Follicular development and atresia in the ovaries of thyroxine treated juvenile rats
Апстракт
The effect of early hyperthyroidism on folliculogenesis in the ovary of juvenile rats was investigated. Hyperthyroidism was induced by injection of 150 μg DL-thyroxine (DL-T 4 ) to females every other day, from the 9 th to the 29 th day of life. Twenty four hours after the last injection treated females and corresponding intact animals were sacrificed, and the ovaries were examined using standard light microscopy and semithin sections. DL-T4 caused a significant decrease of pituitary and ovary mass, compared to intact animals. The population of healthy primary follicles was increased in the ovaries of treated rats. At the same time, the total number of atretic follicles, especially growing, was also significantly increased. Antral follicles without apoptotic changes were scarcely observed. Furthermore, granulosa cells displayed morphological changes characteristic for apoptosis: widened intercellular spaces, condensation of chromatin, cellular fragmentation and formation of atretic bod...ies.
Кључне речи:
DL-thyroxine / hyperthyroidism / ovary / juvenile ratИзвор:
Acta Veterinaria-Beograd, 1997, 47, 2-3, 87-94Издавач:
- Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
Колекције
Институција/група
Fakultet veterinarske medicineTY - JOUR AU - Radovanović, Anita AU - StosicBogdanović, N AU - Gledić, Dušan PY - 1997 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/85 AB - The effect of early hyperthyroidism on folliculogenesis in the ovary of juvenile rats was investigated. Hyperthyroidism was induced by injection of 150 μg DL-thyroxine (DL-T 4 ) to females every other day, from the 9 th to the 29 th day of life. Twenty four hours after the last injection treated females and corresponding intact animals were sacrificed, and the ovaries were examined using standard light microscopy and semithin sections. DL-T4 caused a significant decrease of pituitary and ovary mass, compared to intact animals. The population of healthy primary follicles was increased in the ovaries of treated rats. At the same time, the total number of atretic follicles, especially growing, was also significantly increased. Antral follicles without apoptotic changes were scarcely observed. Furthermore, granulosa cells displayed morphological changes characteristic for apoptosis: widened intercellular spaces, condensation of chromatin, cellular fragmentation and formation of atretic bodies. PB - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd T2 - Acta Veterinaria-Beograd T1 - Follicular development and atresia in the ovaries of thyroxine treated juvenile rats VL - 47 IS - 2-3 SP - 87 EP - 94 UR - https://hdl.handle.net/21.15107/rcub_veterinar_85 ER -
@article{ author = "Radovanović, Anita and StosicBogdanović, N and Gledić, Dušan", year = "1997", abstract = "The effect of early hyperthyroidism on folliculogenesis in the ovary of juvenile rats was investigated. Hyperthyroidism was induced by injection of 150 μg DL-thyroxine (DL-T 4 ) to females every other day, from the 9 th to the 29 th day of life. Twenty four hours after the last injection treated females and corresponding intact animals were sacrificed, and the ovaries were examined using standard light microscopy and semithin sections. DL-T4 caused a significant decrease of pituitary and ovary mass, compared to intact animals. The population of healthy primary follicles was increased in the ovaries of treated rats. At the same time, the total number of atretic follicles, especially growing, was also significantly increased. Antral follicles without apoptotic changes were scarcely observed. Furthermore, granulosa cells displayed morphological changes characteristic for apoptosis: widened intercellular spaces, condensation of chromatin, cellular fragmentation and formation of atretic bodies.", publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd", journal = "Acta Veterinaria-Beograd", title = "Follicular development and atresia in the ovaries of thyroxine treated juvenile rats", volume = "47", number = "2-3", pages = "87-94", url = "https://hdl.handle.net/21.15107/rcub_veterinar_85" }
Radovanović, A., StosicBogdanović, N.,& Gledić, D.. (1997). Follicular development and atresia in the ovaries of thyroxine treated juvenile rats. in Acta Veterinaria-Beograd Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 47(2-3), 87-94. https://hdl.handle.net/21.15107/rcub_veterinar_85
Radovanović A, StosicBogdanović N, Gledić D. Follicular development and atresia in the ovaries of thyroxine treated juvenile rats. in Acta Veterinaria-Beograd. 1997;47(2-3):87-94. https://hdl.handle.net/21.15107/rcub_veterinar_85 .
Radovanović, Anita, StosicBogdanović, N, Gledić, Dušan, "Follicular development and atresia in the ovaries of thyroxine treated juvenile rats" in Acta Veterinaria-Beograd, 47, no. 2-3 (1997):87-94, https://hdl.handle.net/21.15107/rcub_veterinar_85 .