Ekspresija JNK kinaza u THP-1 celijama tretiranim Ru(II) kompleksima
Expression of JNK kinases in THP-1 cells treated with Ru(II) complexes
Authors
Krstić, MilenaSantibanez, Juan Francisco
Poljarević, Jelena
Grgurić-Šipka, Sanja
Borozan, Sunčica
Conference object (Published version)
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Show full item recordAbstract
C-Jun N-terminalne kinaze (JNK) spadaju u mitogen-aktivirane protein kinaze (MAPK) i
imaju važnu ulogu u kontroli niza ćelijskih procesa uključujući proliferaciju,
kancerogenezu i apoptozu. Kompleksi rutenijuma pokazali su izuzetan potencijal kao
mogući citostatici. Upravo iz ovih razloga ispitivan je mehanizam delovanja kompleksa
Ru(II) sa N-alkilfenotiazinima (hlorpromazinom, trifluoperazinom i tioridazinom) na
signalne parametre (t-JNK, p-JNK i β-aktin) u THP-1 ćelijama humane leukemije. U
ćelijama tretiranim kompleksom sa fluoperazinom u koncentraciji od 10 μM (IC50 je 10,5
μM) ekspresija t-JNK povećana je za 47,45%, dok je ekspresija p-JNK dvostruko veća u
poređenju sa netretiranim ćelijama, što sugeriše da su t-JNK i p-JNK uključeni u apoptozu
ovih ćelija.
The c-Jun N-terminal kinase (JNK) belongs to the family of mitogen-activated protein
kinases (MAPKs) that play an important role in the control of a number of celular
processes, including proliferation, cancerogenesis and apoptosis. Ruthenium complexes
have shown remarkable potential as possible cytostatics. Precisely for these reasons, the
mechanism of action of Ru(II) complexes with N-alkylphenothiazines (chlorpromazine,
trifluoperazine, and thioridazine) on signalling parameters (t-JNK, p-JNK and β-actin) in
THP-1 human leucemic cells was investigated. In cells treated with fluoperazine complex
at a concentration of 10 μM (IC50 is 10.5 μM), an increased expression of t-JNK by 47.45%
was found while the expression of p-JNK was twice higher compared to untreated cells,
suggesting that t-JNK and p-JNK are involved in the apoptosis of these cells.
Source:
59. Savetovanje Srpskog hemijskog društva, Novi Sad, 1 - 2. jun 2023, 2023, 51-51Publisher:
- Beograd : Srpsko hemijsko društvo
Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200143 (University of Belgrade, Faculty of Veterinary Medicine) (RS-MESTD-inst-2020-200143)
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- Book of abstracts
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Fakultet veterinarske medicineTY - CONF AU - Krstić, Milena AU - Santibanez, Juan Francisco AU - Poljarević, Jelena AU - Grgurić-Šipka, Sanja AU - Borozan, Sunčica PY - 2023 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/3795 AB - C-Jun N-terminalne kinaze (JNK) spadaju u mitogen-aktivirane protein kinaze (MAPK) i imaju važnu ulogu u kontroli niza ćelijskih procesa uključujući proliferaciju, kancerogenezu i apoptozu. Kompleksi rutenijuma pokazali su izuzetan potencijal kao mogući citostatici. Upravo iz ovih razloga ispitivan je mehanizam delovanja kompleksa Ru(II) sa N-alkilfenotiazinima (hlorpromazinom, trifluoperazinom i tioridazinom) na signalne parametre (t-JNK, p-JNK i β-aktin) u THP-1 ćelijama humane leukemije. U ćelijama tretiranim kompleksom sa fluoperazinom u koncentraciji od 10 μM (IC50 je 10,5 μM) ekspresija t-JNK povećana je za 47,45%, dok je ekspresija p-JNK dvostruko veća u poređenju sa netretiranim ćelijama, što sugeriše da su t-JNK i p-JNK uključeni u apoptozu ovih ćelija. AB - The c-Jun N-terminal kinase (JNK) belongs to the family of mitogen-activated protein kinases (MAPKs) that play an important role in the control of a number of celular processes, including proliferation, cancerogenesis and apoptosis. Ruthenium complexes have shown remarkable potential as possible cytostatics. Precisely for these reasons, the mechanism of action of Ru(II) complexes with N-alkylphenothiazines (chlorpromazine, trifluoperazine, and thioridazine) on signalling parameters (t-JNK, p-JNK and β-actin) in THP-1 human leucemic cells was investigated. In cells treated with fluoperazine complex at a concentration of 10 μM (IC50 is 10.5 μM), an increased expression of t-JNK by 47.45% was found while the expression of p-JNK was twice higher compared to untreated cells, suggesting that t-JNK and p-JNK are involved in the apoptosis of these cells. PB - Beograd : Srpsko hemijsko društvo C3 - 59. Savetovanje Srpskog hemijskog društva, Novi Sad, 1 - 2. jun 2023 T1 - Ekspresija JNK kinaza u THP-1 celijama tretiranim Ru(II) kompleksima T1 - Expression of JNK kinases in THP-1 cells treated with Ru(II) complexes SP - 51 EP - 51 UR - https://hdl.handle.net/21.15107/rcub_veterinar_3795 ER -
@conference{ author = "Krstić, Milena and Santibanez, Juan Francisco and Poljarević, Jelena and Grgurić-Šipka, Sanja and Borozan, Sunčica", year = "2023", abstract = "C-Jun N-terminalne kinaze (JNK) spadaju u mitogen-aktivirane protein kinaze (MAPK) i imaju važnu ulogu u kontroli niza ćelijskih procesa uključujući proliferaciju, kancerogenezu i apoptozu. Kompleksi rutenijuma pokazali su izuzetan potencijal kao mogući citostatici. Upravo iz ovih razloga ispitivan je mehanizam delovanja kompleksa Ru(II) sa N-alkilfenotiazinima (hlorpromazinom, trifluoperazinom i tioridazinom) na signalne parametre (t-JNK, p-JNK i β-aktin) u THP-1 ćelijama humane leukemije. U ćelijama tretiranim kompleksom sa fluoperazinom u koncentraciji od 10 μM (IC50 je 10,5 μM) ekspresija t-JNK povećana je za 47,45%, dok je ekspresija p-JNK dvostruko veća u poređenju sa netretiranim ćelijama, što sugeriše da su t-JNK i p-JNK uključeni u apoptozu ovih ćelija., The c-Jun N-terminal kinase (JNK) belongs to the family of mitogen-activated protein kinases (MAPKs) that play an important role in the control of a number of celular processes, including proliferation, cancerogenesis and apoptosis. Ruthenium complexes have shown remarkable potential as possible cytostatics. Precisely for these reasons, the mechanism of action of Ru(II) complexes with N-alkylphenothiazines (chlorpromazine, trifluoperazine, and thioridazine) on signalling parameters (t-JNK, p-JNK and β-actin) in THP-1 human leucemic cells was investigated. In cells treated with fluoperazine complex at a concentration of 10 μM (IC50 is 10.5 μM), an increased expression of t-JNK by 47.45% was found while the expression of p-JNK was twice higher compared to untreated cells, suggesting that t-JNK and p-JNK are involved in the apoptosis of these cells.", publisher = "Beograd : Srpsko hemijsko društvo", journal = "59. Savetovanje Srpskog hemijskog društva, Novi Sad, 1 - 2. jun 2023", title = "Ekspresija JNK kinaza u THP-1 celijama tretiranim Ru(II) kompleksima, Expression of JNK kinases in THP-1 cells treated with Ru(II) complexes", pages = "51-51", url = "https://hdl.handle.net/21.15107/rcub_veterinar_3795" }
Krstić, M., Santibanez, J. F., Poljarević, J., Grgurić-Šipka, S.,& Borozan, S.. (2023). Ekspresija JNK kinaza u THP-1 celijama tretiranim Ru(II) kompleksima. in 59. Savetovanje Srpskog hemijskog društva, Novi Sad, 1 - 2. jun 2023 Beograd : Srpsko hemijsko društvo., 51-51. https://hdl.handle.net/21.15107/rcub_veterinar_3795
Krstić M, Santibanez JF, Poljarević J, Grgurić-Šipka S, Borozan S. Ekspresija JNK kinaza u THP-1 celijama tretiranim Ru(II) kompleksima. in 59. Savetovanje Srpskog hemijskog društva, Novi Sad, 1 - 2. jun 2023. 2023;:51-51. https://hdl.handle.net/21.15107/rcub_veterinar_3795 .
Krstić, Milena, Santibanez, Juan Francisco, Poljarević, Jelena, Grgurić-Šipka, Sanja, Borozan, Sunčica, "Ekspresija JNK kinaza u THP-1 celijama tretiranim Ru(II) kompleksima" in 59. Savetovanje Srpskog hemijskog društva, Novi Sad, 1 - 2. jun 2023 (2023):51-51, https://hdl.handle.net/21.15107/rcub_veterinar_3795 .