Parathyroid hormone response in treatment of subclinical hypocalcemia inpostpartum dairy cows
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2020
Authors
Nedić, SretenPalamarević, Milija
Arsić, Sveta
Jovanović, Ljubomir
Prodanović, Radiša
Kirovski, Danijela
Vujanac, Ivan
Article (Published version)
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The aim of this study was to evaluate different treatments of postpartum subclinical hypocalcemia in dairy cows with emphasis on PTH response. Twenty four cows with subclinical hypocalcemia (Ca 1.4–2.0 mmol/L), out of 180 Holstein cows tested, were assigned in one of three equal groups: (1) CON received no Ca supplementation, (2) PO-Ca received 1000 mL of oral Ca suspension, immediately after establishing hypocalcemia, and 500 mL of the suspension 12 h after, (3) IV-Ca intravenously received 500 mL of Ca immediately after establishing hypocalcemia. The blood samples were taken up to 48 h after initial treatment for determination of Ca, iP, Mg and PTH concentrations. Urine pH was also evaluated up to 48 h after initial treatment. Compered to CON cows that were hypocalcemic up to the 48 h, Ca concentrations were significantly higher in PO-Ca up to hour 8 and IV-Ca up to hour 24. At first 2 h, PTH concentrations were significantly lower, compared to CON, only in IV-Ca, while at hour 4 PTH... concentrations were significantly lower in both treated groups. At hours 24 and 48, PTH concentrations were significantly lower only in PO-Ca compared to CON group. Urine pH values in CON indicate alkalosis and were significantly lower both in PO-Ca and IV-Ca group, up to 12 h and 24 h respectively. In conclusion, both treatments mitigated hypocalcemia in cows, but with significantly different PTH response. Due to adequate PTH response, normocalcemia is established in CON and expected transient hypocalcemia is avoided in IV-Ca cows.
Keywords:
Ca application / Dairy cows / PTH / Subclinical hypocalcemiaSource:
Research in Veterinary Science, 2020, 132, 351-356Publisher:
- Elsevier
Funding / projects:
- Development of technologies and products based on mineral raw materials and waste biomass for protection of natural resources for safe food production (RS-MESTD-Technological Development (TD or TR)-31003)
- Molecular genetic and ecophysiological researches on the protection of autochthonous animal genetic resources, sustaining domestic animals’ welfare, health and reproduction, and safe food production (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-46002)
DOI: 10.1016/j.rvsc.2020.07.010
ISSN: 0034-5288
WoS: 000567453100028
Scopus: 2-s2.0-85088667488
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Fakultet veterinarske medicineTY - JOUR AU - Nedić, Sreten AU - Palamarević, Milija AU - Arsić, Sveta AU - Jovanović, Ljubomir AU - Prodanović, Radiša AU - Kirovski, Danijela AU - Vujanac, Ivan PY - 2020 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1852 AB - The aim of this study was to evaluate different treatments of postpartum subclinical hypocalcemia in dairy cows with emphasis on PTH response. Twenty four cows with subclinical hypocalcemia (Ca 1.4–2.0 mmol/L), out of 180 Holstein cows tested, were assigned in one of three equal groups: (1) CON received no Ca supplementation, (2) PO-Ca received 1000 mL of oral Ca suspension, immediately after establishing hypocalcemia, and 500 mL of the suspension 12 h after, (3) IV-Ca intravenously received 500 mL of Ca immediately after establishing hypocalcemia. The blood samples were taken up to 48 h after initial treatment for determination of Ca, iP, Mg and PTH concentrations. Urine pH was also evaluated up to 48 h after initial treatment. Compered to CON cows that were hypocalcemic up to the 48 h, Ca concentrations were significantly higher in PO-Ca up to hour 8 and IV-Ca up to hour 24. At first 2 h, PTH concentrations were significantly lower, compared to CON, only in IV-Ca, while at hour 4 PTH concentrations were significantly lower in both treated groups. At hours 24 and 48, PTH concentrations were significantly lower only in PO-Ca compared to CON group. Urine pH values in CON indicate alkalosis and were significantly lower both in PO-Ca and IV-Ca group, up to 12 h and 24 h respectively. In conclusion, both treatments mitigated hypocalcemia in cows, but with significantly different PTH response. Due to adequate PTH response, normocalcemia is established in CON and expected transient hypocalcemia is avoided in IV-Ca cows. PB - Elsevier T2 - Research in Veterinary Science T1 - Parathyroid hormone response in treatment of subclinical hypocalcemia inpostpartum dairy cows VL - 132 SP - 351 EP - 356 DO - 10.1016/j.rvsc.2020.07.010 ER -
@article{ author = "Nedić, Sreten and Palamarević, Milija and Arsić, Sveta and Jovanović, Ljubomir and Prodanović, Radiša and Kirovski, Danijela and Vujanac, Ivan", year = "2020", abstract = "The aim of this study was to evaluate different treatments of postpartum subclinical hypocalcemia in dairy cows with emphasis on PTH response. Twenty four cows with subclinical hypocalcemia (Ca 1.4–2.0 mmol/L), out of 180 Holstein cows tested, were assigned in one of three equal groups: (1) CON received no Ca supplementation, (2) PO-Ca received 1000 mL of oral Ca suspension, immediately after establishing hypocalcemia, and 500 mL of the suspension 12 h after, (3) IV-Ca intravenously received 500 mL of Ca immediately after establishing hypocalcemia. The blood samples were taken up to 48 h after initial treatment for determination of Ca, iP, Mg and PTH concentrations. Urine pH was also evaluated up to 48 h after initial treatment. Compered to CON cows that were hypocalcemic up to the 48 h, Ca concentrations were significantly higher in PO-Ca up to hour 8 and IV-Ca up to hour 24. At first 2 h, PTH concentrations were significantly lower, compared to CON, only in IV-Ca, while at hour 4 PTH concentrations were significantly lower in both treated groups. At hours 24 and 48, PTH concentrations were significantly lower only in PO-Ca compared to CON group. Urine pH values in CON indicate alkalosis and were significantly lower both in PO-Ca and IV-Ca group, up to 12 h and 24 h respectively. In conclusion, both treatments mitigated hypocalcemia in cows, but with significantly different PTH response. Due to adequate PTH response, normocalcemia is established in CON and expected transient hypocalcemia is avoided in IV-Ca cows.", publisher = "Elsevier", journal = "Research in Veterinary Science", title = "Parathyroid hormone response in treatment of subclinical hypocalcemia inpostpartum dairy cows", volume = "132", pages = "351-356", doi = "10.1016/j.rvsc.2020.07.010" }
Nedić, S., Palamarević, M., Arsić, S., Jovanović, L., Prodanović, R., Kirovski, D.,& Vujanac, I.. (2020). Parathyroid hormone response in treatment of subclinical hypocalcemia inpostpartum dairy cows. in Research in Veterinary Science Elsevier., 132, 351-356. https://doi.org/10.1016/j.rvsc.2020.07.010
Nedić S, Palamarević M, Arsić S, Jovanović L, Prodanović R, Kirovski D, Vujanac I. Parathyroid hormone response in treatment of subclinical hypocalcemia inpostpartum dairy cows. in Research in Veterinary Science. 2020;132:351-356. doi:10.1016/j.rvsc.2020.07.010 .
Nedić, Sreten, Palamarević, Milija, Arsić, Sveta, Jovanović, Ljubomir, Prodanović, Radiša, Kirovski, Danijela, Vujanac, Ivan, "Parathyroid hormone response in treatment of subclinical hypocalcemia inpostpartum dairy cows" in Research in Veterinary Science, 132 (2020):351-356, https://doi.org/10.1016/j.rvsc.2020.07.010 . .