TY  - JOUR
AU  - Ilić Božović, Anja
AU  - Đoković, Petar
AU  - Milanović, Zorana
AU  - Janjić, Filip
AU  - Spariosu, Kristina
AU  - Radonjić, Vladimir
AU  - Radaković, Milena
AU  - Magaš, Vladimir
AU  - Filipović, Dimitrije
AU  - Stanković, Sanja
AU  - Kovačević Filipović, Milica
AU  - Beletić, Andelo
PY  - 2023
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2934
AB  - Homocysteine (Hcy) was investigated as the biomarker of cardiac, renal, and gastrointestinal disorders
in dogs. Data about low Hcy concentrations in the systemic inflammatory response syndrome raised a hypothesis that
Hcy in dogs could be a negative acute-phase reactant. This survey compared Hcy concentrations, serum amyloid A
(SAA), and the routine laboratory parameters between healthy (HD, N=6) and dogs with inflammation of different
extent: mild (dirofilariosis (DIR), N=31), moderate (babesiosis (BAB), N=12), and severe (pyometra (PYO), N=8).
The BAB and PYO groups had lower Hcy er than HD. Also, the levels in the PYO group were below those in the
DIRO group. SAA had the inverse pattern. Across the groups, Hcy and SAA levels correlated negatively (ρ = -0.502,
P<0.001). Hcy and SAA correlated with the erythrocyte count, hematocrit, hemoglobin and mean cellular hemoglobin
concentrations, and neutrophil count, with correlations being positive for Hcy and negative for SAA. Among all dogs,
hemoglobin was the only independent predictor of Hcy concentration. Hcy levels in canine infections, decreased as
acute-phase reaction (APR) intensified. Also, they were related with the hematology changes accompanying the APR.
Further studies will establish the clinical potential of these alterations.
PB  - Hellenic Veterinary Medical Society
T2  - Journal of the Hellenic Veterinary Medical Society
T1  - Could homocysteine represent a negative acute phase reactant in canine infections-a pilot study?
VL  - 74
IS  - 1
SP  - 5463
EP  - 5470
DO  - 10.12681/jhvms.29529
ER  - 

@article{
author = "Ilić Božović, Anja and Đoković, Petar and Milanović, Zorana and Janjić, Filip and Spariosu, Kristina and Radonjić, Vladimir and Radaković, Milena and Magaš, Vladimir and Filipović, Dimitrije and Stanković, Sanja and Kovačević Filipović, Milica and Beletić, Andelo",
year = "2023",
abstract = "Homocysteine (Hcy) was investigated as the biomarker of cardiac, renal, and gastrointestinal disorders
in dogs. Data about low Hcy concentrations in the systemic inflammatory response syndrome raised a hypothesis that
Hcy in dogs could be a negative acute-phase reactant. This survey compared Hcy concentrations, serum amyloid A
(SAA), and the routine laboratory parameters between healthy (HD, N=6) and dogs with inflammation of different
extent: mild (dirofilariosis (DIR), N=31), moderate (babesiosis (BAB), N=12), and severe (pyometra (PYO), N=8).
The BAB and PYO groups had lower Hcy er than HD. Also, the levels in the PYO group were below those in the
DIRO group. SAA had the inverse pattern. Across the groups, Hcy and SAA levels correlated negatively (ρ = -0.502,
P<0.001). Hcy and SAA correlated with the erythrocyte count, hematocrit, hemoglobin and mean cellular hemoglobin
concentrations, and neutrophil count, with correlations being positive for Hcy and negative for SAA. Among all dogs,
hemoglobin was the only independent predictor of Hcy concentration. Hcy levels in canine infections, decreased as
acute-phase reaction (APR) intensified. Also, they were related with the hematology changes accompanying the APR.
Further studies will establish the clinical potential of these alterations.",
publisher = "Hellenic Veterinary Medical Society",
journal = "Journal of the Hellenic Veterinary Medical Society",
title = "Could homocysteine represent a negative acute phase reactant in canine infections-a pilot study?",
volume = "74",
number = "1",
pages = "5463-5470",
doi = "10.12681/jhvms.29529"
}

Ilić Božović, A., Đoković, P., Milanović, Z., Janjić, F., Spariosu, K., Radonjić, V., Radaković, M., Magaš, V., Filipović, D., Stanković, S., Kovačević Filipović, M.,& Beletić, A.. (2023). Could homocysteine represent a negative acute phase reactant in canine infections-a pilot study?. in Journal of the Hellenic Veterinary Medical Society
Hellenic Veterinary Medical Society., 74(1), 5463-5470.
https://doi.org/10.12681/jhvms.29529

Ilić Božović A, Đoković P, Milanović Z, Janjić F, Spariosu K, Radonjić V, Radaković M, Magaš V, Filipović D, Stanković S, Kovačević Filipović M, Beletić A. Could homocysteine represent a negative acute phase reactant in canine infections-a pilot study?. in Journal of the Hellenic Veterinary Medical Society. 2023;74(1):5463-5470.
doi:10.12681/jhvms.29529 .

Ilić Božović, Anja, Đoković, Petar, Milanović, Zorana, Janjić, Filip, Spariosu, Kristina, Radonjić, Vladimir, Radaković, Milena, Magaš, Vladimir, Filipović, Dimitrije, Stanković, Sanja, Kovačević Filipović, Milica, Beletić, Andelo, "Could homocysteine represent a negative acute phase reactant in canine infections-a pilot study?" in Journal of the Hellenic Veterinary Medical Society, 74, no. 1 (2023):5463-5470,
https://doi.org/10.12681/jhvms.29529 . .