Morphological differences of pancreatic lesions in mute swans and hens naturally infected with highly pathogenic avian influenza virus h5n8
2018
Аутори
Bozić, BiljanaPolaček, Vladimir
Vučićević, Ivana
Vidanović, Dejan
Vasković, Nikola
Prodanov-Radulović, Jasna
Aleksić-Kovačević, Sanja
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
During the epizootic of highly pathogenic avian influenza subtype H5N8 in Serbia in the winter of 2016-2017, the highest percent of mortality due to this infection was recorded in mute swans (Cygnus olor). Besides mute swans, avian influenza virus subtype H5N8 was also diagnosed in a small number of hens in rural households. Pancreatic tissues from avian influenza H5N8 positive mute swans and hens that died during this outbreak were collected to determine the character of morphological lesions and the distribution of the viral antigen in this organ. Macroscopic examination of the pancreas of mute swans revealed hemorrhages as well as necrosis, while there were no macroscopic visible lesions in the pancreas of infected hens. Despite the different macroscopic finding, microscopic examination of the pancreas of both infected bird species revealed lesions in the form of acute pancreatitis and multifocal acinar necrosis. The viral antigen was abundantly expressed in the cytoplasm and nucleu...s of necrotic cells, as well as in macrophages in both examined bird species. Immunohistochemical expression of the viral antigen in the pancreas was strongly consistent with histological lesions. According to the above descnbed findings, it could be concluded that highly pathogenic avian influenza virus H5N8 has a high affinity to pancreatic tissue in both mute swans and hens and the distribution and the character of the lesions in the pancreas are similar in both bird species.
Кључне речи:
avian influenza / hens / H5N8 / mute swans / pancreatic lesionsИзвор:
Acta Veterinaria-Beograd, 2018, 68, 2, 217-223Издавач:
- Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
Финансирање / пројекти:
- Утицај квалитета компонената у исхрани ципринида на квалитет меса, губитке и економичност производње (RS-MESTD-Technological Development (TD or TR)-31011)
- Праћење здравственог стања дивљачи и увођење нових биотехнолошких поступака у детекцији заразних и зоонозних агенаса - анализа ризика за здравље људи, домаћих и дивљих животиња и контаминацију животне средине (RS-MESTD-Technological Development (TD or TR)-31084)
- Молекуларно-генетичка и екофизиолошка истраживања у заштити аутохтоних анималних генетичких ресурса, очувању добробити, здравља и репродукције гајених животиња и производњи безбедне хране (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-46002)
DOI: 10.2478/acve-2018-0018
ISSN: 0567-8315
WoS: 000438055500008
Scopus: 2-s2.0-85050315252
Колекције
Институција/група
Fakultet veterinarske medicineTY - JOUR AU - Bozić, Biljana AU - Polaček, Vladimir AU - Vučićević, Ivana AU - Vidanović, Dejan AU - Vasković, Nikola AU - Prodanov-Radulović, Jasna AU - Aleksić-Kovačević, Sanja PY - 2018 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1651 AB - During the epizootic of highly pathogenic avian influenza subtype H5N8 in Serbia in the winter of 2016-2017, the highest percent of mortality due to this infection was recorded in mute swans (Cygnus olor). Besides mute swans, avian influenza virus subtype H5N8 was also diagnosed in a small number of hens in rural households. Pancreatic tissues from avian influenza H5N8 positive mute swans and hens that died during this outbreak were collected to determine the character of morphological lesions and the distribution of the viral antigen in this organ. Macroscopic examination of the pancreas of mute swans revealed hemorrhages as well as necrosis, while there were no macroscopic visible lesions in the pancreas of infected hens. Despite the different macroscopic finding, microscopic examination of the pancreas of both infected bird species revealed lesions in the form of acute pancreatitis and multifocal acinar necrosis. The viral antigen was abundantly expressed in the cytoplasm and nucleus of necrotic cells, as well as in macrophages in both examined bird species. Immunohistochemical expression of the viral antigen in the pancreas was strongly consistent with histological lesions. According to the above descnbed findings, it could be concluded that highly pathogenic avian influenza virus H5N8 has a high affinity to pancreatic tissue in both mute swans and hens and the distribution and the character of the lesions in the pancreas are similar in both bird species. PB - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd T2 - Acta Veterinaria-Beograd T1 - Morphological differences of pancreatic lesions in mute swans and hens naturally infected with highly pathogenic avian influenza virus h5n8 VL - 68 IS - 2 SP - 217 EP - 223 DO - 10.2478/acve-2018-0018 ER -
@article{ author = "Bozić, Biljana and Polaček, Vladimir and Vučićević, Ivana and Vidanović, Dejan and Vasković, Nikola and Prodanov-Radulović, Jasna and Aleksić-Kovačević, Sanja", year = "2018", abstract = "During the epizootic of highly pathogenic avian influenza subtype H5N8 in Serbia in the winter of 2016-2017, the highest percent of mortality due to this infection was recorded in mute swans (Cygnus olor). Besides mute swans, avian influenza virus subtype H5N8 was also diagnosed in a small number of hens in rural households. Pancreatic tissues from avian influenza H5N8 positive mute swans and hens that died during this outbreak were collected to determine the character of morphological lesions and the distribution of the viral antigen in this organ. Macroscopic examination of the pancreas of mute swans revealed hemorrhages as well as necrosis, while there were no macroscopic visible lesions in the pancreas of infected hens. Despite the different macroscopic finding, microscopic examination of the pancreas of both infected bird species revealed lesions in the form of acute pancreatitis and multifocal acinar necrosis. The viral antigen was abundantly expressed in the cytoplasm and nucleus of necrotic cells, as well as in macrophages in both examined bird species. Immunohistochemical expression of the viral antigen in the pancreas was strongly consistent with histological lesions. According to the above descnbed findings, it could be concluded that highly pathogenic avian influenza virus H5N8 has a high affinity to pancreatic tissue in both mute swans and hens and the distribution and the character of the lesions in the pancreas are similar in both bird species.", publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd", journal = "Acta Veterinaria-Beograd", title = "Morphological differences of pancreatic lesions in mute swans and hens naturally infected with highly pathogenic avian influenza virus h5n8", volume = "68", number = "2", pages = "217-223", doi = "10.2478/acve-2018-0018" }
Bozić, B., Polaček, V., Vučićević, I., Vidanović, D., Vasković, N., Prodanov-Radulović, J.,& Aleksić-Kovačević, S.. (2018). Morphological differences of pancreatic lesions in mute swans and hens naturally infected with highly pathogenic avian influenza virus h5n8. in Acta Veterinaria-Beograd Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 68(2), 217-223. https://doi.org/10.2478/acve-2018-0018
Bozić B, Polaček V, Vučićević I, Vidanović D, Vasković N, Prodanov-Radulović J, Aleksić-Kovačević S. Morphological differences of pancreatic lesions in mute swans and hens naturally infected with highly pathogenic avian influenza virus h5n8. in Acta Veterinaria-Beograd. 2018;68(2):217-223. doi:10.2478/acve-2018-0018 .
Bozić, Biljana, Polaček, Vladimir, Vučićević, Ivana, Vidanović, Dejan, Vasković, Nikola, Prodanov-Radulović, Jasna, Aleksić-Kovačević, Sanja, "Morphological differences of pancreatic lesions in mute swans and hens naturally infected with highly pathogenic avian influenza virus h5n8" in Acta Veterinaria-Beograd, 68, no. 2 (2018):217-223, https://doi.org/10.2478/acve-2018-0018 . .