Two structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell lines
Само за регистроване кориснике
2014
Аутори
Aljančić, IvanaVucković, Ivan
Jadranin, Milka
Pesić, Milica
Đorđević, Iris
Podolski-Renić, Ana
Stojković, Sonja
Menković, Nebojša
Vajs, Vlatka
Milosavljević, Slobodan M.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Dimers tomoroside A (1) and tomoroside B (2) of the co-occuring known chalcone monomer (3), along with the seven known flavonoid glucosides (4-10), were isolated from the aerial parts of Helichrysum zivojinii Cernjavski & Soska. The structures of the isolated compounds were elucidated by spectroscopic techniques. Compound 1 inhibited topo Ha and hif-1 alpha expression and stimulated doxorubicin anticancer effect, while 2 increased the expression of hif-1 alpha a, probably acting as antioxidant and redox status modulator. Notably, 2 synergized with Tipifarnib showing potential to improve the action of this new chemotherapeutic involved in the modulation of mitogene activated protein (MAP) kinase signaling pathway.
Кључне речи:
Helichrysum zivojinii / Asteraceae / Chalcone glucoside dimers / Flavonoid glucoside / Topoisomerase II alpha / HIF-1 alpha / MAP kinase pathway / Drug combinationИзвор:
Phytochemistry, 2014, 98, 190-196Издавач:
- Pergamon-Elsevier Science Ltd, Oxford
Финансирање / пројекти:
- Биоактивни природни производи самониклих, гајених и јестивих биљака: одређивање структура и активности (RS-MESTD-Basic Research (BR or ON)-172053)
- Идентификација молекуларних маркера за предикцију прогресије тумора, одговора на терапију и исхода болести (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41031)
DOI: 10.1016/j.phytochem.2013.11.025
ISSN: 0031-9422
PubMed: 24361288
WoS: 000331020000022
Scopus: 2-s2.0-84892946345
Колекције
Институција/група
Fakultet veterinarske medicineTY - JOUR AU - Aljančić, Ivana AU - Vucković, Ivan AU - Jadranin, Milka AU - Pesić, Milica AU - Đorđević, Iris AU - Podolski-Renić, Ana AU - Stojković, Sonja AU - Menković, Nebojša AU - Vajs, Vlatka AU - Milosavljević, Slobodan M. PY - 2014 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1102 AB - Dimers tomoroside A (1) and tomoroside B (2) of the co-occuring known chalcone monomer (3), along with the seven known flavonoid glucosides (4-10), were isolated from the aerial parts of Helichrysum zivojinii Cernjavski & Soska. The structures of the isolated compounds were elucidated by spectroscopic techniques. Compound 1 inhibited topo Ha and hif-1 alpha expression and stimulated doxorubicin anticancer effect, while 2 increased the expression of hif-1 alpha a, probably acting as antioxidant and redox status modulator. Notably, 2 synergized with Tipifarnib showing potential to improve the action of this new chemotherapeutic involved in the modulation of mitogene activated protein (MAP) kinase signaling pathway. PB - Pergamon-Elsevier Science Ltd, Oxford T2 - Phytochemistry T1 - Two structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell lines VL - 98 SP - 190 EP - 196 DO - 10.1016/j.phytochem.2013.11.025 ER -
@article{ author = "Aljančić, Ivana and Vucković, Ivan and Jadranin, Milka and Pesić, Milica and Đorđević, Iris and Podolski-Renić, Ana and Stojković, Sonja and Menković, Nebojša and Vajs, Vlatka and Milosavljević, Slobodan M.", year = "2014", abstract = "Dimers tomoroside A (1) and tomoroside B (2) of the co-occuring known chalcone monomer (3), along with the seven known flavonoid glucosides (4-10), were isolated from the aerial parts of Helichrysum zivojinii Cernjavski & Soska. The structures of the isolated compounds were elucidated by spectroscopic techniques. Compound 1 inhibited topo Ha and hif-1 alpha expression and stimulated doxorubicin anticancer effect, while 2 increased the expression of hif-1 alpha a, probably acting as antioxidant and redox status modulator. Notably, 2 synergized with Tipifarnib showing potential to improve the action of this new chemotherapeutic involved in the modulation of mitogene activated protein (MAP) kinase signaling pathway.", publisher = "Pergamon-Elsevier Science Ltd, Oxford", journal = "Phytochemistry", title = "Two structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell lines", volume = "98", pages = "190-196", doi = "10.1016/j.phytochem.2013.11.025" }
Aljančić, I., Vucković, I., Jadranin, M., Pesić, M., Đorđević, I., Podolski-Renić, A., Stojković, S., Menković, N., Vajs, V.,& Milosavljević, S. M.. (2014). Two structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell lines. in Phytochemistry Pergamon-Elsevier Science Ltd, Oxford., 98, 190-196. https://doi.org/10.1016/j.phytochem.2013.11.025
Aljančić I, Vucković I, Jadranin M, Pesić M, Đorđević I, Podolski-Renić A, Stojković S, Menković N, Vajs V, Milosavljević SM. Two structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell lines. in Phytochemistry. 2014;98:190-196. doi:10.1016/j.phytochem.2013.11.025 .
Aljančić, Ivana, Vucković, Ivan, Jadranin, Milka, Pesić, Milica, Đorđević, Iris, Podolski-Renić, Ana, Stojković, Sonja, Menković, Nebojša, Vajs, Vlatka, Milosavljević, Slobodan M., "Two structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell lines" in Phytochemistry, 98 (2014):190-196, https://doi.org/10.1016/j.phytochem.2013.11.025 . .