The International Atomic Energy Agency (IAEA) through the Research Project entitled “Animal Identification, Pedigree, Exterior and Performance Data Recording in Selected Holstein-Friesian (HF) Cattle Population in Serbia Used for Future Genetic Selection under AI Programmes” (Research Contract 20774), which forms part of the IAEA Coordinated Research Project D31028, entitled “Application of Nuclear and Genomic Tools to Enable for the Selection of Animals with Enhanced Productivity Traits”

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http://vet-erinar.vet.bg.ac.rs/APP/faces/project.xhtml?project_id=The+International+Atomic+Energy+Agency+%28IAEA%29+through+the+Research+Project+entitled+%E2%80%9CAnimal+Identification%2C+Pedigree%2C+Exterior+and+Performance+Data+Recording+in+Selected+Holstein-Friesian+%28HF%29+Cattle+Population+in+Serbia+Used+for+Future+Genetic+Selection+under+AI+Programmes%E2%80%9D+%28Research+Contract+20774%29%2C+which+forms+part+of+the+IAEA+Coordinated+Research+Project+D31028%2C+entitled+%E2%80%9CApplication+of+Nuclear+and+Genomic+Tools+to+Enable+for+the+Selection+of+Animals+with+Enhanced+Productivity+Traits%E2%80%9D&item_offset=0&author_offset=0&sort_by=dc.date.issued

The International Atomic Energy Agency (IAEA) through the Research Project entitled “Animal Identification, Pedigree, Exterior and Performance Data Recording in Selected Holstein-Friesian (HF) Cattle Population in Serbia Used for Future Genetic Selection under AI Programmes” (Research Contract 20774), which forms part of the IAEA Coordinated Research Project D31028, entitled “Application of Nuclear and Genomic Tools to Enable for the Selection of Animals with Enhanced Productivity Traits”

Authors

Publications

Genome-wide analysis of milk production traits and selection signatures in Serbian Holstein-Friesian Cattle

Ristanić, Marko; Zorc, Minja; Glavinić, Uroš; Stevanović, Jevrosima; Blagojević, Jovan; Maletić, Milan; Stanimirović, Zoran

(MDPI, 2024) 

TY  - JOUR
AU  - Ristanić, Marko
AU  - Zorc, Minja
AU  - Glavinić, Uroš
AU  - Stevanović, Jevrosima
AU  - Blagojević, Jovan
AU  - Maletić, Milan
AU  - Stanimirović, Zoran
PY  - 2024
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/3706
AB  - To improve the genomic evaluation of milk-related traits in Holstein-Friesian (HF) cattle it
is essential to identify the associated candidate genes. Novel SNP-based analyses, such as the genetic
mapping of inherited diseases, GWAS, and genomic selection, have led to a new era of research.
The aim of this study was to analyze the association of each individual SNP in Serbian HF cattle
with milk production traits and inbreeding levels. The SNP 60 K chip Axiom Bovine BovMDv3
was deployed for the genotyping of 334 HF cows. The obtained genomic results, together with the
collected phenotypic data, were used for a GWAS. Moreover, the identification of ROH segments
was performed and served for inbreeding coefficient evaluation and ROH island detection. Using a
GWAS, a polymorphism, rs110619097 (located in the intron of the CTNNA3 gene), was detected to be
significantly (p < 0.01) associated with the milk protein concentration in the first lactation (adjusted to
305 days). The average genomic inbreeding value (FROH) was 0.079. ROH islands were discovered
in proximity to genes associated with milk production traits and genomic regions under selection
pressure for other economically important traits of dairy cattle. The findings of this pilot study
provide useful information for a better understanding of the genetic architecture of milk production
traits in Serbian HF dairy cows and can be used to improve lactation performances in Serbian HF
cattle breeding programs.
PB  - MDPI
T2  - Animals
T1  - Genome-wide analysis of milk production traits and selection signatures in Serbian Holstein-Friesian Cattle
VL  - 14
IS  - 5
SP  - 669
DO  - 10.3390/ani14050669
ER  - 
@article{
author = "Ristanić, Marko and Zorc, Minja and Glavinić, Uroš and Stevanović, Jevrosima and Blagojević, Jovan and Maletić, Milan and Stanimirović, Zoran",
year = "2024",
abstract = "To improve the genomic evaluation of milk-related traits in Holstein-Friesian (HF) cattle it
is essential to identify the associated candidate genes. Novel SNP-based analyses, such as the genetic
mapping of inherited diseases, GWAS, and genomic selection, have led to a new era of research.
The aim of this study was to analyze the association of each individual SNP in Serbian HF cattle
with milk production traits and inbreeding levels. The SNP 60 K chip Axiom Bovine BovMDv3
was deployed for the genotyping of 334 HF cows. The obtained genomic results, together with the
collected phenotypic data, were used for a GWAS. Moreover, the identification of ROH segments
was performed and served for inbreeding coefficient evaluation and ROH island detection. Using a
GWAS, a polymorphism, rs110619097 (located in the intron of the CTNNA3 gene), was detected to be
significantly (p < 0.01) associated with the milk protein concentration in the first lactation (adjusted to
305 days). The average genomic inbreeding value (FROH) was 0.079. ROH islands were discovered
in proximity to genes associated with milk production traits and genomic regions under selection
pressure for other economically important traits of dairy cattle. The findings of this pilot study
provide useful information for a better understanding of the genetic architecture of milk production
traits in Serbian HF dairy cows and can be used to improve lactation performances in Serbian HF
cattle breeding programs.",
publisher = "MDPI",
journal = "Animals",
title = "Genome-wide analysis of milk production traits and selection signatures in Serbian Holstein-Friesian Cattle",
volume = "14",
number = "5",
pages = "669",
doi = "10.3390/ani14050669"
}
Ristanić, M., Zorc, M., Glavinić, U., Stevanović, J., Blagojević, J., Maletić, M.,& Stanimirović, Z.. (2024). Genome-wide analysis of milk production traits and selection signatures in Serbian Holstein-Friesian Cattle. in Animals
MDPI., 14(5), 669.
https://doi.org/10.3390/ani14050669
Ristanić M, Zorc M, Glavinić U, Stevanović J, Blagojević J, Maletić M, Stanimirović Z. Genome-wide analysis of milk production traits and selection signatures in Serbian Holstein-Friesian Cattle. in Animals. 2024;14(5):669.
doi:10.3390/ani14050669 .
Ristanić, Marko, Zorc, Minja, Glavinić, Uroš, Stevanović, Jevrosima, Blagojević, Jovan, Maletić, Milan, Stanimirović, Zoran, "Genome-wide analysis of milk production traits and selection signatures in Serbian Holstein-Friesian Cattle" in Animals, 14, no. 5 (2024):669,
https://doi.org/10.3390/ani14050669 . .