Приказ основних података о документу
Oxidative stress, bioelements and androgen status in testes of rats subacutely exposed to cadmium
dc.creator | Đurić, Ana | |
dc.creator | Begić, Aida | |
dc.creator | Gobeljić, Borko | |
dc.creator | Stanojević, Ivan | |
dc.creator | Ninković, Milica | |
dc.creator | Vojvodić, Danilo | |
dc.creator | Pantelić, Ana | |
dc.creator | Zebić, Goran | |
dc.creator | Prokić, Vera | |
dc.creator | Dejanović, Bratislav | |
dc.creator | Stojanović, Ivana | |
dc.creator | Pavlica, Marina | |
dc.creator | Đukić, Dusan | |
dc.creator | Saso, Luciano | |
dc.creator | Đurđević, Dragan | |
dc.creator | Pavlović, Miloš | |
dc.creator | Topić, Aleksandra | |
dc.creator | Vujanović, Dragana | |
dc.creator | Stevanović, Ivana | |
dc.creator | Đukić, Mirjana | |
dc.date.accessioned | 2020-06-03T14:02:31Z | |
dc.date.available | 2020-06-03T14:02:31Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 0278-6915 | |
dc.identifier.uri | https://vet-erinar.vet.bg.ac.rs/handle/123456789/1302 | |
dc.description.abstract | The objective of our study was to examine testicular toxicity of cadmium (Cd), focusing on oxidative stress (OS), essential metals and androgenic status and morphological changes. Male Wistar rats [controls and four Cd-subgroups (n = 6) organized according to the exposure (1, 3, 10 and 21 days)] were intraperitoneally (i.p.) treated with 1 mg CdCl2/kg/day. Testicular Cd deposition was noticed from the 1st day. After 10 and 21 days, copper (Cu) and iron (Fe) increased by 60-109% and 43-67%, respectively, while zinc (Zn) decreased by 24-33%. During 121 days of the exposure, decrease in testicular total superoxide dismutase (SOD) and total glutathione-s-transferase (GST) activities occurred gradually by 30-78% and 15-84%, respectively, while superoxide anion radical (O-2(center dot-)) increased gradually by 114-271%. After 10-21 days, decrease in testicular catalase (CAT) activity appeared by 13-31%. After 21 days, malondialdehyde (MDA) decreased by 44% and the ratio of oxidized glutathione/reduced glutathione (GSSG/GSH) increased by 130% in testes of the rats exposed to Cd. Additionally, decreased testicular testosterone level and the relative testes mass, along with induced microscopic and macroscopic changes were occured, what can be explained as the consequence of instantly developed OS, impaired essential metals status and Cd testicular deposition. | en |
dc.publisher | Pergamon-Elsevier Science Ltd, Oxford | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41018/RS// | |
dc.relation | Ministry of Defense of the Republic of Serbia [MFVMA/3/13-15, MFVMA/6/12-15] | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173056/RS// | |
dc.rights | restrictedAccess | |
dc.source | Food and Chemical Toxicology | |
dc.subject | Cadmium | en |
dc.subject | Oxidative stress | en |
dc.subject | Bio-metals | en |
dc.subject | Testosterone | en |
dc.subject | Testicular toxicity | en |
dc.title | Oxidative stress, bioelements and androgen status in testes of rats subacutely exposed to cadmium | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Стевановић, Ивана; Ђурић, Aна; Павловић, Милош; Ђурђевић, Драган; Станојевић, Иван; Војводић, Данило; Гобељић, Борко; Топић, Aлександра; Зебић, Горан; Прокић, Вера; Дејановић, Братислав; Стојановић, Ивана; Павлица, Марина; Ђукић, Дусан; Вујановић, Драгана; Бегић, Aида; Нинковић, Милица; Сасо, Луциано; Ђукић, Мирјана; Пантелић, Aна; | |
dc.citation.volume | 86 | |
dc.citation.spage | 25 | |
dc.citation.epage | 33 | |
dc.citation.other | 86: 25-33 | |
dc.citation.rank | M21 | |
dc.identifier.wos | 000368203200004 | |
dc.identifier.doi | 10.1016/j.fct.2015.09.004 | |
dc.identifier.pmid | 26385724 | |
dc.identifier.scopus | 2-s2.0-84942583403 | |
dc.type.version | publishedVersion |