@conference{
author = "Petrović, Jelena and Stefanović, Srđan and Baltić, Milan Ž. and Ratajac, Radomir and Rackov, Olga",
year = "2009",
abstract = "Danas su u nauci o bezbednosti hrane definisane dve glavne opasnosti koje nastaju kao direktna posledica primene anitimikrobnih lekova: rezidue u jestivim tkivima i razvijanje rezistencije zoonotskih patogena. Enrofloksacin je antimikrobni lek iz grupe fluorohinolona. U Srbiji je registrovan za upotrebu kod živine. Cilj eksperimentalnih ispitivanja je eliminisanje rizika po zdravlje potrošača na osnovu praćenja sadržaja rezidua enrofloksacina i njegovog glavnog metabolita ciprofloksacina u tkivima lečenih brojlera. U ogledu je ispitano prisustvo rezidua u mesu i jetri pilića koji su tretirani propisanim, terapijskim dozama enrofloksacina. Sadržaj rezidua je izmeren metodom HPLC/Fl (Tečna hromatografije visoke performanse sa fluorescentnim detektorom). Tokom pet dana aplikovanja leka, i prva tri dana karence, koncentracije enrofloksacina i ciprofloksacina su bile veće od MDK vrednosti (MDK−maksimalno dozvoljene količine), propisanih u EU.
Nakon propisanog aplikovanja antimikrobnih lekova sadržaj rezidua u jestivim tkivima opada do dozvoljenih vrednosti (manje od MDK) tokom propisanog perioda karence od sedam dana. Međutim, i nakon isteka karence rezidue se zadržavaju u jestivim tkivima, u dužem vremenskom periodu. Rezidue enrofloksacina mogu da se dokažu u mesu sve do devetog dana od prekida terapije, dok se u jetri zadržavaju mnogo duže. Tek 22. dana od prekida terapije nije potvrđeno prisustvo rezidua u jetri., The most important side effects of antimicrobial drugs usage are veterinary drug residues in edible animal tissues and development of resistance in food borne pathogens. Enrofloxacine is a fluoroquinolone licensed in Serbia for use in poultry treatment. The aim of this study was to examine the target tissue residues of enrofloxacine and its main metabolite ciprofloxacine, in order to eliminate health risks for the consumers. The presence of residues in the muscle and liver after prescribed administration of enrofloxacine to chickens was studied in our experiment. HPLC/ Fl was used for the detection of enrofloxacine and ciprofloxacine residues. During the 5 days administration period, and the first three days of the withdrawal period, enrofloxacine and ciprofloxacine concentrations in breast muscle and liver exceeded the EU MRL values (MRL-maximum residue limit). After correct application of the antimicrobial drug, tissue residue levels decreased to permitted quantities (below MRL) within the prescribed withdrawal period of seven days. However, even after the withdrawal period residues are still present in edible animal tissues. Residues of enrofloxacine can be detected in meat nine days after the end of treatment and residues in the liver are present much longer. Residues were detected in the liver up to 22 days post treatment.",
publisher = "Beograd : Institut za higijenu i tehnologiju mesa",
journal = "Međunarodno 55. savetovanje industrije mesa - Meso i proizvodi od mesa - bezbednost, kvalitet i nove tehnologije, Tara, 15 - 17. jun, 2009",
title = "Primena enrofloksacina u živinarstvu kao potencijalni rizik za bezbednost hrane - rezidue veterinarskih lekova u jestivim tkivima, Usage of enrofloxacine in poultry production, as a potential risk for food safety - veterinary drug residues in edible tissues",
pages = "96-97",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_3866"
}