The efficacy of intravenous application of the Mycobacterium Cell Wall Fraction (AMPLIMUNE) in the treatment of subclinical mastitis caused by S. Aureus
Само за регистроване кориснике
2024
Аутори
Stanišić, LjubodragStanimirović, Zoran
Kovačević, Branislav
Blagojević, Jovan
Nedić, Svetlana
Mašić, Aleksandar
Maletić, Milan
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The aim of the study was to investigate the effect of the immunostimulant Mycobacterium Cell Wall Fraction (MCWF) on
the treatment of S. aureus SCM by intravenous application. The study included 45 HF dairy cows in 2nd and 3rd month
after parturition divided into three groups (n = 15 per group): the MC + group – cows with S. aureus SCM treated with
MCWF; the MC- group – cows with S. aureus SCM, with no treatment; and the C group – the control group of healthy
cow with no treatment. Samples were collected 0th (I sample), 7th (II), and 14th day (III) from the day of SCM diagnosis
and on day 21st (IV). A greater influx of leukocytes was confirmed into milk after 7 days after MCWF treatment in
MC + group, which was followed by increase of WBC and LYM in blood. These results support the hypothesis of effective
action of MCWF, and in quarters with lower-grade infection, bacteriological cure was achieved. The MC- group had
a statistically higher concentration of TBARS and CAT activity... in milk, while MC + group had lower blood serum LDH
activity, which indicates a positive effect of the MCWF application and a lower exposure of the tissue to lipide peroxidation
and inflammation caused by S. aureus. The application of MCWF would give new possibilities in the prevention and
therapy of mammary gland diseases without fear of the presence of residues and the emergence of bacterial resistance.
In future studies, the effects of local and systemic application of MCWF in the treatment of S. aureus SCM should be
compared.
Кључне речи:
Subclinical mastitis / Staphylococcus aureus / Dairy cow / Immunostimulant / Mycobacterium phlei / Oxidative stressИзвор:
Veterinary Research Communications, 2024, n/aИздавач:
- Springer
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200143 (Универзитет у Београду, Факултет ветеринарске медицине) (RS-MESTD-inst-2020-200143)
Колекције
Институција/група
Fakultet veterinarske medicineTY - JOUR AU - Stanišić, Ljubodrag AU - Stanimirović, Zoran AU - Kovačević, Branislav AU - Blagojević, Jovan AU - Nedić, Svetlana AU - Mašić, Aleksandar AU - Maletić, Milan PY - 2024 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/3992 AB - The aim of the study was to investigate the effect of the immunostimulant Mycobacterium Cell Wall Fraction (MCWF) on the treatment of S. aureus SCM by intravenous application. The study included 45 HF dairy cows in 2nd and 3rd month after parturition divided into three groups (n = 15 per group): the MC + group – cows with S. aureus SCM treated with MCWF; the MC- group – cows with S. aureus SCM, with no treatment; and the C group – the control group of healthy cow with no treatment. Samples were collected 0th (I sample), 7th (II), and 14th day (III) from the day of SCM diagnosis and on day 21st (IV). A greater influx of leukocytes was confirmed into milk after 7 days after MCWF treatment in MC + group, which was followed by increase of WBC and LYM in blood. These results support the hypothesis of effective action of MCWF, and in quarters with lower-grade infection, bacteriological cure was achieved. The MC- group had a statistically higher concentration of TBARS and CAT activity in milk, while MC + group had lower blood serum LDH activity, which indicates a positive effect of the MCWF application and a lower exposure of the tissue to lipide peroxidation and inflammation caused by S. aureus. The application of MCWF would give new possibilities in the prevention and therapy of mammary gland diseases without fear of the presence of residues and the emergence of bacterial resistance. In future studies, the effects of local and systemic application of MCWF in the treatment of S. aureus SCM should be compared. PB - Springer T2 - Veterinary Research Communications T1 - The efficacy of intravenous application of the Mycobacterium Cell Wall Fraction (AMPLIMUNE) in the treatment of subclinical mastitis caused by S. Aureus VL - n/a DO - 10.1007/s11259-024-10426-9 ER -
@article{ author = "Stanišić, Ljubodrag and Stanimirović, Zoran and Kovačević, Branislav and Blagojević, Jovan and Nedić, Svetlana and Mašić, Aleksandar and Maletić, Milan", year = "2024", abstract = "The aim of the study was to investigate the effect of the immunostimulant Mycobacterium Cell Wall Fraction (MCWF) on the treatment of S. aureus SCM by intravenous application. The study included 45 HF dairy cows in 2nd and 3rd month after parturition divided into three groups (n = 15 per group): the MC + group – cows with S. aureus SCM treated with MCWF; the MC- group – cows with S. aureus SCM, with no treatment; and the C group – the control group of healthy cow with no treatment. Samples were collected 0th (I sample), 7th (II), and 14th day (III) from the day of SCM diagnosis and on day 21st (IV). A greater influx of leukocytes was confirmed into milk after 7 days after MCWF treatment in MC + group, which was followed by increase of WBC and LYM in blood. These results support the hypothesis of effective action of MCWF, and in quarters with lower-grade infection, bacteriological cure was achieved. The MC- group had a statistically higher concentration of TBARS and CAT activity in milk, while MC + group had lower blood serum LDH activity, which indicates a positive effect of the MCWF application and a lower exposure of the tissue to lipide peroxidation and inflammation caused by S. aureus. The application of MCWF would give new possibilities in the prevention and therapy of mammary gland diseases without fear of the presence of residues and the emergence of bacterial resistance. In future studies, the effects of local and systemic application of MCWF in the treatment of S. aureus SCM should be compared.", publisher = "Springer", journal = "Veterinary Research Communications", title = "The efficacy of intravenous application of the Mycobacterium Cell Wall Fraction (AMPLIMUNE) in the treatment of subclinical mastitis caused by S. Aureus", volume = "n/a", doi = "10.1007/s11259-024-10426-9" }
Stanišić, L., Stanimirović, Z., Kovačević, B., Blagojević, J., Nedić, S., Mašić, A.,& Maletić, M.. (2024). The efficacy of intravenous application of the Mycobacterium Cell Wall Fraction (AMPLIMUNE) in the treatment of subclinical mastitis caused by S. Aureus. in Veterinary Research Communications Springer., n/a. https://doi.org/10.1007/s11259-024-10426-9
Stanišić L, Stanimirović Z, Kovačević B, Blagojević J, Nedić S, Mašić A, Maletić M. The efficacy of intravenous application of the Mycobacterium Cell Wall Fraction (AMPLIMUNE) in the treatment of subclinical mastitis caused by S. Aureus. in Veterinary Research Communications. 2024;n/a. doi:10.1007/s11259-024-10426-9 .
Stanišić, Ljubodrag, Stanimirović, Zoran, Kovačević, Branislav, Blagojević, Jovan, Nedić, Svetlana, Mašić, Aleksandar, Maletić, Milan, "The efficacy of intravenous application of the Mycobacterium Cell Wall Fraction (AMPLIMUNE) in the treatment of subclinical mastitis caused by S. Aureus" in Veterinary Research Communications, n/a (2024), https://doi.org/10.1007/s11259-024-10426-9 . .