TY  - JOUR
AU  - Nieuwenhuijse, D.F.
AU  - Oude Munnink, B.B.
AU  - Phan, M.V.T.
AU  - Hendriksen, R.S.
AU  - Bego, A.
AU  - Rees, C.
AU  - Neilson, E.H.
AU  - Coventry, K.
AU  - Collignon, P.
AU  - Allerberger, F.
AU  - Rahube, T.O.
AU  - Oliveira, G.
AU  - Ivanov, I.
AU  - Sopheak, T.
AU  - Vuthy, Y.
AU  - Yost, C.K.
AU  - Tabo, D.-A.
AU  - Cuadros-Orellana, S.
AU  - Ke, C.
AU  - Zheng, H.
AU  - Baisheng, L.
AU  - Jiao, X.
AU  - Donado-Godoy, P.
AU  - Coulibaly, K.J.
AU  - Hrenovic, J.
AU  - Jergović, M.
AU  - Karpíšková, R.
AU  - Elsborg, B.
AU  - Legesse, M.
AU  - Eguale, T.
AU  - Heikinheimo, A.
AU  - Villacis, J.E.
AU  - Sanneh, B.
AU  - Malania, L.
AU  - Nitsche, A.
AU  - Brinkmann, A.
AU  - Saba, C.K.S.
AU  - Kocsis, B.
AU  - Solymosi, N.
AU  - Thorsteinsdottir, T.R.
AU  - Hatha, A.M.
AU  - Alebouyeh, M.
AU  - Morris, D.
AU  - O’Connor, L.
AU  - Cormican, M.
AU  - Moran-Gilad, J.
AU  - Battisti, A.
AU  - Alba, P.
AU  - Shakenova, Z.
AU  - Kiiyukia, C.
AU  - Ng’eno, E.
AU  - Raka, L.
AU  - Bērziņš, A.
AU  - Avsejenko, J.
AU  - Bartkevics, V.
AU  - Penny, C.
AU  - Rajandas, H.
AU  - Parimannan, S.
AU  - Haber, M.V.
AU  - Pal, P.
AU  - Schmitt, H.
AU  - van Passel, M.
AU  - van de Schans, M.G.M.
AU  - Zuidema, T.
AU  - Jeunen, G.-J.
AU  - Gemmell, N.
AU  - Fashae, K.
AU  - Wester, A.L.
AU  - Holmstad, R.
AU  - Hasan, R.
AU  - Shakoor, S.
AU  - Rojas, M.L.Z.
AU  - Wasyl, D.
AU  - Bosevska, G.
AU  - Kochubovski, M.
AU  - Radu, C.
AU  - Gassama†, A.
AU  - Radosavljević, Vladimir
AU  - Tay, M.Y.F.
AU  - Zuniga-Montanez, R.
AU  - Wuertz, S.
AU  - Gavačová, D.
AU  - Trkov, M.
AU  - Keddy, K.
AU  - Esterhuyse, K.
AU  - Cerdà-Cuéllar, M.
AU  - Pathirage, S.
AU  - Larsson, D.G.J.
AU  - Norrgren, L.
AU  - Örn, S.
AU  - Van der Heijden, T.
AU  - Kumburu, H.H.
AU  - de RodaHusman, A.M.
AU  - Njanpop-Lafourcade, B.-M.
AU  - Bidjada, P.
AU  - Nikiema-Pessinaba, S.C.
AU  - Levent, B.
AU  - Meschke, J.S.
AU  - Beck, N.K.
AU  - Van Dang, C.
AU  - Tran, D.M.N.
AU  - Do Phuc, N.
AU  - Kwenda, G.
AU  - Munk, P.
AU  - Venkatakrishnan, S.
AU  - Aarestrup, F.M.
AU  - Cotten, M.
AU  - Koopmans, M.P.G.
PY  - 2020
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1984
AB  - The rapid development of megacities, and their growing connectedness across the world is becoming a distinct driver for emerging disease outbreaks. Early detection of unusual disease emergence and spread should therefore include such cities as part of risk-based surveillance. A catch-all metagenomic sequencing approach of urban sewage could potentially provide an unbiased insight into the dynamics of viral pathogens circulating in a community irrespective of access to care, a potential which already has been proven for the surveillance of poliovirus. Here, we present a detailed characterization of sewage viromes from a snapshot of 81 high density urban areas across the globe, including in-depth assessment of potential biases, as a proof of concept for catch-all viral pathogen surveillance. We show the ability to detect a wide range of viruses and geographical and seasonal differences for specific viral groups. Our findings offer a cross-sectional baseline for further research in viral surveillance from urban sewage samples and place previous studies in a global perspective.
PB  - Springer Nature
T2  - Scientific Reports
T1  - Setting a baseline for global urban virome surveillance in sewage
VL  - 10
IS  - 1
DO  - 10.1038/s41598-020-69869-0
ER  - 

@article{
author = "Nieuwenhuijse, D.F. and Oude Munnink, B.B. and Phan, M.V.T. and Hendriksen, R.S. and Bego, A. and Rees, C. and Neilson, E.H. and Coventry, K. and Collignon, P. and Allerberger, F. and Rahube, T.O. and Oliveira, G. and Ivanov, I. and Sopheak, T. and Vuthy, Y. and Yost, C.K. and Tabo, D.-A. and Cuadros-Orellana, S. and Ke, C. and Zheng, H. and Baisheng, L. and Jiao, X. and Donado-Godoy, P. and Coulibaly, K.J. and Hrenovic, J. and Jergović, M. and Karpíšková, R. and Elsborg, B. and Legesse, M. and Eguale, T. and Heikinheimo, A. and Villacis, J.E. and Sanneh, B. and Malania, L. and Nitsche, A. and Brinkmann, A. and Saba, C.K.S. and Kocsis, B. and Solymosi, N. and Thorsteinsdottir, T.R. and Hatha, A.M. and Alebouyeh, M. and Morris, D. and O’Connor, L. and Cormican, M. and Moran-Gilad, J. and Battisti, A. and Alba, P. and Shakenova, Z. and Kiiyukia, C. and Ng’eno, E. and Raka, L. and Bērziņš, A. and Avsejenko, J. and Bartkevics, V. and Penny, C. and Rajandas, H. and Parimannan, S. and Haber, M.V. and Pal, P. and Schmitt, H. and van Passel, M. and van de Schans, M.G.M. and Zuidema, T. and Jeunen, G.-J. and Gemmell, N. and Fashae, K. and Wester, A.L. and Holmstad, R. and Hasan, R. and Shakoor, S. and Rojas, M.L.Z. and Wasyl, D. and Bosevska, G. and Kochubovski, M. and Radu, C. and Gassama†, A. and Radosavljević, Vladimir and Tay, M.Y.F. and Zuniga-Montanez, R. and Wuertz, S. and Gavačová, D. and Trkov, M. and Keddy, K. and Esterhuyse, K. and Cerdà-Cuéllar, M. and Pathirage, S. and Larsson, D.G.J. and Norrgren, L. and Örn, S. and Van der Heijden, T. and Kumburu, H.H. and de RodaHusman, A.M. and Njanpop-Lafourcade, B.-M. and Bidjada, P. and Nikiema-Pessinaba, S.C. and Levent, B. and Meschke, J.S. and Beck, N.K. and Van Dang, C. and Tran, D.M.N. and Do Phuc, N. and Kwenda, G. and Munk, P. and Venkatakrishnan, S. and Aarestrup, F.M. and Cotten, M. and Koopmans, M.P.G.",
year = "2020",
abstract = "The rapid development of megacities, and their growing connectedness across the world is becoming a distinct driver for emerging disease outbreaks. Early detection of unusual disease emergence and spread should therefore include such cities as part of risk-based surveillance. A catch-all metagenomic sequencing approach of urban sewage could potentially provide an unbiased insight into the dynamics of viral pathogens circulating in a community irrespective of access to care, a potential which already has been proven for the surveillance of poliovirus. Here, we present a detailed characterization of sewage viromes from a snapshot of 81 high density urban areas across the globe, including in-depth assessment of potential biases, as a proof of concept for catch-all viral pathogen surveillance. We show the ability to detect a wide range of viruses and geographical and seasonal differences for specific viral groups. Our findings offer a cross-sectional baseline for further research in viral surveillance from urban sewage samples and place previous studies in a global perspective.",
publisher = "Springer Nature",
journal = "Scientific Reports",
title = "Setting a baseline for global urban virome surveillance in sewage",
volume = "10",
number = "1",
doi = "10.1038/s41598-020-69869-0"
}

Nieuwenhuijse, D.F., Oude Munnink, B.B., Phan, M.V.T., Hendriksen, R.S., Bego, A., Rees, C., Neilson, E.H., Coventry, K., Collignon, P., Allerberger, F., Rahube, T.O., Oliveira, G., Ivanov, I., Sopheak, T., Vuthy, Y., Yost, C.K., Tabo, D.-A., Cuadros-Orellana, S., Ke, C., Zheng, H., Baisheng, L., Jiao, X., Donado-Godoy, P., Coulibaly, K.J., Hrenovic, J., Jergović, M., Karpíšková, R., Elsborg, B., Legesse, M., Eguale, T., Heikinheimo, A., Villacis, J.E., Sanneh, B., Malania, L., Nitsche, A., Brinkmann, A., Saba, C.K.S., Kocsis, B., Solymosi, N., Thorsteinsdottir, T.R., Hatha, A.M., Alebouyeh, M., Morris, D., O’Connor, L., Cormican, M., Moran-Gilad, J., Battisti, A., Alba, P., Shakenova, Z., Kiiyukia, C., Ng’eno, E., Raka, L., Bērziņš, A., Avsejenko, J., Bartkevics, V., Penny, C., Rajandas, H., Parimannan, S., Haber, M.V., Pal, P., Schmitt, H., van Passel, M., van de Schans, M.G.M., Zuidema, T., Jeunen, G.-J., Gemmell, N., Fashae, K., Wester, A.L., Holmstad, R., Hasan, R., Shakoor, S., Rojas, M.L.Z., Wasyl, D., Bosevska, G., Kochubovski, M., Radu, C., Gassama†, A., Radosavljević, V., Tay, M.Y.F., Zuniga-Montanez, R., Wuertz, S., Gavačová, D., Trkov, M., Keddy, K., Esterhuyse, K., Cerdà-Cuéllar, M., Pathirage, S., Larsson, D.G.J., Norrgren, L., Örn, S., Van der Heijden, T., Kumburu, H.H., de RodaHusman, A.M., Njanpop-Lafourcade, B.-M., Bidjada, P., Nikiema-Pessinaba, S.C., Levent, B., Meschke, J.S., Beck, N.K., Van Dang, C., Tran, D.M.N., Do Phuc, N., Kwenda, G., Munk, P., Venkatakrishnan, S., Aarestrup, F.M., Cotten, M.,& Koopmans, M.P.G.. (2020). Setting a baseline for global urban virome surveillance in sewage. in Scientific Reports
Springer Nature., 10(1).
https://doi.org/10.1038/s41598-020-69869-0

Nieuwenhuijse D, Oude Munnink B, Phan M, Hendriksen R, Bego A, Rees C, Neilson E, Coventry K, Collignon P, Allerberger F, Rahube T, Oliveira G, Ivanov I, Sopheak T, Vuthy Y, Yost C, Tabo D, Cuadros-Orellana S, Ke C, Zheng H, Baisheng L, Jiao X, Donado-Godoy P, Coulibaly K, Hrenovic J, Jergović M, Karpíšková R, Elsborg B, Legesse M, Eguale T, Heikinheimo A, Villacis J, Sanneh B, Malania L, Nitsche A, Brinkmann A, Saba C, Kocsis B, Solymosi N, Thorsteinsdottir T, Hatha A, Alebouyeh M, Morris D, O’Connor L, Cormican M, Moran-Gilad J, Battisti A, Alba P, Shakenova Z, Kiiyukia C, Ng’eno E, Raka L, Bērziņš A, Avsejenko J, Bartkevics V, Penny C, Rajandas H, Parimannan S, Haber M, Pal P, Schmitt H, van Passel M, van de Schans M, Zuidema T, Jeunen G, Gemmell N, Fashae K, Wester A, Holmstad R, Hasan R, Shakoor S, Rojas M, Wasyl D, Bosevska G, Kochubovski M, Radu C, Gassama† A, Radosavljević V, Tay M, Zuniga-Montanez R, Wuertz S, Gavačová D, Trkov M, Keddy K, Esterhuyse K, Cerdà-Cuéllar M, Pathirage S, Larsson D, Norrgren L, Örn S, Van der Heijden T, Kumburu H, de RodaHusman A, Njanpop-Lafourcade B, Bidjada P, Nikiema-Pessinaba S, Levent B, Meschke J, Beck N, Van Dang C, Tran D, Do Phuc N, Kwenda G, Munk P, Venkatakrishnan S, Aarestrup F, Cotten M, Koopmans M. Setting a baseline for global urban virome surveillance in sewage. in Scientific Reports. 2020;10(1).
doi:10.1038/s41598-020-69869-0 .

Nieuwenhuijse, D.F., Oude Munnink, B.B., Phan, M.V.T., Hendriksen, R.S., Bego, A., Rees, C., Neilson, E.H., Coventry, K., Collignon, P., Allerberger, F., Rahube, T.O., Oliveira, G., Ivanov, I., Sopheak, T., Vuthy, Y., Yost, C.K., Tabo, D.-A., Cuadros-Orellana, S., Ke, C., Zheng, H., Baisheng, L., Jiao, X., Donado-Godoy, P., Coulibaly, K.J., Hrenovic, J., Jergović, M., Karpíšková, R., Elsborg, B., Legesse, M., Eguale, T., Heikinheimo, A., Villacis, J.E., Sanneh, B., Malania, L., Nitsche, A., Brinkmann, A., Saba, C.K.S., Kocsis, B., Solymosi, N., Thorsteinsdottir, T.R., Hatha, A.M., Alebouyeh, M., Morris, D., O’Connor, L., Cormican, M., Moran-Gilad, J., Battisti, A., Alba, P., Shakenova, Z., Kiiyukia, C., Ng’eno, E., Raka, L., Bērziņš, A., Avsejenko, J., Bartkevics, V., Penny, C., Rajandas, H., Parimannan, S., Haber, M.V., Pal, P., Schmitt, H., van Passel, M., van de Schans, M.G.M., Zuidema, T., Jeunen, G.-J., Gemmell, N., Fashae, K., Wester, A.L., Holmstad, R., Hasan, R., Shakoor, S., Rojas, M.L.Z., Wasyl, D., Bosevska, G., Kochubovski, M., Radu, C., Gassama†, A., Radosavljević, Vladimir, Tay, M.Y.F., Zuniga-Montanez, R., Wuertz, S., Gavačová, D., Trkov, M., Keddy, K., Esterhuyse, K., Cerdà-Cuéllar, M., Pathirage, S., Larsson, D.G.J., Norrgren, L., Örn, S., Van der Heijden, T., Kumburu, H.H., de RodaHusman, A.M., Njanpop-Lafourcade, B.-M., Bidjada, P., Nikiema-Pessinaba, S.C., Levent, B., Meschke, J.S., Beck, N.K., Van Dang, C., Tran, D.M.N., Do Phuc, N., Kwenda, G., Munk, P., Venkatakrishnan, S., Aarestrup, F.M., Cotten, M., Koopmans, M.P.G., "Setting a baseline for global urban virome surveillance in sewage" in Scientific Reports, 10, no. 1 (2020),
https://doi.org/10.1038/s41598-020-69869-0 . .

TY  - JOUR
AU  - Huszenicza, Gyula
AU  - Kulcsár, M.
AU  - Kóródi, P.
AU  - Bartyik, J.
AU  - Rudas, P.
AU  - Ribiczei-Szabó, P.
AU  - Nikolić-Judith, Anna
AU  - Šamanc, Horea
AU  - Ivanov, I.
AU  - Gvozdić, Dragan
PY  - 2006
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/403
AB  - The involvement of adrenocortical and thyroid hormones in the pathogenesis of ketosis, as well as the ovarian consequences of this metabolic disorder, were studied in _2 parity cows (n=199) in 3 large scale dairy herds. To compare the plasma/serum concentrations of certain hormones Šcortisol, thyroxin (T4), triiodothyronine (T3), insulin, insulin-like growth factor-1 (IGF-1)¹ and metabolites Šglucose (G), acetoacetic acid (ACAC), βOH-butyrate (BHB), non-esterified fatty acid (NEFA), trigliceride (TG), total cholesterol (TCh)¹, and the activity of aspartate aminotransferase (AST), blood samples were taken 1 to 3 days after calving and again 4 times 7 days apart. The ACTH-challenged cortisol responsiveness and the TRH-induced T4/T3 increase were determined between days 1 to 3 and again between days 28 to 35. The resumption of ovarian cyclicity was followed up by individual progesterone (P4) profiles based on milk samples taken 3 times a week for about 80 to 85 days. BHB level of 1 mmol/L was estimated as a border line between hyper- (>1 mmol/L) and normoketonaemic ( lt 1 mmol/L) conditions. Five different ketone patterns were distinguished: (1) non-ketotic (n=98; normoketonaemia in all samples), (2) early type ketosis (n=45; hyperketonemia was detected only in the first week after calving), (3) late type (lactational) ketosis (n=11; after a normoketonaemic period increasing hyperketonaemia was detected in the 5th, or in the 4th and 5th weeks), (4) temporary ketosis (n=11; hyperketonaemia was detected for 1-2 weeks in the 2nd and 3rd or in the 3rd and 4th weeks); (5) long-lasting ketosis (n=34; hyperketonaemia has been detected since calving for 4 to 5 weeks or until dying / emergency slaughtering). Simultaneously with the hyperketonaemic stage increased NEFA, ACAC, depressed TCh, glucose and decreased insulin, IGF-1, T4 and T3 concentrations were detected in almost all the cases. Obvious metabolic and endocrine alterations were found, however, only in long-lasting ketosis. The TRH-stimulated T4 and T3 responses remained almost unaffected proving intact thyroid function in early and late type as well as in temporary ketosis. Depressed thyroid response and delayed onset of cyclic ovarian function were detected only in cases of long-lasting ketosis. The cows characterized by lower than normal ( lt mean-SD of non-ketotic cows) ACTH-stimulated cortisol response on days 1-3 after calving showed poorer chance for spontaneous recovery. There was a significant negative correlation between the IGF-1 level in the 1st week after calving and the duration of the postpartum acyclic period. In late type (lactational) ketosis the cessation of ovarian cyclicity was the most characteristic genital malfunction.
AB  - Uloga adrenokortikalnih i tiroidnih hormona u patogenezi ketoze i poremećaja funkcije jajnika, proučavana je u dve približno jednake grupe krava (n=199) u 3 velika zapata mlečnih krava. U cilju upoređivanja koncentracije određenih hormona Škortizol, tiroksin (T4), trijodtironin (T3), insulin, insulinu-sličan faktor rasta (IGF-1)¹, metabolita Šglikoza (G), acetosirćetna kiselina (ACAC), βOH butirat (BHB), neesterifikovane masne kiseline (NEFA), trigliceridi (TG), ukupni holesterol (TCh)¹, i aktivnosti aspartat aminotransferaze (AST) u krvnoj plazmi/serumu, uzimani su uzorci krvi od prvog do trećeg dana posle teljenja i ponovo 4 puta u razmacima od po 7 dana. Povećanje koncentracije kortizola, posle aplikacije ACTH, i povećanje koncentracije T4/T3 nakon aplikacije TRH je utvrđeno između 1. do 3. dana i ponovo između 28. do 35-og dana. Ponovno uspostavljanje cikličnosti funkcije jajnika bilo je praćeno individualnim profilima progesterona (P4) na osnovu kontrole uzoraka mleka uzetih 3 puta nedeljno tokom perioda od 80 do 85 dana. Nivo BHB od 1 mmol/l je bio utvrđen kao granica između hiperketonemičnih (>1 mmol/l) i normoketonemičnih ( lt 1 mmol/l) stanja. Na osnovu toga krave su razvrstane u pet jasno definisanih grupa: (1) krave koje nisu ketozne (n=98; normoketonemija u svim uzorcima), (2) rani tip ketoze (n=45; hiperketonemija utvrđena samo u prvoj nedelji posle teljenja), (3) kasni (laktacioni) tip ketoze (n=11; posle perioda normoketonemije detektovana je hiperketonemija u 4-oj i 5-oj nedelji, ili u 5-oj nedelji), (4) povremena ketoza (n=11; hiperketonemija je detektovana u trajanju od 1-2 nedelje u drugoj i trećoj ili u trećoj i četvrtoj nedelji), (5) dugotrajna ketoza (n=34; hiperketonemija je bila dijagnostikovana od teljenja tokom 4 do 5 nedelja ili posle uginuća/prinudnog klanja). Istovremeno sa stanjem hiperketonemije bilo je ustanovljeno povećanje koncentracija NEFA, ACAC, i smanjenje TCh, glikoze, IGF-1, T4 i T3 u skoro svim slučajevima. Ipak, očigledne metaboličke i endokrine promene su pronađene, samo kod dugotrajne ketoze. T4 i T3 odgovor stimulisan TRH-om ostao je skoro nepromenjen što dokazuje nepromenjenu funkciju tiroideje u ranom i kasnom kao i u prolaznom tipu ketoze. Hipofunkcija tiroideje i usporeno uspostavljanje ciklične funkcije jajnika bilo je utvrđeno samo u slučajevima dugotrajne ketoze. Krave koje su imale nižu koncentraciju kortizola, kao odgovor na aplikovan ACTH 1-3 dana posle teljenja, imale su manje šanse za spontani oporavak. Postoji značajna negativna korelacija između nivoa IGF-1 u prvoj nedelji posle teljenja i dužine trajanja postpartalnog perioda aciklije. U kasnom (laktacionom) tipu ketoze prekid ciklične funkcije jajnika bio je najkarakterističniji genitalni poremećaj.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta Veterinaria-Beograd
T1  - Adrenocortical and thyroid function, hormone and metabolite profiles and the onset of ovarian cyclicity in dairy cows suffering from various forms of ketosis
T1  - Adrenokortikalna i tiroidna funkcija, hormonski i metabolički profil i poremećaj cikličnosti funkcija jajnika u mlečnih krava koje pate od raznih oblika ketoze
VL  - 56
IS  - 1
SP  - 25
EP  - 36
DO  - 10.2298/AVB0601025H
ER  - 

@article{
author = "Huszenicza, Gyula and Kulcsár, M. and Kóródi, P. and Bartyik, J. and Rudas, P. and Ribiczei-Szabó, P. and Nikolić-Judith, Anna and Šamanc, Horea and Ivanov, I. and Gvozdić, Dragan",
year = "2006",
abstract = "The involvement of adrenocortical and thyroid hormones in the pathogenesis of ketosis, as well as the ovarian consequences of this metabolic disorder, were studied in _2 parity cows (n=199) in 3 large scale dairy herds. To compare the plasma/serum concentrations of certain hormones Šcortisol, thyroxin (T4), triiodothyronine (T3), insulin, insulin-like growth factor-1 (IGF-1)¹ and metabolites Šglucose (G), acetoacetic acid (ACAC), βOH-butyrate (BHB), non-esterified fatty acid (NEFA), trigliceride (TG), total cholesterol (TCh)¹, and the activity of aspartate aminotransferase (AST), blood samples were taken 1 to 3 days after calving and again 4 times 7 days apart. The ACTH-challenged cortisol responsiveness and the TRH-induced T4/T3 increase were determined between days 1 to 3 and again between days 28 to 35. The resumption of ovarian cyclicity was followed up by individual progesterone (P4) profiles based on milk samples taken 3 times a week for about 80 to 85 days. BHB level of 1 mmol/L was estimated as a border line between hyper- (>1 mmol/L) and normoketonaemic ( lt 1 mmol/L) conditions. Five different ketone patterns were distinguished: (1) non-ketotic (n=98; normoketonaemia in all samples), (2) early type ketosis (n=45; hyperketonemia was detected only in the first week after calving), (3) late type (lactational) ketosis (n=11; after a normoketonaemic period increasing hyperketonaemia was detected in the 5th, or in the 4th and 5th weeks), (4) temporary ketosis (n=11; hyperketonaemia was detected for 1-2 weeks in the 2nd and 3rd or in the 3rd and 4th weeks); (5) long-lasting ketosis (n=34; hyperketonaemia has been detected since calving for 4 to 5 weeks or until dying / emergency slaughtering). Simultaneously with the hyperketonaemic stage increased NEFA, ACAC, depressed TCh, glucose and decreased insulin, IGF-1, T4 and T3 concentrations were detected in almost all the cases. Obvious metabolic and endocrine alterations were found, however, only in long-lasting ketosis. The TRH-stimulated T4 and T3 responses remained almost unaffected proving intact thyroid function in early and late type as well as in temporary ketosis. Depressed thyroid response and delayed onset of cyclic ovarian function were detected only in cases of long-lasting ketosis. The cows characterized by lower than normal ( lt mean-SD of non-ketotic cows) ACTH-stimulated cortisol response on days 1-3 after calving showed poorer chance for spontaneous recovery. There was a significant negative correlation between the IGF-1 level in the 1st week after calving and the duration of the postpartum acyclic period. In late type (lactational) ketosis the cessation of ovarian cyclicity was the most characteristic genital malfunction., Uloga adrenokortikalnih i tiroidnih hormona u patogenezi ketoze i poremećaja funkcije jajnika, proučavana je u dve približno jednake grupe krava (n=199) u 3 velika zapata mlečnih krava. U cilju upoređivanja koncentracije određenih hormona Škortizol, tiroksin (T4), trijodtironin (T3), insulin, insulinu-sličan faktor rasta (IGF-1)¹, metabolita Šglikoza (G), acetosirćetna kiselina (ACAC), βOH butirat (BHB), neesterifikovane masne kiseline (NEFA), trigliceridi (TG), ukupni holesterol (TCh)¹, i aktivnosti aspartat aminotransferaze (AST) u krvnoj plazmi/serumu, uzimani su uzorci krvi od prvog do trećeg dana posle teljenja i ponovo 4 puta u razmacima od po 7 dana. Povećanje koncentracije kortizola, posle aplikacije ACTH, i povećanje koncentracije T4/T3 nakon aplikacije TRH je utvrđeno između 1. do 3. dana i ponovo između 28. do 35-og dana. Ponovno uspostavljanje cikličnosti funkcije jajnika bilo je praćeno individualnim profilima progesterona (P4) na osnovu kontrole uzoraka mleka uzetih 3 puta nedeljno tokom perioda od 80 do 85 dana. Nivo BHB od 1 mmol/l je bio utvrđen kao granica između hiperketonemičnih (>1 mmol/l) i normoketonemičnih ( lt 1 mmol/l) stanja. Na osnovu toga krave su razvrstane u pet jasno definisanih grupa: (1) krave koje nisu ketozne (n=98; normoketonemija u svim uzorcima), (2) rani tip ketoze (n=45; hiperketonemija utvrđena samo u prvoj nedelji posle teljenja), (3) kasni (laktacioni) tip ketoze (n=11; posle perioda normoketonemije detektovana je hiperketonemija u 4-oj i 5-oj nedelji, ili u 5-oj nedelji), (4) povremena ketoza (n=11; hiperketonemija je detektovana u trajanju od 1-2 nedelje u drugoj i trećoj ili u trećoj i četvrtoj nedelji), (5) dugotrajna ketoza (n=34; hiperketonemija je bila dijagnostikovana od teljenja tokom 4 do 5 nedelja ili posle uginuća/prinudnog klanja). Istovremeno sa stanjem hiperketonemije bilo je ustanovljeno povećanje koncentracija NEFA, ACAC, i smanjenje TCh, glikoze, IGF-1, T4 i T3 u skoro svim slučajevima. Ipak, očigledne metaboličke i endokrine promene su pronađene, samo kod dugotrajne ketoze. T4 i T3 odgovor stimulisan TRH-om ostao je skoro nepromenjen što dokazuje nepromenjenu funkciju tiroideje u ranom i kasnom kao i u prolaznom tipu ketoze. Hipofunkcija tiroideje i usporeno uspostavljanje ciklične funkcije jajnika bilo je utvrđeno samo u slučajevima dugotrajne ketoze. Krave koje su imale nižu koncentraciju kortizola, kao odgovor na aplikovan ACTH 1-3 dana posle teljenja, imale su manje šanse za spontani oporavak. Postoji značajna negativna korelacija između nivoa IGF-1 u prvoj nedelji posle teljenja i dužine trajanja postpartalnog perioda aciklije. U kasnom (laktacionom) tipu ketoze prekid ciklične funkcije jajnika bio je najkarakterističniji genitalni poremećaj.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta Veterinaria-Beograd",
title = "Adrenocortical and thyroid function, hormone and metabolite profiles and the onset of ovarian cyclicity in dairy cows suffering from various forms of ketosis, Adrenokortikalna i tiroidna funkcija, hormonski i metabolički profil i poremećaj cikličnosti funkcija jajnika u mlečnih krava koje pate od raznih oblika ketoze",
volume = "56",
number = "1",
pages = "25-36",
doi = "10.2298/AVB0601025H"
}

Huszenicza, G., Kulcsár, M., Kóródi, P., Bartyik, J., Rudas, P., Ribiczei-Szabó, P., Nikolić-Judith, A., Šamanc, H., Ivanov, I.,& Gvozdić, D.. (2006). Adrenocortical and thyroid function, hormone and metabolite profiles and the onset of ovarian cyclicity in dairy cows suffering from various forms of ketosis. in Acta Veterinaria-Beograd
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 56(1), 25-36.
https://doi.org/10.2298/AVB0601025H

Huszenicza G, Kulcsár M, Kóródi P, Bartyik J, Rudas P, Ribiczei-Szabó P, Nikolić-Judith A, Šamanc H, Ivanov I, Gvozdić D. Adrenocortical and thyroid function, hormone and metabolite profiles and the onset of ovarian cyclicity in dairy cows suffering from various forms of ketosis. in Acta Veterinaria-Beograd. 2006;56(1):25-36.
doi:10.2298/AVB0601025H .

Huszenicza, Gyula, Kulcsár, M., Kóródi, P., Bartyik, J., Rudas, P., Ribiczei-Szabó, P., Nikolić-Judith, Anna, Šamanc, Horea, Ivanov, I., Gvozdić, Dragan, "Adrenocortical and thyroid function, hormone and metabolite profiles and the onset of ovarian cyclicity in dairy cows suffering from various forms of ketosis" in Acta Veterinaria-Beograd, 56, no. 1 (2006):25-36,
https://doi.org/10.2298/AVB0601025H . .

TY  - JOUR
AU  - Stojić, Velibor
AU  - Gvozdić, Dragan
AU  - Kirovski, Danijela
AU  - Nikolić-Judith, Anna
AU  - Huszenicza, Gyula
AU  - Šamanc, Horea
AU  - Ivanov, I.
PY  - 2001
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/166
AB  - Serum thyroxine (T4) and triiodothyronine (T3) concentrations were determined twice daily (830h and 16h) in seven primiparous Holstein cows from 4 days prior to (-4, -3, -2, -1) to delivery, on the day of calving, and up to 4 days postpartum (1, 2, 3, 4) by radioirnmunoassay (RIA). Serum thyroid hormone concentrations were higher in the afternoon samples on the first two days of investigation (-4 and -3), hut this circadian rhythm was not maintained. Serum thyroid hormones declined significantly after delivery according to a polynomial regression line (R2=0.967 for T4; R2=0.9216 for T3).
AB  - Ispitivanje koncentracije tiroksina (T4) i trijodtironina (T3) u krvnom serumu vršena su radioimunološkom (RIA) metodom kod 7 junica Holštajn rase 4 dana pre porođaja (-4, -3, -2, -1), na dan porođaja (0 dan), i posle pqrpdaja (1, 2, 3, 4 dana) uzimanjem dva uzorka krvnog seruma dneyno (u 8 h ujutro i 16h popodne). Koncentracija hormona tireoideje bilaje visa u popodnevnom uzorku u prva dva dana ispitivanja (- 4 i - 3 dana), ali nije ustanovljen jasan cirkadijalni ritam njihove sekrecije. Koncentracija hormonatireoideje opada značajno nakon partusa prateći regresionu polinomsku liniju (R =0.967 za T4; R =0.9216 za Т3).
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta Veterinaria-Beograd
T1  - Serum thyroxine and triiodothyronine concentrations prior to and after delivery in primiparous Holstein cows
T1  - Koncentracija tiroksina i trijodtironina u krvnom serumu junica Holštajn rase pre i posle partusa
VL  - 51
IS  - 1
SP  - 3
EP  - 8
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_166
ER  - 

@article{
author = "Stojić, Velibor and Gvozdić, Dragan and Kirovski, Danijela and Nikolić-Judith, Anna and Huszenicza, Gyula and Šamanc, Horea and Ivanov, I.",
year = "2001",
abstract = "Serum thyroxine (T4) and triiodothyronine (T3) concentrations were determined twice daily (830h and 16h) in seven primiparous Holstein cows from 4 days prior to (-4, -3, -2, -1) to delivery, on the day of calving, and up to 4 days postpartum (1, 2, 3, 4) by radioirnmunoassay (RIA). Serum thyroid hormone concentrations were higher in the afternoon samples on the first two days of investigation (-4 and -3), hut this circadian rhythm was not maintained. Serum thyroid hormones declined significantly after delivery according to a polynomial regression line (R2=0.967 for T4; R2=0.9216 for T3)., Ispitivanje koncentracije tiroksina (T4) i trijodtironina (T3) u krvnom serumu vršena su radioimunološkom (RIA) metodom kod 7 junica Holštajn rase 4 dana pre porođaja (-4, -3, -2, -1), na dan porođaja (0 dan), i posle pqrpdaja (1, 2, 3, 4 dana) uzimanjem dva uzorka krvnog seruma dneyno (u 8 h ujutro i 16h popodne). Koncentracija hormona tireoideje bilaje visa u popodnevnom uzorku u prva dva dana ispitivanja (- 4 i - 3 dana), ali nije ustanovljen jasan cirkadijalni ritam njihove sekrecije. Koncentracija hormonatireoideje opada značajno nakon partusa prateći regresionu polinomsku liniju (R =0.967 za T4; R =0.9216 za Т3).",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta Veterinaria-Beograd",
title = "Serum thyroxine and triiodothyronine concentrations prior to and after delivery in primiparous Holstein cows, Koncentracija tiroksina i trijodtironina u krvnom serumu junica Holštajn rase pre i posle partusa",
volume = "51",
number = "1",
pages = "3-8",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_166"
}

Stojić, V., Gvozdić, D., Kirovski, D., Nikolić-Judith, A., Huszenicza, G., Šamanc, H.,& Ivanov, I.. (2001). Serum thyroxine and triiodothyronine concentrations prior to and after delivery in primiparous Holstein cows. in Acta Veterinaria-Beograd
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 51(1), 3-8.
https://hdl.handle.net/21.15107/rcub_veterinar_166

Stojić V, Gvozdić D, Kirovski D, Nikolić-Judith A, Huszenicza G, Šamanc H, Ivanov I. Serum thyroxine and triiodothyronine concentrations prior to and after delivery in primiparous Holstein cows. in Acta Veterinaria-Beograd. 2001;51(1):3-8.
https://hdl.handle.net/21.15107/rcub_veterinar_166 .

Stojić, Velibor, Gvozdić, Dragan, Kirovski, Danijela, Nikolić-Judith, Anna, Huszenicza, Gyula, Šamanc, Horea, Ivanov, I., "Serum thyroxine and triiodothyronine concentrations prior to and after delivery in primiparous Holstein cows" in Acta Veterinaria-Beograd, 51, no. 1 (2001):3-8,
https://hdl.handle.net/21.15107/rcub_veterinar_166 .

TY  - JOUR
AU  - Nikolić, Z
AU  - Blagojević, Z.
AU  - Mrvić, Verica
AU  - Ivanov, I
PY  - 1999
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/106
AB  - The ovaries and the uterine as well as vaginal mucous membranes of 80-, 180- and 365-day-old intact female rats and females neonatally treated with a single dose of oestrogen and repeated doses of human chorionic gonadotropin (hCG) were studied. Numerous follicles, interstitial cells and corpora lutea (CL) were present on the ovary of intact females from 80 up to 365 days of age. The number of primary and secondary follicles decreased in the intact female rats between Day 180 and Day 365 of life. On the ovaries of 180- and 365-day-old female rats neonatally treated with oestrogen, interstitial glandular cells and cystic follicles predominated. No CL were present on these ovaries. The height of epithelial cells of the uterine and vaginal mucous membranes increased in intact female rats from 80 to 365 days of age, whereas in oestrogen-treated females the height of epithelium decreased. From 80 up to 365 days of age, the height of epithelial cells of uterine and vaginal mucous membranes of rats neonatally treated with repeated doses of hCG was similar to that in the corresponding control animals.
PB  - Akademiai Kiado Zrt, Budapest
T2  - Acta veterinaria Hungarica
T1  - Effect of neonatal oestrogen and hCG treatment on the genital organs of adult female rats
VL  - 47
IS  - 1
SP  - 109
EP  - 115
DO  - 10.1556/AVet.47.1999.1.11
ER  - 

@article{
author = "Nikolić, Z and Blagojević, Z. and Mrvić, Verica and Ivanov, I",
year = "1999",
abstract = "The ovaries and the uterine as well as vaginal mucous membranes of 80-, 180- and 365-day-old intact female rats and females neonatally treated with a single dose of oestrogen and repeated doses of human chorionic gonadotropin (hCG) were studied. Numerous follicles, interstitial cells and corpora lutea (CL) were present on the ovary of intact females from 80 up to 365 days of age. The number of primary and secondary follicles decreased in the intact female rats between Day 180 and Day 365 of life. On the ovaries of 180- and 365-day-old female rats neonatally treated with oestrogen, interstitial glandular cells and cystic follicles predominated. No CL were present on these ovaries. The height of epithelial cells of the uterine and vaginal mucous membranes increased in intact female rats from 80 to 365 days of age, whereas in oestrogen-treated females the height of epithelium decreased. From 80 up to 365 days of age, the height of epithelial cells of uterine and vaginal mucous membranes of rats neonatally treated with repeated doses of hCG was similar to that in the corresponding control animals.",
publisher = "Akademiai Kiado Zrt, Budapest",
journal = "Acta veterinaria Hungarica",
title = "Effect of neonatal oestrogen and hCG treatment on the genital organs of adult female rats",
volume = "47",
number = "1",
pages = "109-115",
doi = "10.1556/AVet.47.1999.1.11"
}

Nikolić, Z., Blagojević, Z., Mrvić, V.,& Ivanov, I.. (1999). Effect of neonatal oestrogen and hCG treatment on the genital organs of adult female rats. in Acta veterinaria Hungarica
Akademiai Kiado Zrt, Budapest., 47(1), 109-115.
https://doi.org/10.1556/AVet.47.1999.1.11

Nikolić Z, Blagojević Z, Mrvić V, Ivanov I. Effect of neonatal oestrogen and hCG treatment on the genital organs of adult female rats. in Acta veterinaria Hungarica. 1999;47(1):109-115.
doi:10.1556/AVet.47.1999.1.11 .

Nikolić, Z, Blagojević, Z., Mrvić, Verica, Ivanov, I, "Effect of neonatal oestrogen and hCG treatment on the genital organs of adult female rats" in Acta veterinaria Hungarica, 47, no. 1 (1999):109-115,
https://doi.org/10.1556/AVet.47.1999.1.11 . .