Differential in vivo regulation of TH and DBH mRNA in rat atria by maprotiline and fluoxetine
Апстракт
It is well known that antidepressants affect central monoaminergic neurotransmission and that they also modulate hormone release in peripheral tissues. Repeated maprotiline (a noradrenaline reuptake inhibitor) and fluoxetine (a serotonin reuptake inhibitor) treatment on gene expression of the catecholamine biosynthetic enzymes were examined in rat atria and ventricles in vivo. Maprotiline decreased the gene expression of tyrosine hydroxylase (TH) and dopamineβ-hydroxylase (DBH) in the rat atrium. Fluoxetine increased gene expression of TH and DBH, but not of phenylethanolamine N-methyltransferase (PNMT). Chronic application of antidepressants did not change the expression of these enzymes in the ventricles. We conclude that repeated administration of fluoxetine enhances gene transcription of TH and DBH and subsequently stimulates noradrenaline synthesis in rat atria in vivo.
Кључне речи:
antidepressants / catecholamine enzymes / gene expression / atria / ventricles / ratsИзвор:
Archives of Biological Sciences, 2011, 63, 3, 597-601Издавач:
- Srpsko biološko društvo, Beograd, i dr.
Финансирање / пројекти:
- Ефекат метаболичких и неметаболичких стресора на експресију и деловање неуроендокриних регулатора енергетске хомеостазе (RS-MESTD-Basic Research (BR or ON)-173023)
- Молекуларни механизми патофизиолошких промена у ћелијама централног нервног система и периферног ткива код сисара (RS-MESTD-Basic Research (BR or ON)-173044)
DOI: 10.2298/ABS1103597S
ISSN: 0354-4664
WoS: 000294400500010
Scopus: 2-s2.0-79961180596
Колекције
Институција/група
Fakultet veterinarske medicineTY - JOUR AU - Spasojević, Nataša AU - Jovanović, P. AU - Spasojević-Tišma, Vera AU - Đelić, Ninoslav AU - Dronjak, Slađana PY - 2011 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/763 AB - It is well known that antidepressants affect central monoaminergic neurotransmission and that they also modulate hormone release in peripheral tissues. Repeated maprotiline (a noradrenaline reuptake inhibitor) and fluoxetine (a serotonin reuptake inhibitor) treatment on gene expression of the catecholamine biosynthetic enzymes were examined in rat atria and ventricles in vivo. Maprotiline decreased the gene expression of tyrosine hydroxylase (TH) and dopamineβ-hydroxylase (DBH) in the rat atrium. Fluoxetine increased gene expression of TH and DBH, but not of phenylethanolamine N-methyltransferase (PNMT). Chronic application of antidepressants did not change the expression of these enzymes in the ventricles. We conclude that repeated administration of fluoxetine enhances gene transcription of TH and DBH and subsequently stimulates noradrenaline synthesis in rat atria in vivo. PB - Srpsko biološko društvo, Beograd, i dr. T2 - Archives of Biological Sciences T1 - Differential in vivo regulation of TH and DBH mRNA in rat atria by maprotiline and fluoxetine VL - 63 IS - 3 SP - 597 EP - 601 DO - 10.2298/ABS1103597S ER -
@article{ author = "Spasojević, Nataša and Jovanović, P. and Spasojević-Tišma, Vera and Đelić, Ninoslav and Dronjak, Slađana", year = "2011", abstract = "It is well known that antidepressants affect central monoaminergic neurotransmission and that they also modulate hormone release in peripheral tissues. Repeated maprotiline (a noradrenaline reuptake inhibitor) and fluoxetine (a serotonin reuptake inhibitor) treatment on gene expression of the catecholamine biosynthetic enzymes were examined in rat atria and ventricles in vivo. Maprotiline decreased the gene expression of tyrosine hydroxylase (TH) and dopamineβ-hydroxylase (DBH) in the rat atrium. Fluoxetine increased gene expression of TH and DBH, but not of phenylethanolamine N-methyltransferase (PNMT). Chronic application of antidepressants did not change the expression of these enzymes in the ventricles. We conclude that repeated administration of fluoxetine enhances gene transcription of TH and DBH and subsequently stimulates noradrenaline synthesis in rat atria in vivo.", publisher = "Srpsko biološko društvo, Beograd, i dr.", journal = "Archives of Biological Sciences", title = "Differential in vivo regulation of TH and DBH mRNA in rat atria by maprotiline and fluoxetine", volume = "63", number = "3", pages = "597-601", doi = "10.2298/ABS1103597S" }
Spasojević, N., Jovanović, P., Spasojević-Tišma, V., Đelić, N.,& Dronjak, S.. (2011). Differential in vivo regulation of TH and DBH mRNA in rat atria by maprotiline and fluoxetine. in Archives of Biological Sciences Srpsko biološko društvo, Beograd, i dr.., 63(3), 597-601. https://doi.org/10.2298/ABS1103597S
Spasojević N, Jovanović P, Spasojević-Tišma V, Đelić N, Dronjak S. Differential in vivo regulation of TH and DBH mRNA in rat atria by maprotiline and fluoxetine. in Archives of Biological Sciences. 2011;63(3):597-601. doi:10.2298/ABS1103597S .
Spasojević, Nataša, Jovanović, P., Spasojević-Tišma, Vera, Đelić, Ninoslav, Dronjak, Slađana, "Differential in vivo regulation of TH and DBH mRNA in rat atria by maprotiline and fluoxetine" in Archives of Biological Sciences, 63, no. 3 (2011):597-601, https://doi.org/10.2298/ABS1103597S . .