TY  - JOUR
AU  - Krstić, Milena
AU  - Petković, Branka B.
AU  - Milcić, Milos
AU  - Mišić, Dušan
AU  - Francisco Santibanez, Juan
PY  - 2019
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1752
AB  - Two new nitrato complexes of zinc and nickel with 1,4,8,11-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane (tpmc), have been synthesized and characterized. The IR spectral peaks showed that the coordinated and ionic nitrate ions are in agreement with the formula proposed by elemental analysis. Conductometric titrations predicted methanol to be a convenient solvent for synthesis and revealed the stoichiometry of the complexes, while molar electrical conductivities indicated a 1 : 3 complex electrolyte type for the zinc complex, and a 1 : 2 complex electrolyte type for the nickel complex. The optimized complex structure was obtained by molecular modeling and density functional theory calculations. The biological activity of the novel complexes was examined by screening eight different bacterial strains and two cancer cell lines. The zinc complex showed better antimicrobial activity against the bacterial strains, while the complexes did not show significance antiproliferative activity toward cancer cells MCF-7 and MDA-MB-231.
PB  - Soc Chemists Technologists Madeconia, Skopje
T2  - Macedonian Journal of Chemistry and Chemical Engineering
T1  - Synthesis, characterization and biological study of new dinuclear zinc(ii) and nickel(ii) octaaza macrocyclic complexes
VL  - 38
IS  - 1
SP  - 1
EP  - 11
DO  - 10.20450/mjcce.2019.1599
ER  - 

@article{
author = "Krstić, Milena and Petković, Branka B. and Milcić, Milos and Mišić, Dušan and Francisco Santibanez, Juan",
year = "2019",
abstract = "Two new nitrato complexes of zinc and nickel with 1,4,8,11-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane (tpmc), have been synthesized and characterized. The IR spectral peaks showed that the coordinated and ionic nitrate ions are in agreement with the formula proposed by elemental analysis. Conductometric titrations predicted methanol to be a convenient solvent for synthesis and revealed the stoichiometry of the complexes, while molar electrical conductivities indicated a 1 : 3 complex electrolyte type for the zinc complex, and a 1 : 2 complex electrolyte type for the nickel complex. The optimized complex structure was obtained by molecular modeling and density functional theory calculations. The biological activity of the novel complexes was examined by screening eight different bacterial strains and two cancer cell lines. The zinc complex showed better antimicrobial activity against the bacterial strains, while the complexes did not show significance antiproliferative activity toward cancer cells MCF-7 and MDA-MB-231.",
publisher = "Soc Chemists Technologists Madeconia, Skopje",
journal = "Macedonian Journal of Chemistry and Chemical Engineering",
title = "Synthesis, characterization and biological study of new dinuclear zinc(ii) and nickel(ii) octaaza macrocyclic complexes",
volume = "38",
number = "1",
pages = "1-11",
doi = "10.20450/mjcce.2019.1599"
}

Krstić, M., Petković, B. B., Milcić, M., Mišić, D.,& Francisco Santibanez, J.. (2019). Synthesis, characterization and biological study of new dinuclear zinc(ii) and nickel(ii) octaaza macrocyclic complexes. in Macedonian Journal of Chemistry and Chemical Engineering
Soc Chemists Technologists Madeconia, Skopje., 38(1), 1-11.
https://doi.org/10.20450/mjcce.2019.1599

Krstić M, Petković BB, Milcić M, Mišić D, Francisco Santibanez J. Synthesis, characterization and biological study of new dinuclear zinc(ii) and nickel(ii) octaaza macrocyclic complexes. in Macedonian Journal of Chemistry and Chemical Engineering. 2019;38(1):1-11.
doi:10.20450/mjcce.2019.1599 .

Krstić, Milena, Petković, Branka B., Milcić, Milos, Mišić, Dušan, Francisco Santibanez, Juan, "Synthesis, characterization and biological study of new dinuclear zinc(ii) and nickel(ii) octaaza macrocyclic complexes" in Macedonian Journal of Chemistry and Chemical Engineering, 38, no. 1 (2019):1-11,
https://doi.org/10.20450/mjcce.2019.1599 . .

TY  - JOUR
AU  - Krstić, Milena
AU  - Borozan, Sunčica
AU  - Sovilj, Sofija P.
AU  - Grgurić-Šipka, Sanja
AU  - Poljarević, Jelena
PY  - 2016
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1353
AB  - The purpose of the present study was to investigate and compare the effects of two ruthenium complexes with trifluoperazine on acethylcholinesterase enzyme activity and lactate dehydrogenase levels in vivo under physiological conditions in rats blood. Complexes 1 and 2 showed positive effects on acethylcholinesterase at all doses and did not disturb its normal activity. Total LDH activity was inhibited in the presence of both complexes, but Ru(II) complexes showed different effects on the activity of LDH isoenzymes. The activities of LDH1 and LDH2 isoenzymes were decreased in all applied doses of the complex 2, while the activity of LDH2 reduced using complex 1 in the same doses. Results of the present study suggest the neuro- and cardio protective potential of oral administration of complexes 1 and 2, as non-toxic compounds under physiological conditions. These protective effects are the result of their potent antioxidant activity.
AB  - Cilj ovog rada je da se ispitaju i uporede efekti dva kompleksa rutenijuma sa trifluoperazinom na aktivnost enzima acetilholinesteraze i laktat-dehidrogenase in vivo pod fiziološkim uslovima u krvi pacova. Kompleksi 1 i 2 pokazali su pozitivan efekat na aktivnost acetiholinesteraze u svim primenjenim dozama. Ukupna aktivnost LDH je inhibirana u prisustvu oba kompleksa, ali kompleksi Ru(II) pokazuju različite rezultate na izoenzimske oblike ovog enzima. Aktivnosti izoenzima LDH1 i LDH2 su smanjene u svim primenjenim dozama kompleksa 2, dok kompleks 1 smanjuje aktivnost samo izoenzima LDH2 u tim istim koncentracijama. Rezultati prikazanog istraživanja ukazuju na neuro - i kardio zaštitni potencijal oralne primene kompleksa 1 i 2, kao netoksičnih jedinjenja pod fiziološkim uslovima, indukovano preko njihovog snažnog antioksidativnog efekta.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta Veterinaria-Beograd
T1  - In vivo enzymes activities of some Ru(II) compounds with N-alkylphenothiazines
T1  - In vivo ispitivanje enzimske aktivnosti nekih Ru(II) jedinjenja sa N-alkilfenotiazinima
VL  - 66
IS  - 4
SP  - 497
EP  - 508
DO  - 10.1515/acve-2016-0043
ER  - 

@article{
author = "Krstić, Milena and Borozan, Sunčica and Sovilj, Sofija P. and Grgurić-Šipka, Sanja and Poljarević, Jelena",
year = "2016",
abstract = "The purpose of the present study was to investigate and compare the effects of two ruthenium complexes with trifluoperazine on acethylcholinesterase enzyme activity and lactate dehydrogenase levels in vivo under physiological conditions in rats blood. Complexes 1 and 2 showed positive effects on acethylcholinesterase at all doses and did not disturb its normal activity. Total LDH activity was inhibited in the presence of both complexes, but Ru(II) complexes showed different effects on the activity of LDH isoenzymes. The activities of LDH1 and LDH2 isoenzymes were decreased in all applied doses of the complex 2, while the activity of LDH2 reduced using complex 1 in the same doses. Results of the present study suggest the neuro- and cardio protective potential of oral administration of complexes 1 and 2, as non-toxic compounds under physiological conditions. These protective effects are the result of their potent antioxidant activity., Cilj ovog rada je da se ispitaju i uporede efekti dva kompleksa rutenijuma sa trifluoperazinom na aktivnost enzima acetilholinesteraze i laktat-dehidrogenase in vivo pod fiziološkim uslovima u krvi pacova. Kompleksi 1 i 2 pokazali su pozitivan efekat na aktivnost acetiholinesteraze u svim primenjenim dozama. Ukupna aktivnost LDH je inhibirana u prisustvu oba kompleksa, ali kompleksi Ru(II) pokazuju različite rezultate na izoenzimske oblike ovog enzima. Aktivnosti izoenzima LDH1 i LDH2 su smanjene u svim primenjenim dozama kompleksa 2, dok kompleks 1 smanjuje aktivnost samo izoenzima LDH2 u tim istim koncentracijama. Rezultati prikazanog istraživanja ukazuju na neuro - i kardio zaštitni potencijal oralne primene kompleksa 1 i 2, kao netoksičnih jedinjenja pod fiziološkim uslovima, indukovano preko njihovog snažnog antioksidativnog efekta.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta Veterinaria-Beograd",
title = "In vivo enzymes activities of some Ru(II) compounds with N-alkylphenothiazines, In vivo ispitivanje enzimske aktivnosti nekih Ru(II) jedinjenja sa N-alkilfenotiazinima",
volume = "66",
number = "4",
pages = "497-508",
doi = "10.1515/acve-2016-0043"
}

Krstić, M., Borozan, S., Sovilj, S. P., Grgurić-Šipka, S.,& Poljarević, J.. (2016). In vivo enzymes activities of some Ru(II) compounds with N-alkylphenothiazines. in Acta Veterinaria-Beograd
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 66(4), 497-508.
https://doi.org/10.1515/acve-2016-0043

Krstić M, Borozan S, Sovilj SP, Grgurić-Šipka S, Poljarević J. In vivo enzymes activities of some Ru(II) compounds with N-alkylphenothiazines. in Acta Veterinaria-Beograd. 2016;66(4):497-508.
doi:10.1515/acve-2016-0043 .

Krstić, Milena, Borozan, Sunčica, Sovilj, Sofija P., Grgurić-Šipka, Sanja, Poljarević, Jelena, "In vivo enzymes activities of some Ru(II) compounds with N-alkylphenothiazines" in Acta Veterinaria-Beograd, 66, no. 4 (2016):497-508,
https://doi.org/10.1515/acve-2016-0043 . .

TY  - JOUR
AU  - Krstić, Milena
AU  - Sovilj, Sofija P.
AU  - Borozan, Sunčica
AU  - Rancić, Milica
AU  - Poljarević, Jelena
AU  - Grgurić-Šipka, Sanja
PY  - 2016
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1424
AB  - Phenothiazines are a large group of heterocyclic, aromatic molecules with nitrogen and sulphur between two benzene rings. Their derivatives, N-alkylphenothiazines have substituent on heterocyclic nitrogen atom which gives them different properties. Also, a series of these molecules have substitution on carbon atom at place 2 of phenothiazine benzene ring. Alkylphenothiazines contain aminoalkyl substituent and their alkyl, acyl and sulphonil derivatives, as well as monocyclic and bicyclic heterocycles attached at thiazine nitrogen atom or directly linked to benzene ring. The N-alkylphenothiazines have been known as antipsychotic drugs, but they also possess antibacterial, antifungal, anticancer activity, and ability to react with macromolecules and to coordinate to the metals. Metal complexes with N-alkylphenothiazines are biological active compounds with different antimicrobial activities and cytotoxic effect against tumor cell lines. The large field of application of N-alkylphenothiazines is very attractive in terms of synthesis of new related derivatives, metal complexes, studying their properties and applications. This article presents a review of the literature and a contemporary view at N-alkylphenothiazines - their synthesis and application, as well as their metal complexes which have promising biological effects.
PB  - Savez hemijskih inženjera, Beograd
T2  - Hemijska Industrija
T1  - N-alkylphenothiazines - synthesis, structure and application as ligands in metal complexes
VL  - 70
IS  - 4
SP  - 461
EP  - 471
DO  - 10.2298/HEMIND150331052K
ER  - 

@article{
author = "Krstić, Milena and Sovilj, Sofija P. and Borozan, Sunčica and Rancić, Milica and Poljarević, Jelena and Grgurić-Šipka, Sanja",
year = "2016",
abstract = "Phenothiazines are a large group of heterocyclic, aromatic molecules with nitrogen and sulphur between two benzene rings. Their derivatives, N-alkylphenothiazines have substituent on heterocyclic nitrogen atom which gives them different properties. Also, a series of these molecules have substitution on carbon atom at place 2 of phenothiazine benzene ring. Alkylphenothiazines contain aminoalkyl substituent and their alkyl, acyl and sulphonil derivatives, as well as monocyclic and bicyclic heterocycles attached at thiazine nitrogen atom or directly linked to benzene ring. The N-alkylphenothiazines have been known as antipsychotic drugs, but they also possess antibacterial, antifungal, anticancer activity, and ability to react with macromolecules and to coordinate to the metals. Metal complexes with N-alkylphenothiazines are biological active compounds with different antimicrobial activities and cytotoxic effect against tumor cell lines. The large field of application of N-alkylphenothiazines is very attractive in terms of synthesis of new related derivatives, metal complexes, studying their properties and applications. This article presents a review of the literature and a contemporary view at N-alkylphenothiazines - their synthesis and application, as well as their metal complexes which have promising biological effects.",
publisher = "Savez hemijskih inženjera, Beograd",
journal = "Hemijska Industrija",
title = "N-alkylphenothiazines - synthesis, structure and application as ligands in metal complexes",
volume = "70",
number = "4",
pages = "461-471",
doi = "10.2298/HEMIND150331052K"
}

Krstić, M., Sovilj, S. P., Borozan, S., Rancić, M., Poljarević, J.,& Grgurić-Šipka, S.. (2016). N-alkylphenothiazines - synthesis, structure and application as ligands in metal complexes. in Hemijska Industrija
Savez hemijskih inženjera, Beograd., 70(4), 461-471.
https://doi.org/10.2298/HEMIND150331052K

Krstić M, Sovilj SP, Borozan S, Rancić M, Poljarević J, Grgurić-Šipka S. N-alkylphenothiazines - synthesis, structure and application as ligands in metal complexes. in Hemijska Industrija. 2016;70(4):461-471.
doi:10.2298/HEMIND150331052K .

Krstić, Milena, Sovilj, Sofija P., Borozan, Sunčica, Rancić, Milica, Poljarević, Jelena, Grgurić-Šipka, Sanja, "N-alkylphenothiazines - synthesis, structure and application as ligands in metal complexes" in Hemijska Industrija, 70, no. 4 (2016):461-471,
https://doi.org/10.2298/HEMIND150331052K . .

TY  - JOUR
AU  - Poljarević, Jelena
AU  - Krstić, Milena
AU  - Grgurić-Šipka, Sanja
AU  - Sovilj, Sofija P.
AU  - Mišić, Dušan
AU  - Sabo, Tibor J.
PY  - 2013
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/989
AB  - Two new platinum(IV) complexes (1, trifluoperazinehydrochloride-aquapentachloridoplatinate(IV) and 2, chlorpromazine-chlorpromazinehydrochloridepentachloridoplatinate(IV)) were synthesized in the reaction of K-2[PtCl6] with trifluoperazine dihydrochloride (TF center dot 2HCl) or chlorpromazine hydrochloride (CP center dot HCl). The complexes were characterized by elemental analysis, molar conductivity measurement, and spectral (IR, H-1, C-13, 2D H-1-C-13 heteronuclear correlation spectra, Pt-195 NMR, and MS) methods. Outer-coordination sphere was proposed for 1; while in 2, the ligand was coordinated to the metal. The complexes exhibit antibacterial effect on strains of Bacillus subtilis, Bacillus cereus, Bacillus pumilus, and methicillin-resistant Staphylococci as Gram-positive bacteria and an Escherichia coli as Gram-negative bacteria, as well as the reference strains.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Journal of Coordination Chemistry
T1  - Platinum(IV) complexes with N-alkylphenothiazines: synthesis, characterization, and antibacterial activity
VL  - 66
IS  - 21
SP  - 3760
EP  - 3769
DO  - 10.1080/00958972.2013.851788
ER  - 

@article{
author = "Poljarević, Jelena and Krstić, Milena and Grgurić-Šipka, Sanja and Sovilj, Sofija P. and Mišić, Dušan and Sabo, Tibor J.",
year = "2013",
abstract = "Two new platinum(IV) complexes (1, trifluoperazinehydrochloride-aquapentachloridoplatinate(IV) and 2, chlorpromazine-chlorpromazinehydrochloridepentachloridoplatinate(IV)) were synthesized in the reaction of K-2[PtCl6] with trifluoperazine dihydrochloride (TF center dot 2HCl) or chlorpromazine hydrochloride (CP center dot HCl). The complexes were characterized by elemental analysis, molar conductivity measurement, and spectral (IR, H-1, C-13, 2D H-1-C-13 heteronuclear correlation spectra, Pt-195 NMR, and MS) methods. Outer-coordination sphere was proposed for 1; while in 2, the ligand was coordinated to the metal. The complexes exhibit antibacterial effect on strains of Bacillus subtilis, Bacillus cereus, Bacillus pumilus, and methicillin-resistant Staphylococci as Gram-positive bacteria and an Escherichia coli as Gram-negative bacteria, as well as the reference strains.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Journal of Coordination Chemistry",
title = "Platinum(IV) complexes with N-alkylphenothiazines: synthesis, characterization, and antibacterial activity",
volume = "66",
number = "21",
pages = "3760-3769",
doi = "10.1080/00958972.2013.851788"
}

Poljarević, J., Krstić, M., Grgurić-Šipka, S., Sovilj, S. P., Mišić, D.,& Sabo, T. J.. (2013). Platinum(IV) complexes with N-alkylphenothiazines: synthesis, characterization, and antibacterial activity. in Journal of Coordination Chemistry
Taylor & Francis Ltd, Abingdon., 66(21), 3760-3769.
https://doi.org/10.1080/00958972.2013.851788

Poljarević J, Krstić M, Grgurić-Šipka S, Sovilj SP, Mišić D, Sabo TJ. Platinum(IV) complexes with N-alkylphenothiazines: synthesis, characterization, and antibacterial activity. in Journal of Coordination Chemistry. 2013;66(21):3760-3769.
doi:10.1080/00958972.2013.851788 .

Poljarević, Jelena, Krstić, Milena, Grgurić-Šipka, Sanja, Sovilj, Sofija P., Mišić, Dušan, Sabo, Tibor J., "Platinum(IV) complexes with N-alkylphenothiazines: synthesis, characterization, and antibacterial activity" in Journal of Coordination Chemistry, 66, no. 21 (2013):3760-3769,
https://doi.org/10.1080/00958972.2013.851788 . .

TY  - JOUR
AU  - Hollo, Berta
AU  - Krstić, Milena
AU  - Sovilj, Sofija P.
AU  - Meszaros-Szecsenyi, Katalin
PY  - 2013
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1034
AB  - The thermal decomposition of [RuCl2(eta(6)-p-cymene)](2) (1) and its biologically active N-alkylphenothiazine compounds of composition L[RuCl3(eta(6)-p-cymene)] where L = CPH+ (2), TFH+center dot HCl (3), and TRH+ (4) (chlorpromazine hydrochloride, CP center dot HCl; trifluoperazine dihydrochloride, TF center dot 2HCl; and thioridazine hydrochloride, TR center dot HCl, respectively) has been studied. The crystal and molecular structure of compound 3 was determined earlier by single crystal X-ray diffraction analysis. The thermal data were collected by simultaneous TG/DSC measurements. For evolved gas detection, the qualitative reaction of chlorides with AgNO3 in an acidic solution was applied. The measurements were carried out in the temperature range to 700 A degrees C in nitrogen atmosphere. Compounds of L[RuCl3(eta(6)-p-cymene)] crystallize with water or water/2-propanole. On the basis of thermal data, the trend in the solvent bonding energies was assessed.
PB  - Springer, Dordrecht
T2  - Journal of Thermal Analysis and Calorimetry
T1  - Thermal decomposition of new chlorido(p-cymene) ruthenium(II) complexes containing N-alkylphenothiazines
VL  - 111
IS  - 3
SP  - 1927
EP  - 1932
DO  - 10.1007/s10973-011-1969-8
ER  - 

@article{
author = "Hollo, Berta and Krstić, Milena and Sovilj, Sofija P. and Meszaros-Szecsenyi, Katalin",
year = "2013",
abstract = "The thermal decomposition of [RuCl2(eta(6)-p-cymene)](2) (1) and its biologically active N-alkylphenothiazine compounds of composition L[RuCl3(eta(6)-p-cymene)] where L = CPH+ (2), TFH+center dot HCl (3), and TRH+ (4) (chlorpromazine hydrochloride, CP center dot HCl; trifluoperazine dihydrochloride, TF center dot 2HCl; and thioridazine hydrochloride, TR center dot HCl, respectively) has been studied. The crystal and molecular structure of compound 3 was determined earlier by single crystal X-ray diffraction analysis. The thermal data were collected by simultaneous TG/DSC measurements. For evolved gas detection, the qualitative reaction of chlorides with AgNO3 in an acidic solution was applied. The measurements were carried out in the temperature range to 700 A degrees C in nitrogen atmosphere. Compounds of L[RuCl3(eta(6)-p-cymene)] crystallize with water or water/2-propanole. On the basis of thermal data, the trend in the solvent bonding energies was assessed.",
publisher = "Springer, Dordrecht",
journal = "Journal of Thermal Analysis and Calorimetry",
title = "Thermal decomposition of new chlorido(p-cymene) ruthenium(II) complexes containing N-alkylphenothiazines",
volume = "111",
number = "3",
pages = "1927-1932",
doi = "10.1007/s10973-011-1969-8"
}

Hollo, B., Krstić, M., Sovilj, S. P.,& Meszaros-Szecsenyi, K.. (2013). Thermal decomposition of new chlorido(p-cymene) ruthenium(II) complexes containing N-alkylphenothiazines. in Journal of Thermal Analysis and Calorimetry
Springer, Dordrecht., 111(3), 1927-1932.
https://doi.org/10.1007/s10973-011-1969-8

Hollo B, Krstić M, Sovilj SP, Meszaros-Szecsenyi K. Thermal decomposition of new chlorido(p-cymene) ruthenium(II) complexes containing N-alkylphenothiazines. in Journal of Thermal Analysis and Calorimetry. 2013;111(3):1927-1932.
doi:10.1007/s10973-011-1969-8 .

Hollo, Berta, Krstić, Milena, Sovilj, Sofija P., Meszaros-Szecsenyi, Katalin, "Thermal decomposition of new chlorido(p-cymene) ruthenium(II) complexes containing N-alkylphenothiazines" in Journal of Thermal Analysis and Calorimetry, 111, no. 3 (2013):1927-1932,
https://doi.org/10.1007/s10973-011-1969-8 . .

TY  - JOUR
AU  - Krstić, Milena
AU  - Sovilj, Sofija P.
AU  - Grgurić-Šipka, Sanja
AU  - Radosavljevic-Evans, Ivana
AU  - Borozan, Sunčica
AU  - Santibanez, Juan Francisco
PY  - 2011
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/756
AB  - Three new ruthenium(II) complexes 1-3 containing N-alkylphenothiazine molecules were synthesized by reaction of [RuCl2(eta(6)-P-cymene)](2) with chlorpromazine hydrochloride (1), trifluoperazine dihydrochloride (2) or thioridazine hydrochloride (3). The compounds of the general formula L[RuCl3(eta(6)-p-cymene)] were characterized by elemental analysis and spectroscopic methods (FT-IR, UV-Vis, H-1 and C-13 NMR). Complex 2 was structurally characterized by single crystal X-ray diffraction. In vitro cytotoxic activity of complexes 1-3 were assayed in four human carcinoma cell lines MCF-7, MDA-MB-453 (breast carcinoma), SW-480 (colon carcinoma) and IM9 (myeloma multiple cells). The highest cytotoxicity (12.1 <= IC50 <= 17.3 mu M) and induced a total (SW-480) or almost total cell death (MCF-7. MDA-MB-453) at 25 mu M in 48 h of treatment were observed for complex 2. The influence of three different doses (0.4, 4.5 and 90.4 mu M/kg bw) of complex 2 on activities of antioxidants enzymes (superoxide dismutase (SOD) and catalase (CAT)) and lactate dehydrogenase (LDH) were investigated under physiological conditions. The effects on nitrite production (NO2-) and level of erythrocytes malondialdehyde (MDA) in rats blood were evaluated, too.
PB  - Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux
T2  - European Journal of Medicinal Chemistry
T1  - Synthesis, structural and spectroscopic characterization, in vitro cytotoxicity and in vivo activity as free radical scavengers of chlorido(p-cymene) complexes of ruthenium(II) containing N-alkylphenothiazines
VL  - 46
IS  - 9
SP  - 4168
EP  - 4177
DO  - 10.1016/j.ejmech.2011.06.019
ER  - 

@article{
author = "Krstić, Milena and Sovilj, Sofija P. and Grgurić-Šipka, Sanja and Radosavljevic-Evans, Ivana and Borozan, Sunčica and Santibanez, Juan Francisco",
year = "2011",
abstract = "Three new ruthenium(II) complexes 1-3 containing N-alkylphenothiazine molecules were synthesized by reaction of [RuCl2(eta(6)-P-cymene)](2) with chlorpromazine hydrochloride (1), trifluoperazine dihydrochloride (2) or thioridazine hydrochloride (3). The compounds of the general formula L[RuCl3(eta(6)-p-cymene)] were characterized by elemental analysis and spectroscopic methods (FT-IR, UV-Vis, H-1 and C-13 NMR). Complex 2 was structurally characterized by single crystal X-ray diffraction. In vitro cytotoxic activity of complexes 1-3 were assayed in four human carcinoma cell lines MCF-7, MDA-MB-453 (breast carcinoma), SW-480 (colon carcinoma) and IM9 (myeloma multiple cells). The highest cytotoxicity (12.1 <= IC50 <= 17.3 mu M) and induced a total (SW-480) or almost total cell death (MCF-7. MDA-MB-453) at 25 mu M in 48 h of treatment were observed for complex 2. The influence of three different doses (0.4, 4.5 and 90.4 mu M/kg bw) of complex 2 on activities of antioxidants enzymes (superoxide dismutase (SOD) and catalase (CAT)) and lactate dehydrogenase (LDH) were investigated under physiological conditions. The effects on nitrite production (NO2-) and level of erythrocytes malondialdehyde (MDA) in rats blood were evaluated, too.",
publisher = "Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux",
journal = "European Journal of Medicinal Chemistry",
title = "Synthesis, structural and spectroscopic characterization, in vitro cytotoxicity and in vivo activity as free radical scavengers of chlorido(p-cymene) complexes of ruthenium(II) containing N-alkylphenothiazines",
volume = "46",
number = "9",
pages = "4168-4177",
doi = "10.1016/j.ejmech.2011.06.019"
}

Krstić, M., Sovilj, S. P., Grgurić-Šipka, S., Radosavljevic-Evans, I., Borozan, S.,& Santibanez, J. F.. (2011). Synthesis, structural and spectroscopic characterization, in vitro cytotoxicity and in vivo activity as free radical scavengers of chlorido(p-cymene) complexes of ruthenium(II) containing N-alkylphenothiazines. in European Journal of Medicinal Chemistry
Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux., 46(9), 4168-4177.
https://doi.org/10.1016/j.ejmech.2011.06.019

Krstić M, Sovilj SP, Grgurić-Šipka S, Radosavljevic-Evans I, Borozan S, Santibanez JF. Synthesis, structural and spectroscopic characterization, in vitro cytotoxicity and in vivo activity as free radical scavengers of chlorido(p-cymene) complexes of ruthenium(II) containing N-alkylphenothiazines. in European Journal of Medicinal Chemistry. 2011;46(9):4168-4177.
doi:10.1016/j.ejmech.2011.06.019 .

Krstić, Milena, Sovilj, Sofija P., Grgurić-Šipka, Sanja, Radosavljevic-Evans, Ivana, Borozan, Sunčica, Santibanez, Juan Francisco, "Synthesis, structural and spectroscopic characterization, in vitro cytotoxicity and in vivo activity as free radical scavengers of chlorido(p-cymene) complexes of ruthenium(II) containing N-alkylphenothiazines" in European Journal of Medicinal Chemistry, 46, no. 9 (2011):4168-4177,
https://doi.org/10.1016/j.ejmech.2011.06.019 . .

TY  - JOUR
AU  - Hollo, Berta
AU  - Krstić, Milena
AU  - Sovilj, Sofija P.
AU  - Pokol, Gyoergy
AU  - Meszaros-Szecsenyi, Katalin
PY  - 2011
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/798
AB  - Thermal decomposition of chlorpromazine hydrochloride (CP center dot HCl), trifluoperazine dihydrochloride (TF center dot 2HCl) and thioridazine hydrochloride (TR center dot HCl), and the ruthenium complexes with dimethyl sulfoxide (dmso) of composition [RuCl(2)(dmso)(4)] and L[RuCl(3)(dmso)(3)]center dot xEtOH, L = CP center dot HCl, TF center dot 2HCl or TR center dot HCl is described. The phenothiazines are stable to temperature range of 200-280 A degrees C with an increasing stability order of TF center dot 2HCl < CP center dot HCl < TR center dot HCl. The decomposition of all the compounds takes place in superposing steps. For detection of chlorides and sulfides, EGD analysis was performed. The decomposition pattern of the complexes, due to their similar structure, is similar. The thermal data unambiguously resolve the contradiction between the elemental analysis and X-ray structural data for (TF center dot 2HCl)[RuCl(3)(dmso)(3)]Cl center dot EtOH. The compound crystallizes with one EtOH, evaporating in part at room temperature.
PB  - Springer, Dordrecht
T2  - Journal of Thermal Analysis and Calorimetry
T1  - Thermal decomposition of new ruthenium(II) complexes containing N-alkylphenothiazines
VL  - 105
IS  - 1
SP  - 27
EP  - 32
DO  - 10.1007/s10973-011-1455-3
ER  - 

@article{
author = "Hollo, Berta and Krstić, Milena and Sovilj, Sofija P. and Pokol, Gyoergy and Meszaros-Szecsenyi, Katalin",
year = "2011",
abstract = "Thermal decomposition of chlorpromazine hydrochloride (CP center dot HCl), trifluoperazine dihydrochloride (TF center dot 2HCl) and thioridazine hydrochloride (TR center dot HCl), and the ruthenium complexes with dimethyl sulfoxide (dmso) of composition [RuCl(2)(dmso)(4)] and L[RuCl(3)(dmso)(3)]center dot xEtOH, L = CP center dot HCl, TF center dot 2HCl or TR center dot HCl is described. The phenothiazines are stable to temperature range of 200-280 A degrees C with an increasing stability order of TF center dot 2HCl < CP center dot HCl < TR center dot HCl. The decomposition of all the compounds takes place in superposing steps. For detection of chlorides and sulfides, EGD analysis was performed. The decomposition pattern of the complexes, due to their similar structure, is similar. The thermal data unambiguously resolve the contradiction between the elemental analysis and X-ray structural data for (TF center dot 2HCl)[RuCl(3)(dmso)(3)]Cl center dot EtOH. The compound crystallizes with one EtOH, evaporating in part at room temperature.",
publisher = "Springer, Dordrecht",
journal = "Journal of Thermal Analysis and Calorimetry",
title = "Thermal decomposition of new ruthenium(II) complexes containing N-alkylphenothiazines",
volume = "105",
number = "1",
pages = "27-32",
doi = "10.1007/s10973-011-1455-3"
}

Hollo, B., Krstić, M., Sovilj, S. P., Pokol, G.,& Meszaros-Szecsenyi, K.. (2011). Thermal decomposition of new ruthenium(II) complexes containing N-alkylphenothiazines. in Journal of Thermal Analysis and Calorimetry
Springer, Dordrecht., 105(1), 27-32.
https://doi.org/10.1007/s10973-011-1455-3

Hollo B, Krstić M, Sovilj SP, Pokol G, Meszaros-Szecsenyi K. Thermal decomposition of new ruthenium(II) complexes containing N-alkylphenothiazines. in Journal of Thermal Analysis and Calorimetry. 2011;105(1):27-32.
doi:10.1007/s10973-011-1455-3 .

Hollo, Berta, Krstić, Milena, Sovilj, Sofija P., Pokol, Gyoergy, Meszaros-Szecsenyi, Katalin, "Thermal decomposition of new ruthenium(II) complexes containing N-alkylphenothiazines" in Journal of Thermal Analysis and Calorimetry, 105, no. 1 (2011):27-32,
https://doi.org/10.1007/s10973-011-1455-3 . .