Leaf-surface guaianolides from Amphoricarpos neumaeyri showing protective effect on human lymphocytes DNA
Само за регистроване кориснике
2020
Аутори
Cvetković, MirjanaĐorđević, Iris
Jadranin, Milka
Stanković, Miroslava
Mandić, Boris
Milosavljević, Slobodan M.
Vujisić, Ljubodrag
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Analysis of composition of CH2Cl2 surface extract of leaves of Amphoricarpos neumayeri Vis. revealed 16 sesquiterpene lactones with guaianolide skeleton, so called amphoricarpolides, typical for this genus. Four of them, 13-16, were new derivatives and their structures were elucidated by detailed analyses of IR, NMR and MS data. Amphoricarpolide (9), its 15-O-acetyl derivative (5), and two 9 beta-hydroxyamphoricarpolides, 3,15-di-O-acetyl- and 3-O-acetyl-15-O-isovaleroyl derivatives (3 and 6, respectively) were tested for in vitro protective effect on chromosome aberrations in peripheral human lymphocytes using cytochalasin-B blocked micronucleus (CBMN) assay. The tested compound exerted a beneficial effect by decreasing DNA damage of human lymphocytes.
Кључне речи:
Amphoricarpos neumayeri Vis / sesquiterpene lactones / in vitro protective effect on chromosome aberrationsИзвор:
Natural Product Research, 2020Издавач:
- Taylor & Francis Ltd, Abingdon
Финансирање / пројекти:
- Биоактивни природни производи самониклих, гајених и јестивих биљака: одређивање структура и активности (RS-MESTD-Basic Research (BR or ON)-172053)
- Serbian Academy of Sciences and Arts [F-188]
DOI: 10.1080/14786419.2019.1687470
ISSN: 1478-6419
PubMed: 31707853
WoS: 000495535100001
Scopus: 2-s2.0-85075017367
Колекције
Институција/група
Fakultet veterinarske medicineTY - JOUR AU - Cvetković, Mirjana AU - Đorđević, Iris AU - Jadranin, Milka AU - Stanković, Miroslava AU - Mandić, Boris AU - Milosavljević, Slobodan M. AU - Vujisić, Ljubodrag PY - 2020 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1799 AB - Analysis of composition of CH2Cl2 surface extract of leaves of Amphoricarpos neumayeri Vis. revealed 16 sesquiterpene lactones with guaianolide skeleton, so called amphoricarpolides, typical for this genus. Four of them, 13-16, were new derivatives and their structures were elucidated by detailed analyses of IR, NMR and MS data. Amphoricarpolide (9), its 15-O-acetyl derivative (5), and two 9 beta-hydroxyamphoricarpolides, 3,15-di-O-acetyl- and 3-O-acetyl-15-O-isovaleroyl derivatives (3 and 6, respectively) were tested for in vitro protective effect on chromosome aberrations in peripheral human lymphocytes using cytochalasin-B blocked micronucleus (CBMN) assay. The tested compound exerted a beneficial effect by decreasing DNA damage of human lymphocytes. PB - Taylor & Francis Ltd, Abingdon T2 - Natural Product Research T1 - Leaf-surface guaianolides from Amphoricarpos neumaeyri showing protective effect on human lymphocytes DNA DO - 10.1080/14786419.2019.1687470 ER -
@article{ author = "Cvetković, Mirjana and Đorđević, Iris and Jadranin, Milka and Stanković, Miroslava and Mandić, Boris and Milosavljević, Slobodan M. and Vujisić, Ljubodrag", year = "2020", abstract = "Analysis of composition of CH2Cl2 surface extract of leaves of Amphoricarpos neumayeri Vis. revealed 16 sesquiterpene lactones with guaianolide skeleton, so called amphoricarpolides, typical for this genus. Four of them, 13-16, were new derivatives and their structures were elucidated by detailed analyses of IR, NMR and MS data. Amphoricarpolide (9), its 15-O-acetyl derivative (5), and two 9 beta-hydroxyamphoricarpolides, 3,15-di-O-acetyl- and 3-O-acetyl-15-O-isovaleroyl derivatives (3 and 6, respectively) were tested for in vitro protective effect on chromosome aberrations in peripheral human lymphocytes using cytochalasin-B blocked micronucleus (CBMN) assay. The tested compound exerted a beneficial effect by decreasing DNA damage of human lymphocytes.", publisher = "Taylor & Francis Ltd, Abingdon", journal = "Natural Product Research", title = "Leaf-surface guaianolides from Amphoricarpos neumaeyri showing protective effect on human lymphocytes DNA", doi = "10.1080/14786419.2019.1687470" }
Cvetković, M., Đorđević, I., Jadranin, M., Stanković, M., Mandić, B., Milosavljević, S. M.,& Vujisić, L.. (2020). Leaf-surface guaianolides from Amphoricarpos neumaeyri showing protective effect on human lymphocytes DNA. in Natural Product Research Taylor & Francis Ltd, Abingdon.. https://doi.org/10.1080/14786419.2019.1687470
Cvetković M, Đorđević I, Jadranin M, Stanković M, Mandić B, Milosavljević SM, Vujisić L. Leaf-surface guaianolides from Amphoricarpos neumaeyri showing protective effect on human lymphocytes DNA. in Natural Product Research. 2020;. doi:10.1080/14786419.2019.1687470 .
Cvetković, Mirjana, Đorđević, Iris, Jadranin, Milka, Stanković, Miroslava, Mandić, Boris, Milosavljević, Slobodan M., Vujisić, Ljubodrag, "Leaf-surface guaianolides from Amphoricarpos neumaeyri showing protective effect on human lymphocytes DNA" in Natural Product Research (2020), https://doi.org/10.1080/14786419.2019.1687470 . .