TY  - JOUR
AU  - Đoković, Radojica
AU  - Cincović, Marko
AU  - Kurcubić, Vladimir
AU  - Petrović, Milun D.
AU  - Lalović, Miroslav
AU  - Jasović, Boban
AU  - Stanimirović, Zoran
PY  - 2014
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1113
AB  - The objective of this study was to determine blood levels of cortisol, insulin, triiodothyronine (T3), thyroxine (T4), glucose, non-esterified fatty acids (NEFA), β-hydroxybutyrate (BHB), triglycerides (TG) and total cholesterol in dairy Holstein cows (n = 40) during the transition period. The test cows were classified into four groups: Group A (n = 10), clinically healthy late-pregnant cows from day 20 to day 10 before calving. Group B (n = 10), clinically healthy late-pregnant cows from day 10 to day 1 before calving. Group C (n = 10), clinically healthy puerperal cows. Group D (n = 10), puerperal ketotic cows. The blood serum of ketotic cows was found to have lower levels of T3 (p < 0.01), T4 (p < 0.05), insulin (p > 0.05), cortisol (p > 0.05), glucose (p < 0.01), TG (p < 0.01) and total cholesterol (p < 0.05), and higher (p < 0.01) levels of NEFA and BHB, as compared to the blood levels in healthy pregnant and healthy puerperal cows. Results suggest that ketotic cows undergo homeorhetic adaptation of the regulation of organic nutrient metabolism being manifested through a decrease in the blood levels of the test hormones, resulting in increased lipomobilization, hypoglycemia, and intensive ketogenesis and lipogenesis in liver cells.
PB  - Chulalongkorn Univ, Bangkok
T2  - Thai Journal of Veterinary Medicine
T1  - Endocrine and metabolic status of dairy cows during transition period
VL  - 44
IS  - 1
SP  - 59
EP  - 66
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_1113
ER  - 

@article{
author = "Đoković, Radojica and Cincović, Marko and Kurcubić, Vladimir and Petrović, Milun D. and Lalović, Miroslav and Jasović, Boban and Stanimirović, Zoran",
year = "2014",
abstract = "The objective of this study was to determine blood levels of cortisol, insulin, triiodothyronine (T3), thyroxine (T4), glucose, non-esterified fatty acids (NEFA), β-hydroxybutyrate (BHB), triglycerides (TG) and total cholesterol in dairy Holstein cows (n = 40) during the transition period. The test cows were classified into four groups: Group A (n = 10), clinically healthy late-pregnant cows from day 20 to day 10 before calving. Group B (n = 10), clinically healthy late-pregnant cows from day 10 to day 1 before calving. Group C (n = 10), clinically healthy puerperal cows. Group D (n = 10), puerperal ketotic cows. The blood serum of ketotic cows was found to have lower levels of T3 (p < 0.01), T4 (p < 0.05), insulin (p > 0.05), cortisol (p > 0.05), glucose (p < 0.01), TG (p < 0.01) and total cholesterol (p < 0.05), and higher (p < 0.01) levels of NEFA and BHB, as compared to the blood levels in healthy pregnant and healthy puerperal cows. Results suggest that ketotic cows undergo homeorhetic adaptation of the regulation of organic nutrient metabolism being manifested through a decrease in the blood levels of the test hormones, resulting in increased lipomobilization, hypoglycemia, and intensive ketogenesis and lipogenesis in liver cells.",
publisher = "Chulalongkorn Univ, Bangkok",
journal = "Thai Journal of Veterinary Medicine",
title = "Endocrine and metabolic status of dairy cows during transition period",
volume = "44",
number = "1",
pages = "59-66",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_1113"
}

Đoković, R., Cincović, M., Kurcubić, V., Petrović, M. D., Lalović, M., Jasović, B.,& Stanimirović, Z.. (2014). Endocrine and metabolic status of dairy cows during transition period. in Thai Journal of Veterinary Medicine
Chulalongkorn Univ, Bangkok., 44(1), 59-66.
https://hdl.handle.net/21.15107/rcub_veterinar_1113

Đoković R, Cincović M, Kurcubić V, Petrović MD, Lalović M, Jasović B, Stanimirović Z. Endocrine and metabolic status of dairy cows during transition period. in Thai Journal of Veterinary Medicine. 2014;44(1):59-66.
https://hdl.handle.net/21.15107/rcub_veterinar_1113 .

Đoković, Radojica, Cincović, Marko, Kurcubić, Vladimir, Petrović, Milun D., Lalović, Miroslav, Jasović, Boban, Stanimirović, Zoran, "Endocrine and metabolic status of dairy cows during transition period" in Thai Journal of Veterinary Medicine, 44, no. 1 (2014):59-66,
https://hdl.handle.net/21.15107/rcub_veterinar_1113 .

TY  - JOUR
AU  - Đoković, Radojica
AU  - Kurcubić, Vladimir
AU  - Ilić, Zoran
AU  - Cincović, Marko
AU  - Petrović, Milun D.
AU  - Fratrić, Natalija
AU  - Jasović, Boban
PY  - 2013
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/955
AB  - The objective of this experiment was to evaluate the metabolic status of late pregnant and early lactation dairy cows based on changes in characteristic blood metabolites. Blood samples were collected from 15 late pregnant cows and 15 early lactation cows to measure beta-hydroxybutyrate (BHB), non-esterifified fatty acids (NEFA), triglycerides (TG), glucose, total protein (TP), albumin, total bilirubin, urea and the activity of aspartate transaminase (AST) and gamma-glutamyl transferase (GGT). Cows in early lactation had signififi cantly higher (P lt 0.05) levels of serum BHB and NEFA, and lower (P lt 0.05) glycaemia compared to the late pregnant cows. High lipomobilization (NEFA>0.4 mmol/L) was detected in 6 (40%) of early lactation cows but in none of the late pregnant cows, while subclinical ketosis (BHB>1.2 mmol/L) was detected in 14 (94.4%) of the early lactation cows and 4 (26.6%) of the late pregnant cows. AST activities above 100 U/L were detected in 2 early lactation cows and in none of the late pregnant cows. TG levels below 0.12 mmol/L and glucose below 2.5 mmol/L were found in 7 (44%) and 10 (66.6%) of the early lactation cows, respectively, and in none of the late pregnant cows. Early lactation cows were found to have lower blood serum levels of TG (P lt 0.05), albumin (P lt 0.05) urea (P lt 0.05) and GTT (P>0.05) activities and higher concentrations of total bilirubin (P>0.05) TP (P>0.05) and AST activities (P lt 0.05) compared to the late pregnant cows. The results of blood serum levels of glucose, TG, BHB, NEFA and AST in early lactation cows suggest metabolic disorders associated with ketosis, and some degree of hepatic lesions, probably due to fat infifiltration. These serum parameters may have a key role in evaluating metabolic status in late pregnant and early lactation dairy cows.
PB  - Univ Zagreb Vet Faculty, Zagreb
T2  - Veterinarski Arhiv
T1  - Evaluation of metabolic status in Simmental dairy cows during late pregnancy and early lactation
T1  - Prosudba metaboličkog statusa mliječnih krava simentalske pasmine tijekom kasne gravidnosti i na početku laktacije
VL  - 83
IS  - 6
SP  - 593
EP  - 602
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_955
ER  - 

@article{
author = "Đoković, Radojica and Kurcubić, Vladimir and Ilić, Zoran and Cincović, Marko and Petrović, Milun D. and Fratrić, Natalija and Jasović, Boban",
year = "2013",
abstract = "The objective of this experiment was to evaluate the metabolic status of late pregnant and early lactation dairy cows based on changes in characteristic blood metabolites. Blood samples were collected from 15 late pregnant cows and 15 early lactation cows to measure beta-hydroxybutyrate (BHB), non-esterifified fatty acids (NEFA), triglycerides (TG), glucose, total protein (TP), albumin, total bilirubin, urea and the activity of aspartate transaminase (AST) and gamma-glutamyl transferase (GGT). Cows in early lactation had signififi cantly higher (P lt 0.05) levels of serum BHB and NEFA, and lower (P lt 0.05) glycaemia compared to the late pregnant cows. High lipomobilization (NEFA>0.4 mmol/L) was detected in 6 (40%) of early lactation cows but in none of the late pregnant cows, while subclinical ketosis (BHB>1.2 mmol/L) was detected in 14 (94.4%) of the early lactation cows and 4 (26.6%) of the late pregnant cows. AST activities above 100 U/L were detected in 2 early lactation cows and in none of the late pregnant cows. TG levels below 0.12 mmol/L and glucose below 2.5 mmol/L were found in 7 (44%) and 10 (66.6%) of the early lactation cows, respectively, and in none of the late pregnant cows. Early lactation cows were found to have lower blood serum levels of TG (P lt 0.05), albumin (P lt 0.05) urea (P lt 0.05) and GTT (P>0.05) activities and higher concentrations of total bilirubin (P>0.05) TP (P>0.05) and AST activities (P lt 0.05) compared to the late pregnant cows. The results of blood serum levels of glucose, TG, BHB, NEFA and AST in early lactation cows suggest metabolic disorders associated with ketosis, and some degree of hepatic lesions, probably due to fat infifiltration. These serum parameters may have a key role in evaluating metabolic status in late pregnant and early lactation dairy cows.",
publisher = "Univ Zagreb Vet Faculty, Zagreb",
journal = "Veterinarski Arhiv",
title = "Evaluation of metabolic status in Simmental dairy cows during late pregnancy and early lactation, Prosudba metaboličkog statusa mliječnih krava simentalske pasmine tijekom kasne gravidnosti i na početku laktacije",
volume = "83",
number = "6",
pages = "593-602",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_955"
}

Đoković, R., Kurcubić, V., Ilić, Z., Cincović, M., Petrović, M. D., Fratrić, N.,& Jasović, B.. (2013). Evaluation of metabolic status in Simmental dairy cows during late pregnancy and early lactation. in Veterinarski Arhiv
Univ Zagreb Vet Faculty, Zagreb., 83(6), 593-602.
https://hdl.handle.net/21.15107/rcub_veterinar_955

Đoković R, Kurcubić V, Ilić Z, Cincović M, Petrović MD, Fratrić N, Jasović B. Evaluation of metabolic status in Simmental dairy cows during late pregnancy and early lactation. in Veterinarski Arhiv. 2013;83(6):593-602.
https://hdl.handle.net/21.15107/rcub_veterinar_955 .

Đoković, Radojica, Kurcubić, Vladimir, Ilić, Zoran, Cincović, Marko, Petrović, Milun D., Fratrić, Natalija, Jasović, Boban, "Evaluation of metabolic status in Simmental dairy cows during late pregnancy and early lactation" in Veterinarski Arhiv, 83, no. 6 (2013):593-602,
https://hdl.handle.net/21.15107/rcub_veterinar_955 .

TY  - JOUR
AU  - Đoković, Radojica
AU  - Kurcubić, Vladimir
AU  - Ilić, Zoran
AU  - Cincović, Marko
AU  - Fratrić, Natalija
AU  - Stanimirović, Zoran
AU  - Petrović, Milun D.
AU  - Petrović, Milan P.
PY  - 2013
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1022
AB  - Fifteen early-lactation cows and 15 mid-lactation cows were chosen for the analysis. Blood samples were collected to measure the beta-hydroxybutyrate (BHB), non-esterified fatty acids (NEFA), triglycerides (TG), glucose (Glu), total protein (TP), albumin (ALB), total bilirubin (TB), urea (U) and the activity of aspartate transaminase (AST) and gamma-glutamyl transferase (GGT). Earlylactation cows showed significantly higher (P lt 0.05) values of serum BHB and NEFA, and lower of (P lt 0.05) glycemia levels compared to mid-lactation cows. High lipomobilization (NEFA >0.4 mmol/l) and subclinical ketosis (BHB >1.2 mmol/L) were detected in 6 (40%) and 14 (94.4%) early-lactation cows, respectively, and in none of the mid lactation cows. AST activities above 100 IU/l were detected in two early-lactation and none of the mid-lactation cows. TG concentrations below 0.12 mmol/l were found in 7 (44%) early-lactation and 2 (13.3%) mid-lactation cows. Glucose levels were below 2.5 mmol/l in 10 (66.6%) early-lactation and 5 (33.3%) mid-lactation cows. Early-lactation cows showed lower blood serum concentrations of TG (P>0.05), ALB (P>0.05), TP (P lt 0.05), U (P>0.05) and GTT (P>0.05) activities and higher concentrations of TB (P>0.05) and AST activities (P lt 0.05), as compared to mid-lactation cows. These metabolic characteristics were correlated with DMI and energy balance (EB). Blood serum values for glucose, TG, BHB, NEFA and AST showed that earlylactation cows suffered from metabolic disturbances, associated with ketosis, and some degree of hepatic lesions, probably due to fat infiltration. These serum parameters may have a key role in evaluating the metabolic status of dairy cows.
PB  - Polska Akad Nauk, Inst Genetyki I Hodowli Zwierzat, Mrokow
T2  - Animal Science Papers and Reports
T1  - Evaluation of the metabolic status of Simmental dairy cows in early and mid lactation
VL  - 31
IS  - 2
SP  - 101
EP  - 110
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_1022
ER  - 

@article{
author = "Đoković, Radojica and Kurcubić, Vladimir and Ilić, Zoran and Cincović, Marko and Fratrić, Natalija and Stanimirović, Zoran and Petrović, Milun D. and Petrović, Milan P.",
year = "2013",
abstract = "Fifteen early-lactation cows and 15 mid-lactation cows were chosen for the analysis. Blood samples were collected to measure the beta-hydroxybutyrate (BHB), non-esterified fatty acids (NEFA), triglycerides (TG), glucose (Glu), total protein (TP), albumin (ALB), total bilirubin (TB), urea (U) and the activity of aspartate transaminase (AST) and gamma-glutamyl transferase (GGT). Earlylactation cows showed significantly higher (P lt 0.05) values of serum BHB and NEFA, and lower of (P lt 0.05) glycemia levels compared to mid-lactation cows. High lipomobilization (NEFA >0.4 mmol/l) and subclinical ketosis (BHB >1.2 mmol/L) were detected in 6 (40%) and 14 (94.4%) early-lactation cows, respectively, and in none of the mid lactation cows. AST activities above 100 IU/l were detected in two early-lactation and none of the mid-lactation cows. TG concentrations below 0.12 mmol/l were found in 7 (44%) early-lactation and 2 (13.3%) mid-lactation cows. Glucose levels were below 2.5 mmol/l in 10 (66.6%) early-lactation and 5 (33.3%) mid-lactation cows. Early-lactation cows showed lower blood serum concentrations of TG (P>0.05), ALB (P>0.05), TP (P lt 0.05), U (P>0.05) and GTT (P>0.05) activities and higher concentrations of TB (P>0.05) and AST activities (P lt 0.05), as compared to mid-lactation cows. These metabolic characteristics were correlated with DMI and energy balance (EB). Blood serum values for glucose, TG, BHB, NEFA and AST showed that earlylactation cows suffered from metabolic disturbances, associated with ketosis, and some degree of hepatic lesions, probably due to fat infiltration. These serum parameters may have a key role in evaluating the metabolic status of dairy cows.",
publisher = "Polska Akad Nauk, Inst Genetyki I Hodowli Zwierzat, Mrokow",
journal = "Animal Science Papers and Reports",
title = "Evaluation of the metabolic status of Simmental dairy cows in early and mid lactation",
volume = "31",
number = "2",
pages = "101-110",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_1022"
}

Đoković, R., Kurcubić, V., Ilić, Z., Cincović, M., Fratrić, N., Stanimirović, Z., Petrović, M. D.,& Petrović, M. P.. (2013). Evaluation of the metabolic status of Simmental dairy cows in early and mid lactation. in Animal Science Papers and Reports
Polska Akad Nauk, Inst Genetyki I Hodowli Zwierzat, Mrokow., 31(2), 101-110.
https://hdl.handle.net/21.15107/rcub_veterinar_1022

Đoković R, Kurcubić V, Ilić Z, Cincović M, Fratrić N, Stanimirović Z, Petrović MD, Petrović MP. Evaluation of the metabolic status of Simmental dairy cows in early and mid lactation. in Animal Science Papers and Reports. 2013;31(2):101-110.
https://hdl.handle.net/21.15107/rcub_veterinar_1022 .

Đoković, Radojica, Kurcubić, Vladimir, Ilić, Zoran, Cincović, Marko, Fratrić, Natalija, Stanimirović, Zoran, Petrović, Milun D., Petrović, Milan P., "Evaluation of the metabolic status of Simmental dairy cows in early and mid lactation" in Animal Science Papers and Reports, 31, no. 2 (2013):101-110,
https://hdl.handle.net/21.15107/rcub_veterinar_1022 .

TY  - JOUR
AU  - Kurcubić, Vladimir
AU  - Milić, Nenad
AU  - Đoković, Radojica
AU  - Ilić, Zoran
PY  - 2011
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/770
AB  - This study is aimed at evaluating the immunogenicity of two inactivated (mono- and polyvalent) vaccines containing bovine virus diarrhea virus (BVDV) reference and field strains. Three experimental groups were formed: 10 calves vaccinated twice (days 1 and 28) subcutaneously (s/c) with 2 ml of inactivated polyvalent vaccine per animal (Group 1); 10 calves vaccinated twice (days 1 and 28) subcutaneously (s/c) with 2 ml of inactivated monovalent vaccine per animal (Group 2) and 9 unvaccinated calves (Control, Group C). Blood sera were obtained from immunized animals (standard procedure: on days 0, 14, 28, 42 and 56 post-immunization). Geometric mean titer (GMT) values for BVDV neutralizing antibodies were substantially higher in blood sera of calves receiving the inactivated monovalent vaccine. The immune response developed more rapidly in calves immunized with the monovalent vaccine.
PB  - Academic Journals, Victoria Island
T2  - African Journal of Microbiology Research
T1  - Evaluation of immunogenic properties of monovalent and polyvalent inactivated bovine virus diarrhea virus (BVDV) vaccines
VL  - 5
IS  - 17
SP  - 2422
EP  - 2427
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_770
ER  - 

@article{
author = "Kurcubić, Vladimir and Milić, Nenad and Đoković, Radojica and Ilić, Zoran",
year = "2011",
abstract = "This study is aimed at evaluating the immunogenicity of two inactivated (mono- and polyvalent) vaccines containing bovine virus diarrhea virus (BVDV) reference and field strains. Three experimental groups were formed: 10 calves vaccinated twice (days 1 and 28) subcutaneously (s/c) with 2 ml of inactivated polyvalent vaccine per animal (Group 1); 10 calves vaccinated twice (days 1 and 28) subcutaneously (s/c) with 2 ml of inactivated monovalent vaccine per animal (Group 2) and 9 unvaccinated calves (Control, Group C). Blood sera were obtained from immunized animals (standard procedure: on days 0, 14, 28, 42 and 56 post-immunization). Geometric mean titer (GMT) values for BVDV neutralizing antibodies were substantially higher in blood sera of calves receiving the inactivated monovalent vaccine. The immune response developed more rapidly in calves immunized with the monovalent vaccine.",
publisher = "Academic Journals, Victoria Island",
journal = "African Journal of Microbiology Research",
title = "Evaluation of immunogenic properties of monovalent and polyvalent inactivated bovine virus diarrhea virus (BVDV) vaccines",
volume = "5",
number = "17",
pages = "2422-2427",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_770"
}

Kurcubić, V., Milić, N., Đoković, R.,& Ilić, Z.. (2011). Evaluation of immunogenic properties of monovalent and polyvalent inactivated bovine virus diarrhea virus (BVDV) vaccines. in African Journal of Microbiology Research
Academic Journals, Victoria Island., 5(17), 2422-2427.
https://hdl.handle.net/21.15107/rcub_veterinar_770

Kurcubić V, Milić N, Đoković R, Ilić Z. Evaluation of immunogenic properties of monovalent and polyvalent inactivated bovine virus diarrhea virus (BVDV) vaccines. in African Journal of Microbiology Research. 2011;5(17):2422-2427.
https://hdl.handle.net/21.15107/rcub_veterinar_770 .

Kurcubić, Vladimir, Milić, Nenad, Đoković, Radojica, Ilić, Zoran, "Evaluation of immunogenic properties of monovalent and polyvalent inactivated bovine virus diarrhea virus (BVDV) vaccines" in African Journal of Microbiology Research, 5, no. 17 (2011):2422-2427,
https://hdl.handle.net/21.15107/rcub_veterinar_770 .