@article{
author = "Fromes, Yves and Liu, Jian-Miao and Kovačević, Milica and Bignon, Jerome and Wdzieczak-Bakala, Joanna",
year = "2006",
abstract = "The tetrapeptide acetyl-serine-aspartyl-lysine-proline (AcSDKP) has recently
been recognized as a potent angiogenic factor. Given the importance of vascular
blood supply in the process of tissue repair we have investigated the ability of
AcSDKP to contribute to the repair of cutaneous injuries by using dorsal and
abdominal skin flap models. Postoperative subdermal AcSDKP injections (5 mg/
kg/injection twice a day for 3 days following flap elevation) prevented marginally
perfused areas from undergoing necrosis. Mean skin survival area of abdominal
and dorsal flaps ranged, respectively, from 50.9 19.3 and 53.4 4.2% in the
control groups to 66.4 7.5 and 74.7 6.6% in AcSDKP-treated groups. Furthermore,
in an ex vivo assay, AcSDKP applied locally to skin explants at doses
from 10 8 to 10 5M improved survival of the explanted skin exposed to UVB
irradiation at 10 J/cm2. Increased reepithelialization, as well as higher levels of
expression of basal keratin 14 and increased expression of fibronectin was observed
after topical application of AcSDKP. These data provide experimental
evidence that AcSDKP can improve the viability of ischemic skin flaps in the rat
by promoting angiogenesis. Moreover, it enhances wound healing of injured
avascular skin explants. Thus, these findings identify AcSDKP as a new tissuerepair
agent and suggest its potential clinical use for the management of skin
wounds.",
publisher = "Wiley",
journal = "Wound Repair and Regeneration",
title = "The tetrapeptide acetyl-serine-aspartyl-lysine-proline improves skin flap survival and accelerates wound healing",
volume = "14",
pages = "306-312",
doi = "10.1111/j.1743-6109.2006.00125.x"
}
