TY  - JOUR
AU  - Trailović, Saša
AU  - Nedeljković-Trailović, Jelena
PY  - 2011
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/788
AB  - Ivermectin is considered a very safe drug; however, there are reports of toxic effects in particularly sensitive populations or due to accidental overdose. The aim of this study was (1) to further characterize the central and peripheral toxic effects of ivermectin in animals and (2) to determine possible therapeutic strategies for use in cases of ivermectin poisoning. We tested the effects of experimental doses of ivermectin previously reported to cause various intensities of CNS depression. However, in our study, ivermectin at 2.5, 5.0 and 7.5 mg/kg i.v. did not produce visible CNS depression in rats and 10 mg/kg resulted in sleepiness and staggering 10 to 40 min after application, while a dose of 15 mg/kg caused CNS depression very similar to general anesthesia. Ivermectin dose-dependently potentiates thiopentone-induced sleeping time in rats. Flumazenil (0.2 mg/kg), the benzodiazepine antagonist, did not affect the action of thiopentone; however, it significantly reduced sleeping time in rats treated with a combination of ivermectin (10 mg/kg) and thiopentone (25 mg/kg; from 189.86 +/- 45.28 min to 83.13 +/- 32.22 min; mean +/- SD). Ivermectin causes an increase in the tonus (EC50=50.18 mu M) and contraction amplitude (EC50=59.32 mu M) of isolated guinea pig ileum, very similar to GABA, but without the initial relaxation period. These effects are dose-dependent and sensitive to atropine. Our results confirm the central and peripheral GABAergic properties of ivermectin in mammals and also indicate involvement of the cholinergic system in its toxicity. In addition, the results suggest that flumazenil and atropine have potential clinical roles in the treatment of ivermectin toxicity.
PB  - Japan Soc Vet Sci, Tokyo
T2  - Journal of Veterinary Medical Science
T1  - Central and Peripheral Neurotoxic Effects of Ivermectin in Rats
VL  - 73
IS  - 5
SP  - 591
EP  - 599
DO  - 10.1292/jvms.10-0424
ER  - 

@article{
author = "Trailović, Saša and Nedeljković-Trailović, Jelena",
year = "2011",
abstract = "Ivermectin is considered a very safe drug; however, there are reports of toxic effects in particularly sensitive populations or due to accidental overdose. The aim of this study was (1) to further characterize the central and peripheral toxic effects of ivermectin in animals and (2) to determine possible therapeutic strategies for use in cases of ivermectin poisoning. We tested the effects of experimental doses of ivermectin previously reported to cause various intensities of CNS depression. However, in our study, ivermectin at 2.5, 5.0 and 7.5 mg/kg i.v. did not produce visible CNS depression in rats and 10 mg/kg resulted in sleepiness and staggering 10 to 40 min after application, while a dose of 15 mg/kg caused CNS depression very similar to general anesthesia. Ivermectin dose-dependently potentiates thiopentone-induced sleeping time in rats. Flumazenil (0.2 mg/kg), the benzodiazepine antagonist, did not affect the action of thiopentone; however, it significantly reduced sleeping time in rats treated with a combination of ivermectin (10 mg/kg) and thiopentone (25 mg/kg; from 189.86 +/- 45.28 min to 83.13 +/- 32.22 min; mean +/- SD). Ivermectin causes an increase in the tonus (EC50=50.18 mu M) and contraction amplitude (EC50=59.32 mu M) of isolated guinea pig ileum, very similar to GABA, but without the initial relaxation period. These effects are dose-dependent and sensitive to atropine. Our results confirm the central and peripheral GABAergic properties of ivermectin in mammals and also indicate involvement of the cholinergic system in its toxicity. In addition, the results suggest that flumazenil and atropine have potential clinical roles in the treatment of ivermectin toxicity.",
publisher = "Japan Soc Vet Sci, Tokyo",
journal = "Journal of Veterinary Medical Science",
title = "Central and Peripheral Neurotoxic Effects of Ivermectin in Rats",
volume = "73",
number = "5",
pages = "591-599",
doi = "10.1292/jvms.10-0424"
}

Trailović, S.,& Nedeljković-Trailović, J.. (2011). Central and Peripheral Neurotoxic Effects of Ivermectin in Rats. in Journal of Veterinary Medical Science
Japan Soc Vet Sci, Tokyo., 73(5), 591-599.
https://doi.org/10.1292/jvms.10-0424

Trailović S, Nedeljković-Trailović J. Central and Peripheral Neurotoxic Effects of Ivermectin in Rats. in Journal of Veterinary Medical Science. 2011;73(5):591-599.
doi:10.1292/jvms.10-0424 .

Trailović, Saša, Nedeljković-Trailović, Jelena, "Central and Peripheral Neurotoxic Effects of Ivermectin in Rats" in Journal of Veterinary Medical Science, 73, no. 5 (2011):591-599,
https://doi.org/10.1292/jvms.10-0424 . .

TY  - JOUR
AU  - Trailović, Saša
AU  - Ivanović, Saša
AU  - Varagić, Vladislav M.
PY  - 2011
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/761
AB  - Ivermectin, the antiparasitic drug from the macrocyclic lactones class raises attention due to its high efficiency against nematodes and arthropods and very specific toxic and side effects that it may produce in host. Dominant clinical symptoms of adverse effects and toxicity of ivermectin in animals are tremor, ataxia, CNS depression and coma which often results in mortality. In our study increasing intravenous doses of ivermectin, (6 or more times higher than therapeutic dose: 1.25, 2.5, 3.75, 5.0, 6.25 and 7.5 mg/kg), caused dose-dependent disturbance of motor coordination in treated rats. The median effective dose (ED50) that was able to impair the rota-rod performance in rats treated 3 min before testing was 2.52 mg/kg. This effect weakens over time, while in the rats treated 60 min before the rota-rod test. ED50 of ivermectin was 4.21 mg/kg. Whereas, all tested doses of ivermectin did not cause any other clinical symptoms of toxicity. Ivermectin has no effect on the contractions of isolated diaphragm caused by the EFS, which effectively blocked mecamylamine (100 mu M) and pancuronium (1 and 2 mu M). Effect on motor coordination is the first detectable clinical symptom of ivermectin toxicity and apparently is a result of its central effects.
PB  - Elsevier Sci Ltd, Oxford
T2  - Research in Veterinary Science
T1  - Ivermectin effects on motor coordination and contractions of isolated rat diaphragm
VL  - 91
IS  - 3
SP  - 426
EP  - 433
DO  - 10.1016/j.rvsc.2010.09.016
ER  - 

@article{
author = "Trailović, Saša and Ivanović, Saša and Varagić, Vladislav M.",
year = "2011",
abstract = "Ivermectin, the antiparasitic drug from the macrocyclic lactones class raises attention due to its high efficiency against nematodes and arthropods and very specific toxic and side effects that it may produce in host. Dominant clinical symptoms of adverse effects and toxicity of ivermectin in animals are tremor, ataxia, CNS depression and coma which often results in mortality. In our study increasing intravenous doses of ivermectin, (6 or more times higher than therapeutic dose: 1.25, 2.5, 3.75, 5.0, 6.25 and 7.5 mg/kg), caused dose-dependent disturbance of motor coordination in treated rats. The median effective dose (ED50) that was able to impair the rota-rod performance in rats treated 3 min before testing was 2.52 mg/kg. This effect weakens over time, while in the rats treated 60 min before the rota-rod test. ED50 of ivermectin was 4.21 mg/kg. Whereas, all tested doses of ivermectin did not cause any other clinical symptoms of toxicity. Ivermectin has no effect on the contractions of isolated diaphragm caused by the EFS, which effectively blocked mecamylamine (100 mu M) and pancuronium (1 and 2 mu M). Effect on motor coordination is the first detectable clinical symptom of ivermectin toxicity and apparently is a result of its central effects.",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "Research in Veterinary Science",
title = "Ivermectin effects on motor coordination and contractions of isolated rat diaphragm",
volume = "91",
number = "3",
pages = "426-433",
doi = "10.1016/j.rvsc.2010.09.016"
}

Trailović, S., Ivanović, S.,& Varagić, V. M.. (2011). Ivermectin effects on motor coordination and contractions of isolated rat diaphragm. in Research in Veterinary Science
Elsevier Sci Ltd, Oxford., 91(3), 426-433.
https://doi.org/10.1016/j.rvsc.2010.09.016

Trailović S, Ivanović S, Varagić VM. Ivermectin effects on motor coordination and contractions of isolated rat diaphragm. in Research in Veterinary Science. 2011;91(3):426-433.
doi:10.1016/j.rvsc.2010.09.016 .

Trailović, Saša, Ivanović, Saša, Varagić, Vladislav M., "Ivermectin effects on motor coordination and contractions of isolated rat diaphragm" in Research in Veterinary Science, 91, no. 3 (2011):426-433,
https://doi.org/10.1016/j.rvsc.2010.09.016 . .

TY  - JOUR
AU  - Trailović, Saša
AU  - Robertson, Alan P.
AU  - Nedeljković-Trailović, Jelena
PY  - 2009
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/570
AB  - Eugenol, an essential oil of clove oil possesses several different pharmacological properties, including antimicrobial, antifungal, insecticidal and antihelmintic. With regard to the digestive tract, eugenol has shown spasmolitic and relaxant effects. To elucidate some of the mechanisms involved, the effects of eugenol on contractions of isolated rat ileum induced by electrical field stimulation (EFS) were investigated. Eugenol (100 µM) significantly and reversibly reduced EFS induced contractions by approximately 80%. Control contractions were 2.00±0.18 g, while contractions in the presence of eugenol decreased to 0.40±0.02 g (n=7; P=0.0001), respectively. Moreover, eugenol (100 µM) reversibly decreased ileal basal tonus from 0.88±0.04 g to 0.65±0.04 g (n=7; P=0.0002). After incubation with the nitric oxide synthase inhibitor nitro-Larginine methyl ester (L-NAME), eugenol (100 µM) still significantly inhibited ileum contractions (reduction by 75.30%), from 1.70±0.09 g to 0.42±0.08 g (n=6; P=0.0001), respectively. Likewise, incubation with L-NAME did not alter the eugenol relaxant effect on ileal basal tonus. Mean control basal tonus was 0.84±0.07 g and significantly decreased after the addition of eugenol (100 µM), to 0.37±0.09 g (n=6; P=0.0003). After incubation with 300 µM of L-NAME mean basal tonus was 0.85±0.08 g, while eugenol significantly relaxed ileal preparations in the presence of L-NAME to 0.34±0.11 g (n=6; P=0.0003). Our results suggest that eugenol reversibly inhibits contractions caused by EFS and induces relaxation of rat ileum via a mechanism largely independent of NO activity.
AB  - Eugenol, aktivni princip ulja karanfilića, poseduje različita farmakološka svojstva, kao što su antimikrobno, antimikotičko, insekticidno i antihelmintičko. U digestivnom traktu deluje spazmolitički i relaksantno. U cilju bližeg upoznavanja mehanizma dejstva eugenola, ispitan je njegov efekt na kontrakcije iziolovanog ileuma pacova izazvane spoljnom stimulacijom (electrical field stimulation-EFS). Eugenol (100 µM) signifikantno, reverzibilno redukuje kontrakcije ileuma izazvane EFS za oko 80%. Kontrolne kontrakcije iznosile su 2,00 ± 0,18 g, dok su kontrakcije u prisutvu eugenola bile 0,40 ± 0,02 g (n=7; P=0,0001). Eugenol (100 µM), takođe signifikantno smanjuje i bazalni tonus izolovanog ileuma sa 0,88 ± 0,04 g na 0,65 ± 0,04 g (n=7; P=0,0002). Posle inkubacije sa ihibitorom sintaze azotnog oksida L-NAME, eugenol i dalje signifikantno redukuje kontrakcije ileuma (za 75,30%) sa kontrolnih 1,70 ± 0,09 g na 0,42±0,08 g (n=6; P=0,0001). Isto tako, inkubacija sa L-NAME ne utiče na relaksantni efekt eugenola na bazalni tonus ileuma. Kontrolna srednja vrednost bazalnog tonusa bila je 0,84 ± 0,07 g i signifikantno je smanjena posle dodavanja eugenola (100 µM) na 0,37 ± 0,09 g (n=6; P=0,0003). Posle inkubacije sa 300 µML-NAME, srednji bazalni tonus bio je 0,85±0,08 g, dok je eugenol i u prisustvu L-NAME relaksirao izolovani ileum na 0,34 ± 0,11 g (n=6; P=0,0003). Dobijeni rezultati ukazuju da eugenol reverzibilno inhibiše kontrakcije ileuma izazvane spoljnom stimulacijom i dovodi do relaksacije izolovanog ileuma pacova mehanizmom nezavisnim od aktivnosti azotnog oksida.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta Veterinaria-Beograd
T1  - Inhibitory effect of eugenol on rat ileal motility in vitro
T1  - Inhibitorni efekt eugenola na motilitet ileuma pacova in vitro
VL  - 59
IS  - 2-3
SP  - 123
EP  - 131
DO  - 10.2298/AVB0903123T
ER  - 

@article{
author = "Trailović, Saša and Robertson, Alan P. and Nedeljković-Trailović, Jelena",
year = "2009",
abstract = "Eugenol, an essential oil of clove oil possesses several different pharmacological properties, including antimicrobial, antifungal, insecticidal and antihelmintic. With regard to the digestive tract, eugenol has shown spasmolitic and relaxant effects. To elucidate some of the mechanisms involved, the effects of eugenol on contractions of isolated rat ileum induced by electrical field stimulation (EFS) were investigated. Eugenol (100 µM) significantly and reversibly reduced EFS induced contractions by approximately 80%. Control contractions were 2.00±0.18 g, while contractions in the presence of eugenol decreased to 0.40±0.02 g (n=7; P=0.0001), respectively. Moreover, eugenol (100 µM) reversibly decreased ileal basal tonus from 0.88±0.04 g to 0.65±0.04 g (n=7; P=0.0002). After incubation with the nitric oxide synthase inhibitor nitro-Larginine methyl ester (L-NAME), eugenol (100 µM) still significantly inhibited ileum contractions (reduction by 75.30%), from 1.70±0.09 g to 0.42±0.08 g (n=6; P=0.0001), respectively. Likewise, incubation with L-NAME did not alter the eugenol relaxant effect on ileal basal tonus. Mean control basal tonus was 0.84±0.07 g and significantly decreased after the addition of eugenol (100 µM), to 0.37±0.09 g (n=6; P=0.0003). After incubation with 300 µM of L-NAME mean basal tonus was 0.85±0.08 g, while eugenol significantly relaxed ileal preparations in the presence of L-NAME to 0.34±0.11 g (n=6; P=0.0003). Our results suggest that eugenol reversibly inhibits contractions caused by EFS and induces relaxation of rat ileum via a mechanism largely independent of NO activity., Eugenol, aktivni princip ulja karanfilića, poseduje različita farmakološka svojstva, kao što su antimikrobno, antimikotičko, insekticidno i antihelmintičko. U digestivnom traktu deluje spazmolitički i relaksantno. U cilju bližeg upoznavanja mehanizma dejstva eugenola, ispitan je njegov efekt na kontrakcije iziolovanog ileuma pacova izazvane spoljnom stimulacijom (electrical field stimulation-EFS). Eugenol (100 µM) signifikantno, reverzibilno redukuje kontrakcije ileuma izazvane EFS za oko 80%. Kontrolne kontrakcije iznosile su 2,00 ± 0,18 g, dok su kontrakcije u prisutvu eugenola bile 0,40 ± 0,02 g (n=7; P=0,0001). Eugenol (100 µM), takođe signifikantno smanjuje i bazalni tonus izolovanog ileuma sa 0,88 ± 0,04 g na 0,65 ± 0,04 g (n=7; P=0,0002). Posle inkubacije sa ihibitorom sintaze azotnog oksida L-NAME, eugenol i dalje signifikantno redukuje kontrakcije ileuma (za 75,30%) sa kontrolnih 1,70 ± 0,09 g na 0,42±0,08 g (n=6; P=0,0001). Isto tako, inkubacija sa L-NAME ne utiče na relaksantni efekt eugenola na bazalni tonus ileuma. Kontrolna srednja vrednost bazalnog tonusa bila je 0,84 ± 0,07 g i signifikantno je smanjena posle dodavanja eugenola (100 µM) na 0,37 ± 0,09 g (n=6; P=0,0003). Posle inkubacije sa 300 µML-NAME, srednji bazalni tonus bio je 0,85±0,08 g, dok je eugenol i u prisustvu L-NAME relaksirao izolovani ileum na 0,34 ± 0,11 g (n=6; P=0,0003). Dobijeni rezultati ukazuju da eugenol reverzibilno inhibiše kontrakcije ileuma izazvane spoljnom stimulacijom i dovodi do relaksacije izolovanog ileuma pacova mehanizmom nezavisnim od aktivnosti azotnog oksida.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta Veterinaria-Beograd",
title = "Inhibitory effect of eugenol on rat ileal motility in vitro, Inhibitorni efekt eugenola na motilitet ileuma pacova in vitro",
volume = "59",
number = "2-3",
pages = "123-131",
doi = "10.2298/AVB0903123T"
}

Trailović, S., Robertson, A. P.,& Nedeljković-Trailović, J.. (2009). Inhibitory effect of eugenol on rat ileal motility in vitro. in Acta Veterinaria-Beograd
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 59(2-3), 123-131.
https://doi.org/10.2298/AVB0903123T

Trailović S, Robertson AP, Nedeljković-Trailović J. Inhibitory effect of eugenol on rat ileal motility in vitro. in Acta Veterinaria-Beograd. 2009;59(2-3):123-131.
doi:10.2298/AVB0903123T .

Trailović, Saša, Robertson, Alan P., Nedeljković-Trailović, Jelena, "Inhibitory effect of eugenol on rat ileal motility in vitro" in Acta Veterinaria-Beograd, 59, no. 2-3 (2009):123-131,
https://doi.org/10.2298/AVB0903123T . .

TY  - JOUR
AU  - Trailović, Saša
AU  - Varagić, Vladislav M.
PY  - 2007
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/450
AB  - Ivermectin is one of the most commonly used drugs in pharmacotherapy of parasitic diseases in domestic and wild animals caused by parasitic nematodes and arthropods. However, ivermectin and other avermectins very often produce side-effects in hosts. The most dominant clinical symptom of ivermectin toxicity in domestic and wild animals is CNS depression. In nematodes, the target site of ivermectins action is glutamate-gated chloride-channel receptor and GABA receptor. The depressive effect of ivermectin in mammals might include more than one mechanism; therefore, the anticonvulsive effect of ivermectin against convulsions caused by lidocaine and strychnine was evaluated. Ivermectin antagonized lidocaine- and strychnine-induced convulsions in rats, although these have different mechanisms. In the present study, the anticonvulsive ED50 of ivermectin for lidocaine-induced convulsions was 2.44 mg/kg (95% CL 1.67 to 3.57 mg/kg), whereas for convulsions induced by strychnine it was higher at 4.25 mg/kg (95% CL 2.32 to 3.78 mg/kg). At the same time, both anticonvulsive doses are significantly lower then the observed LD50 of ivermectin (18.20 mg/kg). Furthermore, flumazenil (0.1 and 0.2 mg/kg), an antagonist of benzodiazepine receptors, antagonizes just one part of these anticonvulsive effects of ivermectin. Our results show the significant anticonvulsive properties of ivermectin and support the findings that ivermectin in the CNS of mammals produces multiple inhibitory effects, probably through participation in the function of GABA-sensitive and GABA-insensitive chloride channels.
PB  - Springer, Dordrecht
T2  - Veterinary Research Communications
T1  - The effect of ivermectin on convulsions in rats produced by lidocaine and strychnine
VL  - 31
IS  - 7
SP  - 863
EP  - 872
DO  - 10.1007/s11259-007-0050-3
ER  - 

@article{
author = "Trailović, Saša and Varagić, Vladislav M.",
year = "2007",
abstract = "Ivermectin is one of the most commonly used drugs in pharmacotherapy of parasitic diseases in domestic and wild animals caused by parasitic nematodes and arthropods. However, ivermectin and other avermectins very often produce side-effects in hosts. The most dominant clinical symptom of ivermectin toxicity in domestic and wild animals is CNS depression. In nematodes, the target site of ivermectins action is glutamate-gated chloride-channel receptor and GABA receptor. The depressive effect of ivermectin in mammals might include more than one mechanism; therefore, the anticonvulsive effect of ivermectin against convulsions caused by lidocaine and strychnine was evaluated. Ivermectin antagonized lidocaine- and strychnine-induced convulsions in rats, although these have different mechanisms. In the present study, the anticonvulsive ED50 of ivermectin for lidocaine-induced convulsions was 2.44 mg/kg (95% CL 1.67 to 3.57 mg/kg), whereas for convulsions induced by strychnine it was higher at 4.25 mg/kg (95% CL 2.32 to 3.78 mg/kg). At the same time, both anticonvulsive doses are significantly lower then the observed LD50 of ivermectin (18.20 mg/kg). Furthermore, flumazenil (0.1 and 0.2 mg/kg), an antagonist of benzodiazepine receptors, antagonizes just one part of these anticonvulsive effects of ivermectin. Our results show the significant anticonvulsive properties of ivermectin and support the findings that ivermectin in the CNS of mammals produces multiple inhibitory effects, probably through participation in the function of GABA-sensitive and GABA-insensitive chloride channels.",
publisher = "Springer, Dordrecht",
journal = "Veterinary Research Communications",
title = "The effect of ivermectin on convulsions in rats produced by lidocaine and strychnine",
volume = "31",
number = "7",
pages = "863-872",
doi = "10.1007/s11259-007-0050-3"
}

Trailović, S.,& Varagić, V. M.. (2007). The effect of ivermectin on convulsions in rats produced by lidocaine and strychnine. in Veterinary Research Communications
Springer, Dordrecht., 31(7), 863-872.
https://doi.org/10.1007/s11259-007-0050-3

Trailović S, Varagić VM. The effect of ivermectin on convulsions in rats produced by lidocaine and strychnine. in Veterinary Research Communications. 2007;31(7):863-872.
doi:10.1007/s11259-007-0050-3 .

Trailović, Saša, Varagić, Vladislav M., "The effect of ivermectin on convulsions in rats produced by lidocaine and strychnine" in Veterinary Research Communications, 31, no. 7 (2007):863-872,
https://doi.org/10.1007/s11259-007-0050-3 . .

TY  - JOUR
AU  - Jezdimirović, Milanka
AU  - Kulišić, Zoran
AU  - Aleksić, Nevenka
AU  - Bjelić, Nebojša
AU  - Ivanović, Saša
PY  - 2006
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/416
AB  - The acaricide efficacy, tolerability and safety of the active ingredient of the etheric oil of cloves eugenol was investigated in the treatment of mange in swine, and the obtained results were compared with the results of acaricide efficacy of the synthetic acaricide permethrin, which has been in use for quite a some time. A single application of permethrin in the form of a 1% solution showed maximum efficacy of 62.5%, and after three applications of 75.0% in the treatment of sarcoptes in swine mange. A single application of eugenol in the form of a 10% solution had maximum efficacy of 75.0%, and applied three times an efficacy of 100% in curbing Sarcoptes scabiei var. suis. A single administration of 20% eugenol solution showed maximum efficacy of 87.5%, and applied three times it was 100% efficient in curbing Sarcoptes scabeiei var. suis. The best efficacy in the treatment of sarcoptes mange in swine was achieved with three applications of eugenol in a concentration of 20%. This maximum effect (100%) was obtained already after the second treatment. Eugenol in a concentration of 10% was safe for local application on skin because it does not cause any undesired reactions, while a 20% concentration caused irritation followed by a passing redness and disquiet in a smaller number of treated animals. The results of comparative investigations of acaricide efficacy of permethrin and eugenol demonstrate that there is resistence in Sarcoptes scabiei var. suis to permethrin. The biocide eugenol can safely be recommended for the treatment of sarcoptes mange in swine.
AB  - Ispitivana je akaricidna efikasnost, podnošljivost i bezbednost aktivnog sastojka eteričnog ulja karanfilića, eugenola, u lečenju šuge svinja i dobijeni rezultati su upoređeni sa rezultatima akaricidne efikasnosti, već duže vreme korišćenog sintetskog akaricida permetrina. Jednokratno primenjen permetrin u obliku rastvora koncentracije od 1% pokazao je maksimalnu efikasnost od 62,5%, a posle trokratne aplikacije od 75,0% u lečenju sarkoptes šuge svinja. Jednokratno primenjen eugenol u obliku rastvora koncentracije od 10% imao je maksimalnu efikasnost od 75,0%, a trokratno primenjen od 100,0% u suzbijanju Sarcoptes scabiei var. suis. Jednokratno primenjen rastvor eugenola u koncentraciji od 20% pokazao je najveću efikasnost od 87,5%, a trokratno primenjen od 100,0% u suzbijanju sa Sarcoptes scabiei var. suis. Najbolja efikasnost u lečenju sarkoptes šuge svinja je postignuta trokratnom primenom eugenola u koncentraciji od 20%. Ovaj maksimalni efekat (100,0%) dobijen je već posle drugog tretmana. Eugenol u koncentraciji od 10% bio je bezbedan za lokalnu primenu na koži, jer ne prouzrokuje bilo kakve neželjene reakcije, dok u koncentraciji od 20% kod manjeg broja tretiranih životinja izazivao je iritaciju praćenu prolaznim crvenilom i uznemirenošću. Rezultati uporednih ispitivanja akaricidne efikasnosti permetrina i eugenola ukazuju da postoji rezistencija Sarcoptes scabiei var. suis na permetrin. Biocid eugenol sa sigurnošću može da se preporuči u lečenju sarkoptes šuge svinja.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Veterinarski Glasnik
T1  - Investigations of eugenol efficacy in treatment of mange in swine
T1  - Efikasnost eugenola u lečenju šuge svinja
VL  - 60
IS  - 1-2
SP  - 33
EP  - 42
DO  - 10.2298/VETGL0602033J
ER  - 

@article{
author = "Jezdimirović, Milanka and Kulišić, Zoran and Aleksić, Nevenka and Bjelić, Nebojša and Ivanović, Saša",
year = "2006",
abstract = "The acaricide efficacy, tolerability and safety of the active ingredient of the etheric oil of cloves eugenol was investigated in the treatment of mange in swine, and the obtained results were compared with the results of acaricide efficacy of the synthetic acaricide permethrin, which has been in use for quite a some time. A single application of permethrin in the form of a 1% solution showed maximum efficacy of 62.5%, and after three applications of 75.0% in the treatment of sarcoptes in swine mange. A single application of eugenol in the form of a 10% solution had maximum efficacy of 75.0%, and applied three times an efficacy of 100% in curbing Sarcoptes scabiei var. suis. A single administration of 20% eugenol solution showed maximum efficacy of 87.5%, and applied three times it was 100% efficient in curbing Sarcoptes scabeiei var. suis. The best efficacy in the treatment of sarcoptes mange in swine was achieved with three applications of eugenol in a concentration of 20%. This maximum effect (100%) was obtained already after the second treatment. Eugenol in a concentration of 10% was safe for local application on skin because it does not cause any undesired reactions, while a 20% concentration caused irritation followed by a passing redness and disquiet in a smaller number of treated animals. The results of comparative investigations of acaricide efficacy of permethrin and eugenol demonstrate that there is resistence in Sarcoptes scabiei var. suis to permethrin. The biocide eugenol can safely be recommended for the treatment of sarcoptes mange in swine., Ispitivana je akaricidna efikasnost, podnošljivost i bezbednost aktivnog sastojka eteričnog ulja karanfilića, eugenola, u lečenju šuge svinja i dobijeni rezultati su upoređeni sa rezultatima akaricidne efikasnosti, već duže vreme korišćenog sintetskog akaricida permetrina. Jednokratno primenjen permetrin u obliku rastvora koncentracije od 1% pokazao je maksimalnu efikasnost od 62,5%, a posle trokratne aplikacije od 75,0% u lečenju sarkoptes šuge svinja. Jednokratno primenjen eugenol u obliku rastvora koncentracije od 10% imao je maksimalnu efikasnost od 75,0%, a trokratno primenjen od 100,0% u suzbijanju Sarcoptes scabiei var. suis. Jednokratno primenjen rastvor eugenola u koncentraciji od 20% pokazao je najveću efikasnost od 87,5%, a trokratno primenjen od 100,0% u suzbijanju sa Sarcoptes scabiei var. suis. Najbolja efikasnost u lečenju sarkoptes šuge svinja je postignuta trokratnom primenom eugenola u koncentraciji od 20%. Ovaj maksimalni efekat (100,0%) dobijen je već posle drugog tretmana. Eugenol u koncentraciji od 10% bio je bezbedan za lokalnu primenu na koži, jer ne prouzrokuje bilo kakve neželjene reakcije, dok u koncentraciji od 20% kod manjeg broja tretiranih životinja izazivao je iritaciju praćenu prolaznim crvenilom i uznemirenošću. Rezultati uporednih ispitivanja akaricidne efikasnosti permetrina i eugenola ukazuju da postoji rezistencija Sarcoptes scabiei var. suis na permetrin. Biocid eugenol sa sigurnošću može da se preporuči u lečenju sarkoptes šuge svinja.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Veterinarski Glasnik",
title = "Investigations of eugenol efficacy in treatment of mange in swine, Efikasnost eugenola u lečenju šuge svinja",
volume = "60",
number = "1-2",
pages = "33-42",
doi = "10.2298/VETGL0602033J"
}

Jezdimirović, M., Kulišić, Z., Aleksić, N., Bjelić, N.,& Ivanović, S.. (2006). Investigations of eugenol efficacy in treatment of mange in swine. in Veterinarski Glasnik
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 60(1-2), 33-42.
https://doi.org/10.2298/VETGL0602033J

Jezdimirović M, Kulišić Z, Aleksić N, Bjelić N, Ivanović S. Investigations of eugenol efficacy in treatment of mange in swine. in Veterinarski Glasnik. 2006;60(1-2):33-42.
doi:10.2298/VETGL0602033J .

Jezdimirović, Milanka, Kulišić, Zoran, Aleksić, Nevenka, Bjelić, Nebojša, Ivanović, Saša, "Investigations of eugenol efficacy in treatment of mange in swine" in Veterinarski Glasnik, 60, no. 1-2 (2006):33-42,
https://doi.org/10.2298/VETGL0602033J . .