Fowl Adenovirus Infection-Potential Cause of a Suppressed Humoral Immune Response of Broilers to Newcastle Disease Vaccination
Аутори
Maletić, JelenaSpalević, Ljiljana
Kureljušić, Branislav
Veljović, Ljubiša
Maksimović-Zorić, Jelena
Maletić, Milan
Milićević, Vesna
Чланак у часопису (Објављена верзија)
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Приказ свих података о документуАпстракт
Fowl adenovirus infections have a significant economic impact, especially in the production of broilers. It is considered the leading cause of three syndromes: Adenoviral gizzard erosions and ulcerations, inclusion body hepatitis, and hepatitis-hydropericardium syndrome. A critical feature of this virus is its immunosuppressive effect, via suppressing humoral and cellular immunity. In this study, we examined the humoral immune response after administration of the Newcastle disease vaccine in broiler flocks with previously confirmed seroconversion against Fowl adenovirus. The study was conducted on 5 farms. A total of 220 chickens, five weeks of age, showing no clinical signs of the disease, were included in this study. The control group consisted of 20 chickens from a negative farm. Chickens were vaccinated with commercially available live NDV vaccines between 11 and 13 days of life. ELISA determined the presence of specific antibodies against FAdV in a total of 130/200 (65%) blood ser...a. Depending on the farm, seroprevalence ranged from 30-100%. The presence of specific antibodies against NDV was determined three weeks after vaccination using the hemagglutination inhibition assay. A positive hemagglutination inhibition (HI) titer (≥ 16) was found in 41/200 (20.5%) sera, which was significantly less compared to the control farm, where a positive HI titer was found in 20/20 (100%) sera. The results of our study indicate the immunosuppressive effect of FAdV in subclinically infected birds and highlight the need for its diagnosis, prevention, and control
Кључне речи:
Fowl adenoviruses / Newcastle disease / vaccination / immunosuppressionИзвор:
Acta Veterinaria, 2023, 73, 1, 133-142Издавач:
- Sciendo
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200030 (Научни институт за ветеринарство Србије, Београд) (RS-MESTD-inst-2020-200030)
Колекције
Институција/група
Fakultet veterinarske medicineTY - JOUR AU - Maletić, Jelena AU - Spalević, Ljiljana AU - Kureljušić, Branislav AU - Veljović, Ljubiša AU - Maksimović-Zorić, Jelena AU - Maletić, Milan AU - Milićević, Vesna PY - 2023 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2815 AB - Fowl adenovirus infections have a significant economic impact, especially in the production of broilers. It is considered the leading cause of three syndromes: Adenoviral gizzard erosions and ulcerations, inclusion body hepatitis, and hepatitis-hydropericardium syndrome. A critical feature of this virus is its immunosuppressive effect, via suppressing humoral and cellular immunity. In this study, we examined the humoral immune response after administration of the Newcastle disease vaccine in broiler flocks with previously confirmed seroconversion against Fowl adenovirus. The study was conducted on 5 farms. A total of 220 chickens, five weeks of age, showing no clinical signs of the disease, were included in this study. The control group consisted of 20 chickens from a negative farm. Chickens were vaccinated with commercially available live NDV vaccines between 11 and 13 days of life. ELISA determined the presence of specific antibodies against FAdV in a total of 130/200 (65%) blood sera. Depending on the farm, seroprevalence ranged from 30-100%. The presence of specific antibodies against NDV was determined three weeks after vaccination using the hemagglutination inhibition assay. A positive hemagglutination inhibition (HI) titer (≥ 16) was found in 41/200 (20.5%) sera, which was significantly less compared to the control farm, where a positive HI titer was found in 20/20 (100%) sera. The results of our study indicate the immunosuppressive effect of FAdV in subclinically infected birds and highlight the need for its diagnosis, prevention, and control PB - Sciendo T2 - Acta Veterinaria T1 - Fowl Adenovirus Infection-Potential Cause of a Suppressed Humoral Immune Response of Broilers to Newcastle Disease Vaccination VL - 73 IS - 1 SP - 133 EP - 142 DO - 10.2478/acve-2023-0010 ER -
@article{ author = "Maletić, Jelena and Spalević, Ljiljana and Kureljušić, Branislav and Veljović, Ljubiša and Maksimović-Zorić, Jelena and Maletić, Milan and Milićević, Vesna", year = "2023", abstract = "Fowl adenovirus infections have a significant economic impact, especially in the production of broilers. It is considered the leading cause of three syndromes: Adenoviral gizzard erosions and ulcerations, inclusion body hepatitis, and hepatitis-hydropericardium syndrome. A critical feature of this virus is its immunosuppressive effect, via suppressing humoral and cellular immunity. In this study, we examined the humoral immune response after administration of the Newcastle disease vaccine in broiler flocks with previously confirmed seroconversion against Fowl adenovirus. The study was conducted on 5 farms. A total of 220 chickens, five weeks of age, showing no clinical signs of the disease, were included in this study. The control group consisted of 20 chickens from a negative farm. Chickens were vaccinated with commercially available live NDV vaccines between 11 and 13 days of life. ELISA determined the presence of specific antibodies against FAdV in a total of 130/200 (65%) blood sera. Depending on the farm, seroprevalence ranged from 30-100%. The presence of specific antibodies against NDV was determined three weeks after vaccination using the hemagglutination inhibition assay. A positive hemagglutination inhibition (HI) titer (≥ 16) was found in 41/200 (20.5%) sera, which was significantly less compared to the control farm, where a positive HI titer was found in 20/20 (100%) sera. The results of our study indicate the immunosuppressive effect of FAdV in subclinically infected birds and highlight the need for its diagnosis, prevention, and control", publisher = "Sciendo", journal = "Acta Veterinaria", title = "Fowl Adenovirus Infection-Potential Cause of a Suppressed Humoral Immune Response of Broilers to Newcastle Disease Vaccination", volume = "73", number = "1", pages = "133-142", doi = "10.2478/acve-2023-0010" }
Maletić, J., Spalević, L., Kureljušić, B., Veljović, L., Maksimović-Zorić, J., Maletić, M.,& Milićević, V.. (2023). Fowl Adenovirus Infection-Potential Cause of a Suppressed Humoral Immune Response of Broilers to Newcastle Disease Vaccination. in Acta Veterinaria Sciendo., 73(1), 133-142. https://doi.org/10.2478/acve-2023-0010
Maletić J, Spalević L, Kureljušić B, Veljović L, Maksimović-Zorić J, Maletić M, Milićević V. Fowl Adenovirus Infection-Potential Cause of a Suppressed Humoral Immune Response of Broilers to Newcastle Disease Vaccination. in Acta Veterinaria. 2023;73(1):133-142. doi:10.2478/acve-2023-0010 .
Maletić, Jelena, Spalević, Ljiljana, Kureljušić, Branislav, Veljović, Ljubiša, Maksimović-Zorić, Jelena, Maletić, Milan, Milićević, Vesna, "Fowl Adenovirus Infection-Potential Cause of a Suppressed Humoral Immune Response of Broilers to Newcastle Disease Vaccination" in Acta Veterinaria, 73, no. 1 (2023):133-142, https://doi.org/10.2478/acve-2023-0010 . .