@conference{
author = "Milivojević, Marija and Radovanović, Željko and Dimitrijević, Suzana and Petrović, Rada and Marković, Danica and Janaćković, Đorđe",
year = "2021",
abstract = "Tissue engineering strategies for a treatment of large bone defects, which is currently implantation of
bone grafts, are based on the development of biomaterials that mimic the bone tissue and improve
regeneration. 3D printed macroporous titanium-based scaffolds, designed specifically for large bone
defect implantation, provide both good mechanical support and architecture of pores suitable for
ingrowth of bone tissue and better osseointegration. However, the bioinert surface of Ti6Al4V alloy
is not the finest substrate for the growth of cells and mineral matrix deposition.
The aim of this study was to modify the surface of the macroporous Ti scaffold, by coating it with
multiple layers of bioceramics: silicate bioactive glasses (BAG) and Ag-doped calcium
hydroxyapatite (AgHAP), in order to provide bioactivity, biocompatibility, and antibacterial
properties. A dip-coating technique was optimized to provide a thin coating that is homogenous and
uniform inside the porous structure of titanium samples, followed by its melting at optimized
temperature to acquire a continuous BAG layer covered with AgHAP particles.
The characterization of the synthesized bioceramic powders and surface morphology of specimen
were conducted using scanning electron microscopy (SEM) and energy-dispersive X-ray
spectroscopy. The bioactivity was evaluated as the growth of hydroxyapatite crystals on the surface
of the samples after 14 days in Simulated body fluid (SBF), which was determined using SEM.
Biocompatibility of the obtained coatings and bare Ti samples was analyzed in vitro on the L929 cell
line, applying the MTT test. Finally, the antibacterial properties of coated scaffolds were evaluated on
E.coli, S. aureus, and C. albicans.
Evaluation of the morphology of the coatings showed that the homogenous deposition was achieved
by a dip-coating method. Improved bioactivity, biocompatibility, and antimicrobial properties of the
coated scaffold showed the great potential of this approach for future clinical application.",
publisher = "Belgrade : Materials Research Society of Serbia, 2021",
journal = "Twenty-second Annual Conference Yucomat 2021, Herceg Novi, August 30 - September 3, 2021",
title = "Improvement of bioactivity, biocompatibility, and antibacterial properties of titanium scaffold by coating with bioactive glasses and Ag - doped HAP",
pages = "123-123",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_2682"
}
