TY  - JOUR
AU  - Begić, Aida
AU  - Đurić, Ana
AU  - Ninković, Milica
AU  - Stevanović, Ivana
AU  - Đurđević, Dragan
AU  - Pavlović, Miloš
AU  - Jelić, Katarina
AU  - Pantelić, Ana
AU  - Zebić, Goran
AU  - Dejanović, Bratislav
AU  - Stanojević, Ivan
AU  - Vojvodić, Danilo
AU  - Milosavljević, Petar
AU  - Đukić, Mirjana
AU  - Saso, Luciano
PY  - 2017
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1496
AB  - Examination of cadmium (Cd) toxicity and disulfiram (DSF) effect on liver was focused on oxidative stress (OS), bioelements status, morphological and functional changes. Male Wistar rats were intraperitoneally treated with 1mg CdCl2/kg BW/day; orally with 178.5 mg DSF/kg BW/day for 1, 3, 10 and 21 days; and co-exposed from 22nd to 42nd day. The co-exposure nearly restored previously suppressed total superoxide dismutase (SOD), catalase (CAT) and increased glutathione peroxidase (GPx) activities; increased previously reduced glutathione reductase (GR) and total glutathione-S-transferase (GST) activities; reduced previously increased superoxide anion radical (O-2(center dot-)) and malondialdehyde (MDA) levels; increased zinc (Zn) and iron (Fe), and decreased copper (Cu) (yet above control value), while magnesium (Mg) was not affected; and decreased serum alanine aminotransferases (ALT) levels. Histopathological examination showed signs of inflammation process as previously demonstrated by exposure to Cd. Overall, we ascertained partial liver redox status improvement, compared with the formerly Cd-induced impact.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Journal of Enzyme Inhibition and Medicinal Chemistry
T1  - Disulfiram moderately restores impaired hepatic redox status of rats subchronically exposed to cadmium
VL  - 32
IS  - 1
SP  - 478
EP  - 489
DO  - 10.1080/14756366.2016.1261132
ER  - 

@article{
author = "Begić, Aida and Đurić, Ana and Ninković, Milica and Stevanović, Ivana and Đurđević, Dragan and Pavlović, Miloš and Jelić, Katarina and Pantelić, Ana and Zebić, Goran and Dejanović, Bratislav and Stanojević, Ivan and Vojvodić, Danilo and Milosavljević, Petar and Đukić, Mirjana and Saso, Luciano",
year = "2017",
abstract = "Examination of cadmium (Cd) toxicity and disulfiram (DSF) effect on liver was focused on oxidative stress (OS), bioelements status, morphological and functional changes. Male Wistar rats were intraperitoneally treated with 1mg CdCl2/kg BW/day; orally with 178.5 mg DSF/kg BW/day for 1, 3, 10 and 21 days; and co-exposed from 22nd to 42nd day. The co-exposure nearly restored previously suppressed total superoxide dismutase (SOD), catalase (CAT) and increased glutathione peroxidase (GPx) activities; increased previously reduced glutathione reductase (GR) and total glutathione-S-transferase (GST) activities; reduced previously increased superoxide anion radical (O-2(center dot-)) and malondialdehyde (MDA) levels; increased zinc (Zn) and iron (Fe), and decreased copper (Cu) (yet above control value), while magnesium (Mg) was not affected; and decreased serum alanine aminotransferases (ALT) levels. Histopathological examination showed signs of inflammation process as previously demonstrated by exposure to Cd. Overall, we ascertained partial liver redox status improvement, compared with the formerly Cd-induced impact.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Journal of Enzyme Inhibition and Medicinal Chemistry",
title = "Disulfiram moderately restores impaired hepatic redox status of rats subchronically exposed to cadmium",
volume = "32",
number = "1",
pages = "478-489",
doi = "10.1080/14756366.2016.1261132"
}

Begić, A., Đurić, A., Ninković, M., Stevanović, I., Đurđević, D., Pavlović, M., Jelić, K., Pantelić, A., Zebić, G., Dejanović, B., Stanojević, I., Vojvodić, D., Milosavljević, P., Đukić, M.,& Saso, L.. (2017). Disulfiram moderately restores impaired hepatic redox status of rats subchronically exposed to cadmium. in Journal of Enzyme Inhibition and Medicinal Chemistry
Taylor & Francis Ltd, Abingdon., 32(1), 478-489.
https://doi.org/10.1080/14756366.2016.1261132

Begić A, Đurić A, Ninković M, Stevanović I, Đurđević D, Pavlović M, Jelić K, Pantelić A, Zebić G, Dejanović B, Stanojević I, Vojvodić D, Milosavljević P, Đukić M, Saso L. Disulfiram moderately restores impaired hepatic redox status of rats subchronically exposed to cadmium. in Journal of Enzyme Inhibition and Medicinal Chemistry. 2017;32(1):478-489.
doi:10.1080/14756366.2016.1261132 .

Begić, Aida, Đurić, Ana, Ninković, Milica, Stevanović, Ivana, Đurđević, Dragan, Pavlović, Miloš, Jelić, Katarina, Pantelić, Ana, Zebić, Goran, Dejanović, Bratislav, Stanojević, Ivan, Vojvodić, Danilo, Milosavljević, Petar, Đukić, Mirjana, Saso, Luciano, "Disulfiram moderately restores impaired hepatic redox status of rats subchronically exposed to cadmium" in Journal of Enzyme Inhibition and Medicinal Chemistry, 32, no. 1 (2017):478-489,
https://doi.org/10.1080/14756366.2016.1261132 . .

TY  - JOUR
AU  - Jaćević, Vesna
AU  - Zolotarevski, Lidija
AU  - Milosavljević, I.
AU  - Jelić, Katarina
AU  - Resanović, Radmila
AU  - Bokonjić, Dubravko
AU  - Stojiljković, M.
PY  - 2006
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/382
AB  - In this study the protective effect of methylprednisolone (soluble form Lemod-solu® and depot form, Lemod-depo®) (40 mg/kg im) on pathohistological changes in hearts of Wistar rats poisoned with T-2 toxin (0.23 mg/kg sc) was examined. Pathohistological, quantitative and morphometric analysis was based on the haematoxylin and eosin (HE) method. Animals were sacrificed after the end of day 1, 3, 5 and 7 of the study. In the hearts of poisoned animals T-2 toxin caused massive, diffuse degenerative and vascular changes associated with gross necrotic areas. The described changes could be found only sporadically in poisoned rats protected with tested methylprednisolone formulation. The best protective effect was produced by the soluble form of methylprednisolone and the least one with a combination of both tested formulations of the drug. The pathohistological alterations in the methylprednisolone protected animals varied from parenchymatous dystrophy to hyaloid degeneration, hyperaemia and haemorrhages with mononuclear cell infiltration. These histological deformations of the myocardial architecture were focal. Based on these results, it could be concluded that methylprednisolone formulations, both short and long-acting ones, exert a significant protection of rat hearts from T-2 toxin- induced pathohistological changes.
AB  - U okviru ovog rada praćen je uticaj različitih oblika metilprednizolona (Lemod- solu® i Lemod-depo®) apikovanih u dozi od 40 mg/kg im na patohistološke promene u srcu Wistar pacova akutno trovanih citotoksičnim trihotecenskim mikotoksinom, T-2 toksinom (0.23 mg/kg sc). Patohistološka kvantitaivna i morfometrijska analiza histoloških preparata je vršena primenom nakon njihovog bojenja hematoksilin-eozinom (HE). Ispitivane životinje su žrtvovane 1, 3, 5. i 7. dana eksperimenta. U srcu trovanih pacova T-2 toksin je izazvao masivne, difuzne, degenerativne i vaskularne promene koje su bile okružene sa velikim nekrotičnim poljima. Opisane promene bile su najmanje izražene kod trovanih životinja koje su primale preparat Lemod-solu®. Ove fokalne patohistološke promene varirale su od parenhimatozne distrofije do hijaline degeneracije, hiperemije, hemoragija i mononuklearnog ćelijskog infiltrata. Kod malog broja ćelija citoplazma je bila razložena, a njihova jedra su imala normalan izgled ili su bila blago izdužena ili okrugla. Prisustvo bazofilnog, granuliranog ćelijskog detritusa moglo se uočiti na jednom polu malog broja miofibrila. Veoma je važno naglasiti da su ove promene normalne histološke arhitekture miokarda bile isključivo fokalnog karaktera. Na osnovu prikazanih rezultata može da se zaključi da metilprednizolonske formulacije - i kratko- i dugo delujuća proizvode značajne antidotske efekte kod pacova trovanih T-2 toksinom.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta Veterinaria-Beograd
T1  - Influence of different glucocorticosteroid treatment regimens on pathohistological changes in hearts of rats poisoned with T-2 toxin
T1  - Uticaj različitih glukokortikosteroidnih terapijskih režima na patohistološke promene u srcu pacova trovanih T-2 toksinom
VL  - 56
IS  - 2-3
SP  - 243
EP  - 257
DO  - 10.2298/AVB0603243J
ER  - 

@article{
author = "Jaćević, Vesna and Zolotarevski, Lidija and Milosavljević, I. and Jelić, Katarina and Resanović, Radmila and Bokonjić, Dubravko and Stojiljković, M.",
year = "2006",
abstract = "In this study the protective effect of methylprednisolone (soluble form Lemod-solu® and depot form, Lemod-depo®) (40 mg/kg im) on pathohistological changes in hearts of Wistar rats poisoned with T-2 toxin (0.23 mg/kg sc) was examined. Pathohistological, quantitative and morphometric analysis was based on the haematoxylin and eosin (HE) method. Animals were sacrificed after the end of day 1, 3, 5 and 7 of the study. In the hearts of poisoned animals T-2 toxin caused massive, diffuse degenerative and vascular changes associated with gross necrotic areas. The described changes could be found only sporadically in poisoned rats protected with tested methylprednisolone formulation. The best protective effect was produced by the soluble form of methylprednisolone and the least one with a combination of both tested formulations of the drug. The pathohistological alterations in the methylprednisolone protected animals varied from parenchymatous dystrophy to hyaloid degeneration, hyperaemia and haemorrhages with mononuclear cell infiltration. These histological deformations of the myocardial architecture were focal. Based on these results, it could be concluded that methylprednisolone formulations, both short and long-acting ones, exert a significant protection of rat hearts from T-2 toxin- induced pathohistological changes., U okviru ovog rada praćen je uticaj različitih oblika metilprednizolona (Lemod- solu® i Lemod-depo®) apikovanih u dozi od 40 mg/kg im na patohistološke promene u srcu Wistar pacova akutno trovanih citotoksičnim trihotecenskim mikotoksinom, T-2 toksinom (0.23 mg/kg sc). Patohistološka kvantitaivna i morfometrijska analiza histoloških preparata je vršena primenom nakon njihovog bojenja hematoksilin-eozinom (HE). Ispitivane životinje su žrtvovane 1, 3, 5. i 7. dana eksperimenta. U srcu trovanih pacova T-2 toksin je izazvao masivne, difuzne, degenerativne i vaskularne promene koje su bile okružene sa velikim nekrotičnim poljima. Opisane promene bile su najmanje izražene kod trovanih životinja koje su primale preparat Lemod-solu®. Ove fokalne patohistološke promene varirale su od parenhimatozne distrofije do hijaline degeneracije, hiperemije, hemoragija i mononuklearnog ćelijskog infiltrata. Kod malog broja ćelija citoplazma je bila razložena, a njihova jedra su imala normalan izgled ili su bila blago izdužena ili okrugla. Prisustvo bazofilnog, granuliranog ćelijskog detritusa moglo se uočiti na jednom polu malog broja miofibrila. Veoma je važno naglasiti da su ove promene normalne histološke arhitekture miokarda bile isključivo fokalnog karaktera. Na osnovu prikazanih rezultata može da se zaključi da metilprednizolonske formulacije - i kratko- i dugo delujuća proizvode značajne antidotske efekte kod pacova trovanih T-2 toksinom.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta Veterinaria-Beograd",
title = "Influence of different glucocorticosteroid treatment regimens on pathohistological changes in hearts of rats poisoned with T-2 toxin, Uticaj različitih glukokortikosteroidnih terapijskih režima na patohistološke promene u srcu pacova trovanih T-2 toksinom",
volume = "56",
number = "2-3",
pages = "243-257",
doi = "10.2298/AVB0603243J"
}

Jaćević, V., Zolotarevski, L., Milosavljević, I., Jelić, K., Resanović, R., Bokonjić, D.,& Stojiljković, M.. (2006). Influence of different glucocorticosteroid treatment regimens on pathohistological changes in hearts of rats poisoned with T-2 toxin. in Acta Veterinaria-Beograd
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 56(2-3), 243-257.
https://doi.org/10.2298/AVB0603243J

Jaćević V, Zolotarevski L, Milosavljević I, Jelić K, Resanović R, Bokonjić D, Stojiljković M. Influence of different glucocorticosteroid treatment regimens on pathohistological changes in hearts of rats poisoned with T-2 toxin. in Acta Veterinaria-Beograd. 2006;56(2-3):243-257.
doi:10.2298/AVB0603243J .

Jaćević, Vesna, Zolotarevski, Lidija, Milosavljević, I., Jelić, Katarina, Resanović, Radmila, Bokonjić, Dubravko, Stojiljković, M., "Influence of different glucocorticosteroid treatment regimens on pathohistological changes in hearts of rats poisoned with T-2 toxin" in Acta Veterinaria-Beograd, 56, no. 2-3 (2006):243-257,
https://doi.org/10.2298/AVB0603243J . .