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Identification of serotonergic (5HT1A-type) receptors in broiler small intestine by application of serotonin and its agonists and antagonists
Utvrđivanje serotonergičnih receptora 5HT1A tipa u tankom crijevu brojlera primjenom serotonina i njegovih agonista i antagonista
dc.creator | Mujezinović, Indira | |
dc.creator | Ćupić, Vitomir | |
dc.creator | Smajlović, Ahmed | |
dc.creator | Muminović, Mehmed | |
dc.date.accessioned | 2020-06-03T13:27:11Z | |
dc.date.available | 2020-06-03T13:27:11Z | |
dc.date.issued | 2011 | |
dc.identifier.issn | 0350-2457 | |
dc.identifier.uri | https://vet-erinar.vet.bg.ac.rs/handle/123456789/790 | |
dc.description.abstract | Serotonin or 5-hydroxytryptamine (5-HT), is a monoamine neurotransmitter synthesised from L-tryptophan in serotonergic neurons and enterochromaffin cells of the gastrointestinal tract. This neurotransmitter is widely distributed in the animal and plant kingdom and regulates some central and peripheral functions through several types of specific serotonergic (5-HT) receptors. Since it is known that the effect of serotonin, especially in pathological conditions, is very important, we believe that determining the types of receptors for this substance would make it possible to use their agonist or antagonists, which would undoubtedly enhance the pharmacotherapy of functional disruption of the small intestine in broilers. Investigations were carried out on isolated smooth muscle strips of the circular and longitudinal layer of the broiler small intestine (strip dimension 3-4 mm x 2 cm). The muscle strips were placed in an isolated organ bath. The mechanical activity of the preparations was recorded via an isotonic force transducer coupled to a pen recorder. This was done following the addition of serotonin (nonselective 5-HT agonist), 8-OH-DPAT (selective 5-HT1A agonist) and spiroxatrin (selective 5-HT1A antagonist). The sensitivity of the tissues to acetylcholine was tested before starting the experiments. Using the obtained results, it can be concluded that 5HT1A type receptors are present in smooth muscles of the broiler small intestine, duodenum and ileum, especially in the longitudinal smooth muscle layer which reacted with contractions even to low serotonin concentration (10-6), but not in the jejunum. | en |
dc.description.abstract | Serotonin ili 5-hidroksitriptamin (5-HT) je monoaminski neurotransmiter kojeg iz L-triptofana sintetišu serotonergični neuroni i enterohrmofine ćelije gastrointestinalnog trakta. Ovaj neurotransmiter se nalazi kod velikog broja životinja i biljaka i reguliše neke centralne i periferne funkcije posredstvom nekoliko tipova specifičnih serotonergičnih (5- HT) receptora. Pošto je poznato da je efekat serotonina,posebno u patološkim uslovima, veoma značajan, mi mislimo da određivanje tipa receptora za ovu supstancu može učiniti mogućom upotrebu njenih agonista ili antagonista, što bi nedvosmisleno povećalo farmakoterapiju poremećaja funkcije tankog creva kod brojlera. Istraživanja su izvršena na izolovanim trakama glatkih mišića kružnog i uzdužnog sloja tankog creva brojlera (dimenzije trake 3-4 mm x 2 cm). Trake mišića su bile stavljane u kupatila za izolovane organe. Mehanička aktivnost preparata je registrovana pomoću izotoničnog transdjusera povezanog sa štampačem. Registrovanje je vršeno posle dodavanja serotonina (neselektivni 5-HT agonist), 8-OH-DPAT (selektivni agonist) i spiroksatrina (selektivni 5-HT1A antagonist). Osetljivost tkiva na acetilholin testirana je pre početka eksperimenta. Imajući u vidu dobijene rezultate može se zaključiti da su receptori 5HT1A tipa prisutni u glatkim mišićima tankog creva brojlera, duodenumu i ileumu, posebno u uzdužnom sloju glatkih mišića koji je reagovao kontrakcijama čak i na niske koncentracije serotonina (10-6), ali ne i u jejunumu. | sr |
dc.publisher | Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Veterinarski Glasnik | |
dc.subject | broilers | en |
dc.subject | serotonin | en |
dc.subject | serotonergic receptors | en |
dc.subject | isolated smooth muscle | en |
dc.subject | small intestine | en |
dc.subject | brojler | sr |
dc.subject | serotonin | sr |
dc.subject | serotonergički receptori | sr |
dc.subject | izolovni glatki mišić | sr |
dc.subject | tanko crevo | sr |
dc.title | Identification of serotonergic (5HT1A-type) receptors in broiler small intestine by application of serotonin and its agonists and antagonists | en |
dc.title | Utvrđivanje serotonergičnih receptora 5HT1A tipa u tankom crijevu brojlera primjenom serotonina i njegovih agonista i antagonista | sr |
dc.type | article | |
dc.rights.license | BY | |
dcterms.abstract | Ћупић, Витомир; Смајловић, Aхмед; Муминовић, Мехмед; Мујезиновић, Индира; Утврђивање серотонергичних рецептора 5ХТ1A типа у танком цријеву бројлера примјеном серотонина и његових агониста и антагониста; Утврђивање серотонергичних рецептора 5ХТ1A типа у танком цријеву бројлера примјеном серотонина и његових агониста и антагониста; | |
dc.citation.volume | 65 | |
dc.citation.issue | 1-2 | |
dc.citation.spage | 51 | |
dc.citation.epage | 59 | |
dc.citation.other | 65(1-2): 51-59 | |
dc.citation.rank | M24 | |
dc.identifier.doi | 10.2298/VETGL1102051M | |
dc.identifier.fulltext | https://vet-erinar.vet.bg.ac.rs/bitstream/id/1325/789.pdf | |
dc.type.version | publishedVersion |