dc.creator | Spasojević, Dragica | |
dc.creator | Zmejkoski, Danica | |
dc.creator | Milčić Matić, Natalija | |
dc.creator | Krnjaić, Dejan | |
dc.creator | Radotić, Ksenija | |
dc.date.accessioned | 2024-02-21T09:51:24Z | |
dc.date.available | 2024-02-21T09:51:24Z | |
dc.date.issued | 2024 | |
dc.identifier.issn | 0165-7380 | |
dc.identifier.uri | https://vet-erinar.vet.bg.ac.rs/handle/123456789/3702 | |
dc.description.abstract | Bacterial infections and resistance to antibiotics are increasingly severe problems. In recent years, Staphylococcus species
have emerged as important pathogens in animals and humans. Current therapeutic methods against these species have serious disadvantages; therefore new agents with antibacterial potential, such as plant-based substances, are very important in
therapy. We report a pilot study with new method of fractioning the dehydrogenate polymer DHP obtained from coniferyl
alcohol and application of the low-MW fractions of 200–3000 Da for antibacterial activity in healing animal lesions. In
vivo experiments were conducted on the dogs having a skin lesion. Dogs were treated with the suspension containing the
low-MW DHP fractions as the active ingredient, in combination with alginate for 7 days. Cytological smears and microbiological analyses of the afected area were performed. Staphylococcus spp. was isolated from lesions in all dogs from
our research. The results show that the low-MW DHP suspension in alginate promotes skin healing and reduction of the
infection of the lesions in the afected animals. Pharmaceutical composition containing the low-MW DHP fractions exerts
a soothing efect on the subject in wound treatment. Reduction in the number of bacteria by 30% and more were noticed
in 6 dogs, while in 4 dogs this percentage is above 50%. No side efects were noticed. Synthesized lignin oligomers may
have a signifcant place as antimicrobial and skin healing agents, especially since an increasing number of multidrugresistant staphylococci are found on the skin lesions in animals. | sr |
dc.language.iso | en | sr |
dc.publisher | Springer | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200053/RS// | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200143/RS// | sr |
dc.rights | restrictedAccess | sr |
dc.source | Veterinary Research Communications | sr |
dc.subject | Lignin model compound | sr |
dc.subject | Low-molecular weight DHP fractions | sr |
dc.subject | Staphylococcus spp. | sr |
dc.subject | Antibacterial agent | sr |
dc.subject | Skin lesions | sr |
dc.title | Therapeutic potential of low-molecular weight lignin model polymer fractions for treating skin lesions in animals: a pilot study | sr |
dc.type | article | sr |
dc.rights.license | ARR | sr |
dc.citation.volume | 48 | |
dc.citation.issue | 1 | |
dc.citation.spage | 591 | |
dc.citation.epage | 596 | |
dc.identifier.doi | 10.1007/s11259-023-10224-9 | |
dc.type.version | publishedVersion | sr |