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The hCOMET project: International database comparison of results with the comet assay in human biomonitoring. Baseline frequency of DNA damage and effect of main confounders
dc.creator | Milić, Mirta | |
dc.creator | Ceppi, Marcello | |
dc.creator | Bruzzone, Marco | |
dc.creator | Azqueta, Amaya | |
dc.creator | Brunborg, Gunnar | |
dc.creator | Godschalk, Roger | |
dc.creator | Koppen, Gudrun | |
dc.creator | Langie, Sabine | |
dc.creator | Møller, Peter | |
dc.creator | Teixeira, João Paulo | |
dc.creator | Alija, Avdulla | |
dc.creator | Anderson, Diana | |
dc.creator | Andrade, Vanessa | |
dc.creator | Andreoli, Cristina | |
dc.creator | Asllani, Fisnik | |
dc.creator | Bangkoglu, Ezgi Eyluel | |
dc.creator | Barančoková, Magdalena | |
dc.creator | Basaran, Nursen | |
dc.creator | Boutet-Robinet, Elisa | |
dc.creator | Buschini, Annamaria | |
dc.creator | Cavallo, Delia | |
dc.creator | Costa Pereira, Cristiana | |
dc.creator | Costa, Carla | |
dc.creator | Costa, Solange | |
dc.creator | Da Silva, Juliana | |
dc.creator | Del Boˊ, Cristian | |
dc.creator | Dimitrijević Srećković, Vesna | |
dc.creator | Đelić, Ninoslav | |
dc.creator | Dobrzyńska, Malgorzata | |
dc.creator | Duračková, Zdenka | |
dc.creator | Dvořáková, Monika | |
dc.creator | Gajski, Goran | |
dc.creator | Galati, Serena | |
dc.creator | García Lima, Omar | |
dc.creator | Giovannelli, Lisa | |
dc.creator | Goroshinskaya, Irina A. | |
dc.creator | Grindel, Annemarie | |
dc.creator | Gutzkow, Kristine B. | |
dc.creator | Hernández, Alba | |
dc.creator | Hernández, Carlos | |
dc.creator | Holven, Kirsten B. | |
dc.creator | Ibero-Baraibar, Idoia | |
dc.creator | Ottestad, Inger | |
dc.creator | Kadioglu, Ela | |
dc.creator | Kažimirová, Alena | |
dc.creator | Kuznetsova, Elena | |
dc.creator | Ladeira, Carina | |
dc.creator | Laffon, Blanca | |
dc.creator | Lamonaca, Palma | |
dc.creator | Lebailly, Pierre | |
dc.creator | Louro, Henriqueta | |
dc.creator | Mandina Cardoso, Tania | |
dc.creator | Marcon, Francesca | |
dc.creator | Marcos, Ricard | |
dc.creator | Moretti, Massimo | |
dc.creator | Moretti, Silvia | |
dc.creator | Najafzadeh, Mojgan | |
dc.creator | Nemeth, Zsuzsanna | |
dc.creator | Neri, Monica | |
dc.creator | Novotna, Bozena | |
dc.creator | Orlow, Irene | |
dc.creator | Paduchova, Zuzana | |
dc.creator | Pastor, Susana | |
dc.creator | Perdry, Hervé | |
dc.creator | Spremo-Potparević, Biljana | |
dc.creator | Ramadhani, Dwi | |
dc.creator | Riso, Patrizia | |
dc.creator | Rohr, Paula | |
dc.creator | Rojas, Emilio | |
dc.creator | Rossner, Pavel | |
dc.creator | Safar, Anna | |
dc.creator | Sardas, Semra | |
dc.creator | Silva, Maria João | |
dc.creator | Sirota, Nikolay | |
dc.creator | Smolkova, Bozena | |
dc.creator | Staruchova, Marta | |
dc.creator | Stetina, Rudolf | |
dc.creator | Stopper, Helga | |
dc.creator | Surikova, Ekaterina I. | |
dc.creator | Ulven, Stine M. | |
dc.creator | Ursini, Cinzia Lucia | |
dc.creator | Valdiglesias, Vanessa | |
dc.creator | Valverde, Mahara | |
dc.creator | Vodicka, Pavel | |
dc.creator | Volkovova, Katarina | |
dc.creator | Wagner, Karl-Heinz | |
dc.creator | Živković, Lada | |
dc.creator | Dušinská, Maria | |
dc.creator | Collins, Andrew R. | |
dc.creator | Bonassi, Stefano | |
dc.date.accessioned | 2021-03-04T08:58:58Z | |
dc.date.available | 2021-03-04T08:58:58Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 1383-5742 | |
dc.identifier.uri | https://vet-erinar.vet.bg.ac.rs/handle/123456789/2020 | |
dc.description.abstract | The alkaline comet assay, or single cell gel electrophoresis, is one of the most popular methods for assessing DNA damage in human population. One of the open issues concerning this assay is the identification of those factors that can explain the large inter-individual and inter-laboratory variation. International collaborative initiatives such as the hCOMET project - a COST Action launched in 2016 - represent a valuable tool to meet this challenge. The aims of hCOMET were to establish reference values for the level of DNA damage in humans, to investigate the effect of host factors, lifestyle and exposure to genotoxic agents, and to compare different sources of assay variability. A database of 19,320 subjects was generated, pooling data from 105 studies run by 44 laboratories in 26 countries between 1999 and 2019. A mixed random effect log-linear model, in parallel with a classic meta-analysis, was applied to take into account the extensive heterogeneity of data, due to descriptor, specimen and protocol variability. As a result of this analysis interquartile intervals of DNA strand breaks (which includes alkali-labile sites) were reported for tail intensity, tail length, and tail moment (comet assay descriptors). A small variation by age was reported in some datasets, suggesting higher DNA damage in oldest age-classes, while no effect could be shown for sex or smoking habit, although the lack of data on heavy smokers has still to be considered. Finally, highly significant differences in DNA damage were found for most exposures investigated in specific studies. In conclusion, these data, which confirm that DNA damage measured by the comet assay is an excellent biomarker of exposure in several conditions, may contribute to improving the quality of study design and to the standardization of results of the comet assay in human populations. | |
dc.publisher | Elsevier | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173034/RS// | |
dc.rights | restrictedAccess | |
dc.source | Mutation Research/Reviews in Mutation Research | |
dc.subject | Biomarkers | |
dc.subject | Comet assay | |
dc.subject | DNA damage | |
dc.subject | Human biomonitoring | |
dc.subject | Pooled analysis | |
dc.title | The hCOMET project: International database comparison of results with the comet assay in human biomonitoring. Baseline frequency of DNA damage and effect of main confounders | |
dc.type | article | en |
dc.rights.license | ARR | |
dcterms.abstract | Бонасси, Стефано; Стоппер, Хелга; Живковић, Лада; Спремо-Потпаревић, Биљана; Милић, Мирта; Ђелић, Нинослав; Кажимировá, Aлена; Цеппи, Марцелло; Бруззоне, Марцо; Aзqуета, Aмаyа; Брунборг, Гуннар; Годсцхалк, Рогер; Коппен, Гудрун; Лангие, Сабине; Мøллер, Петер; Теиxеира, Јоãо Пауло; Aлија, Aвдулла; Aндерсон, Диана; Aндраде, Ванесса; Aндреоли, Цристина; Aсллани, Фисник; Бангкоглу, Езги Еyлуел; Баранчоковá, Магдалена; Басаран, Нурсен; Боутет-Робинет, Елиса; Бусцхини, Aннамариа; Цавалло, Делиа; Цоста Переира, Цристиана; Цоста, Царла; Цоста, Соланге; Да Силва, Јулиана; Дел Боˊ, Цристиан; Димитријевић Срећковић, Весна; Добрзyńска, Малгорзата; Дурачковá, Зденка; Двоřáковá, Моника; Гајски, Горан; Галати, Серена; Гарцíа Лима, Омар; Гиованнелли, Лиса; Горосхинскаyа, Ирина A.; Гриндел, Aннемарие; Гутзкоw, Кристине Б.; Хернáндез, Aлба; Хернáндез, Царлос; Холвен, Кирстен Б.; Иберо-Бараибар, Идоиа; Оттестад, Ингер; Кадиоглу, Ела; Кузнетсова, Елена; Ладеира, Царина; Лаффон, Бланца; Ламонаца, Палма; Лебаиллy, Пиерре; Лоуро, Хенриqуета; Мандина Цардосо, Таниа; Марцон, Францесца; Марцос, Рицард; Моретти, Массимо; Моретти, Силвиа; Најафзадех, Мојган; Неметх, Зсузсанна; Нери, Моница; Новотна, Бозена; Орлоw, Ирене; Падуцхова, Зузана; Пастор, Сусана; Пердрy, Хервé; Рамадхани, Дwи; Рисо, Патризиа; Рохр, Паула; Ројас, Емилио; Росснер, Павел; Сафар, Aнна; Сардас, Семра; Силва, Мариа Јоãо; Сирота, Николаy; Смолкова, Бозена; Старуцхова, Марта; Стетина, Рудолф; Сурикова, Екатерина И.; Улвен, Стине М.; Урсини, Цинзиа Луциа; Валдиглесиас, Ванесса; Валверде, Махара; Водицка, Павел; Волковова, Катарина; Wагнер, Карл-Хеинз; Душинскá, Мариа; Цоллинс, Aндреw Р.; | |
dc.citation.volume | 787 | |
dc.citation.spage | 108371 | |
dc.citation.rank | aM21 | |
dc.identifier.wos | 000658539600011 | |
dc.identifier.doi | 10.1016/j.mrrev.2021.108371 | |
dc.identifier.scopus | 2-s2.0-85101040695 | |
dc.type.version | publishedVersion |