Principles of age-related changes in the canine and feline brain
Promene na mozgu pasa i mačaka tokom starenja
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In the aged dog and cat, especially dog, a cognitive decline develops naturally in many different domains, but at the same time it also exhibits human-like individual variability in the aging process. In the aging dog and cat brain lesions develop spontaneously. Dogs share some morphological characteristics with those of Alzheimer’s disease in man. The canine brain with its plaques and tangles which show oxidative changes, forms a spontaneous model for understanding the early changes and their interrela-tionships in Alzheimer’s disease. Additionally, the aged dog represents a useful model for the development of preventive or therapeutic interventions to improve aged brain function. These interventions can then be translated into human clinical trials.
Kod ostarelih pasa i mačaka, posebno pasa, gubitak kognitivnih sposobnosti se prirodno razvija na različitim poljima, ali istovremeno ispoljava slično kao i kod ljudi sa individualnim razlikama u procesu starenja. U toku starenja kod pasa i mačaka promene u mozgu se razvijaju spontano. Kod pasa se javljaju neke morfološke promene, slične promenama kod ljudi koji su oboleli od Alchajmerove bolesti. Pored toga, ostareli pas predstavlja koristan model za razvoj preventivnih ili terapeutskih intervencija radi poboljšanja funkcije ostarelog mozga. Ovakve intervencije se mogu preneti na klinička ispitivanja na ljudima.
Ključne reči:
aged dogs / aged cats / amyloid / Alzheimer disease / oxidative damageIzvor:
Acta Veterinaria-Beograd, 2014, 64, 1, 1-9Izdavač:
- Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
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Institucija/grupa
Fakultet veterinarske medicineTY - JOUR AU - Papaioannou, Nikolaos PY - 2014 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2139 AB - In the aged dog and cat, especially dog, a cognitive decline develops naturally in many different domains, but at the same time it also exhibits human-like individual variability in the aging process. In the aging dog and cat brain lesions develop spontaneously. Dogs share some morphological characteristics with those of Alzheimer’s disease in man. The canine brain with its plaques and tangles which show oxidative changes, forms a spontaneous model for understanding the early changes and their interrela-tionships in Alzheimer’s disease. Additionally, the aged dog represents a useful model for the development of preventive or therapeutic interventions to improve aged brain function. These interventions can then be translated into human clinical trials. AB - Kod ostarelih pasa i mačaka, posebno pasa, gubitak kognitivnih sposobnosti se prirodno razvija na različitim poljima, ali istovremeno ispoljava slično kao i kod ljudi sa individualnim razlikama u procesu starenja. U toku starenja kod pasa i mačaka promene u mozgu se razvijaju spontano. Kod pasa se javljaju neke morfološke promene, slične promenama kod ljudi koji su oboleli od Alchajmerove bolesti. Pored toga, ostareli pas predstavlja koristan model za razvoj preventivnih ili terapeutskih intervencija radi poboljšanja funkcije ostarelog mozga. Ovakve intervencije se mogu preneti na klinička ispitivanja na ljudima. PB - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd T2 - Acta Veterinaria-Beograd T1 - Principles of age-related changes in the canine and feline brain T1 - Promene na mozgu pasa i mačaka tokom starenja VL - 64 IS - 1 SP - 1 EP - 9 DO - 10.2478/acve-2014-0001 ER -
@article{ author = "Papaioannou, Nikolaos", year = "2014", abstract = "In the aged dog and cat, especially dog, a cognitive decline develops naturally in many different domains, but at the same time it also exhibits human-like individual variability in the aging process. In the aging dog and cat brain lesions develop spontaneously. Dogs share some morphological characteristics with those of Alzheimer’s disease in man. The canine brain with its plaques and tangles which show oxidative changes, forms a spontaneous model for understanding the early changes and their interrela-tionships in Alzheimer’s disease. Additionally, the aged dog represents a useful model for the development of preventive or therapeutic interventions to improve aged brain function. These interventions can then be translated into human clinical trials., Kod ostarelih pasa i mačaka, posebno pasa, gubitak kognitivnih sposobnosti se prirodno razvija na različitim poljima, ali istovremeno ispoljava slično kao i kod ljudi sa individualnim razlikama u procesu starenja. U toku starenja kod pasa i mačaka promene u mozgu se razvijaju spontano. Kod pasa se javljaju neke morfološke promene, slične promenama kod ljudi koji su oboleli od Alchajmerove bolesti. Pored toga, ostareli pas predstavlja koristan model za razvoj preventivnih ili terapeutskih intervencija radi poboljšanja funkcije ostarelog mozga. Ovakve intervencije se mogu preneti na klinička ispitivanja na ljudima.", publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd", journal = "Acta Veterinaria-Beograd", title = "Principles of age-related changes in the canine and feline brain, Promene na mozgu pasa i mačaka tokom starenja", volume = "64", number = "1", pages = "1-9", doi = "10.2478/acve-2014-0001" }
Papaioannou, N.. (2014). Principles of age-related changes in the canine and feline brain. in Acta Veterinaria-Beograd Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 64(1), 1-9. https://doi.org/10.2478/acve-2014-0001
Papaioannou N. Principles of age-related changes in the canine and feline brain. in Acta Veterinaria-Beograd. 2014;64(1):1-9. doi:10.2478/acve-2014-0001 .
Papaioannou, Nikolaos, "Principles of age-related changes in the canine and feline brain" in Acta Veterinaria-Beograd, 64, no. 1 (2014):1-9, https://doi.org/10.2478/acve-2014-0001 . .