TY  - JOUR
AU  - Kureljušić, Branislav
AU  - Maksimović, Slobodan
AU  - Vujinović, Slobodan
AU  - Savić, Božidar
AU  - Milićević, Vesna
AU  - Veljović, Ljubiša
AU  - Jezdimirović, Nemanja
AU  - Žutić, Jadranka
PY  - 2019
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1901
AB  - U ovom radu prikazan je slučaj krave simentalske rase, starosti dve godine i šest meseci kod koje je postojala sumnja na nodularni dermatitis, sredinom 2017 godine. Kliničkim pregledom ustanovljeni su brojni noduli veličine od nekoliko milimetara do približno 10 centimetara diseminovani dominantno po koži vimena i perineuma, od kojih su neki konfluirali i egzulcerisali. Opšte stanje krave je bilo nepromenjeno. Krava je prema rezultatima laboratorijskih analiza bila negativna na prisustvo antitela protiv virusa leukoze goveda, pokazala je negativnu reakciju pri tuberkulinizaciji i bila je vakcinisana protiv nodularnog dermatitisa. Nakon hirurške ekscizije kožnog čvora, uzorak je bio negativan na prisustvo genoma virusa nodularnog dermatitisa. Kako bismo ustanovili morfologiju kožne lezije, urađena je histopatološka analiza. Histopatološka analiza je pokazala infiltraciju dermisa i subkutisa brojnim mononukleranim ćelijama koje pokazuju ćelijsku atipiju. Tada je postavljena sumnja da se radi o kutanom limfomu. Nadalje, imunohistohemijsko ispitivanje je potvrdilo da se u infiltratu nalaze isključivo CD3 imunopozitivne ćelije što sugeriše da se radi o T-ćelijskom neepiteliotropnom limfomu
AB  - In this paper the case of a 2.5-year-old Simmental cow, with suspicion of lumpy skin disease in mid-2017 in Serbia will be presented. Clinical examination revealed numerous nodules of varied size from a few millimeters to approximately 10 centimeters disseminated predominantly on the skin of the udder and the perineum, some of which were coalescing and exulcerated. The general condition of the affected animal was unchanged. According to the results of laboratory analysis, the cow was negative for the presence of antibodies against the bovine leukemia virus, showed a negative reaction in tuberculinization and was vaccinated against lumpy skin disease virus. After the surgical excision of one skin node, the sample tested negative for the genome of lumpy skin disease virus. In order to establish the morphology of the skin lesion, a histopathological analysis was performed. Histopathological analysis showed the infiltration of the corium and subcutaneous tissue by numerous mononuclear cells showing cellular atypia. Suspicion of cutaneous lymphoma was established. Furthermore, the immunohistochemical examination confirmed that the infiltrate contained exclusively CD3-immunopositive cells, suggesting a T-cell origin nonepitheliotropic lymphoma.
PB  - FVM
T2  - Veterinarski Glasnik
T1  - Cutaneous lymphoma in a cow - a case report
T1  - Kutani limfom kod krave – prikaz slučaja
VL  - 73
IS  - 1
SP  - 50
EP  - 56
DO  - 10.2298/VETGL180904004K
ER  - 

@article{
author = "Kureljušić, Branislav and Maksimović, Slobodan and Vujinović, Slobodan and Savić, Božidar and Milićević, Vesna and Veljović, Ljubiša and Jezdimirović, Nemanja and Žutić, Jadranka",
year = "2019",
abstract = "U ovom radu prikazan je slučaj krave simentalske rase, starosti dve godine i šest meseci kod koje je postojala sumnja na nodularni dermatitis, sredinom 2017 godine. Kliničkim pregledom ustanovljeni su brojni noduli veličine od nekoliko milimetara do približno 10 centimetara diseminovani dominantno po koži vimena i perineuma, od kojih su neki konfluirali i egzulcerisali. Opšte stanje krave je bilo nepromenjeno. Krava je prema rezultatima laboratorijskih analiza bila negativna na prisustvo antitela protiv virusa leukoze goveda, pokazala je negativnu reakciju pri tuberkulinizaciji i bila je vakcinisana protiv nodularnog dermatitisa. Nakon hirurške ekscizije kožnog čvora, uzorak je bio negativan na prisustvo genoma virusa nodularnog dermatitisa. Kako bismo ustanovili morfologiju kožne lezije, urađena je histopatološka analiza. Histopatološka analiza je pokazala infiltraciju dermisa i subkutisa brojnim mononukleranim ćelijama koje pokazuju ćelijsku atipiju. Tada je postavljena sumnja da se radi o kutanom limfomu. Nadalje, imunohistohemijsko ispitivanje je potvrdilo da se u infiltratu nalaze isključivo CD3 imunopozitivne ćelije što sugeriše da se radi o T-ćelijskom neepiteliotropnom limfomu, In this paper the case of a 2.5-year-old Simmental cow, with suspicion of lumpy skin disease in mid-2017 in Serbia will be presented. Clinical examination revealed numerous nodules of varied size from a few millimeters to approximately 10 centimeters disseminated predominantly on the skin of the udder and the perineum, some of which were coalescing and exulcerated. The general condition of the affected animal was unchanged. According to the results of laboratory analysis, the cow was negative for the presence of antibodies against the bovine leukemia virus, showed a negative reaction in tuberculinization and was vaccinated against lumpy skin disease virus. After the surgical excision of one skin node, the sample tested negative for the genome of lumpy skin disease virus. In order to establish the morphology of the skin lesion, a histopathological analysis was performed. Histopathological analysis showed the infiltration of the corium and subcutaneous tissue by numerous mononuclear cells showing cellular atypia. Suspicion of cutaneous lymphoma was established. Furthermore, the immunohistochemical examination confirmed that the infiltrate contained exclusively CD3-immunopositive cells, suggesting a T-cell origin nonepitheliotropic lymphoma.",
publisher = "FVM",
journal = "Veterinarski Glasnik",
title = "Cutaneous lymphoma in a cow - a case report, Kutani limfom kod krave – prikaz slučaja",
volume = "73",
number = "1",
pages = "50-56",
doi = "10.2298/VETGL180904004K"
}

Kureljušić, B., Maksimović, S., Vujinović, S., Savić, B., Milićević, V., Veljović, L., Jezdimirović, N.,& Žutić, J.. (2019). Cutaneous lymphoma in a cow - a case report. in Veterinarski Glasnik
FVM., 73(1), 50-56.
https://doi.org/10.2298/VETGL180904004K

Kureljušić B, Maksimović S, Vujinović S, Savić B, Milićević V, Veljović L, Jezdimirović N, Žutić J. Cutaneous lymphoma in a cow - a case report. in Veterinarski Glasnik. 2019;73(1):50-56.
doi:10.2298/VETGL180904004K .

Kureljušić, Branislav, Maksimović, Slobodan, Vujinović, Slobodan, Savić, Božidar, Milićević, Vesna, Veljović, Ljubiša, Jezdimirović, Nemanja, Žutić, Jadranka, "Cutaneous lymphoma in a cow - a case report" in Veterinarski Glasnik, 73, no. 1 (2019):50-56,
https://doi.org/10.2298/VETGL180904004K . .

TY  - JOUR
AU  - Jezdimirović, Nemanja
AU  - Kureljušić, Branislav
AU  - Ivetić, Vojin
AU  - Kureljušić, Jasna
AU  - Cvetojević, Đ.
AU  - Maslić-Strižak, Danka
AU  - Radanović, O.
AU  - Jezdimirović, Milanka
PY  - 2014
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1921
AB  - Ispitivanja su imala za cilj da se utvrdi uticaj Clostridium perfringens tip A na razvoj patomorfološkog supstrata, njegov intenzitet i distribuciju kod teških roditelja uzrasta petnaest nedelja. Ispitivanje je obavljeno na leševima 8 koka i 7 petlova teških roditelja provenijencije COBB 500. Posle izvršene obdukcije, za histopatološko ispitivanje uzeti su uzorci promenjenih delova jejunuma i jetre, a za bakteriološko i molekularno ispitivanje crevni sadržaj jejunuma.  Kod svih leševa u otvorenoj pleuroperitonealnoj šupljini, već in situ, uočava se promenjeni deo jejunuma. On je bio izrazito dilatiran celom dužinom, a njegov zid plavičasto-sive boje sa diseminiranim subseroznim punktiformnim krvnim ekstravazatima. Njegovim otvaranjem iz lumena je izlazio polutečni sadržaj u kojem plivaju krvni koagulumi i krpičasti delovi nekrotične mukoze. Mikroskopskim pregledom isečaka tkiva tankih creva bojenih HE metodom zapažena je difuzna nekroza crevnih resica. One su destruisane i zamenjene eozinofilnom bestrukturnom masom. Pored toga, uočava se edem submukoze, kongestija kapilara i krvni ekstravazati u mukozi, kao i infiltracija neutrofilnih granulocita u lamini propriji. Navedene mikroskopske alteracije oslikavaju hemoragično-nekrotični enteritis. Mikroskopskim pregledom isečka tankih creva bojenih Brown & Brenn metodom ustanovljene su kolonije bakterija u distalnim delovima submukoze.  Bakteriološkim ispitivanjem u anaerobnim uslovima, izolovana kultura je identifikovana kao Clostridium perfringens. Primenom multiplex PCR dobijeni izolat je genotipiziran kao Clostridium perfringens tip A. Na osnovu patomorfoloških, bakterioloških i molekularnih ispitivanja može da se zaključi da infekcija teških roditelja Clostridium perfringens tipa A protiče sa slikom difuznog hemoragično-nekrotičnog jejunitisa, da uzročnik duboko penetrira u tkivo jejunuma i da su pšenica i pšenične mekinje činili favorizujući faktor za proliferaciju etiološkog agensa.
AB  - The aim of the investigation was to determine the influence of Clostridium perfringens type A on the development of pathomorphological substrate, its intensity and distribution in fifteen weeks old heavy breeds broilers. The investigation was carried out on corpses of 8 hens and 7 roosters of heavy breeds of provenance COBB 500. After the completion of the autopsy, samples of altered parts of jejunum and liver were taken for histopathological examination, and jejunum intestinal contents for bacteriological examination. In all the corpses, in open pleuroperitoneal cavity, even in situ, an altered part of jejunum can be noticed. It was extremely dilated the entire length, and its wall was bluish-gray with disseminated subserous punctiform blood extravasates. When opened, semi-liquid content with blood coagulums and patches of necrotic mucosa went out of it. By microscopic examination of small intestine tissue cuttings, colored by HE method, there was observed a diffuse necrosis of intestinal villi. They were desroyed and replaced by eosinophilic structureless mass. Furthermore, there could be noticed submucose oedema, capillary congestion and blood extravasates in mucosa, as well as infiltration of neutrophilic granulocytes in lamina propria. These microscopic alterations reflect hemorrhagic necrotic enteritis. By microscopic examining of small intestine cuttings colored according to Brown & Brenn method, colonies of bacteria in distal parts of the submucosa were found out.  Using bacteriological tests in anaerobic conditions, there was isolated a culture identified as Clostridium perfringens. After applying of multiplex PCR, the obtained isolate was genotyped as Clostridium perfringens type A.  On the basis of pathomorphological, bacteriological and molecular examinations, it can be concluded that the infection of heavy breeds with Clostridium perfringens type A is manifested by appearance of haemorrhagic-necrotic jejunitis, that the causer penetrates deeply into jejunum tissue and that wheat and wheat bran were a favoring factor for proliferation of the etiological agent.
PB  - Fakultet veterinarske medicine, Beograd, Srbija
T2  - Veterinarski Glasnik
T1  - Haemorrhagic-necrotic enteritis in heavy breeds broilers
T1  - Hemoragično-nekrotični enteritis kod roditelja brojlera
VL  - 68
IS  - 3-4
SP  - 265
EP  - 273
DO  - 10.2298/VETGL1404265J
ER  - 

@article{
author = "Jezdimirović, Nemanja and Kureljušić, Branislav and Ivetić, Vojin and Kureljušić, Jasna and Cvetojević, Đ. and Maslić-Strižak, Danka and Radanović, O. and Jezdimirović, Milanka",
year = "2014",
abstract = "Ispitivanja su imala za cilj da se utvrdi uticaj Clostridium perfringens tip A na razvoj patomorfološkog supstrata, njegov intenzitet i distribuciju kod teških roditelja uzrasta petnaest nedelja. Ispitivanje je obavljeno na leševima 8 koka i 7 petlova teških roditelja provenijencije COBB 500. Posle izvršene obdukcije, za histopatološko ispitivanje uzeti su uzorci promenjenih delova jejunuma i jetre, a za bakteriološko i molekularno ispitivanje crevni sadržaj jejunuma.  Kod svih leševa u otvorenoj pleuroperitonealnoj šupljini, već in situ, uočava se promenjeni deo jejunuma. On je bio izrazito dilatiran celom dužinom, a njegov zid plavičasto-sive boje sa diseminiranim subseroznim punktiformnim krvnim ekstravazatima. Njegovim otvaranjem iz lumena je izlazio polutečni sadržaj u kojem plivaju krvni koagulumi i krpičasti delovi nekrotične mukoze. Mikroskopskim pregledom isečaka tkiva tankih creva bojenih HE metodom zapažena je difuzna nekroza crevnih resica. One su destruisane i zamenjene eozinofilnom bestrukturnom masom. Pored toga, uočava se edem submukoze, kongestija kapilara i krvni ekstravazati u mukozi, kao i infiltracija neutrofilnih granulocita u lamini propriji. Navedene mikroskopske alteracije oslikavaju hemoragično-nekrotični enteritis. Mikroskopskim pregledom isečka tankih creva bojenih Brown & Brenn metodom ustanovljene su kolonije bakterija u distalnim delovima submukoze.  Bakteriološkim ispitivanjem u anaerobnim uslovima, izolovana kultura je identifikovana kao Clostridium perfringens. Primenom multiplex PCR dobijeni izolat je genotipiziran kao Clostridium perfringens tip A. Na osnovu patomorfoloških, bakterioloških i molekularnih ispitivanja može da se zaključi da infekcija teških roditelja Clostridium perfringens tipa A protiče sa slikom difuznog hemoragično-nekrotičnog jejunitisa, da uzročnik duboko penetrira u tkivo jejunuma i da su pšenica i pšenične mekinje činili favorizujući faktor za proliferaciju etiološkog agensa., The aim of the investigation was to determine the influence of Clostridium perfringens type A on the development of pathomorphological substrate, its intensity and distribution in fifteen weeks old heavy breeds broilers. The investigation was carried out on corpses of 8 hens and 7 roosters of heavy breeds of provenance COBB 500. After the completion of the autopsy, samples of altered parts of jejunum and liver were taken for histopathological examination, and jejunum intestinal contents for bacteriological examination. In all the corpses, in open pleuroperitoneal cavity, even in situ, an altered part of jejunum can be noticed. It was extremely dilated the entire length, and its wall was bluish-gray with disseminated subserous punctiform blood extravasates. When opened, semi-liquid content with blood coagulums and patches of necrotic mucosa went out of it. By microscopic examination of small intestine tissue cuttings, colored by HE method, there was observed a diffuse necrosis of intestinal villi. They were desroyed and replaced by eosinophilic structureless mass. Furthermore, there could be noticed submucose oedema, capillary congestion and blood extravasates in mucosa, as well as infiltration of neutrophilic granulocytes in lamina propria. These microscopic alterations reflect hemorrhagic necrotic enteritis. By microscopic examining of small intestine cuttings colored according to Brown & Brenn method, colonies of bacteria in distal parts of the submucosa were found out.  Using bacteriological tests in anaerobic conditions, there was isolated a culture identified as Clostridium perfringens. After applying of multiplex PCR, the obtained isolate was genotyped as Clostridium perfringens type A.  On the basis of pathomorphological, bacteriological and molecular examinations, it can be concluded that the infection of heavy breeds with Clostridium perfringens type A is manifested by appearance of haemorrhagic-necrotic jejunitis, that the causer penetrates deeply into jejunum tissue and that wheat and wheat bran were a favoring factor for proliferation of the etiological agent.",
publisher = "Fakultet veterinarske medicine, Beograd, Srbija",
journal = "Veterinarski Glasnik",
title = "Haemorrhagic-necrotic enteritis in heavy breeds broilers, Hemoragično-nekrotični enteritis kod roditelja brojlera",
volume = "68",
number = "3-4",
pages = "265-273",
doi = "10.2298/VETGL1404265J"
}

Jezdimirović, N., Kureljušić, B., Ivetić, V., Kureljušić, J., Cvetojević, Đ., Maslić-Strižak, D., Radanović, O.,& Jezdimirović, M.. (2014). Haemorrhagic-necrotic enteritis in heavy breeds broilers. in Veterinarski Glasnik
Fakultet veterinarske medicine, Beograd, Srbija., 68(3-4), 265-273.
https://doi.org/10.2298/VETGL1404265J

Jezdimirović N, Kureljušić B, Ivetić V, Kureljušić J, Cvetojević Đ, Maslić-Strižak D, Radanović O, Jezdimirović M. Haemorrhagic-necrotic enteritis in heavy breeds broilers. in Veterinarski Glasnik. 2014;68(3-4):265-273.
doi:10.2298/VETGL1404265J .

Jezdimirović, Nemanja, Kureljušić, Branislav, Ivetić, Vojin, Kureljušić, Jasna, Cvetojević, Đ., Maslić-Strižak, Danka, Radanović, O., Jezdimirović, Milanka, "Haemorrhagic-necrotic enteritis in heavy breeds broilers" in Veterinarski Glasnik, 68, no. 3-4 (2014):265-273,
https://doi.org/10.2298/VETGL1404265J . .