TY  - JOUR
AU  - Vlašković, Tatjana
AU  - Brkić Georgievski, Biljana
AU  - Stević, Zorica
AU  - Kostić, Dejan
AU  - Stanisavljević, Nataša
AU  - Marinković, Ivan
AU  - Vojvodić, Aleksandra
AU  - Nikolić, Valentina
AU  - Puškaš, Laslo
AU  - Blagojević, Miloš
AU  - Marinković, Slobodan
PY  - 2022
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2835
AB  - There is a low incidence of the medullary infarctions and sparse data about
the vascular territories, as well as a correlation among the anatomic, magnetic resonance
imaging (MRI) and neurologic signs. Materials and methods: Arteries of the 10 right and
left sides of the brain stem were injected with India ink, fixed in formalin and microdissected. The enrolled 34 patients with medullary infarctions underwent a neurologic,
MRI and Doppler examination. Results: Four types of the infarctions were distinguished
according to the involved vascular territories. The isolated medial medullary infarctions
(MMIs) were present in 14.7%. The complete MMIs comprised one bilateral infarction
(2.9%), whilst the incomplete and partial MMIs were observed in 5.9% and 8.9%, respectively. The anterolateral infarctions (ALMIs) were very rare (2.9%). The complete and
incomplete lateral infarctions (LMIs), noted in 35.3%, comprised 11.8% and 23.6%,
respectively, that is, the anterior (5.9%), posterior (8.9%), deep (2.9%), and peripheral
(5.9%). Dorsal ischemic lesions (DMIs) occurred in 11.8%, either as a complete (2.9%), or
isolated lateral (5.9%) or medial infarctions (2.9%). The remaining ischemic regions
belonged to various combined infarctions of the MMI, ALMI, LMI and DMI (35.3%).
The infarctions most often affected the upper medulla (47.1%), middle (11.8%), or both
(29.5%). Several motor and sensory signs were manifested following infarctions, including vestibular, cerebellar, ocular, sympathetic, respiratory and auditory symptoms.
Conclusions: There was a good correlation among the vascular territories, MRI ischemia
features, and neurologic findings regarding the medullary infarctions.
PB  - Elsevier
T2  - Journal of Stroke and Cerebrovascular Diseases
T1  - Anatomic and MRI bases for medullary infarctions with patients’ presentation
VL  - 31
IS  - 10
SP  - 106730
DO  - 10.1016/j.jstrokecerebrovasdis.2022.106730
ER  - 

@article{
author = "Vlašković, Tatjana and Brkić Georgievski, Biljana and Stević, Zorica and Kostić, Dejan and Stanisavljević, Nataša and Marinković, Ivan and Vojvodić, Aleksandra and Nikolić, Valentina and Puškaš, Laslo and Blagojević, Miloš and Marinković, Slobodan",
year = "2022",
abstract = "There is a low incidence of the medullary infarctions and sparse data about
the vascular territories, as well as a correlation among the anatomic, magnetic resonance
imaging (MRI) and neurologic signs. Materials and methods: Arteries of the 10 right and
left sides of the brain stem were injected with India ink, fixed in formalin and microdissected. The enrolled 34 patients with medullary infarctions underwent a neurologic,
MRI and Doppler examination. Results: Four types of the infarctions were distinguished
according to the involved vascular territories. The isolated medial medullary infarctions
(MMIs) were present in 14.7%. The complete MMIs comprised one bilateral infarction
(2.9%), whilst the incomplete and partial MMIs were observed in 5.9% and 8.9%, respectively. The anterolateral infarctions (ALMIs) were very rare (2.9%). The complete and
incomplete lateral infarctions (LMIs), noted in 35.3%, comprised 11.8% and 23.6%,
respectively, that is, the anterior (5.9%), posterior (8.9%), deep (2.9%), and peripheral
(5.9%). Dorsal ischemic lesions (DMIs) occurred in 11.8%, either as a complete (2.9%), or
isolated lateral (5.9%) or medial infarctions (2.9%). The remaining ischemic regions
belonged to various combined infarctions of the MMI, ALMI, LMI and DMI (35.3%).
The infarctions most often affected the upper medulla (47.1%), middle (11.8%), or both
(29.5%). Several motor and sensory signs were manifested following infarctions, including vestibular, cerebellar, ocular, sympathetic, respiratory and auditory symptoms.
Conclusions: There was a good correlation among the vascular territories, MRI ischemia
features, and neurologic findings regarding the medullary infarctions.",
publisher = "Elsevier",
journal = "Journal of Stroke and Cerebrovascular Diseases",
title = "Anatomic and MRI bases for medullary infarctions with patients’ presentation",
volume = "31",
number = "10",
pages = "106730",
doi = "10.1016/j.jstrokecerebrovasdis.2022.106730"
}

Vlašković, T., Brkić Georgievski, B., Stević, Z., Kostić, D., Stanisavljević, N., Marinković, I., Vojvodić, A., Nikolić, V., Puškaš, L., Blagojević, M.,& Marinković, S.. (2022). Anatomic and MRI bases for medullary infarctions with patients’ presentation. in Journal of Stroke and Cerebrovascular Diseases
Elsevier., 31(10), 106730.
https://doi.org/10.1016/j.jstrokecerebrovasdis.2022.106730

Vlašković T, Brkić Georgievski B, Stević Z, Kostić D, Stanisavljević N, Marinković I, Vojvodić A, Nikolić V, Puškaš L, Blagojević M, Marinković S. Anatomic and MRI bases for medullary infarctions with patients’ presentation. in Journal of Stroke and Cerebrovascular Diseases. 2022;31(10):106730.
doi:10.1016/j.jstrokecerebrovasdis.2022.106730 .

Vlašković, Tatjana, Brkić Georgievski, Biljana, Stević, Zorica, Kostić, Dejan, Stanisavljević, Nataša, Marinković, Ivan, Vojvodić, Aleksandra, Nikolić, Valentina, Puškaš, Laslo, Blagojević, Miloš, Marinković, Slobodan, "Anatomic and MRI bases for medullary infarctions with patients’ presentation" in Journal of Stroke and Cerebrovascular Diseases, 31, no. 10 (2022):106730,
https://doi.org/10.1016/j.jstrokecerebrovasdis.2022.106730 . .

TY  - JOUR
AU  - Samardžić, Janko
AU  - Puškaš, Laslo
AU  - Obradović, Miljana
AU  - Lazić-Puškaš, Dijana
PY  - 2014
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2187
AB  - It has been shown in electrophysiological studies that the ligand L-655,708 possesses a binding selectivity and a moderate inverse agonist functional selectivity for α5-containing GABA-A receptors. The present study is aimed to investigate the antidepressant effects of the ligand L-655,708 in the forced swim test (FST) and its impact on locomotor activity in rats. The behavior of the animals was recorded with a digital camera, and the data were analyzed by one-way ANOVA, followed by Dunnett’s test. In FST, L-655,708 significantly decreased immobility time at a dose of 3 mg/kg after a single and repeated administration (p<0.05), exerting acute and chronic antidepressant effects. However, it did not induce significant differences in the time of struggling behavior during FST. Furthermore, L-655,708 did not show a significant effect on locomotor activity (p>0.05). These data suggest that negative modulation at GABA-A receptors containing the α5 subunit may produce antidepressant effects in rats. These effects were not confounded by locomotor influences.
AB  - U elektrofi ziološkim ispitivanjima pokazano je da ligand L-655,708 poseduje selektivnost u vezivanju i umerenu inverznu agonističku aktivnost za GABA-A receptore koji sadrže α5 podjedinicu. Ova studija ima za cilj ispitivanje antidepresivnih efekata liganda L-655,708 u testu forsiranog plivanja (FST) i njegov uticaj na lokomotornu aktivnost kod pacova. Ponašanje životinja je praćeno pomoću digitalne kamere, a podaci su analizirani primenom jednostepene analize varijanse (ANOVA) i Dunett-ovim testom. U testu forsiranog plivanja L-655,708 statistički značajno smanjuje vreme imobilnosti pri dozi od 3 mg/kg, nakon jednokratne i ponavljane primene (p0,05). Ovi podaci ukazuju da negativna modulacija GABA-A receptora koji sadrže α5 podjedinicu može ispoljiti antidepresivne efekte kod pacova. Ovi efekti su bez izraženih lokomotornih uticaja.
T2  - Acta Veterinaria-Beograd
T1  - Antidepressant effects of an inverse agonist selective for α5 GABA-A receptors in the rat forced swim test
T1  - Antidepresivni efekti inverznog agoniste selektivnog za α5 gaba-a receptore u testu forsiranog plivanja pacova
VL  - 64
IS  - 1
SP  - 52
EP  - 60
DO  - 10.2478/acve-2014-0006
ER  - 

@article{
author = "Samardžić, Janko and Puškaš, Laslo and Obradović, Miljana and Lazić-Puškaš, Dijana",
year = "2014",
abstract = "It has been shown in electrophysiological studies that the ligand L-655,708 possesses a binding selectivity and a moderate inverse agonist functional selectivity for α5-containing GABA-A receptors. The present study is aimed to investigate the antidepressant effects of the ligand L-655,708 in the forced swim test (FST) and its impact on locomotor activity in rats. The behavior of the animals was recorded with a digital camera, and the data were analyzed by one-way ANOVA, followed by Dunnett’s test. In FST, L-655,708 significantly decreased immobility time at a dose of 3 mg/kg after a single and repeated administration (p<0.05), exerting acute and chronic antidepressant effects. However, it did not induce significant differences in the time of struggling behavior during FST. Furthermore, L-655,708 did not show a significant effect on locomotor activity (p>0.05). These data suggest that negative modulation at GABA-A receptors containing the α5 subunit may produce antidepressant effects in rats. These effects were not confounded by locomotor influences., U elektrofi ziološkim ispitivanjima pokazano je da ligand L-655,708 poseduje selektivnost u vezivanju i umerenu inverznu agonističku aktivnost za GABA-A receptore koji sadrže α5 podjedinicu. Ova studija ima za cilj ispitivanje antidepresivnih efekata liganda L-655,708 u testu forsiranog plivanja (FST) i njegov uticaj na lokomotornu aktivnost kod pacova. Ponašanje životinja je praćeno pomoću digitalne kamere, a podaci su analizirani primenom jednostepene analize varijanse (ANOVA) i Dunett-ovim testom. U testu forsiranog plivanja L-655,708 statistički značajno smanjuje vreme imobilnosti pri dozi od 3 mg/kg, nakon jednokratne i ponavljane primene (p0,05). Ovi podaci ukazuju da negativna modulacija GABA-A receptora koji sadrže α5 podjedinicu može ispoljiti antidepresivne efekte kod pacova. Ovi efekti su bez izraženih lokomotornih uticaja.",
journal = "Acta Veterinaria-Beograd",
title = "Antidepressant effects of an inverse agonist selective for α5 GABA-A receptors in the rat forced swim test, Antidepresivni efekti inverznog agoniste selektivnog za α5 gaba-a receptore u testu forsiranog plivanja pacova",
volume = "64",
number = "1",
pages = "52-60",
doi = "10.2478/acve-2014-0006"
}

Samardžić, J., Puškaš, L., Obradović, M.,& Lazić-Puškaš, D.. (2014). Antidepressant effects of an inverse agonist selective for α5 GABA-A receptors in the rat forced swim test. in Acta Veterinaria-Beograd, 64(1), 52-60.
https://doi.org/10.2478/acve-2014-0006

Samardžić J, Puškaš L, Obradović M, Lazić-Puškaš D. Antidepressant effects of an inverse agonist selective for α5 GABA-A receptors in the rat forced swim test. in Acta Veterinaria-Beograd. 2014;64(1):52-60.
doi:10.2478/acve-2014-0006 .

Samardžić, Janko, Puškaš, Laslo, Obradović, Miljana, Lazić-Puškaš, Dijana, "Antidepressant effects of an inverse agonist selective for α5 GABA-A receptors in the rat forced swim test" in Acta Veterinaria-Beograd, 64, no. 1 (2014):52-60,
https://doi.org/10.2478/acve-2014-0006 . .