ishranu brojlera, na proizvodne rezultate i zdravstveno stanje izveden je ogled ishrane po grupno kontrolnom sistemu. Za ogled je korišćeno ukupno 120 jednodnevnih brojlera Arbor Acres provinijence podeljenih u dve grupe. Ogled je trajao 42 dana a obe grupe pilića su tokom ogleda hranjene sa tri vrste potpunih smeša standardnog sirovinskog i hemijskog sastava. Prva smeša je korišćena od 1-21., druga od 21-35., a treća od 35-42. dana ogleda. Kontrolna grupa piladi je hranjena smešama u kojima su kao izvor mikroelemenata korišćene sulfatne soli Fe, Cu, Mn i Zn, a ogledna grupa smešama istog sirovinskog sastava u kojima je 30% sulfata zamenjeno mikroelementima vezanim za ugljene hidrate. Brojleri hranjeni smešama standardnog sirovinskog sastava sa sulfatnim solima kao izvorima mikroelemenata i uobičajene hranljive vrednosti postigli su prosečan dnevni prirast od 50.68 g pri dnevnoj konzumaciji hrane od 115.5 g i uz konverziju hrane od 2.28. Korišćenjem smeša sa organski vezanim mikroelementima postižu se značajno veći dnevni prirasti (za 12.78 %) pri nižoj konzumaciji (za 5.81 %) i uz bolju konverziju hrane za 16.7 %.
PB  - Institut PKB Agroekonomik, Padinska skela
T2  - Zbornik naučnih radova Instituta PKB Agroekonomik
T1  - Carbo-hydrate protected oligoelements and productivity of Arbor acre broilers
T1  - Mikroelementi vezani za ugljene hidrate i proizvodne karakteristike brojlera hibrida Arbor acre
VL  - 8
IS  - 1
SP  - 355
EP  - 363
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_209
ER  - 

@article{
author = "Sinovec, Zlatan and Lazarević, Miodrag",
year = "2002",
abstract = "In order to investigate the influence of carbo-hydrate protected oligoelements in broiler food on their productivity and health status, a control grouped based experiment was conducted. A total of 120 one-day old broiler "Arbor Acres" chickens was used and divided in two groups during fattening period of 42 days. During the experiment, chickens were fed three complete mixtures with standard composition. First mixture was used during the first three weeks, second during days 21-35 and third during 35-42 day of experiment. Control group of chickens was fed mixtures containing oligoelements (Fe, Cu, Zn and Mn) in the form of sulphates while in mixtures for experimental group, 30% of inorganic oligoelements was substituted with carbo-hydrate protected oligoelements. Broilers fed mixtures containing inorganic forms of oligoelements and usual energetic level had average daily gain of 50.68 g with daily food consumption of 115.5 g and feed conversion of 2.28. Usage of mixtures with carbo-hydrate protected oligoelements resulted in significantly higher average daily gain (12,78 %), lower daily consumption (5.81 %) and better feed conversion rate (16.7 %)., U cilju izučavanja uticaja mikroelemenata vezanih za ugljene - hidrate u smešama za ishranu brojlera, na proizvodne rezultate i zdravstveno stanje izveden je ogled ishrane po grupno kontrolnom sistemu. Za ogled je korišćeno ukupno 120 jednodnevnih brojlera Arbor Acres provinijence podeljenih u dve grupe. Ogled je trajao 42 dana a obe grupe pilića su tokom ogleda hranjene sa tri vrste potpunih smeša standardnog sirovinskog i hemijskog sastava. Prva smeša je korišćena od 1-21., druga od 21-35., a treća od 35-42. dana ogleda. Kontrolna grupa piladi je hranjena smešama u kojima su kao izvor mikroelemenata korišćene sulfatne soli Fe, Cu, Mn i Zn, a ogledna grupa smešama istog sirovinskog sastava u kojima je 30% sulfata zamenjeno mikroelementima vezanim za ugljene hidrate. Brojleri hranjeni smešama standardnog sirovinskog sastava sa sulfatnim solima kao izvorima mikroelemenata i uobičajene hranljive vrednosti postigli su prosečan dnevni prirast od 50.68 g pri dnevnoj konzumaciji hrane od 115.5 g i uz konverziju hrane od 2.28. Korišćenjem smeša sa organski vezanim mikroelementima postižu se značajno veći dnevni prirasti (za 12.78 %) pri nižoj konzumaciji (za 5.81 %) i uz bolju konverziju hrane za 16.7 %.",
publisher = "Institut PKB Agroekonomik, Padinska skela",
journal = "Zbornik naučnih radova Instituta PKB Agroekonomik",
title = "Carbo-hydrate protected oligoelements and productivity of Arbor acre broilers, Mikroelementi vezani za ugljene hidrate i proizvodne karakteristike brojlera hibrida Arbor acre",
volume = "8",
number = "1",
pages = "355-363",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_209"
}

Sinovec, Z.,& Lazarević, M.. (2002). Carbo-hydrate protected oligoelements and productivity of Arbor acre broilers. in Zbornik naučnih radova Instituta PKB Agroekonomik
Institut PKB Agroekonomik, Padinska skela., 8(1), 355-363.
https://hdl.handle.net/21.15107/rcub_veterinar_209

Sinovec Z, Lazarević M. Carbo-hydrate protected oligoelements and productivity of Arbor acre broilers. in Zbornik naučnih radova Instituta PKB Agroekonomik. 2002;8(1):355-363.
https://hdl.handle.net/21.15107/rcub_veterinar_209 .

Sinovec, Zlatan, Lazarević, Miodrag, "Carbo-hydrate protected oligoelements and productivity of Arbor acre broilers" in Zbornik naučnih radova Instituta PKB Agroekonomik, 8, no. 1 (2002):355-363,
https://hdl.handle.net/21.15107/rcub_veterinar_209 .

TY  - JOUR
AU  - Nedeljković-Trailović, Jelena
AU  - Sinovec, Snežana M.
AU  - Sinovec, Zlatan
PY  - 2001
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/184
AB  - A 42-day long trial was performed on a total of 48 Hybro broilers divided into four groups. After a 14 day pre-experimental period, the experimental groups were offered feed contaminated with 0.5, 1.0 or 1.5 ppm ochratoxin A, respectively. After that period all groups were normally fed a mixture without added OTA until the end of the trial. Kidney samples were taken after the period of using contaminated feed, as well as after withdrawal the contaminated feed and a 3 week resting period. Proximal tubules were predominantly affected, while glomerules were chiefly preserved. The cytoplasm of tubulocytes was microgranulated and the nuclei were masked. Vacuolization was noticed in a certain number of altered cells. Foci of acute tubular necrosis were noticed in a few tubules. In some cases weak hemorrhage could be seen in affected areas. In the kidney samples of the group offered contaminated feed followed by a 3 week resting period morphological alterations were expressed in the form of intracellular edema. Epithelial cells of proximal tubules were enlarged with opaque cytoplasm, which caused tubule lumen stenosis. Apoptotic bodies could be noticed between some tubulocytes. The obtained results suggest that kidney alterations induced by OTA could be restored only to a certain extent as well as that minimum three week resting period is necessary for this process.
AB  - Ogled je izveden na 48 Hybro brojlera podeljenih u četiri grupe i trajao je 42 dana. Od 14 dana ogledne grupe su tokom 7 dana dobijale hranu koja je sadržala 0.5,1.0 ili 1.5 ppm OA. Uzorci bubrega za patohistološka ispitivanja uzeti su nakon završetka tretmana, a preostali brojleri su hranjeni i pojeni bez aplikacije toksina do 42. dana kada su uzorci bubrega ponovo uzeti. Patohistološkim ispitivanjem utvrđeno je da su pretežno proksimalni tubuli zahvaćeni promenama, dok su glomeruli uglavnom očuvani. Citoplazma tubulocita je sitnozrnasta, a jedra su maskirana. U pojedinim ćelijama uočena je vakuolizacija, dok su u manjem broju tubula uočeni fokusi akutne nekroze. U promenjenim zonama uočena su slaba krvavljenja. U uzorcima bubrega grupa hranjenih kontaminiranom, a zatim nekontaminiranom hranom promene su se ispoljile u vidu intracelularnog edema. Epitelne ćelije proksimalnih tubula su povećane sa zamućenom citoplazmom što je u pojedinim slučajevima izazvalo su'avanje lumena tubula. Apoptotična tela su uočena između pojedinih tubulocita. Dobijeni rezultati ukazuju da se promene u bubrezima izazvane OA mogu samo delom i u određenom stepenu restituisati, a da za je ove procese potreban period od najmanje tri nedelje.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta Veterinaria-Beograd
T1  - Pathomorphological alterations and reparatory processes in the kidneys of broilers treated with ochtratoxin A
T1  - Patohistološke promene i stepen sanacionih procesa u bubrezima brojlera tretiranih ohratoksinom A
VL  - 51
IS  - 5-6
SP  - 333
EP  - 341
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_184
ER  - 

@article{
author = "Nedeljković-Trailović, Jelena and Sinovec, Snežana M. and Sinovec, Zlatan",
year = "2001",
abstract = "A 42-day long trial was performed on a total of 48 Hybro broilers divided into four groups. After a 14 day pre-experimental period, the experimental groups were offered feed contaminated with 0.5, 1.0 or 1.5 ppm ochratoxin A, respectively. After that period all groups were normally fed a mixture without added OTA until the end of the trial. Kidney samples were taken after the period of using contaminated feed, as well as after withdrawal the contaminated feed and a 3 week resting period. Proximal tubules were predominantly affected, while glomerules were chiefly preserved. The cytoplasm of tubulocytes was microgranulated and the nuclei were masked. Vacuolization was noticed in a certain number of altered cells. Foci of acute tubular necrosis were noticed in a few tubules. In some cases weak hemorrhage could be seen in affected areas. In the kidney samples of the group offered contaminated feed followed by a 3 week resting period morphological alterations were expressed in the form of intracellular edema. Epithelial cells of proximal tubules were enlarged with opaque cytoplasm, which caused tubule lumen stenosis. Apoptotic bodies could be noticed between some tubulocytes. The obtained results suggest that kidney alterations induced by OTA could be restored only to a certain extent as well as that minimum three week resting period is necessary for this process., Ogled je izveden na 48 Hybro brojlera podeljenih u četiri grupe i trajao je 42 dana. Od 14 dana ogledne grupe su tokom 7 dana dobijale hranu koja je sadržala 0.5,1.0 ili 1.5 ppm OA. Uzorci bubrega za patohistološka ispitivanja uzeti su nakon završetka tretmana, a preostali brojleri su hranjeni i pojeni bez aplikacije toksina do 42. dana kada su uzorci bubrega ponovo uzeti. Patohistološkim ispitivanjem utvrđeno je da su pretežno proksimalni tubuli zahvaćeni promenama, dok su glomeruli uglavnom očuvani. Citoplazma tubulocita je sitnozrnasta, a jedra su maskirana. U pojedinim ćelijama uočena je vakuolizacija, dok su u manjem broju tubula uočeni fokusi akutne nekroze. U promenjenim zonama uočena su slaba krvavljenja. U uzorcima bubrega grupa hranjenih kontaminiranom, a zatim nekontaminiranom hranom promene su se ispoljile u vidu intracelularnog edema. Epitelne ćelije proksimalnih tubula su povećane sa zamućenom citoplazmom što je u pojedinim slučajevima izazvalo su'avanje lumena tubula. Apoptotična tela su uočena između pojedinih tubulocita. Dobijeni rezultati ukazuju da se promene u bubrezima izazvane OA mogu samo delom i u određenom stepenu restituisati, a da za je ove procese potreban period od najmanje tri nedelje.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta Veterinaria-Beograd",
title = "Pathomorphological alterations and reparatory processes in the kidneys of broilers treated with ochtratoxin A, Patohistološke promene i stepen sanacionih procesa u bubrezima brojlera tretiranih ohratoksinom A",
volume = "51",
number = "5-6",
pages = "333-341",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_184"
}

Nedeljković-Trailović, J., Sinovec, S. M.,& Sinovec, Z.. (2001). Pathomorphological alterations and reparatory processes in the kidneys of broilers treated with ochtratoxin A. in Acta Veterinaria-Beograd
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 51(5-6), 333-341.
https://hdl.handle.net/21.15107/rcub_veterinar_184

Nedeljković-Trailović J, Sinovec SM, Sinovec Z. Pathomorphological alterations and reparatory processes in the kidneys of broilers treated with ochtratoxin A. in Acta Veterinaria-Beograd. 2001;51(5-6):333-341.
https://hdl.handle.net/21.15107/rcub_veterinar_184 .

Nedeljković-Trailović, Jelena, Sinovec, Snežana M., Sinovec, Zlatan, "Pathomorphological alterations and reparatory processes in the kidneys of broilers treated with ochtratoxin A" in Acta Veterinaria-Beograd, 51, no. 5-6 (2001):333-341,
https://hdl.handle.net/21.15107/rcub_veterinar_184 .

TY  - JOUR
AU  - Nedeljković-Trailović, Jelena
AU  - Stevanović, Jelka
AU  - Sinovec, Zlatan
PY  - 2000
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/130
AB  - The 42 day long trial was performed on Hybro broilers divided into four groups. After a 14 day preexperimental period, the groups were offered feed contaminated by 0.5 ppm ochratoxin A (OA) for 0, 7, 14 or 21 days. Blood samples were taken after the period of toxin addition and the remaining birds from the control and experimental groups were normally fed with mash without added OA until the 42nd day of the trial, when blood samples were taken again. The total level of serum proteins was not changed during of prolonged treatment with OA, but a significant increase of albumin together with a decrease of the γ-globulin fraction were noted. A/G ratio suggested that globulins were the dominant protein fraction in blood serum samples obtained from all broilers included in this trail. The concentrations of α and β globulins in serum were within the physiological limits. It could be concluded that the low dietary OA level (0.5 ppm) had a possible cumulative, but not acute effect on blood serum protein status in broilers, dependent on the duration of exposure.
AB  - Ogled je izveden na Hybro brojlerima podeljenim u četiri grupe a trajao je 42 dana. Nakon četrnaestodnevnog pripremnog periodaogledne grupe su hranjene hranom kontaminiranom ohratoksinom A u količini od 5 ppm u toku 7, 14 Hi 21 dan. Uzorci krvi za ispitivanje uzimani su nakon perioda ishrane kontaminiranom hranom a preostale jedinke hranjene su hranom bez dodatog toksina do kraja ogleda. Na kraju ogleda uzeti su uzorci krvi za ispitivanje od svih grupa. Korišćena količina OA u ispitivanom vremenu ekspozicije nema uticaj na koncentraciju ukupnih proteina. Uočeno je signifikantno povećanje albumina zajedno sa smanjenjem γ-globulina. Odnos AG ukazuje da su globulini dominantna frakcija proteina u svim ispitivanim uzorcima. Koncentracija α i β globulina u krvnom serumu kretala se u okvirima fizioloških granica. Može se zaključiti da prisustvo malih količina OA u hrani (5 ppm) poseduje moguće kumulativne ali ne i akutne efekte na proteine krvnog seruma brojlera koji zavise od vremena ekspozicije štetnom dejstvu.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta Veterinaria-Beograd
T1  - Blood serum protein status of broilers exposed to prolonged treatment with a low dose of ochratoxin A
T1  - Uticaj produženog tretiranja ohratoksinom A na status proteina krvnog seruma brojlera
VL  - 50
IS  - 1
SP  - 13
EP  - 21
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_130
ER  - 

@article{
author = "Nedeljković-Trailović, Jelena and Stevanović, Jelka and Sinovec, Zlatan",
year = "2000",
abstract = "The 42 day long trial was performed on Hybro broilers divided into four groups. After a 14 day preexperimental period, the groups were offered feed contaminated by 0.5 ppm ochratoxin A (OA) for 0, 7, 14 or 21 days. Blood samples were taken after the period of toxin addition and the remaining birds from the control and experimental groups were normally fed with mash without added OA until the 42nd day of the trial, when blood samples were taken again. The total level of serum proteins was not changed during of prolonged treatment with OA, but a significant increase of albumin together with a decrease of the γ-globulin fraction were noted. A/G ratio suggested that globulins were the dominant protein fraction in blood serum samples obtained from all broilers included in this trail. The concentrations of α and β globulins in serum were within the physiological limits. It could be concluded that the low dietary OA level (0.5 ppm) had a possible cumulative, but not acute effect on blood serum protein status in broilers, dependent on the duration of exposure., Ogled je izveden na Hybro brojlerima podeljenim u četiri grupe a trajao je 42 dana. Nakon četrnaestodnevnog pripremnog periodaogledne grupe su hranjene hranom kontaminiranom ohratoksinom A u količini od 5 ppm u toku 7, 14 Hi 21 dan. Uzorci krvi za ispitivanje uzimani su nakon perioda ishrane kontaminiranom hranom a preostale jedinke hranjene su hranom bez dodatog toksina do kraja ogleda. Na kraju ogleda uzeti su uzorci krvi za ispitivanje od svih grupa. Korišćena količina OA u ispitivanom vremenu ekspozicije nema uticaj na koncentraciju ukupnih proteina. Uočeno je signifikantno povećanje albumina zajedno sa smanjenjem γ-globulina. Odnos AG ukazuje da su globulini dominantna frakcija proteina u svim ispitivanim uzorcima. Koncentracija α i β globulina u krvnom serumu kretala se u okvirima fizioloških granica. Može se zaključiti da prisustvo malih količina OA u hrani (5 ppm) poseduje moguće kumulativne ali ne i akutne efekte na proteine krvnog seruma brojlera koji zavise od vremena ekspozicije štetnom dejstvu.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta Veterinaria-Beograd",
title = "Blood serum protein status of broilers exposed to prolonged treatment with a low dose of ochratoxin A, Uticaj produženog tretiranja ohratoksinom A na status proteina krvnog seruma brojlera",
volume = "50",
number = "1",
pages = "13-21",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_130"
}

Nedeljković-Trailović, J., Stevanović, J.,& Sinovec, Z.. (2000). Blood serum protein status of broilers exposed to prolonged treatment with a low dose of ochratoxin A. in Acta Veterinaria-Beograd
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 50(1), 13-21.
https://hdl.handle.net/21.15107/rcub_veterinar_130

Nedeljković-Trailović J, Stevanović J, Sinovec Z. Blood serum protein status of broilers exposed to prolonged treatment with a low dose of ochratoxin A. in Acta Veterinaria-Beograd. 2000;50(1):13-21.
https://hdl.handle.net/21.15107/rcub_veterinar_130 .

Nedeljković-Trailović, Jelena, Stevanović, Jelka, Sinovec, Zlatan, "Blood serum protein status of broilers exposed to prolonged treatment with a low dose of ochratoxin A" in Acta Veterinaria-Beograd, 50, no. 1 (2000):13-21,
https://hdl.handle.net/21.15107/rcub_veterinar_130 .

TY  - JOUR
AU  - Pupavac, Snježana
AU  - Sinovec, Zlatan
AU  - Jarak, Mirjana
AU  - Adamović, M.
AU  - Krstić, Nikola
AU  - Milošević, Nada
PY  - 2000
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/151
AB  - The 31 day long trial included 24 Yorkshire piglets divided into three groups. Before weaning, the piglets were given the experimental diets in a 7-day adjustment period. During this period as well as for 22 days following, the piglets were fed on diets containing 22% CP and then diets containing 20% CP for the remaining 19 days. The desired level of phosphorus in the diet for the control group and experimental group III was achieved by the addition of dicalcium phosphate, while the diet for group II was without added dicalcium phosphate. In addition the, diets for groups II and III were enriched with crude phytase (produced by growing an isolate of Aspergillus awamori) in an amount sufficient to provide 800 FU/kg. Performance and state of health were monitored during the trial and at the end the piglets were killed for collection of bone samples. Growth performance was improved by adding microbial phytase. Ash and calcium content in the tibia showed no statistical differences between the groups, while content of phosphorus was significantly increased in both groups fed added phytase in the diet. The length and width of the tibia and the intensity of its shadow indicated normal physiological processes in bone formation and ossification. The best ossification was obtained in the first experimental group, based on almost invisible nutrition channels inside the thick shadow of compacta, as well as the homogenous appearance of tibiae spongiosa in the mid diaphysis area.
AB  - Ogled je izveden na 24 odbijene Jorkšir prasadi podeljenih u tri grupe, a trajao je 31 dan. U pripremnom periodu od 7 dana pre odbijanja, kao i tokom naredna 22 dana prasad su hranjena smešom sa 22% proteina, a zatim smešom sa 20% proteina do kraja ogleda. Planirani nivoi fosfora u I i III grupu postignuti su dodavanjem dikalcijum fosfata, dok su smeše za ishranu II grupe prasadi bile bez dodatog dikalcijum fosfata. Smešama za K i O-ll grupu prasadi dodata je sirova fitaza (izolovana iz gljivica Aspergillus awamori) u količini koja je obezbedila 800 FU/kg hrane. Tokom ogleda praćeni su proizvodni rezultati i zdravstveno stanje, a na kraju ogleda izvršeno je žrtvovanje prasadi u cilju uzimanja uzoraka kostiju za predviđena ispitivanja. Proizvodni rezultati su bili poboljšani korišćenjem fitaze mikrobijalnog porekla. Razlike u sadržaju pepela i kalcijuma tibije nije se statistički razlikovao, dok je sadržaj fosfora signifikantno rastao u grupama sa dodatom fitazom mikrobijalnog porekla. Rezultati morfometrijskih i radiografskih ispitivanja ukazala su na normalne fiziološke procese osifikacije kostiju. Na osnovu dobijenih rezultatanajbolje izražen proces osifikacije kostiju bio je u prvoj oglednoj grupi prasadi.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta Veterinaria-Beograd
T1  - The effect of supplemental fungal phytase on the performances and bone characteristic of piglets
T1  - Uticaj fitaze mikrobioloskog porekla na proizvodne rezultate i karakteristike kostiju prasadi
VL  - 50
IS  - 2-3
SP  - 119
EP  - 129
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_151
ER  - 

@article{
author = "Pupavac, Snježana and Sinovec, Zlatan and Jarak, Mirjana and Adamović, M. and Krstić, Nikola and Milošević, Nada",
year = "2000",
abstract = "The 31 day long trial included 24 Yorkshire piglets divided into three groups. Before weaning, the piglets were given the experimental diets in a 7-day adjustment period. During this period as well as for 22 days following, the piglets were fed on diets containing 22% CP and then diets containing 20% CP for the remaining 19 days. The desired level of phosphorus in the diet for the control group and experimental group III was achieved by the addition of dicalcium phosphate, while the diet for group II was without added dicalcium phosphate. In addition the, diets for groups II and III were enriched with crude phytase (produced by growing an isolate of Aspergillus awamori) in an amount sufficient to provide 800 FU/kg. Performance and state of health were monitored during the trial and at the end the piglets were killed for collection of bone samples. Growth performance was improved by adding microbial phytase. Ash and calcium content in the tibia showed no statistical differences between the groups, while content of phosphorus was significantly increased in both groups fed added phytase in the diet. The length and width of the tibia and the intensity of its shadow indicated normal physiological processes in bone formation and ossification. The best ossification was obtained in the first experimental group, based on almost invisible nutrition channels inside the thick shadow of compacta, as well as the homogenous appearance of tibiae spongiosa in the mid diaphysis area., Ogled je izveden na 24 odbijene Jorkšir prasadi podeljenih u tri grupe, a trajao je 31 dan. U pripremnom periodu od 7 dana pre odbijanja, kao i tokom naredna 22 dana prasad su hranjena smešom sa 22% proteina, a zatim smešom sa 20% proteina do kraja ogleda. Planirani nivoi fosfora u I i III grupu postignuti su dodavanjem dikalcijum fosfata, dok su smeše za ishranu II grupe prasadi bile bez dodatog dikalcijum fosfata. Smešama za K i O-ll grupu prasadi dodata je sirova fitaza (izolovana iz gljivica Aspergillus awamori) u količini koja je obezbedila 800 FU/kg hrane. Tokom ogleda praćeni su proizvodni rezultati i zdravstveno stanje, a na kraju ogleda izvršeno je žrtvovanje prasadi u cilju uzimanja uzoraka kostiju za predviđena ispitivanja. Proizvodni rezultati su bili poboljšani korišćenjem fitaze mikrobijalnog porekla. Razlike u sadržaju pepela i kalcijuma tibije nije se statistički razlikovao, dok je sadržaj fosfora signifikantno rastao u grupama sa dodatom fitazom mikrobijalnog porekla. Rezultati morfometrijskih i radiografskih ispitivanja ukazala su na normalne fiziološke procese osifikacije kostiju. Na osnovu dobijenih rezultatanajbolje izražen proces osifikacije kostiju bio je u prvoj oglednoj grupi prasadi.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta Veterinaria-Beograd",
title = "The effect of supplemental fungal phytase on the performances and bone characteristic of piglets, Uticaj fitaze mikrobioloskog porekla na proizvodne rezultate i karakteristike kostiju prasadi",
volume = "50",
number = "2-3",
pages = "119-129",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_151"
}

Pupavac, S., Sinovec, Z., Jarak, M., Adamović, M., Krstić, N.,& Milošević, N.. (2000). The effect of supplemental fungal phytase on the performances and bone characteristic of piglets. in Acta Veterinaria-Beograd
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 50(2-3), 119-129.
https://hdl.handle.net/21.15107/rcub_veterinar_151

Pupavac S, Sinovec Z, Jarak M, Adamović M, Krstić N, Milošević N. The effect of supplemental fungal phytase on the performances and bone characteristic of piglets. in Acta Veterinaria-Beograd. 2000;50(2-3):119-129.
https://hdl.handle.net/21.15107/rcub_veterinar_151 .

Pupavac, Snježana, Sinovec, Zlatan, Jarak, Mirjana, Adamović, M., Krstić, Nikola, Milošević, Nada, "The effect of supplemental fungal phytase on the performances and bone characteristic of piglets" in Acta Veterinaria-Beograd, 50, no. 2-3 (2000):119-129,
https://hdl.handle.net/21.15107/rcub_veterinar_151 .

TY  - JOUR
AU  - Sinovec, Zlatan
AU  - Janković, Ljiljana
AU  - Radenković, Brana
AU  - Jovanović, N
PY  - 1999
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/119
AB  - The 42 day long trial was performed on 94 Hybro broilers divided into four groups. All groups of chickens were fed with commercial feed mixtures and the lead was added as lead acetate of quantities enough to supply 0; 9.2; 92.0 or 920.0 mg Pb/kg food. After 28 days, each group was divided into two subgroups. The first subgroup was continuously fed with diets containing lead and the other subgroup with the control feed mixture without added lead. Increasing dietary lead intake level linearly decreased broiler performances, even at 100 ppm. The lower performance caused by the dietary lead was lessended by excluding the contaminated feed from the broilers diet, but only after a certain period which depended on the dietary level of lead, primarily. Early detection of lead presence in feed and elimination of contaminated mixtures from the diet can reduce negative effects on performance to an acceptable level.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta Veterinaria-Beograd
T1  - The effect of feeding various dietary lead level on the performances of broilers
VL  - 49
IS  - 5-6
SP  - 335
EP  - 341
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_119
ER  - 

@article{
author = "Sinovec, Zlatan and Janković, Ljiljana and Radenković, Brana and Jovanović, N",
year = "1999",
abstract = "The 42 day long trial was performed on 94 Hybro broilers divided into four groups. All groups of chickens were fed with commercial feed mixtures and the lead was added as lead acetate of quantities enough to supply 0; 9.2; 92.0 or 920.0 mg Pb/kg food. After 28 days, each group was divided into two subgroups. The first subgroup was continuously fed with diets containing lead and the other subgroup with the control feed mixture without added lead. Increasing dietary lead intake level linearly decreased broiler performances, even at 100 ppm. The lower performance caused by the dietary lead was lessended by excluding the contaminated feed from the broilers diet, but only after a certain period which depended on the dietary level of lead, primarily. Early detection of lead presence in feed and elimination of contaminated mixtures from the diet can reduce negative effects on performance to an acceptable level.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta Veterinaria-Beograd",
title = "The effect of feeding various dietary lead level on the performances of broilers",
volume = "49",
number = "5-6",
pages = "335-341",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_119"
}

Sinovec, Z., Janković, L., Radenković, B.,& Jovanović, N.. (1999). The effect of feeding various dietary lead level on the performances of broilers. in Acta Veterinaria-Beograd
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 49(5-6), 335-341.
https://hdl.handle.net/21.15107/rcub_veterinar_119

Sinovec Z, Janković L, Radenković B, Jovanović N. The effect of feeding various dietary lead level on the performances of broilers. in Acta Veterinaria-Beograd. 1999;49(5-6):335-341.
https://hdl.handle.net/21.15107/rcub_veterinar_119 .

Sinovec, Zlatan, Janković, Ljiljana, Radenković, Brana, Jovanović, N, "The effect of feeding various dietary lead level on the performances of broilers" in Acta Veterinaria-Beograd, 49, no. 5-6 (1999):335-341,
https://hdl.handle.net/21.15107/rcub_veterinar_119 .

TY  - JOUR
AU  - Šefer, Dragan
AU  - Sinovec, Zlatan
AU  - Marković, R
PY  - 1999
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/114
AB  - The influence ofT-2 toxin on blood serum protein status was examined in Hybro broilers in two trials. In the first trial experimental groups were daily treated with T-2 toxin at 0.02 and 0.20 mg/kg BM for 7 days. In the second trial the experimental groups were daily treated with T-2 toxin at 0.02 mg/kg BM, during intervals lasting 7,14 or 21 days. Blood samples were taken after the period of toxin administration in both trials and the remaining animals from the control and experimental groups were·normally fed and watered without toxin application until the 42 nd day when blood samples were taken again. The tested amounts of T-2 toxin had a negative non-significant influence on total protein concentration with an increase of alpha and gamma globulins and a decrease of albumins but a relatively stable concentration of beta globulins. Consequently a closer A/G ratio was found. By comparative analysis of the biochemical results in both trials it could be concluded that the lower amount of T-2 toxin given for a longer period of time showed analogous effects as the higher amount given for a shorter period of time, which indicates a possible cumulative effect of T-2 toxin.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta Veterinaria-Beograd
T1  - Blood serum protein status of broilers treated by T-2 toxin
VL  - 49
IS  - 2-3
SP  - 139
EP  - 147
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_114
ER  - 

@article{
author = "Šefer, Dragan and Sinovec, Zlatan and Marković, R",
year = "1999",
abstract = "The influence ofT-2 toxin on blood serum protein status was examined in Hybro broilers in two trials. In the first trial experimental groups were daily treated with T-2 toxin at 0.02 and 0.20 mg/kg BM for 7 days. In the second trial the experimental groups were daily treated with T-2 toxin at 0.02 mg/kg BM, during intervals lasting 7,14 or 21 days. Blood samples were taken after the period of toxin administration in both trials and the remaining animals from the control and experimental groups were·normally fed and watered without toxin application until the 42 nd day when blood samples were taken again. The tested amounts of T-2 toxin had a negative non-significant influence on total protein concentration with an increase of alpha and gamma globulins and a decrease of albumins but a relatively stable concentration of beta globulins. Consequently a closer A/G ratio was found. By comparative analysis of the biochemical results in both trials it could be concluded that the lower amount of T-2 toxin given for a longer period of time showed analogous effects as the higher amount given for a shorter period of time, which indicates a possible cumulative effect of T-2 toxin.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta Veterinaria-Beograd",
title = "Blood serum protein status of broilers treated by T-2 toxin",
volume = "49",
number = "2-3",
pages = "139-147",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_114"
}

Šefer, D., Sinovec, Z.,& Marković, R.. (1999). Blood serum protein status of broilers treated by T-2 toxin. in Acta Veterinaria-Beograd
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 49(2-3), 139-147.
https://hdl.handle.net/21.15107/rcub_veterinar_114

Šefer D, Sinovec Z, Marković R. Blood serum protein status of broilers treated by T-2 toxin. in Acta Veterinaria-Beograd. 1999;49(2-3):139-147.
https://hdl.handle.net/21.15107/rcub_veterinar_114 .

Šefer, Dragan, Sinovec, Zlatan, Marković, R, "Blood serum protein status of broilers treated by T-2 toxin" in Acta Veterinaria-Beograd, 49, no. 2-3 (1999):139-147,
https://hdl.handle.net/21.15107/rcub_veterinar_114 .

TY  - JOUR
AU  - Sinovec, Zlatan
AU  - Nedeljković-Trailović, Jelena
PY  - 1998
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/101
AB  - Three groups of 10 weaned female lambs of average body weight 20-30 kg, were fed with hay and concentrates for a 99 day trial. The feed for groups I, II and III containd 10.000, 20.000 and 30.000 IU vitamin A/kg, respectively. Blood samples were taken on days 1,52 and 99 of the trial and the concentration of total proteins and their fractions were measured. At the beginning of the trial there no significant differences in the concentration of total proteins and their fractions among the groups. The increased quantity of vitamin A in the feed (20.000/U/kg) positively influenced the total protein concentration, but the established increase was limited and further increase of dietary vitamin A was withaut effect. The increase of total protein occurred through an increase of α-and β-globulin at the expense of albumin with stable b-globulin fractions. The decline of the A/G ratio was proportional to the increase of dietary vitamin A content.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta Veterinaria-Beograd
T1  - Influence of different levels of dietary vitamin A on protein status in blood serum of lambs
VL  - 48
IS  - 1
SP  - 51
EP  - 58
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_101
ER  - 

@article{
author = "Sinovec, Zlatan and Nedeljković-Trailović, Jelena",
year = "1998",
abstract = "Three groups of 10 weaned female lambs of average body weight 20-30 kg, were fed with hay and concentrates for a 99 day trial. The feed for groups I, II and III containd 10.000, 20.000 and 30.000 IU vitamin A/kg, respectively. Blood samples were taken on days 1,52 and 99 of the trial and the concentration of total proteins and their fractions were measured. At the beginning of the trial there no significant differences in the concentration of total proteins and their fractions among the groups. The increased quantity of vitamin A in the feed (20.000/U/kg) positively influenced the total protein concentration, but the established increase was limited and further increase of dietary vitamin A was withaut effect. The increase of total protein occurred through an increase of α-and β-globulin at the expense of albumin with stable b-globulin fractions. The decline of the A/G ratio was proportional to the increase of dietary vitamin A content.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta Veterinaria-Beograd",
title = "Influence of different levels of dietary vitamin A on protein status in blood serum of lambs",
volume = "48",
number = "1",
pages = "51-58",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_101"
}

Sinovec, Z.,& Nedeljković-Trailović, J.. (1998). Influence of different levels of dietary vitamin A on protein status in blood serum of lambs. in Acta Veterinaria-Beograd
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 48(1), 51-58.
https://hdl.handle.net/21.15107/rcub_veterinar_101

Sinovec Z, Nedeljković-Trailović J. Influence of different levels of dietary vitamin A on protein status in blood serum of lambs. in Acta Veterinaria-Beograd. 1998;48(1):51-58.
https://hdl.handle.net/21.15107/rcub_veterinar_101 .

Sinovec, Zlatan, Nedeljković-Trailović, Jelena, "Influence of different levels of dietary vitamin A on protein status in blood serum of lambs" in Acta Veterinaria-Beograd, 48, no. 1 (1998):51-58,
https://hdl.handle.net/21.15107/rcub_veterinar_101 .