Reproductive immunology in viviparous mammals: evolutionary paradox of interactions among immune mechanisms and autologous or allogeneic gametes and semiallogeneic foetuses
2020
Authors
Samardžija, MarkoLojkić, Martina
Maćešić, Nino
Valpotić, Hrvoje
Butković, Ivan
Šavorić, Juraj
Žura Žaja, Ivona
Leiner, Denis
Đuričić, Dražen
Marković, Franjo
Kočila, Predrag
Vidas, Željko
Gerenčer, Marijan
Kaštelan, Andrija
Milovanović, Aleksandar
Lazarević, Miodrag
Rukavina, Daniel
Valpotić, Ivica
Article (Published version)
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Show full item recordAbstract
Literally, reproductive immunology was born in bovine on-farm reproduction where seminal experiments intended for developing methods for embryo transfer in cattle were performed. Actually, these experiments led to two of major concepts and fundamental principles of reproductive immunology using the bovine species as a model for biomedical research, namely the concept of acquired immunological tolerance and the paradox of the semiallogeneic bovine foetus whereby such organism can develop within an immunologically competent host. Peter Medawar, a scientist who together with Frank Macfarlande Burnet shared the 1960 Nobel Prize in physiology or medicine for discovery of acquired immunological tolerance, while studying dizygotic cattle twins, thereby giving birth to reproductive immunology. Also, these findings significantly influenced development of organ transplants and showed that using farm animals as models for studying transplantation immunology had general relevance for mammalian bio...logy and health including those of humans. However, the interest for further research of the fascinating maternal immune influences on pregnancy and perinatal outcomes and of the prevention and treatment of immunologically mediated reproductive disorders in viviparous mammals of veterinary relevance by veterinary immunologists and reproductive clinicians have been very scarce regarding the application of nonspecific immunomodulatory agents for prevention and treatment of subfertility and infertility in pigs and cattle, but still broadening knowledge in this area and hold great potential for improving such therapy in the future. The aim of the current overview is to provide up-to-date information and explaining/translating relevant immunology phenomena into veterinary practice for specialists and scientists/clinicians in reproduction of animals.
Keywords:
allogeneic gamete / CD45 / immunotrophism / Reproductive immunology / semiallogeneic foetus / transplantation immunology / viviparous mammalsSource:
Veterinary Quarterly, 2020, 40, 1, 353-383Publisher:
- Taylor & Francis
Note:
- Link to the corrected article: https://vet-erinar.vet.bg.ac.rs/handle/123456789/2052
Related info:
- Referenced by
https://vet-erinar.vet.bg.ac.rs/handle/123456789/2052
DOI: 10.1080/01652176.2020.1852336
ISSN: 0165-2176
WoS: 000596859900001
Scopus: 2-s2.0-85097384464
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Fakultet veterinarske medicineTY - JOUR AU - Samardžija, Marko AU - Lojkić, Martina AU - Maćešić, Nino AU - Valpotić, Hrvoje AU - Butković, Ivan AU - Šavorić, Juraj AU - Žura Žaja, Ivona AU - Leiner, Denis AU - Đuričić, Dražen AU - Marković, Franjo AU - Kočila, Predrag AU - Vidas, Željko AU - Gerenčer, Marijan AU - Kaštelan, Andrija AU - Milovanović, Aleksandar AU - Lazarević, Miodrag AU - Rukavina, Daniel AU - Valpotić, Ivica PY - 2020 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1967 AB - Literally, reproductive immunology was born in bovine on-farm reproduction where seminal experiments intended for developing methods for embryo transfer in cattle were performed. Actually, these experiments led to two of major concepts and fundamental principles of reproductive immunology using the bovine species as a model for biomedical research, namely the concept of acquired immunological tolerance and the paradox of the semiallogeneic bovine foetus whereby such organism can develop within an immunologically competent host. Peter Medawar, a scientist who together with Frank Macfarlande Burnet shared the 1960 Nobel Prize in physiology or medicine for discovery of acquired immunological tolerance, while studying dizygotic cattle twins, thereby giving birth to reproductive immunology. Also, these findings significantly influenced development of organ transplants and showed that using farm animals as models for studying transplantation immunology had general relevance for mammalian biology and health including those of humans. However, the interest for further research of the fascinating maternal immune influences on pregnancy and perinatal outcomes and of the prevention and treatment of immunologically mediated reproductive disorders in viviparous mammals of veterinary relevance by veterinary immunologists and reproductive clinicians have been very scarce regarding the application of nonspecific immunomodulatory agents for prevention and treatment of subfertility and infertility in pigs and cattle, but still broadening knowledge in this area and hold great potential for improving such therapy in the future. The aim of the current overview is to provide up-to-date information and explaining/translating relevant immunology phenomena into veterinary practice for specialists and scientists/clinicians in reproduction of animals. PB - Taylor & Francis T2 - Veterinary Quarterly T1 - Reproductive immunology in viviparous mammals: evolutionary paradox of interactions among immune mechanisms and autologous or allogeneic gametes and semiallogeneic foetuses VL - 40 IS - 1 SP - 353 EP - 383 DO - 10.1080/01652176.2020.1852336 ER -
@article{ author = "Samardžija, Marko and Lojkić, Martina and Maćešić, Nino and Valpotić, Hrvoje and Butković, Ivan and Šavorić, Juraj and Žura Žaja, Ivona and Leiner, Denis and Đuričić, Dražen and Marković, Franjo and Kočila, Predrag and Vidas, Željko and Gerenčer, Marijan and Kaštelan, Andrija and Milovanović, Aleksandar and Lazarević, Miodrag and Rukavina, Daniel and Valpotić, Ivica", year = "2020", abstract = "Literally, reproductive immunology was born in bovine on-farm reproduction where seminal experiments intended for developing methods for embryo transfer in cattle were performed. Actually, these experiments led to two of major concepts and fundamental principles of reproductive immunology using the bovine species as a model for biomedical research, namely the concept of acquired immunological tolerance and the paradox of the semiallogeneic bovine foetus whereby such organism can develop within an immunologically competent host. Peter Medawar, a scientist who together with Frank Macfarlande Burnet shared the 1960 Nobel Prize in physiology or medicine for discovery of acquired immunological tolerance, while studying dizygotic cattle twins, thereby giving birth to reproductive immunology. Also, these findings significantly influenced development of organ transplants and showed that using farm animals as models for studying transplantation immunology had general relevance for mammalian biology and health including those of humans. However, the interest for further research of the fascinating maternal immune influences on pregnancy and perinatal outcomes and of the prevention and treatment of immunologically mediated reproductive disorders in viviparous mammals of veterinary relevance by veterinary immunologists and reproductive clinicians have been very scarce regarding the application of nonspecific immunomodulatory agents for prevention and treatment of subfertility and infertility in pigs and cattle, but still broadening knowledge in this area and hold great potential for improving such therapy in the future. The aim of the current overview is to provide up-to-date information and explaining/translating relevant immunology phenomena into veterinary practice for specialists and scientists/clinicians in reproduction of animals.", publisher = "Taylor & Francis", journal = "Veterinary Quarterly", title = "Reproductive immunology in viviparous mammals: evolutionary paradox of interactions among immune mechanisms and autologous or allogeneic gametes and semiallogeneic foetuses", volume = "40", number = "1", pages = "353-383", doi = "10.1080/01652176.2020.1852336" }
Samardžija, M., Lojkić, M., Maćešić, N., Valpotić, H., Butković, I., Šavorić, J., Žura Žaja, I., Leiner, D., Đuričić, D., Marković, F., Kočila, P., Vidas, Ž., Gerenčer, M., Kaštelan, A., Milovanović, A., Lazarević, M., Rukavina, D.,& Valpotić, I.. (2020). Reproductive immunology in viviparous mammals: evolutionary paradox of interactions among immune mechanisms and autologous or allogeneic gametes and semiallogeneic foetuses. in Veterinary Quarterly Taylor & Francis., 40(1), 353-383. https://doi.org/10.1080/01652176.2020.1852336
Samardžija M, Lojkić M, Maćešić N, Valpotić H, Butković I, Šavorić J, Žura Žaja I, Leiner D, Đuričić D, Marković F, Kočila P, Vidas Ž, Gerenčer M, Kaštelan A, Milovanović A, Lazarević M, Rukavina D, Valpotić I. Reproductive immunology in viviparous mammals: evolutionary paradox of interactions among immune mechanisms and autologous or allogeneic gametes and semiallogeneic foetuses. in Veterinary Quarterly. 2020;40(1):353-383. doi:10.1080/01652176.2020.1852336 .
Samardžija, Marko, Lojkić, Martina, Maćešić, Nino, Valpotić, Hrvoje, Butković, Ivan, Šavorić, Juraj, Žura Žaja, Ivona, Leiner, Denis, Đuričić, Dražen, Marković, Franjo, Kočila, Predrag, Vidas, Željko, Gerenčer, Marijan, Kaštelan, Andrija, Milovanović, Aleksandar, Lazarević, Miodrag, Rukavina, Daniel, Valpotić, Ivica, "Reproductive immunology in viviparous mammals: evolutionary paradox of interactions among immune mechanisms and autologous or allogeneic gametes and semiallogeneic foetuses" in Veterinary Quarterly, 40, no. 1 (2020):353-383, https://doi.org/10.1080/01652176.2020.1852336 . .