TY  - JOUR
AU  - Relić, Renata
AU  - Lakić, Nada
AU  - Janković, Ljiljana
AU  - Davidović, Vesna
AU  - Staric, Joze
AU  - Jezek, Jozica
PY  - 2021
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2053
AB  - Aim of the study: Calf rearing practices vary in different countries and may be affected by many factors. Poor management is related to diseases outbreak and death in calves. This study aimed to analyze practices in calf rearing and the occurrence of common calf diseases on family farms in two European countries and to examine the characteristics of a farmer and his farm as factors that may affect the way of performing practices related to calves’ health.Area of study: Slovenia and Serbia.Material and methods: For collecting data, the same questionnaire-based survey was distributed among cattle farm owners in Slovenia and Serbia.Main results: The following factors showed a significant influence (p<0.05) on certain rearing practices: farm size (on time for checking calves, milk reheating, and providing rehydration fluids to the calf with diarrhea in Slovenia), specialization of the production (on preventive antiparasitic treatments and restriction of drinking water for calves with diarrhea in Slovenia, and the time for checking calves in Serbia), breeder’s age (on colostrum quality checking in Slovenia), and breeder’s education (on time for checking calves and checking colostrum quality in Serbia). The results pointed out the rearing practices to be improved in both countries, Slovenia and Serbia, such as colostrum management and prevention strategies of calf diseases.Research highlights: Characteristics of the farmer and his farm may affect many aspects of calves’ rearing. Continuous education of farmers and appropriate production planning can contribute to better farm productivity and better health and welfare of calves.
PB  - Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria
T2  - Spanish Journal of Agricultural Research
T1  - Factors affecting rearing practices and health of calves on family farms
VL  - 19
IS  - 1
SP  - 0501
DO  - 10.5424/sjar/2021191-17181
ER  - 

@article{
author = "Relić, Renata and Lakić, Nada and Janković, Ljiljana and Davidović, Vesna and Staric, Joze and Jezek, Jozica",
year = "2021",
abstract = "Aim of the study: Calf rearing practices vary in different countries and may be affected by many factors. Poor management is related to diseases outbreak and death in calves. This study aimed to analyze practices in calf rearing and the occurrence of common calf diseases on family farms in two European countries and to examine the characteristics of a farmer and his farm as factors that may affect the way of performing practices related to calves’ health.Area of study: Slovenia and Serbia.Material and methods: For collecting data, the same questionnaire-based survey was distributed among cattle farm owners in Slovenia and Serbia.Main results: The following factors showed a significant influence (p<0.05) on certain rearing practices: farm size (on time for checking calves, milk reheating, and providing rehydration fluids to the calf with diarrhea in Slovenia), specialization of the production (on preventive antiparasitic treatments and restriction of drinking water for calves with diarrhea in Slovenia, and the time for checking calves in Serbia), breeder’s age (on colostrum quality checking in Slovenia), and breeder’s education (on time for checking calves and checking colostrum quality in Serbia). The results pointed out the rearing practices to be improved in both countries, Slovenia and Serbia, such as colostrum management and prevention strategies of calf diseases.Research highlights: Characteristics of the farmer and his farm may affect many aspects of calves’ rearing. Continuous education of farmers and appropriate production planning can contribute to better farm productivity and better health and welfare of calves.",
publisher = "Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria",
journal = "Spanish Journal of Agricultural Research",
title = "Factors affecting rearing practices and health of calves on family farms",
volume = "19",
number = "1",
pages = "0501",
doi = "10.5424/sjar/2021191-17181"
}

Relić, R., Lakić, N., Janković, L., Davidović, V., Staric, J.,& Jezek, J.. (2021). Factors affecting rearing practices and health of calves on family farms. in Spanish Journal of Agricultural Research
Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria., 19(1), 0501.
https://doi.org/10.5424/sjar/2021191-17181

Relić R, Lakić N, Janković L, Davidović V, Staric J, Jezek J. Factors affecting rearing practices and health of calves on family farms. in Spanish Journal of Agricultural Research. 2021;19(1):0501.
doi:10.5424/sjar/2021191-17181 .

Relić, Renata, Lakić, Nada, Janković, Ljiljana, Davidović, Vesna, Staric, Joze, Jezek, Jozica, "Factors affecting rearing practices and health of calves on family farms" in Spanish Journal of Agricultural Research, 19, no. 1 (2021):0501,
https://doi.org/10.5424/sjar/2021191-17181 . .

TY  - JOUR
AU  - Milošević-Stanković, Ivana
AU  - Hristov, Slavica
AU  - Maksimović, Nevena
AU  - Popović, Blaženka
AU  - Davidović, Vesna
AU  - Mekić, Cvijan
AU  - Dimitrijević, Blagoje
AU  - Cincović, Marko
AU  - Stanković, Branislav
PY  - 2020
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1870
AB  - The investigation was performed on two groups of primiparous and multiparous healthy dewormed Alpine dairy goats (25 each) during peripartal period. Blood samples were collected (jugular venipuncture) 10-15 days before and 10-15 and 30 days after the parturition into BD SST-II Advance (3.5 mL) and BD NaF 3.0 mg Na2EDTA 6.0 mg (2 mL) vacutainers, cooled and centrifuged (1500 r/min, 15 minutes and ≤1300 r/min, 10 minutes, respectively). Glucose, non-esterified fatty acids (NEFA) and β-hydroxybutyrate (BHBA) concentrations in blood sera were determined using A15 automatic spectrophotometric analyzer (Biosystem, Spain). Simultaneously, body condition scoring (BCS) was performed by Villaquiran et al. (2007) method. The obtained data were analyzed by IBM SPSS statistics 21. The glucose concentration inclined to increase in both groups. Differences between glucose levels were significant (P<0.05) 15 days before and 15 days after, as well as 15 and 30 days after the parturition, and very significant (P<0.01) 15 days before and 30 days after the parturition. The BHBA blood levels significantly differed 15 days before and 30 days after and 15 and 30 days after the parturition (P<0.05). BHBA concentration peaked at week 2 postpartum, following the increase of NEFA, providing the substrate for BHBA synthesis. NEFA levels significantly (P<0.05) differed 15 days before and 15 days after the parturition. Goats’ BCS ranged from 2 to 4 and significantly depended on glucose (r=0.392; P<0.05) and BHBA (r=0.317; P<0.05) level 15 days before parturition. BCS 30 days postpartum very significantly depended on the glucose level (r=0.450; P<0.01), significantly higher than the concentration of BHBA (r=0.351; P<0.05) and NEFA concentration (r=-0.304; P<0.05). BCS 15 days before parturition did not depend on the NEFA concentration. Fifteen days after the parturition BCS did not statistically depend on the observed indicators. Obtained data suggest that knowledge of BCS and energy indicators levels may be very useful in research and practice in order to appreciate energy metabolism of pregnant and lactating dairy ruminants, particularly dairy goats. These data are poorly documented for goats, but they can reveal early pathological metabolic changes in transiting female goat organism, enabling successful prophylactic, as well as, therapeutic intervention.
PB  - Sivar-Soc Italiana Veterinari Animali Reddito, Cremona
T2  - Large Animal Review
T1  - Energy metabolism indicators and body condition in peripartal period of alpine goats
VL  - 26
IS  - 1
SP  - 13
EP  - 18
UR  - https://hdl.handle.net/21.15107/rcub_agrospace_5444
ER  - 

@article{
author = "Milošević-Stanković, Ivana and Hristov, Slavica and Maksimović, Nevena and Popović, Blaženka and Davidović, Vesna and Mekić, Cvijan and Dimitrijević, Blagoje and Cincović, Marko and Stanković, Branislav",
year = "2020",
abstract = "The investigation was performed on two groups of primiparous and multiparous healthy dewormed Alpine dairy goats (25 each) during peripartal period. Blood samples were collected (jugular venipuncture) 10-15 days before and 10-15 and 30 days after the parturition into BD SST-II Advance (3.5 mL) and BD NaF 3.0 mg Na2EDTA 6.0 mg (2 mL) vacutainers, cooled and centrifuged (1500 r/min, 15 minutes and ≤1300 r/min, 10 minutes, respectively). Glucose, non-esterified fatty acids (NEFA) and β-hydroxybutyrate (BHBA) concentrations in blood sera were determined using A15 automatic spectrophotometric analyzer (Biosystem, Spain). Simultaneously, body condition scoring (BCS) was performed by Villaquiran et al. (2007) method. The obtained data were analyzed by IBM SPSS statistics 21. The glucose concentration inclined to increase in both groups. Differences between glucose levels were significant (P<0.05) 15 days before and 15 days after, as well as 15 and 30 days after the parturition, and very significant (P<0.01) 15 days before and 30 days after the parturition. The BHBA blood levels significantly differed 15 days before and 30 days after and 15 and 30 days after the parturition (P<0.05). BHBA concentration peaked at week 2 postpartum, following the increase of NEFA, providing the substrate for BHBA synthesis. NEFA levels significantly (P<0.05) differed 15 days before and 15 days after the parturition. Goats’ BCS ranged from 2 to 4 and significantly depended on glucose (r=0.392; P<0.05) and BHBA (r=0.317; P<0.05) level 15 days before parturition. BCS 30 days postpartum very significantly depended on the glucose level (r=0.450; P<0.01), significantly higher than the concentration of BHBA (r=0.351; P<0.05) and NEFA concentration (r=-0.304; P<0.05). BCS 15 days before parturition did not depend on the NEFA concentration. Fifteen days after the parturition BCS did not statistically depend on the observed indicators. Obtained data suggest that knowledge of BCS and energy indicators levels may be very useful in research and practice in order to appreciate energy metabolism of pregnant and lactating dairy ruminants, particularly dairy goats. These data are poorly documented for goats, but they can reveal early pathological metabolic changes in transiting female goat organism, enabling successful prophylactic, as well as, therapeutic intervention.",
publisher = "Sivar-Soc Italiana Veterinari Animali Reddito, Cremona",
journal = "Large Animal Review",
title = "Energy metabolism indicators and body condition in peripartal period of alpine goats",
volume = "26",
number = "1",
pages = "13-18",
url = "https://hdl.handle.net/21.15107/rcub_agrospace_5444"
}

Milošević-Stanković, I., Hristov, S., Maksimović, N., Popović, B., Davidović, V., Mekić, C., Dimitrijević, B., Cincović, M.,& Stanković, B.. (2020). Energy metabolism indicators and body condition in peripartal period of alpine goats. in Large Animal Review
Sivar-Soc Italiana Veterinari Animali Reddito, Cremona., 26(1), 13-18.
https://hdl.handle.net/21.15107/rcub_agrospace_5444

Milošević-Stanković I, Hristov S, Maksimović N, Popović B, Davidović V, Mekić C, Dimitrijević B, Cincović M, Stanković B. Energy metabolism indicators and body condition in peripartal period of alpine goats. in Large Animal Review. 2020;26(1):13-18.
https://hdl.handle.net/21.15107/rcub_agrospace_5444 .

Milošević-Stanković, Ivana, Hristov, Slavica, Maksimović, Nevena, Popović, Blaženka, Davidović, Vesna, Mekić, Cvijan, Dimitrijević, Blagoje, Cincović, Marko, Stanković, Branislav, "Energy metabolism indicators and body condition in peripartal period of alpine goats" in Large Animal Review, 26, no. 1 (2020):13-18,
https://hdl.handle.net/21.15107/rcub_agrospace_5444 .

TY  - JOUR
AU  - Maletić, Milan
AU  - Paprikić, Nevres
AU  - Lazarević, Miodrag
AU  - Hodzić, Aida
AU  - Davidović, Vesna
AU  - Stanišić, Ljubodrag
AU  - Stanimirović, Zoran
PY  - 2019
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1747
AB  - Leptin, a biomolecule secreted by adipose tissue, enchances productivity in cattle, especially affecting milk traits. The aim of this study was to detect leptin gene polymorphism on exon 3 (A59V locus) and intron 2 (SAU3AI locus) in the endangered population of autochtonous Busha cattle and associations with milk traits. The study included 46 cows: 36 Busha and 10 half-bred. Milk analyses comprised determination of somatic cell counts, fat, protein, lactose, total solids and solids-not-fat (SNF) concentrations and freezing point depression (FPD). Polymorphisms were determined by PCR-RFLP technique. A single A59V genotype (CC) was affirmed, and two SAU3AI genotypes, AA and AB, with frequencies of 78.26% and 21.74%, respectively. Comparing the obtained results for chemical characteristics of milk between cows with AA and AB, no significant differences were found, except for SNF content and FPD values. Cows with AA genotype had significantly lower (p = 0.021) average SNF content (8.74%) in milk compared to the average SNF content (9.28%) in those with genotype AB, while cows with genotype AA (-0.54 degrees C) had significantly higher (p = 0.004) average FPD values than those with AB genotype (-0.58 degrees C). The absence of BB genotype and significant differences in the investigated functional traits between two SAU3AI genotypes and the absence of A59V polymorphism (presence of only CC genotype) show that the Busha cattle breed, although being an autochtonous low-producing native breed used for meat and milk production, harbours polymorphism on gentic markers characteristic of high production dairy cows.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta Veterinaria-Beograd
T1  - Insight in leptin gene polymorphism and impact on milk traits in autochtonous busha cattle
VL  - 69
IS  - 2
SP  - 153
EP  - 163
DO  - 10.2478/acve-2019-0012
ER  - 

@article{
author = "Maletić, Milan and Paprikić, Nevres and Lazarević, Miodrag and Hodzić, Aida and Davidović, Vesna and Stanišić, Ljubodrag and Stanimirović, Zoran",
year = "2019",
abstract = "Leptin, a biomolecule secreted by adipose tissue, enchances productivity in cattle, especially affecting milk traits. The aim of this study was to detect leptin gene polymorphism on exon 3 (A59V locus) and intron 2 (SAU3AI locus) in the endangered population of autochtonous Busha cattle and associations with milk traits. The study included 46 cows: 36 Busha and 10 half-bred. Milk analyses comprised determination of somatic cell counts, fat, protein, lactose, total solids and solids-not-fat (SNF) concentrations and freezing point depression (FPD). Polymorphisms were determined by PCR-RFLP technique. A single A59V genotype (CC) was affirmed, and two SAU3AI genotypes, AA and AB, with frequencies of 78.26% and 21.74%, respectively. Comparing the obtained results for chemical characteristics of milk between cows with AA and AB, no significant differences were found, except for SNF content and FPD values. Cows with AA genotype had significantly lower (p = 0.021) average SNF content (8.74%) in milk compared to the average SNF content (9.28%) in those with genotype AB, while cows with genotype AA (-0.54 degrees C) had significantly higher (p = 0.004) average FPD values than those with AB genotype (-0.58 degrees C). The absence of BB genotype and significant differences in the investigated functional traits between two SAU3AI genotypes and the absence of A59V polymorphism (presence of only CC genotype) show that the Busha cattle breed, although being an autochtonous low-producing native breed used for meat and milk production, harbours polymorphism on gentic markers characteristic of high production dairy cows.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta Veterinaria-Beograd",
title = "Insight in leptin gene polymorphism and impact on milk traits in autochtonous busha cattle",
volume = "69",
number = "2",
pages = "153-163",
doi = "10.2478/acve-2019-0012"
}

Maletić, M., Paprikić, N., Lazarević, M., Hodzić, A., Davidović, V., Stanišić, L.,& Stanimirović, Z.. (2019). Insight in leptin gene polymorphism and impact on milk traits in autochtonous busha cattle. in Acta Veterinaria-Beograd
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 69(2), 153-163.
https://doi.org/10.2478/acve-2019-0012

Maletić M, Paprikić N, Lazarević M, Hodzić A, Davidović V, Stanišić L, Stanimirović Z. Insight in leptin gene polymorphism and impact on milk traits in autochtonous busha cattle. in Acta Veterinaria-Beograd. 2019;69(2):153-163.
doi:10.2478/acve-2019-0012 .

Maletić, Milan, Paprikić, Nevres, Lazarević, Miodrag, Hodzić, Aida, Davidović, Vesna, Stanišić, Ljubodrag, Stanimirović, Zoran, "Insight in leptin gene polymorphism and impact on milk traits in autochtonous busha cattle" in Acta Veterinaria-Beograd, 69, no. 2 (2019):153-163,
https://doi.org/10.2478/acve-2019-0012 . .

TY  - JOUR
AU  - Davidović, Vesna
AU  - Jovetić, Branko
AU  - Joksimović-Todorović, Mirjana
AU  - Stojanović, Bojan
AU  - Lazarević, Miodrag
AU  - Perisić, Predrag
AU  - Radivojević, Mihailo
AU  - Maletić, Milan
AU  - Miletić, Aleksandar
PY  - 2019
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1699
AB  - The aim of this study was to examine the effect of using tannin supplement in ration for mid-lactation dairy cows (90 +/- 17 days in milk) and the number of lactation on metabolic profile parameters values. Additionally, the effect of tannin supplementation on cows production characteristics in the 2nd lactation was evaluated. Research was conducted on 80 Holstein cows divided into two groups of 40 cows (control and experimental group) that included 16 cows in 2nd and 12 in 3rd and 4th lactation. The tannin supplement Tanimil SCC (40 g/cow/day; 40% of tannins) was added in the total mixed ration (TMR) of experimental group, while the control group of cows was fed ration without the tannin supplement. The trial lasted 60 days. Dairy cows, fed diet supplemented with tannin, had markedly lower values (P<0.05) of B-hydroxybutyrate concentration (0.79 vs. 0.96 mmol/L) and lower blood urea concentration (5.89 vs. 6.93 mmol/L). Difference in the blood glucose concentrations (3.92 vs. 3.89 mmol/L) was not significant. The lactation number had no significant effect on values of metabolic profile parameters (concentration of glucose, B-hydroxybutyrate and urea). The effect of interaction of lactation number and tannin supplement on the values of examined parameters of metabolic profile was not significant. Supplementation of tannin in the diet for cows in the second lactation, had a positive effect (P<0.05) on the milk yield (4.42%) and yield of 4% fat corrected milk (FCM, 5.24%). The use of tannin, improved concentration (3.20 vs. 3.12%) and yield (from 1.16 to 1.24 kg/day) of milk protein (P<0.05). Addition of tannin also improved concentration and yield of milk fat, as well as the concentration of lactose. The supplementation of Tanimil SCC to mid-lactation dairy cows had a positive impacts on reduction of blood content of B-hydroxybutyrate and urea, and improved productive performances of cows in the second lactation.
PB  - Univ Ljubljana, Veterinary Faculty, Ljubljana
T2  - Slovenian Veterinary Research
T1  - The effect of tannin supplementation of mid-lactation dairy cows diets on metabolic profile parameters and production characteristics
VL  - 56
IS  - 4
SP  - 143
EP  - 151
DO  - 10.26873/SVR-552-2019
ER  - 

@article{
author = "Davidović, Vesna and Jovetić, Branko and Joksimović-Todorović, Mirjana and Stojanović, Bojan and Lazarević, Miodrag and Perisić, Predrag and Radivojević, Mihailo and Maletić, Milan and Miletić, Aleksandar",
year = "2019",
abstract = "The aim of this study was to examine the effect of using tannin supplement in ration for mid-lactation dairy cows (90 +/- 17 days in milk) and the number of lactation on metabolic profile parameters values. Additionally, the effect of tannin supplementation on cows production characteristics in the 2nd lactation was evaluated. Research was conducted on 80 Holstein cows divided into two groups of 40 cows (control and experimental group) that included 16 cows in 2nd and 12 in 3rd and 4th lactation. The tannin supplement Tanimil SCC (40 g/cow/day; 40% of tannins) was added in the total mixed ration (TMR) of experimental group, while the control group of cows was fed ration without the tannin supplement. The trial lasted 60 days. Dairy cows, fed diet supplemented with tannin, had markedly lower values (P<0.05) of B-hydroxybutyrate concentration (0.79 vs. 0.96 mmol/L) and lower blood urea concentration (5.89 vs. 6.93 mmol/L). Difference in the blood glucose concentrations (3.92 vs. 3.89 mmol/L) was not significant. The lactation number had no significant effect on values of metabolic profile parameters (concentration of glucose, B-hydroxybutyrate and urea). The effect of interaction of lactation number and tannin supplement on the values of examined parameters of metabolic profile was not significant. Supplementation of tannin in the diet for cows in the second lactation, had a positive effect (P<0.05) on the milk yield (4.42%) and yield of 4% fat corrected milk (FCM, 5.24%). The use of tannin, improved concentration (3.20 vs. 3.12%) and yield (from 1.16 to 1.24 kg/day) of milk protein (P<0.05). Addition of tannin also improved concentration and yield of milk fat, as well as the concentration of lactose. The supplementation of Tanimil SCC to mid-lactation dairy cows had a positive impacts on reduction of blood content of B-hydroxybutyrate and urea, and improved productive performances of cows in the second lactation.",
publisher = "Univ Ljubljana, Veterinary Faculty, Ljubljana",
journal = "Slovenian Veterinary Research",
title = "The effect of tannin supplementation of mid-lactation dairy cows diets on metabolic profile parameters and production characteristics",
volume = "56",
number = "4",
pages = "143-151",
doi = "10.26873/SVR-552-2019"
}

Davidović, V., Jovetić, B., Joksimović-Todorović, M., Stojanović, B., Lazarević, M., Perisić, P., Radivojević, M., Maletić, M.,& Miletić, A.. (2019). The effect of tannin supplementation of mid-lactation dairy cows diets on metabolic profile parameters and production characteristics. in Slovenian Veterinary Research
Univ Ljubljana, Veterinary Faculty, Ljubljana., 56(4), 143-151.
https://doi.org/10.26873/SVR-552-2019

Davidović V, Jovetić B, Joksimović-Todorović M, Stojanović B, Lazarević M, Perisić P, Radivojević M, Maletić M, Miletić A. The effect of tannin supplementation of mid-lactation dairy cows diets on metabolic profile parameters and production characteristics. in Slovenian Veterinary Research. 2019;56(4):143-151.
doi:10.26873/SVR-552-2019 .

Davidović, Vesna, Jovetić, Branko, Joksimović-Todorović, Mirjana, Stojanović, Bojan, Lazarević, Miodrag, Perisić, Predrag, Radivojević, Mihailo, Maletić, Milan, Miletić, Aleksandar, "The effect of tannin supplementation of mid-lactation dairy cows diets on metabolic profile parameters and production characteristics" in Slovenian Veterinary Research, 56, no. 4 (2019):143-151,
https://doi.org/10.26873/SVR-552-2019 . .

TY  - JOUR
AU  - Dimitrijević, Blagoje
AU  - Jović, Slavoljub
AU  - Ostojić-Andrić, Dušica
AU  - Savić, Mila
AU  - Becskei, Zsolt
AU  - Davidović, Vesna
AU  - Joksimović-Todorović, Mirjana
PY  - 2016
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1321
AB  - The aim of this study was to determine and evaluate the basic haematological parameters in conditions of natural infection of sheep with Strongyloides papillosus, as well as after the administration of antihelminthic albendazole (ABZ). Based on the intensity of infection with S. papillosus the sheep were divided into three groups: mild, moderate and high, and after that the sheep received a single dose of ABZ of 5mg/kg per body weight, per orally. Sampling of faeces and blood for parasitological and haematological assaying respectively, was performed on the 0 and the 21st day after the treatment with ABZ. The presence of parasitic infection with S. papillosus leads to a decrease of erythrocyte count, while the lowest values were established in the group with the highest intensity of parasitic infection (p ˂ 0.001). After treatment with ABZ the decrease of erythrocyte count was more prominent, which was, based on comparison with control groups C1 and C2, unequivocally established to be the consequence of treatment with ABZ. Detected values of haematocrit and erythrocyte indices indicated the presence of parasitic infection: the lowest values were established in the group with the highest intensity of parasitic infection. After treatment with ABZ haematocrit levels in control group C2 were statistically significantly lower compared to the control group C1 (p ˂ 0.001). In the presence of parasitic infection, the neutrophil and eosinophil counts increased almost linearly up to the value of 44.24±2.50% and 13.29±0.61% respectively, in the group of sheep with the highest intensity of parasitic infection (p ˂ 0.001; compared to control group C1). After treatment with ABZ the decrease of the number of these white blood cells is statistically significant (p ˂ 0.001). Bearing in mind our previous research and the connection of disbalanced redox equilibrium after the treatment with ABZ with changes, it is necessary to include antioxidative substances in the anti-parasitic treatment protocols.
AB  - Cilj ovog istraživanja bio je da se utvrde i procene osnovni hematološki parametri u uslovima prirodne infekcije ovaca sa Strongyloides papillosus, kao i nakon primene antihelmintika albendazola (ABZ). Na osnovu intenziteta infekcije sa S. papillosus ovce su podeljene u tri grupe: niski, srednji i visoki intenzitet infekcije, a zatim su ovce jednokratno dobile peroralno ABZ, u terapijskoj dozi od 5 mg/kg telesne mase. Uzorkovanje fecesa za parazitološka i za hematološka ispitivanja obavljeno je nultog i 21. dana od primene ABZ. Utvrđeno je da prisustvo parazitske infekcije sa S. papillosus dovodi do pada broja eritrocita, pri čemu su najniže vrednosti utvrđene u grupi sa najvećim intenzitetom parazitske infekcije (p ˂ 0,001). Nakon terapije sa ABZ pad broja eritrocita je izraženiji, što je nesumnjivo nastalo kao posledica terapije ABZ (na osnovu poređenja C1 i C2). Utvrđene vrednosti hematokrita i eritrocitnih indeksa su ukazivali na postojanje parazitske infekcije; najniže vrednosti su utvrđene kod grupe sa najvećim intenzitetom parazitske infekcije. Nakon terapije sa ABZ vrednosti hematokrita kod C2 bile su statistički značajno niže u odnosu na kontrolnu grupu C1 (p ˂ 0,001). U prisustvu parazitske infekcije broj neutrofila i eozinofila povećava se gotovo linearno, do vrednosti od 44,24±2,50% kod neutrofila, odnosno od 13,29±0,61% kod eozinofila u grupi ovaca sa najvećim intenzitetom parazitske infekcije (p ˂ 0,001). Nakon terapije sa ABZ broj ovih ćelija bele krvne loze smanjuje se statistički značajno (p ˂ 0,001). Imajući u vidu naša prethodna istraživanja i povezanost narušene redoks ravnoteže posle terapije sa ABZ sa promenama utvrđenim u ovom istraživanju, neophodno je u antiparazitske terapijske protokole uključiti antioksidativne supstance.
PB  - Institut za stočarstvo, Beograd
T2  - Biotechnology in Animal Husbandry
T1  - Infection with Strongyloides papillosus in sheep: Effect of parasitic infection and treatment with albendazole on basic haematological parameters
T1  - Infekcija ovaca sa Strongyloides papillosus - uticaj intenziteta parazitske infekcije i terapije albendazolom na vrednosti osnovnih hematoloških parametara
VL  - 32
IS  - 4
SP  - 369
EP  - 381
DO  - 10.2298/bah1604369D
ER  - 

@article{
author = "Dimitrijević, Blagoje and Jović, Slavoljub and Ostojić-Andrić, Dušica and Savić, Mila and Becskei, Zsolt and Davidović, Vesna and Joksimović-Todorović, Mirjana",
year = "2016",
abstract = "The aim of this study was to determine and evaluate the basic haematological parameters in conditions of natural infection of sheep with Strongyloides papillosus, as well as after the administration of antihelminthic albendazole (ABZ). Based on the intensity of infection with S. papillosus the sheep were divided into three groups: mild, moderate and high, and after that the sheep received a single dose of ABZ of 5mg/kg per body weight, per orally. Sampling of faeces and blood for parasitological and haematological assaying respectively, was performed on the 0 and the 21st day after the treatment with ABZ. The presence of parasitic infection with S. papillosus leads to a decrease of erythrocyte count, while the lowest values were established in the group with the highest intensity of parasitic infection (p ˂ 0.001). After treatment with ABZ the decrease of erythrocyte count was more prominent, which was, based on comparison with control groups C1 and C2, unequivocally established to be the consequence of treatment with ABZ. Detected values of haematocrit and erythrocyte indices indicated the presence of parasitic infection: the lowest values were established in the group with the highest intensity of parasitic infection. After treatment with ABZ haematocrit levels in control group C2 were statistically significantly lower compared to the control group C1 (p ˂ 0.001). In the presence of parasitic infection, the neutrophil and eosinophil counts increased almost linearly up to the value of 44.24±2.50% and 13.29±0.61% respectively, in the group of sheep with the highest intensity of parasitic infection (p ˂ 0.001; compared to control group C1). After treatment with ABZ the decrease of the number of these white blood cells is statistically significant (p ˂ 0.001). Bearing in mind our previous research and the connection of disbalanced redox equilibrium after the treatment with ABZ with changes, it is necessary to include antioxidative substances in the anti-parasitic treatment protocols., Cilj ovog istraživanja bio je da se utvrde i procene osnovni hematološki parametri u uslovima prirodne infekcije ovaca sa Strongyloides papillosus, kao i nakon primene antihelmintika albendazola (ABZ). Na osnovu intenziteta infekcije sa S. papillosus ovce su podeljene u tri grupe: niski, srednji i visoki intenzitet infekcije, a zatim su ovce jednokratno dobile peroralno ABZ, u terapijskoj dozi od 5 mg/kg telesne mase. Uzorkovanje fecesa za parazitološka i za hematološka ispitivanja obavljeno je nultog i 21. dana od primene ABZ. Utvrđeno je da prisustvo parazitske infekcije sa S. papillosus dovodi do pada broja eritrocita, pri čemu su najniže vrednosti utvrđene u grupi sa najvećim intenzitetom parazitske infekcije (p ˂ 0,001). Nakon terapije sa ABZ pad broja eritrocita je izraženiji, što je nesumnjivo nastalo kao posledica terapije ABZ (na osnovu poređenja C1 i C2). Utvrđene vrednosti hematokrita i eritrocitnih indeksa su ukazivali na postojanje parazitske infekcije; najniže vrednosti su utvrđene kod grupe sa najvećim intenzitetom parazitske infekcije. Nakon terapije sa ABZ vrednosti hematokrita kod C2 bile su statistički značajno niže u odnosu na kontrolnu grupu C1 (p ˂ 0,001). U prisustvu parazitske infekcije broj neutrofila i eozinofila povećava se gotovo linearno, do vrednosti od 44,24±2,50% kod neutrofila, odnosno od 13,29±0,61% kod eozinofila u grupi ovaca sa najvećim intenzitetom parazitske infekcije (p ˂ 0,001). Nakon terapije sa ABZ broj ovih ćelija bele krvne loze smanjuje se statistički značajno (p ˂ 0,001). Imajući u vidu naša prethodna istraživanja i povezanost narušene redoks ravnoteže posle terapije sa ABZ sa promenama utvrđenim u ovom istraživanju, neophodno je u antiparazitske terapijske protokole uključiti antioksidativne supstance.",
publisher = "Institut za stočarstvo, Beograd",
journal = "Biotechnology in Animal Husbandry",
title = "Infection with Strongyloides papillosus in sheep: Effect of parasitic infection and treatment with albendazole on basic haematological parameters, Infekcija ovaca sa Strongyloides papillosus - uticaj intenziteta parazitske infekcije i terapije albendazolom na vrednosti osnovnih hematoloških parametara",
volume = "32",
number = "4",
pages = "369-381",
doi = "10.2298/bah1604369D"
}

Dimitrijević, B., Jović, S., Ostojić-Andrić, D., Savić, M., Becskei, Z., Davidović, V.,& Joksimović-Todorović, M.. (2016). Infection with Strongyloides papillosus in sheep: Effect of parasitic infection and treatment with albendazole on basic haematological parameters. in Biotechnology in Animal Husbandry
Institut za stočarstvo, Beograd., 32(4), 369-381.
https://doi.org/10.2298/bah1604369D

Dimitrijević B, Jović S, Ostojić-Andrić D, Savić M, Becskei Z, Davidović V, Joksimović-Todorović M. Infection with Strongyloides papillosus in sheep: Effect of parasitic infection and treatment with albendazole on basic haematological parameters. in Biotechnology in Animal Husbandry. 2016;32(4):369-381.
doi:10.2298/bah1604369D .

Dimitrijević, Blagoje, Jović, Slavoljub, Ostojić-Andrić, Dušica, Savić, Mila, Becskei, Zsolt, Davidović, Vesna, Joksimović-Todorović, Mirjana, "Infection with Strongyloides papillosus in sheep: Effect of parasitic infection and treatment with albendazole on basic haematological parameters" in Biotechnology in Animal Husbandry, 32, no. 4 (2016):369-381,
https://doi.org/10.2298/bah1604369D . .

TY  - JOUR
AU  - Davidović, Vesna
AU  - Lazarević, Miodrag
AU  - Joksimović-Todorović, Mirjana
AU  - Maksimović, Zoran
AU  - Jovanović, M.
PY  - 2010
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/660
AB  - The objective of this research was to study the effects that the extract of rhizome and root of Helleborus odorus W. et K. (Ranunculaceae) can have on modifications in the parameter values of white blood cells count and degree of phagocytosis by peritoneal macrophages and neutrophil granulocytes in Wistar rats. The trial was conducted on 28 rats divided into 4 groups with 7 animals in each group. To the control group of rats sterile physiological solution in the quantity of 0.25 mL/100 g BW was applied intramuscularly. For the purpose of monitoring the effect of the extract of rhizome and root of hellebore (HE) during a time period, the HE was applied intramuscularly to rats in a dose of 10 mg/100 g BW, while the blood samples for analysis were taken after 24h, 48h and 72h. The consequence of intramuscular application of HE was an increased count of total leukocytes in all trial groups, the most expressed leukocytosis being registered 24h after application of HE. Statistically significant higher value in the count and percent of neutrophil granulocytes in the blood was recorded 24h after treatment in relation to the control and two other trial groups (p lt 0.001), among which a statistical significance was not established. The extract of hellebore rhizome and root has led to lymphopenia, resulting in the increase of the neutrophil/limphocyte index in the trial groups 24h and 48h after treatment. The application of HE had no significant effect on the count of monocytes in treated animals. The applied extract has caused a significant increase in the degree of phagocytosis by residing peritoneal macrophages and neutrophil granulocytes in blood.
AB  - Cilj ovog rada je bio da se ispita uticaj ekstrakta rizoma i korena H. odorus W. et K. na promenu vrednosti parametara bele krvne slike i stepen fagocitoze od strane peritonealnih makrofaga i neutrofilnih granulocita kod pacova soja Wistar. Ogled je izveden na 28 pacova podeljenih u 4 grupe po 7 jedinki. Kontrolnoj grupi pacova je intramuskularno aplikovan sterilan fiziološki rastvor u količini od 0,25 ml/100 g TM. U cilju praćenja efekta ekstrakta rizoma i korena kukureka (EK) u toku vremena, pacovima je intramuskularno aplikovan EK u dozi od 10mg/100g TM, a krv za analizu je uzimana posle 24h, 48h i 72h. Intramuskularna aplikacija EK imala je za posledicu povećanje broja ukupnih leukocita u svim oglednim grupama, pri čemu je najizraženija leukocitoza registrovana 24h nakon aplikovanja EK. Statistički značajno veća vrednost broja i procenta neutrofilnih granulocita u krvi zabeležena je 24h posle tretmana u odnosu na kontrolnu i ostale dve ogledne grupe (p lt 0,001), između kojih nije utvrđena statistička značajnost. Ekstrakt rizoma i korena kukureka doveo je do nastanka limfopenije, što je imalo za posledicu povećanje neutrofilno/limfocitnog indeksa u oglednim grupama 24h i 48h nakon tretmana. Aplikacija EK nije značajno uticala na broj monocita kod tretiranih životinja. Upotrebljeni ekstrakt doveo je do značajnog povećanja stepena fagocitoze od strane rezidentnih peritonealnih makrofaga i neutrofilnih granulocita krvi.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta Veterinaria-Beograd
T1  - The effect of the extract of rhizome and root of hellebore (Helleborus odorus W. et K.) on parameters of white blood count and degree of phagocytosis in wistar rats
T1  - Uticaj ekstrakta rizoma i korena kukureka (Helleborus odorus W. et K.) na parametre bele krvne slike i stepen fagocitoze kod wistar pacova
VL  - 60
IS  - 5-6
SP  - 605
EP  - 618
DO  - 10.2298/AVB1006605D
ER  - 

@article{
author = "Davidović, Vesna and Lazarević, Miodrag and Joksimović-Todorović, Mirjana and Maksimović, Zoran and Jovanović, M.",
year = "2010",
abstract = "The objective of this research was to study the effects that the extract of rhizome and root of Helleborus odorus W. et K. (Ranunculaceae) can have on modifications in the parameter values of white blood cells count and degree of phagocytosis by peritoneal macrophages and neutrophil granulocytes in Wistar rats. The trial was conducted on 28 rats divided into 4 groups with 7 animals in each group. To the control group of rats sterile physiological solution in the quantity of 0.25 mL/100 g BW was applied intramuscularly. For the purpose of monitoring the effect of the extract of rhizome and root of hellebore (HE) during a time period, the HE was applied intramuscularly to rats in a dose of 10 mg/100 g BW, while the blood samples for analysis were taken after 24h, 48h and 72h. The consequence of intramuscular application of HE was an increased count of total leukocytes in all trial groups, the most expressed leukocytosis being registered 24h after application of HE. Statistically significant higher value in the count and percent of neutrophil granulocytes in the blood was recorded 24h after treatment in relation to the control and two other trial groups (p lt 0.001), among which a statistical significance was not established. The extract of hellebore rhizome and root has led to lymphopenia, resulting in the increase of the neutrophil/limphocyte index in the trial groups 24h and 48h after treatment. The application of HE had no significant effect on the count of monocytes in treated animals. The applied extract has caused a significant increase in the degree of phagocytosis by residing peritoneal macrophages and neutrophil granulocytes in blood., Cilj ovog rada je bio da se ispita uticaj ekstrakta rizoma i korena H. odorus W. et K. na promenu vrednosti parametara bele krvne slike i stepen fagocitoze od strane peritonealnih makrofaga i neutrofilnih granulocita kod pacova soja Wistar. Ogled je izveden na 28 pacova podeljenih u 4 grupe po 7 jedinki. Kontrolnoj grupi pacova je intramuskularno aplikovan sterilan fiziološki rastvor u količini od 0,25 ml/100 g TM. U cilju praćenja efekta ekstrakta rizoma i korena kukureka (EK) u toku vremena, pacovima je intramuskularno aplikovan EK u dozi od 10mg/100g TM, a krv za analizu je uzimana posle 24h, 48h i 72h. Intramuskularna aplikacija EK imala je za posledicu povećanje broja ukupnih leukocita u svim oglednim grupama, pri čemu je najizraženija leukocitoza registrovana 24h nakon aplikovanja EK. Statistički značajno veća vrednost broja i procenta neutrofilnih granulocita u krvi zabeležena je 24h posle tretmana u odnosu na kontrolnu i ostale dve ogledne grupe (p lt 0,001), između kojih nije utvrđena statistička značajnost. Ekstrakt rizoma i korena kukureka doveo je do nastanka limfopenije, što je imalo za posledicu povećanje neutrofilno/limfocitnog indeksa u oglednim grupama 24h i 48h nakon tretmana. Aplikacija EK nije značajno uticala na broj monocita kod tretiranih životinja. Upotrebljeni ekstrakt doveo je do značajnog povećanja stepena fagocitoze od strane rezidentnih peritonealnih makrofaga i neutrofilnih granulocita krvi.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta Veterinaria-Beograd",
title = "The effect of the extract of rhizome and root of hellebore (Helleborus odorus W. et K.) on parameters of white blood count and degree of phagocytosis in wistar rats, Uticaj ekstrakta rizoma i korena kukureka (Helleborus odorus W. et K.) na parametre bele krvne slike i stepen fagocitoze kod wistar pacova",
volume = "60",
number = "5-6",
pages = "605-618",
doi = "10.2298/AVB1006605D"
}

Davidović, V., Lazarević, M., Joksimović-Todorović, M., Maksimović, Z.,& Jovanović, M.. (2010). The effect of the extract of rhizome and root of hellebore (Helleborus odorus W. et K.) on parameters of white blood count and degree of phagocytosis in wistar rats. in Acta Veterinaria-Beograd
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 60(5-6), 605-618.
https://doi.org/10.2298/AVB1006605D

Davidović V, Lazarević M, Joksimović-Todorović M, Maksimović Z, Jovanović M. The effect of the extract of rhizome and root of hellebore (Helleborus odorus W. et K.) on parameters of white blood count and degree of phagocytosis in wistar rats. in Acta Veterinaria-Beograd. 2010;60(5-6):605-618.
doi:10.2298/AVB1006605D .

Davidović, Vesna, Lazarević, Miodrag, Joksimović-Todorović, Mirjana, Maksimović, Zoran, Jovanović, M., "The effect of the extract of rhizome and root of hellebore (Helleborus odorus W. et K.) on parameters of white blood count and degree of phagocytosis in wistar rats" in Acta Veterinaria-Beograd, 60, no. 5-6 (2010):605-618,
https://doi.org/10.2298/AVB1006605D . .

TY  - JOUR
AU  - Davidović, Vesna
AU  - Lazarević, Miodrag
AU  - Joksimović-Todorović, Mirjana
AU  - Maksimović, Zoran
AU  - Jovanović, Milan
AU  - Miljas, Niko
PY  - 2010
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/707
AB  - This paper presents the results of investigations of parameter values of the red blood cell count in Wistar rats, after intramuscular application of rhizome and root extract of Helleborus odorus W. et K (HE). The trial was conducted in experimental conditions on 49 Wistar rats divided into 7 groups with 7 animals per unit (control and six experimental groups). The control group was treated by an intramuscular injection of sterile saline (0.25 ml/100 g BM). For the purpose of determing the duration of the HE effects, the animals were injected with a dose of 10 mg/100 g BMand blood was collected by cardial taps after 24, 48 and 72 hrs. Moreover, we investigated the influence of elevated temperatures on the noted HE extract effects, 24 hrs after the application of the inactivated (56oC 30 min) or denaturized (100oC 5 min) extract, as well as the influence of dialyzed HE. The obtained results of haematological analyses have pointed out the weak hemolyses activity of the extract. In all experimental groups, the erythrocyte count was decreased, but remained within reference values. Haemoglobin concentration and haematocrit values in the experimental and the control groups of rats were decreased in comparison to the physiological values, while the applied extract did not significantly affect the examined parameters. .
AB  - U ovom radu su prikazani rezultati ispitivanja vrednosti parametara crvene krvne slike pacova soja Wistar, nakon intramuskularne aplikacije ekstrakta rizoma i korena Helleborus odorus W. et K. Ogled je izveden u eksperimentalnim uslovima na 49 pacova soja Wistar, podeljenih u 7 grupa sa po 7 jedinki (jedna kontrolna i šest oglednih grupa). Kontrolnoj grupi pacova je intramuskularno aplikovan fiziološki rastvor (0,25 ml/100 g t.m.). U cilju određivanja dužine trajanja efekata ekstrakta, pacovima je aplikovan tečni ekstrakt podzemnih organa kukureka u koncentraciji od 10 mg/100 g t.m., a krv je uzorkovana kardijalnom punkcijom nakon 24h, 48h i 72h. Ispitivan je i uticaj ekstrakta izlaganog povišenoj temperaturi na uočene efekte, 24h posle aplikacije inaktivisanog (56oC 30 min) ili denaturisanog ekstrakta (100oC 5 min), kao i efekat dijalizata ekstrakta. Dobijeni rezultati hematoloških analiza su ukazali na slabu hemolitičku aktivnost ekstrakta. Kod svih oglednih grupa, prosečan broj eritrocita bio je smanjen, ali se održao u granicama referentnih vrednosti. Zabeležene koncentracije hemoglobina i hematokrita u krvi pacova kontrolne i oglednih grupa bile su niže u odnosu na fiziološke vrednosti, pri čemu korišćeni ekstrakt nije značajno uticao na ispitivane parametre.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Veterinarski Glasnik
T1  - Influence of Helleborus odorus W. et K. underground parts extracts on red blood pictures of Wistar rats
T1  - Uticaj ekstrakta podzemnih organa Helleborus odorus w. et K. na crvenu krvnu sliku Wistar pacova
VL  - 64
IS  - 3-4
SP  - 219
EP  - 229
DO  - 10.2298/VETGL1004219D
ER  - 

@article{
author = "Davidović, Vesna and Lazarević, Miodrag and Joksimović-Todorović, Mirjana and Maksimović, Zoran and Jovanović, Milan and Miljas, Niko",
year = "2010",
abstract = "This paper presents the results of investigations of parameter values of the red blood cell count in Wistar rats, after intramuscular application of rhizome and root extract of Helleborus odorus W. et K (HE). The trial was conducted in experimental conditions on 49 Wistar rats divided into 7 groups with 7 animals per unit (control and six experimental groups). The control group was treated by an intramuscular injection of sterile saline (0.25 ml/100 g BM). For the purpose of determing the duration of the HE effects, the animals were injected with a dose of 10 mg/100 g BMand blood was collected by cardial taps after 24, 48 and 72 hrs. Moreover, we investigated the influence of elevated temperatures on the noted HE extract effects, 24 hrs after the application of the inactivated (56oC 30 min) or denaturized (100oC 5 min) extract, as well as the influence of dialyzed HE. The obtained results of haematological analyses have pointed out the weak hemolyses activity of the extract. In all experimental groups, the erythrocyte count was decreased, but remained within reference values. Haemoglobin concentration and haematocrit values in the experimental and the control groups of rats were decreased in comparison to the physiological values, while the applied extract did not significantly affect the examined parameters. ., U ovom radu su prikazani rezultati ispitivanja vrednosti parametara crvene krvne slike pacova soja Wistar, nakon intramuskularne aplikacije ekstrakta rizoma i korena Helleborus odorus W. et K. Ogled je izveden u eksperimentalnim uslovima na 49 pacova soja Wistar, podeljenih u 7 grupa sa po 7 jedinki (jedna kontrolna i šest oglednih grupa). Kontrolnoj grupi pacova je intramuskularno aplikovan fiziološki rastvor (0,25 ml/100 g t.m.). U cilju određivanja dužine trajanja efekata ekstrakta, pacovima je aplikovan tečni ekstrakt podzemnih organa kukureka u koncentraciji od 10 mg/100 g t.m., a krv je uzorkovana kardijalnom punkcijom nakon 24h, 48h i 72h. Ispitivan je i uticaj ekstrakta izlaganog povišenoj temperaturi na uočene efekte, 24h posle aplikacije inaktivisanog (56oC 30 min) ili denaturisanog ekstrakta (100oC 5 min), kao i efekat dijalizata ekstrakta. Dobijeni rezultati hematoloških analiza su ukazali na slabu hemolitičku aktivnost ekstrakta. Kod svih oglednih grupa, prosečan broj eritrocita bio je smanjen, ali se održao u granicama referentnih vrednosti. Zabeležene koncentracije hemoglobina i hematokrita u krvi pacova kontrolne i oglednih grupa bile su niže u odnosu na fiziološke vrednosti, pri čemu korišćeni ekstrakt nije značajno uticao na ispitivane parametre.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Veterinarski Glasnik",
title = "Influence of Helleborus odorus W. et K. underground parts extracts on red blood pictures of Wistar rats, Uticaj ekstrakta podzemnih organa Helleborus odorus w. et K. na crvenu krvnu sliku Wistar pacova",
volume = "64",
number = "3-4",
pages = "219-229",
doi = "10.2298/VETGL1004219D"
}

Davidović, V., Lazarević, M., Joksimović-Todorović, M., Maksimović, Z., Jovanović, M.,& Miljas, N.. (2010). Influence of Helleborus odorus W. et K. underground parts extracts on red blood pictures of Wistar rats. in Veterinarski Glasnik
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 64(3-4), 219-229.
https://doi.org/10.2298/VETGL1004219D

Davidović V, Lazarević M, Joksimović-Todorović M, Maksimović Z, Jovanović M, Miljas N. Influence of Helleborus odorus W. et K. underground parts extracts on red blood pictures of Wistar rats. in Veterinarski Glasnik. 2010;64(3-4):219-229.
doi:10.2298/VETGL1004219D .

Davidović, Vesna, Lazarević, Miodrag, Joksimović-Todorović, Mirjana, Maksimović, Zoran, Jovanović, Milan, Miljas, Niko, "Influence of Helleborus odorus W. et K. underground parts extracts on red blood pictures of Wistar rats" in Veterinarski Glasnik, 64, no. 3-4 (2010):219-229,
https://doi.org/10.2298/VETGL1004219D . .

TY  - JOUR
AU  - Davidović, Vesna
AU  - Lazarević, Miodrag
AU  - Joksimović-Todorović, Mirjana
AU  - Maksimović, Zoran
AU  - Jovanović, Milan
PY  - 2008
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/565
AB  - In the prevention and treatment of milder forms of diseases, chronic diseases and recurrent infections in farm animals the application of individual or combined medicinal herb preparations has long been used. The application of some herbal preparations can initiate the function of the effectors defensive cells and potentiate their defensive capacities. On the other hand, some immuno-suppresive phytopreparations are used in order to reduce or prevent undesired activities of immune system (allergic reactions and autoimmune disease). By the regulations of the European Union from 2006 the use of antibiotics as growth stimulators in livestock production was forbidden so aromatic herbs and their extracts have recently been more and more used for that purposes. .
AB  - U prevenciji i lečenju blažih oblika bolesti, bolesti hroničnog toka i rekurentnih infekcija domaćih životinja, već dugo se primenjuju pojedinačna ili kombinovana biljna lekovita sredstva. Primena pojedinih biljnih preparata podstiče funkcije efektorskih odbrambenih ćelija organizma i potencira njegove odbrambene sposobnosti. Sa druge strane, neki imunosupresivni fitopreparati se upotrebljavaju u cilju smanjenja ili sprečavanja neželjenih aktivnosti imunog sistema (alergijskih reakcija i autoimunih bolesti). Propisima Evropske Unije zabranjena je od 2006. godine upotreba antibiotika kao stimulatora rasta u stočarskoj proizvodnji, pa se poslednjih godina u te svrhe sve više koriste aromatične biljke i njihovi ekstrakti. .
PB  - Institut za proučavanje lekovitog bilja Dr Josif Pančić, Beograd
T2  - Lekovite sirovine
T1  - The application of Helleborus L. and other herbs in prophylaxis and therapy in animal diseases
T1  - Primena Helleborus L. i drugog bilja u profilaksi i terapiji bolesti životinja
IS  - 28
SP  - 63
EP  - 69
UR  - https://hdl.handle.net/21.15107/rcub_agrospace_1646
ER  - 

@article{
author = "Davidović, Vesna and Lazarević, Miodrag and Joksimović-Todorović, Mirjana and Maksimović, Zoran and Jovanović, Milan",
year = "2008",
abstract = "In the prevention and treatment of milder forms of diseases, chronic diseases and recurrent infections in farm animals the application of individual or combined medicinal herb preparations has long been used. The application of some herbal preparations can initiate the function of the effectors defensive cells and potentiate their defensive capacities. On the other hand, some immuno-suppresive phytopreparations are used in order to reduce or prevent undesired activities of immune system (allergic reactions and autoimmune disease). By the regulations of the European Union from 2006 the use of antibiotics as growth stimulators in livestock production was forbidden so aromatic herbs and their extracts have recently been more and more used for that purposes. ., U prevenciji i lečenju blažih oblika bolesti, bolesti hroničnog toka i rekurentnih infekcija domaćih životinja, već dugo se primenjuju pojedinačna ili kombinovana biljna lekovita sredstva. Primena pojedinih biljnih preparata podstiče funkcije efektorskih odbrambenih ćelija organizma i potencira njegove odbrambene sposobnosti. Sa druge strane, neki imunosupresivni fitopreparati se upotrebljavaju u cilju smanjenja ili sprečavanja neželjenih aktivnosti imunog sistema (alergijskih reakcija i autoimunih bolesti). Propisima Evropske Unije zabranjena je od 2006. godine upotreba antibiotika kao stimulatora rasta u stočarskoj proizvodnji, pa se poslednjih godina u te svrhe sve više koriste aromatične biljke i njihovi ekstrakti. .",
publisher = "Institut za proučavanje lekovitog bilja Dr Josif Pančić, Beograd",
journal = "Lekovite sirovine",
title = "The application of Helleborus L. and other herbs in prophylaxis and therapy in animal diseases, Primena Helleborus L. i drugog bilja u profilaksi i terapiji bolesti životinja",
number = "28",
pages = "63-69",
url = "https://hdl.handle.net/21.15107/rcub_agrospace_1646"
}

Davidović, V., Lazarević, M., Joksimović-Todorović, M., Maksimović, Z.,& Jovanović, M.. (2008). The application of Helleborus L. and other herbs in prophylaxis and therapy in animal diseases. in Lekovite sirovine
Institut za proučavanje lekovitog bilja Dr Josif Pančić, Beograd.(28), 63-69.
https://hdl.handle.net/21.15107/rcub_agrospace_1646

Davidović V, Lazarević M, Joksimović-Todorović M, Maksimović Z, Jovanović M. The application of Helleborus L. and other herbs in prophylaxis and therapy in animal diseases. in Lekovite sirovine. 2008;(28):63-69.
https://hdl.handle.net/21.15107/rcub_agrospace_1646 .

Davidović, Vesna, Lazarević, Miodrag, Joksimović-Todorović, Mirjana, Maksimović, Zoran, Jovanović, Milan, "The application of Helleborus L. and other herbs in prophylaxis and therapy in animal diseases" in Lekovite sirovine, no. 28 (2008):63-69,
https://hdl.handle.net/21.15107/rcub_agrospace_1646 .

TY  - JOUR
AU  - Joksimović-Todorović, Mirjana
AU  - Davidović, Vesna
AU  - Hristov, Slavča
AU  - Stanković, Branislav
AU  - Bojkovski, Jovan
PY  - 2007
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/439
AB  - This review paper shows data from published articles concerning to the affect of selenium for maintenance of the health, productive and reproductive characteristics of cow. Just in recent years the prominent progress is achieved in providing the adequate levels and sources of Se. It is highlighted the advantages of organic Se in relation to inorganic form specially with dairy cows because better bioavailability, higher concentration in milk and in plasma of the newborn calf. Selenium is essential nutrient, because its supplementation in the adequate amounts in case of deficiency results in immunological answer. .
AB  - U ovom preglednom radu sagledani su literaturni podaci o značaju selena za očuvanje zdravlja, proizvodne i reproduktivne karakteristike goveda. Poslednjih godina vidan napredak je ostvaren u obezbeđenju adekvatnih nivoa i oblika ovog mikronutricijenta. Prikazane su prednosti organskog selena u odnosu na neorgansku formu, posebno kod mlečnih krava, zbog bolje biološke iskoristivosti, veće koncentracije u mleku i u plazmi novorođene teladi. Selen je esencijalni nutricijent, jer njegovo dodavanje u odgovarajućim količinama kod deficita rezultira i u poboljšanju imunološkog odgovora. .
PB  - Institut PKB Agroekonomik, Padinska skela
T2  - Zbornik naučnih radova Instituta PKB Agroekonomik
T1  - Selenium deficiency in dairy cows
T1  - Deficit selena kod mlečnih krava
VL  - 13
IS  - 3-4
SP  - 41
EP  - 46
UR  - https://hdl.handle.net/21.15107/rcub_agrospace_1520
ER  - 

@article{
author = "Joksimović-Todorović, Mirjana and Davidović, Vesna and Hristov, Slavča and Stanković, Branislav and Bojkovski, Jovan",
year = "2007",
abstract = "This review paper shows data from published articles concerning to the affect of selenium for maintenance of the health, productive and reproductive characteristics of cow. Just in recent years the prominent progress is achieved in providing the adequate levels and sources of Se. It is highlighted the advantages of organic Se in relation to inorganic form specially with dairy cows because better bioavailability, higher concentration in milk and in plasma of the newborn calf. Selenium is essential nutrient, because its supplementation in the adequate amounts in case of deficiency results in immunological answer. ., U ovom preglednom radu sagledani su literaturni podaci o značaju selena za očuvanje zdravlja, proizvodne i reproduktivne karakteristike goveda. Poslednjih godina vidan napredak je ostvaren u obezbeđenju adekvatnih nivoa i oblika ovog mikronutricijenta. Prikazane su prednosti organskog selena u odnosu na neorgansku formu, posebno kod mlečnih krava, zbog bolje biološke iskoristivosti, veće koncentracije u mleku i u plazmi novorođene teladi. Selen je esencijalni nutricijent, jer njegovo dodavanje u odgovarajućim količinama kod deficita rezultira i u poboljšanju imunološkog odgovora. .",
publisher = "Institut PKB Agroekonomik, Padinska skela",
journal = "Zbornik naučnih radova Instituta PKB Agroekonomik",
title = "Selenium deficiency in dairy cows, Deficit selena kod mlečnih krava",
volume = "13",
number = "3-4",
pages = "41-46",
url = "https://hdl.handle.net/21.15107/rcub_agrospace_1520"
}

Joksimović-Todorović, M., Davidović, V., Hristov, S., Stanković, B.,& Bojkovski, J.. (2007). Selenium deficiency in dairy cows. in Zbornik naučnih radova Instituta PKB Agroekonomik
Institut PKB Agroekonomik, Padinska skela., 13(3-4), 41-46.
https://hdl.handle.net/21.15107/rcub_agrospace_1520

Joksimović-Todorović M, Davidović V, Hristov S, Stanković B, Bojkovski J. Selenium deficiency in dairy cows. in Zbornik naučnih radova Instituta PKB Agroekonomik. 2007;13(3-4):41-46.
https://hdl.handle.net/21.15107/rcub_agrospace_1520 .

Joksimović-Todorović, Mirjana, Davidović, Vesna, Hristov, Slavča, Stanković, Branislav, Bojkovski, Jovan, "Selenium deficiency in dairy cows" in Zbornik naučnih radova Instituta PKB Agroekonomik, 13, no. 3-4 (2007):41-46,
https://hdl.handle.net/21.15107/rcub_agrospace_1520 .

TY  - JOUR
AU  - Hristov, Slavča
AU  - Stanković, Bojan
AU  - Joksimović-Todorović, Mirjana
AU  - Bojkovski, Jovan
AU  - Davidović, Vesna
PY  - 2007
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/486
AB  - During the hottest summer months in our country, conditions for thermal stress development in cows are present, especially when values of temperature and air humidity increase simultaneously. When temperature rises, cow organism becomes less efficient, due to primary non-evaporative patterns of heat release (radiation, conduction, convection), relying mostly on evaporative cooling through sweating and gasping. High relative humidity impedes evaporative cooling, so cows do not use enough body heat to prevent body temperature increase during hot and humid conditions, which are very common during summers in Serbia. Increase of ambient temperature, temperature-humidity index and rectal temperature of the cows above critical values are accompanied by decrease of dry matter intake and milk production, making dairy production less remunerative. Modifications which include shade, increase of passive ventilation and additional usage of fans and sprinklers in stables increase body heat release, decrease body temperature and support dry matter intake. New technologies, which include tunnel system of ventilation, were studied in order to evaluate cooling efficiency. Selection of cows for heat tolerance is possible, and it must be emphasized that continual selection for productive traits improvement and neglect of heat tolerance leads to increased sensitivity to heat stress. Nutritive needs of dairy cows change during heat stress demanding modifications of meal composition in order to decrease dry matter content, increase of its nutritive value, to prevent nutritive oversteps and to maintain normal function of rumen. In the future, maintenance of dairy production during hot and humid climate conditions will demand improvement of possibility of cooling, continuous improvement of meal composition, as well as genetic advances which include selection for heat tolerance and identification of genetic traits responsible for heat tolerance. .
AB  - U našoj zemlji, u toku najtoplijih letnjih meseci, postoje uslovi za razvoj termalnog stresa kod krava, naročito kod istovremenog povećanja temperature i relativne vlažnosti. Zbog primarnih neevaporativnih načina odavanja toplote (radijacija, kondukcija, konvekcija), organizam krava postaje manje efikasan sa povećanjem ambijentne temperature i oslanja se u znatnoj meri na evaporativno rashlađivanje u obliku znojenja i dahtanja. Visoka relativna vlažnost ometa evaporativno rashlađivanje, tako da za vreme toplih i vlažnih uslova, čestih u Srbiji u letnjem periodu, mlečne krave ne troše telesnu toplotu u dovoljnoj meri, da bi se sprečilo podizanje telesne temperature. Povećanje temperature sredine, indeksa temperature i vlažnosti i rektalne temperature krava iznad kritičnih granica prati smanjenje unošenja suve materije i proizvodnje mleka, čime se smanjuje rentabilnost u proizvodnji mleka. Modifikacije koje uključuju hladovinu, povećanje intenziteta prirodne ventilacije i dopunsko korišćenje mehaničkih ventilatora i prskalica u stajama povećavaju odavanje telesne toplote, snižavaju telesnu temperaturu i pospešuju unošenje suve materije. Nove tehnologije koje uključuju tunelski sistem ventilaticije su proučavane radi procene efikasnosti rashlađivanja. Selekcija krava na toplotnu toleranciju je moguća, ali treba imati u vidu da kontinuirana selekcija na poboljšanje proizvodnih osobina, zbog zanemarivanja toplotne tolerancije, dovodi do porasta osetljivosti na toplotni stres. Nutritivne potrebe krava se menjaju tokom toplotnog stresa zbog čega su potrebne izmene u sastavu obroka u pravcu smanjenja unošenja suve materije, povećanja hranljive vrednosti obroka, sprečavanja nutritivnih prekoračenja i održavanja normalne funkcije rumena. Održanje proizvodnje krava u toku toplih i vlažnih klimatskih uslova zahtevaće u budućnosti unapređenje mogućnosti rashlađenja, kontinuirani napredak u sastavljanju obroka, kao i genetska poboljšanja koja uključuju selekciju na toplotnu toleranciju i identifikaciju genetskih osobina koje povećavaju toplotnu toleranciju. .
PB  - Institut PKB Agroekonomik, Padinska skela
T2  - Zbornik naučnih radova Instituta PKB Agroekonomik
T1  - Influence of heat stress on dairy cows production
T1  - Uticaj toplotnog stresa na proizvodnju mlečnih krava
VL  - 13
IS  - 3-4
SP  - 47
EP  - 54
UR  - https://hdl.handle.net/21.15107/rcub_agrospace_1519
ER  - 

@article{
author = "Hristov, Slavča and Stanković, Bojan and Joksimović-Todorović, Mirjana and Bojkovski, Jovan and Davidović, Vesna",
year = "2007",
abstract = "During the hottest summer months in our country, conditions for thermal stress development in cows are present, especially when values of temperature and air humidity increase simultaneously. When temperature rises, cow organism becomes less efficient, due to primary non-evaporative patterns of heat release (radiation, conduction, convection), relying mostly on evaporative cooling through sweating and gasping. High relative humidity impedes evaporative cooling, so cows do not use enough body heat to prevent body temperature increase during hot and humid conditions, which are very common during summers in Serbia. Increase of ambient temperature, temperature-humidity index and rectal temperature of the cows above critical values are accompanied by decrease of dry matter intake and milk production, making dairy production less remunerative. Modifications which include shade, increase of passive ventilation and additional usage of fans and sprinklers in stables increase body heat release, decrease body temperature and support dry matter intake. New technologies, which include tunnel system of ventilation, were studied in order to evaluate cooling efficiency. Selection of cows for heat tolerance is possible, and it must be emphasized that continual selection for productive traits improvement and neglect of heat tolerance leads to increased sensitivity to heat stress. Nutritive needs of dairy cows change during heat stress demanding modifications of meal composition in order to decrease dry matter content, increase of its nutritive value, to prevent nutritive oversteps and to maintain normal function of rumen. In the future, maintenance of dairy production during hot and humid climate conditions will demand improvement of possibility of cooling, continuous improvement of meal composition, as well as genetic advances which include selection for heat tolerance and identification of genetic traits responsible for heat tolerance. ., U našoj zemlji, u toku najtoplijih letnjih meseci, postoje uslovi za razvoj termalnog stresa kod krava, naročito kod istovremenog povećanja temperature i relativne vlažnosti. Zbog primarnih neevaporativnih načina odavanja toplote (radijacija, kondukcija, konvekcija), organizam krava postaje manje efikasan sa povećanjem ambijentne temperature i oslanja se u znatnoj meri na evaporativno rashlađivanje u obliku znojenja i dahtanja. Visoka relativna vlažnost ometa evaporativno rashlađivanje, tako da za vreme toplih i vlažnih uslova, čestih u Srbiji u letnjem periodu, mlečne krave ne troše telesnu toplotu u dovoljnoj meri, da bi se sprečilo podizanje telesne temperature. Povećanje temperature sredine, indeksa temperature i vlažnosti i rektalne temperature krava iznad kritičnih granica prati smanjenje unošenja suve materije i proizvodnje mleka, čime se smanjuje rentabilnost u proizvodnji mleka. Modifikacije koje uključuju hladovinu, povećanje intenziteta prirodne ventilacije i dopunsko korišćenje mehaničkih ventilatora i prskalica u stajama povećavaju odavanje telesne toplote, snižavaju telesnu temperaturu i pospešuju unošenje suve materije. Nove tehnologije koje uključuju tunelski sistem ventilaticije su proučavane radi procene efikasnosti rashlađivanja. Selekcija krava na toplotnu toleranciju je moguća, ali treba imati u vidu da kontinuirana selekcija na poboljšanje proizvodnih osobina, zbog zanemarivanja toplotne tolerancije, dovodi do porasta osetljivosti na toplotni stres. Nutritivne potrebe krava se menjaju tokom toplotnog stresa zbog čega su potrebne izmene u sastavu obroka u pravcu smanjenja unošenja suve materije, povećanja hranljive vrednosti obroka, sprečavanja nutritivnih prekoračenja i održavanja normalne funkcije rumena. Održanje proizvodnje krava u toku toplih i vlažnih klimatskih uslova zahtevaće u budućnosti unapređenje mogućnosti rashlađenja, kontinuirani napredak u sastavljanju obroka, kao i genetska poboljšanja koja uključuju selekciju na toplotnu toleranciju i identifikaciju genetskih osobina koje povećavaju toplotnu toleranciju. .",
publisher = "Institut PKB Agroekonomik, Padinska skela",
journal = "Zbornik naučnih radova Instituta PKB Agroekonomik",
title = "Influence of heat stress on dairy cows production, Uticaj toplotnog stresa na proizvodnju mlečnih krava",
volume = "13",
number = "3-4",
pages = "47-54",
url = "https://hdl.handle.net/21.15107/rcub_agrospace_1519"
}

Hristov, S., Stanković, B., Joksimović-Todorović, M., Bojkovski, J.,& Davidović, V.. (2007). Influence of heat stress on dairy cows production. in Zbornik naučnih radova Instituta PKB Agroekonomik
Institut PKB Agroekonomik, Padinska skela., 13(3-4), 47-54.
https://hdl.handle.net/21.15107/rcub_agrospace_1519

Hristov S, Stanković B, Joksimović-Todorović M, Bojkovski J, Davidović V. Influence of heat stress on dairy cows production. in Zbornik naučnih radova Instituta PKB Agroekonomik. 2007;13(3-4):47-54.
https://hdl.handle.net/21.15107/rcub_agrospace_1519 .

Hristov, Slavča, Stanković, Bojan, Joksimović-Todorović, Mirjana, Bojkovski, Jovan, Davidović, Vesna, "Influence of heat stress on dairy cows production" in Zbornik naučnih radova Instituta PKB Agroekonomik, 13, no. 3-4 (2007):47-54,
https://hdl.handle.net/21.15107/rcub_agrospace_1519 .