Sapundžić Zurovac, Zorana

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  • Sapundžić Zurovac, Zorana (5)

Author's Bibliography

First Report of Brucella Seroprevalence in Wild Boar Population in Serbia

Sapundžić Zurovac, Zorana; Žutić, Jadranka; Stević, Nataša; Milićević, Vesna; Radojičić, Marina; Stanojević, Slavoljub; Radojičić, Sonja

(MDPI, 2022)

TY  - JOUR
AU  - Sapundžić Zurovac, Zorana
AU  - Žutić, Jadranka
AU  - Stević, Nataša
AU  - Milićević, Vesna
AU  - Radojičić, Marina
AU  - Stanojević, Slavoljub
AU  - Radojičić, Sonja
PY  - 2022
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2510
AB  - Brucellosis is one of the most important bacterial zoonotic diseases worldwide, characterized in domestic animals by long-term reproductive disorders. As known, wild boars (Sus scrofa) are
natural hosts for Brucella suis biovar 2, in which the infection passes in inapparent form, increasing
the pathogen transmission risk to domestic pigs, other domestic animals and humans. So far, no
studies regarding brucellosis in wild boars in Serbia have been published. During the hunting
season 2020/2021, 480 sera of wild boars living in Serbia were collected and tested for the presence
of anti-Brucella antibodies. For the serological survey, the Rose Bengal Test (RBT) and competitive
enzyme-linked immunosorbent assay (c-ELISA) were used. Of the 480 sera, 45 sera tested positive,
indicating the acquired Brucella seroprevalence in wild boars of 9.4%. The greatest numbers of
Brucella seropositive animals were detected in the eastern parts of the country and in one of the
central districts, i.e., Pomoravski, Branicevski, Borski and Juznobanatski. This study provides the
first data regarding brucellosis in the wild boar population in Serbia, revealing the seroprevalence of
Brucella, thus indicating that wild boars as natural hosts and/or vectors of Brucella likely present a
risk for the infection of other animals.
PB  - MDPI
T2  - Veterinary Sciences
T1  - First Report of Brucella Seroprevalence in Wild Boar Population in Serbia
VL  - 9
IS  - 10
SP  - 575
DO  - 10.3390/vetsci9100575
ER  - 
@article{
author = "Sapundžić Zurovac, Zorana and Žutić, Jadranka and Stević, Nataša and Milićević, Vesna and Radojičić, Marina and Stanojević, Slavoljub and Radojičić, Sonja",
year = "2022",
abstract = "Brucellosis is one of the most important bacterial zoonotic diseases worldwide, characterized in domestic animals by long-term reproductive disorders. As known, wild boars (Sus scrofa) are
natural hosts for Brucella suis biovar 2, in which the infection passes in inapparent form, increasing
the pathogen transmission risk to domestic pigs, other domestic animals and humans. So far, no
studies regarding brucellosis in wild boars in Serbia have been published. During the hunting
season 2020/2021, 480 sera of wild boars living in Serbia were collected and tested for the presence
of anti-Brucella antibodies. For the serological survey, the Rose Bengal Test (RBT) and competitive
enzyme-linked immunosorbent assay (c-ELISA) were used. Of the 480 sera, 45 sera tested positive,
indicating the acquired Brucella seroprevalence in wild boars of 9.4%. The greatest numbers of
Brucella seropositive animals were detected in the eastern parts of the country and in one of the
central districts, i.e., Pomoravski, Branicevski, Borski and Juznobanatski. This study provides the
first data regarding brucellosis in the wild boar population in Serbia, revealing the seroprevalence of
Brucella, thus indicating that wild boars as natural hosts and/or vectors of Brucella likely present a
risk for the infection of other animals.",
publisher = "MDPI",
journal = "Veterinary Sciences",
title = "First Report of Brucella Seroprevalence in Wild Boar Population in Serbia",
volume = "9",
number = "10",
pages = "575",
doi = "10.3390/vetsci9100575"
}
Sapundžić Zurovac, Z., Žutić, J., Stević, N., Milićević, V., Radojičić, M., Stanojević, S.,& Radojičić, S.. (2022). First Report of Brucella Seroprevalence in Wild Boar Population in Serbia. in Veterinary Sciences
MDPI., 9(10), 575.
https://doi.org/10.3390/vetsci9100575
Sapundžić Zurovac Z, Žutić J, Stević N, Milićević V, Radojičić M, Stanojević S, Radojičić S. First Report of Brucella Seroprevalence in Wild Boar Population in Serbia. in Veterinary Sciences. 2022;9(10):575.
doi:10.3390/vetsci9100575 .
Sapundžić Zurovac, Zorana, Žutić, Jadranka, Stević, Nataša, Milićević, Vesna, Radojičić, Marina, Stanojević, Slavoljub, Radojičić, Sonja, "First Report of Brucella Seroprevalence in Wild Boar Population in Serbia" in Veterinary Sciences, 9, no. 10 (2022):575,
https://doi.org/10.3390/vetsci9100575 . .
8

Concurrent infection by Clostridium perfringens type A, Clostridium septicum, and Clostridium sordelli in mouflon (Ovis aries musimon) - a case report

Milovanović, Bojan; Đorđević, Milutin; Savić, Božidar; Jezdimirović, Nemanja; Zdravković, Nemanja; Sapundžić Zurovac, Zorana; Glišić, Dimitrije; Ninković, Milan; Kureljušić, Branislav

(Hellenic Veterinary Medical Society, 2022)

TY  - JOUR
AU  - Milovanović, Bojan
AU  - Đorđević, Milutin
AU  - Savić, Božidar
AU  - Jezdimirović, Nemanja
AU  - Zdravković, Nemanja
AU  - Sapundžić Zurovac, Zorana
AU  - Glišić, Dimitrije
AU  - Ninković, Milan
AU  - Kureljušić, Branislav
PY  - 2022
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2830
AB  - A female mouflon, weighing 40 kilograms, was submitted to the diagnostic laboratory of the Institute of Veterinary Medicine of Serbia for determining the potential cause of death. Necropsy revealed massive hemorrhages in subcutaneous andintermuscular tissue and on papillary muscle. Petechiae and ecchymoses were found on the omentum, mesentery and adipose tissue of heart, kidneyand costal pleura.Haemorrhagic-necrotic enteritis in duodenum and jejunum was characterized by catarrhal hemorrhagic inflammation withthe presence of mucous and bloody content, whereas gas bubbles in the submucosa have also been confirmed. Bacterial cultures from sampled organs were identified as Clostridium perfringens type A, Clostridium septicum, and Clostridium sordelli.Based on the established pathological and histological changes and the results of the bacteriological, biochemical, and molecular examination, the state of septic shock and toxemia with disseminated massive bleeding was the immediate cause of mouflon death. The septic condition is a consequence of enterotoxemia caused by Clostridium perfringens type A, Clostridium septicum, and Clostridium sordelliinfection.
PB  - Hellenic Veterinary Medical Society
T2  - Journal of the Hellenic Veterinary Medical Society
T1  - Concurrent infection by Clostridium perfringens type A, Clostridium septicum, and Clostridium sordelli in mouflon (Ovis aries musimon) - a case report
VL  - 73
IS  - 4
SP  - 5067
EP  - 5072
DO  - 10.12681/jhvms.28086
ER  - 
@article{
author = "Milovanović, Bojan and Đorđević, Milutin and Savić, Božidar and Jezdimirović, Nemanja and Zdravković, Nemanja and Sapundžić Zurovac, Zorana and Glišić, Dimitrije and Ninković, Milan and Kureljušić, Branislav",
year = "2022",
abstract = "A female mouflon, weighing 40 kilograms, was submitted to the diagnostic laboratory of the Institute of Veterinary Medicine of Serbia for determining the potential cause of death. Necropsy revealed massive hemorrhages in subcutaneous andintermuscular tissue and on papillary muscle. Petechiae and ecchymoses were found on the omentum, mesentery and adipose tissue of heart, kidneyand costal pleura.Haemorrhagic-necrotic enteritis in duodenum and jejunum was characterized by catarrhal hemorrhagic inflammation withthe presence of mucous and bloody content, whereas gas bubbles in the submucosa have also been confirmed. Bacterial cultures from sampled organs were identified as Clostridium perfringens type A, Clostridium septicum, and Clostridium sordelli.Based on the established pathological and histological changes and the results of the bacteriological, biochemical, and molecular examination, the state of septic shock and toxemia with disseminated massive bleeding was the immediate cause of mouflon death. The septic condition is a consequence of enterotoxemia caused by Clostridium perfringens type A, Clostridium septicum, and Clostridium sordelliinfection.",
publisher = "Hellenic Veterinary Medical Society",
journal = "Journal of the Hellenic Veterinary Medical Society",
title = "Concurrent infection by Clostridium perfringens type A, Clostridium septicum, and Clostridium sordelli in mouflon (Ovis aries musimon) - a case report",
volume = "73",
number = "4",
pages = "5067-5072",
doi = "10.12681/jhvms.28086"
}
Milovanović, B., Đorđević, M., Savić, B., Jezdimirović, N., Zdravković, N., Sapundžić Zurovac, Z., Glišić, D., Ninković, M.,& Kureljušić, B.. (2022). Concurrent infection by Clostridium perfringens type A, Clostridium septicum, and Clostridium sordelli in mouflon (Ovis aries musimon) - a case report. in Journal of the Hellenic Veterinary Medical Society
Hellenic Veterinary Medical Society., 73(4), 5067-5072.
https://doi.org/10.12681/jhvms.28086
Milovanović B, Đorđević M, Savić B, Jezdimirović N, Zdravković N, Sapundžić Zurovac Z, Glišić D, Ninković M, Kureljušić B. Concurrent infection by Clostridium perfringens type A, Clostridium septicum, and Clostridium sordelli in mouflon (Ovis aries musimon) - a case report. in Journal of the Hellenic Veterinary Medical Society. 2022;73(4):5067-5072.
doi:10.12681/jhvms.28086 .
Milovanović, Bojan, Đorđević, Milutin, Savić, Božidar, Jezdimirović, Nemanja, Zdravković, Nemanja, Sapundžić Zurovac, Zorana, Glišić, Dimitrije, Ninković, Milan, Kureljušić, Branislav, "Concurrent infection by Clostridium perfringens type A, Clostridium septicum, and Clostridium sordelli in mouflon (Ovis aries musimon) - a case report" in Journal of the Hellenic Veterinary Medical Society, 73, no. 4 (2022):5067-5072,
https://doi.org/10.12681/jhvms.28086 . .

First Molecular Detection of Pneumocystis spp. in the Golden Jackal (Canis aureus)

Kureljušić, Branislav; Milićević, Vesna; Ćirović, Duško; Kuručki, Milica; Glišić, Dimitrije; Sapundžić Zurovac, Zorana; Milovanović, Bojan; Weissenbacher-Lang, Christiane

(Wildlife Disease Association, 2022)

TY  - JOUR
AU  - Kureljušić, Branislav
AU  - Milićević, Vesna
AU  - Ćirović, Duško
AU  - Kuručki, Milica
AU  - Glišić, Dimitrije
AU  - Sapundžić Zurovac, Zorana
AU  - Milovanović, Bojan
AU  - Weissenbacher-Lang, Christiane
PY  - 2022
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2545
AB  - Forty-six golden jackals (Canis aureus) were collected between November 2020 and February 2021 in five counties of Serbia. Lung samples were screened for the presence of Pneumocystis DNA by pan-Pneumocystis PCR on the mtLSU rRNA gene obtaining PCR products of 370 bp in length. Pneumocystis DNA was detected in the lungs from 6/46 (13.04%) golden jackals. Four were females and two were males; four were classified as adults and two as subadults. Positive samples were confirmed in 4/5 investigated counties. No gross pathologic lung lesions were observed in this study. The sequences of Pneumocystis spp. from golden jackals were identical to one another and showed the highest similarity with Pneumocystis spp. sequences of dogs (98% nucleotide identity). The genetic variation was comparable to Pneumocystis spp. of raccoon dogs (95-97% nucleotide identity), red foxes (91-95% nucleotide identity), ferrets (86% nucleotide identity), and another Pneumocystis type in dogs (P. canis Ck2, 81% nucleotide identity) was higher. Golden jackals may be carriers and may play a nonnegligible role in the spread of Pneumocystis spp. Although this finding cannot be directly related to any clinical manifestation or pathologic lesions, a possible role in the exacerbation of different pulmonary disorders should be considered.
PB  - Wildlife Disease Association
T2  - Journal of wildlife diseases
T1  - First Molecular Detection of Pneumocystis spp. in the Golden Jackal (Canis aureus)
VL  - 58
IS  - 4
SP  - 897
EP  - 901
DO  - 10.7589/JWD-D-22-00007
ER  - 
@article{
author = "Kureljušić, Branislav and Milićević, Vesna and Ćirović, Duško and Kuručki, Milica and Glišić, Dimitrije and Sapundžić Zurovac, Zorana and Milovanović, Bojan and Weissenbacher-Lang, Christiane",
year = "2022",
abstract = "Forty-six golden jackals (Canis aureus) were collected between November 2020 and February 2021 in five counties of Serbia. Lung samples were screened for the presence of Pneumocystis DNA by pan-Pneumocystis PCR on the mtLSU rRNA gene obtaining PCR products of 370 bp in length. Pneumocystis DNA was detected in the lungs from 6/46 (13.04%) golden jackals. Four were females and two were males; four were classified as adults and two as subadults. Positive samples were confirmed in 4/5 investigated counties. No gross pathologic lung lesions were observed in this study. The sequences of Pneumocystis spp. from golden jackals were identical to one another and showed the highest similarity with Pneumocystis spp. sequences of dogs (98% nucleotide identity). The genetic variation was comparable to Pneumocystis spp. of raccoon dogs (95-97% nucleotide identity), red foxes (91-95% nucleotide identity), ferrets (86% nucleotide identity), and another Pneumocystis type in dogs (P. canis Ck2, 81% nucleotide identity) was higher. Golden jackals may be carriers and may play a nonnegligible role in the spread of Pneumocystis spp. Although this finding cannot be directly related to any clinical manifestation or pathologic lesions, a possible role in the exacerbation of different pulmonary disorders should be considered.",
publisher = "Wildlife Disease Association",
journal = "Journal of wildlife diseases",
title = "First Molecular Detection of Pneumocystis spp. in the Golden Jackal (Canis aureus)",
volume = "58",
number = "4",
pages = "897-901",
doi = "10.7589/JWD-D-22-00007"
}
Kureljušić, B., Milićević, V., Ćirović, D., Kuručki, M., Glišić, D., Sapundžić Zurovac, Z., Milovanović, B.,& Weissenbacher-Lang, C.. (2022). First Molecular Detection of Pneumocystis spp. in the Golden Jackal (Canis aureus). in Journal of wildlife diseases
Wildlife Disease Association., 58(4), 897-901.
https://doi.org/10.7589/JWD-D-22-00007
Kureljušić B, Milićević V, Ćirović D, Kuručki M, Glišić D, Sapundžić Zurovac Z, Milovanović B, Weissenbacher-Lang C. First Molecular Detection of Pneumocystis spp. in the Golden Jackal (Canis aureus). in Journal of wildlife diseases. 2022;58(4):897-901.
doi:10.7589/JWD-D-22-00007 .
Kureljušić, Branislav, Milićević, Vesna, Ćirović, Duško, Kuručki, Milica, Glišić, Dimitrije, Sapundžić Zurovac, Zorana, Milovanović, Bojan, Weissenbacher-Lang, Christiane, "First Molecular Detection of Pneumocystis spp. in the Golden Jackal (Canis aureus)" in Journal of wildlife diseases, 58, no. 4 (2022):897-901,
https://doi.org/10.7589/JWD-D-22-00007 . .
3

Frequency of White line disease and Sole ulcers and impact of hoof trimming in examined herds of Simmental cows

Ninković, Milan; Arsić, Sveta; Žutić, Jadranka; Zdravković, Nemanja; Glišić, Dimitrije; Sapundžić Zurovac, Zorana; Bojkovski, Jovan

(Massimo Morgante, 2021)

TY  - JOUR
AU  - Ninković, Milan
AU  - Arsić, Sveta
AU  - Žutić, Jadranka
AU  - Zdravković, Nemanja
AU  - Glišić, Dimitrije
AU  - Sapundžić Zurovac, Zorana
AU  - Bojkovski, Jovan
PY  - 2021
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2578
AB  - Lameness as a consequence of hoof disorders is gaining significance in animal health considerations with a particular impact in tie-hold systems. Preventive hoof trimming becomes an important zootechnic measure and procedure for the health and welfare improvement of cows. The objective of our study was to demonstrate findings of sole ulcers and white line diseases of cattle on smallholder farms. Another aspect was to display our observations on hoof trimming within the perspective of sole ulcers and white line disease in the examined herds. A total of 108 Simmental cows from 14 small noncommercial farms located in the Mačva district, Western Serbia, from March to October in 2020 were observed. The trimming procedure was performed by the Dutch method with cows fixed in a mobile chute for hoof trimming. Also, medical treatment of the hoof was provided as needed, using orthopedic foot blocks (wooden and rubberized blocks). Before treatment the white line disease and sole ulcers were present in 12 herds (85.7%). After treatment, there was a decrease in the frequency of sole ulcers positive herds (from 85.7% to 78.5%), while the frequency of white line disease in herds remained unchanged. Regarding cows, a frequency of white line disease of 25.0% was reduced to 18.5%, showing a significant difference (p<0.05) before and after treatment. The frequency of sole ulcers in cows of 23.1% was reduced to 15.7% on re-examination six months after trimming though the difference was not significant, respectively (P<0.05). White line disease and sole ulcers are widespread diseases of hooves on small noncommercial farms in Serbia. This study also provides insights that show the health status of cows’ hooves and demonstrated the importance of regular hoof trimming. Our findings suggest that regular hoof trimming (twice a year) and adequate housing conditions are crucial for improving the health of hooves.
PB  - Massimo Morgante
T2  - Large Animal Review
T1  - Frequency of White line disease and Sole ulcers and impact of hoof trimming in examined herds of Simmental cows
VL  - 27
IS  - 6
SP  - 329
EP  - 332
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_2578
ER  - 
@article{
author = "Ninković, Milan and Arsić, Sveta and Žutić, Jadranka and Zdravković, Nemanja and Glišić, Dimitrije and Sapundžić Zurovac, Zorana and Bojkovski, Jovan",
year = "2021",
abstract = "Lameness as a consequence of hoof disorders is gaining significance in animal health considerations with a particular impact in tie-hold systems. Preventive hoof trimming becomes an important zootechnic measure and procedure for the health and welfare improvement of cows. The objective of our study was to demonstrate findings of sole ulcers and white line diseases of cattle on smallholder farms. Another aspect was to display our observations on hoof trimming within the perspective of sole ulcers and white line disease in the examined herds. A total of 108 Simmental cows from 14 small noncommercial farms located in the Mačva district, Western Serbia, from March to October in 2020 were observed. The trimming procedure was performed by the Dutch method with cows fixed in a mobile chute for hoof trimming. Also, medical treatment of the hoof was provided as needed, using orthopedic foot blocks (wooden and rubberized blocks). Before treatment the white line disease and sole ulcers were present in 12 herds (85.7%). After treatment, there was a decrease in the frequency of sole ulcers positive herds (from 85.7% to 78.5%), while the frequency of white line disease in herds remained unchanged. Regarding cows, a frequency of white line disease of 25.0% was reduced to 18.5%, showing a significant difference (p<0.05) before and after treatment. The frequency of sole ulcers in cows of 23.1% was reduced to 15.7% on re-examination six months after trimming though the difference was not significant, respectively (P<0.05). White line disease and sole ulcers are widespread diseases of hooves on small noncommercial farms in Serbia. This study also provides insights that show the health status of cows’ hooves and demonstrated the importance of regular hoof trimming. Our findings suggest that regular hoof trimming (twice a year) and adequate housing conditions are crucial for improving the health of hooves.",
publisher = "Massimo Morgante",
journal = "Large Animal Review",
title = "Frequency of White line disease and Sole ulcers and impact of hoof trimming in examined herds of Simmental cows",
volume = "27",
number = "6",
pages = "329-332",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_2578"
}
Ninković, M., Arsić, S., Žutić, J., Zdravković, N., Glišić, D., Sapundžić Zurovac, Z.,& Bojkovski, J.. (2021). Frequency of White line disease and Sole ulcers and impact of hoof trimming in examined herds of Simmental cows. in Large Animal Review
Massimo Morgante., 27(6), 329-332.
https://hdl.handle.net/21.15107/rcub_veterinar_2578
Ninković M, Arsić S, Žutić J, Zdravković N, Glišić D, Sapundžić Zurovac Z, Bojkovski J. Frequency of White line disease and Sole ulcers and impact of hoof trimming in examined herds of Simmental cows. in Large Animal Review. 2021;27(6):329-332.
https://hdl.handle.net/21.15107/rcub_veterinar_2578 .
Ninković, Milan, Arsić, Sveta, Žutić, Jadranka, Zdravković, Nemanja, Glišić, Dimitrije, Sapundžić Zurovac, Zorana, Bojkovski, Jovan, "Frequency of White line disease and Sole ulcers and impact of hoof trimming in examined herds of Simmental cows" in Large Animal Review, 27, no. 6 (2021):329-332,
https://hdl.handle.net/21.15107/rcub_veterinar_2578 .

Presynaptic and postsynaptic regulation of muscle contractions in the ascarid nematode Ascaris suum: a target for drug action

Trailović, Saša; Sapundžić Zurovac, Zorana; Gruborović, S.; Marjanović, Đorđe; Nedeljković-Trailović, Jelena

(Cambridge Univ Press, Cambridge, 2016)

TY  - JOUR
AU  - Trailović, Saša
AU  - Sapundžić Zurovac, Zorana
AU  - Gruborović, S.
AU  - Marjanović, Đorđe
AU  - Nedeljković-Trailović, Jelena
PY  - 2016
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1425
AB  - The aim of this study was to determine the role in contractions of postsynaptic nicotinic acetylcholine (nACh) and gamma- aminobutyric acid (GABA) receptors, in the bag region of Ascaris suum muscle cells, as well as the role of synaptic receptors between interneurons and motor neurons in the dorsal and ventral nerve cord. We have measured the isometric contractions of isolated segments of A. suum, with or without the nerve cord (dorsal or ventral). Contractions were caused by increasing concentrations of ACh or by electrical field stimulation (EFS). Based on our results, the presence of the nerve cord is essential for the contractile effects of ACh. The EC50 value of ACh for innervated muscle strips was 10.88 mu M. Unlike intact (innervated) preparations, there was no contraction of the muscle flaps when the nerve cord was mechanically removed. Furthermore, continuous EFS produced stable contractions of innervated muscle strips, but they are not sensitive to mecamylamine (100 mu M). However, GABA (30 mu M) significantly inhibited the EFS- induced contractions. EFS with the same characteristics did not cause muscle contractions of denervated muscle strips, but EFS with a wider pulse induced the increasing of tone and irregular contractions. These contractions were completely insensitive to the effect of GABA. The EC50 for ACh did not differ between the dorsal and ventral segments (9.83 mu M and 9.45 mu M), while GABA exhibited features of competitive and noncompetitive antagonists, regardless of whether it acted on the dorsal or ventral segments of A. suum. It is obvious that drugs will be more effective if they act on both the synaptic and extrasynaptic nACh and GABA receptors.
PB  - Cambridge Univ Press, Cambridge
T2  - Journal of Helminthology
T1  - Presynaptic and postsynaptic regulation of muscle contractions in the ascarid nematode Ascaris suum: a target for drug action
VL  - 90
IS  - 6
SP  - 698
EP  - 705
DO  - 10.1017/S0022149X15000978
ER  - 
@article{
author = "Trailović, Saša and Sapundžić Zurovac, Zorana and Gruborović, S. and Marjanović, Đorđe and Nedeljković-Trailović, Jelena",
year = "2016",
abstract = "The aim of this study was to determine the role in contractions of postsynaptic nicotinic acetylcholine (nACh) and gamma- aminobutyric acid (GABA) receptors, in the bag region of Ascaris suum muscle cells, as well as the role of synaptic receptors between interneurons and motor neurons in the dorsal and ventral nerve cord. We have measured the isometric contractions of isolated segments of A. suum, with or without the nerve cord (dorsal or ventral). Contractions were caused by increasing concentrations of ACh or by electrical field stimulation (EFS). Based on our results, the presence of the nerve cord is essential for the contractile effects of ACh. The EC50 value of ACh for innervated muscle strips was 10.88 mu M. Unlike intact (innervated) preparations, there was no contraction of the muscle flaps when the nerve cord was mechanically removed. Furthermore, continuous EFS produced stable contractions of innervated muscle strips, but they are not sensitive to mecamylamine (100 mu M). However, GABA (30 mu M) significantly inhibited the EFS- induced contractions. EFS with the same characteristics did not cause muscle contractions of denervated muscle strips, but EFS with a wider pulse induced the increasing of tone and irregular contractions. These contractions were completely insensitive to the effect of GABA. The EC50 for ACh did not differ between the dorsal and ventral segments (9.83 mu M and 9.45 mu M), while GABA exhibited features of competitive and noncompetitive antagonists, regardless of whether it acted on the dorsal or ventral segments of A. suum. It is obvious that drugs will be more effective if they act on both the synaptic and extrasynaptic nACh and GABA receptors.",
publisher = "Cambridge Univ Press, Cambridge",
journal = "Journal of Helminthology",
title = "Presynaptic and postsynaptic regulation of muscle contractions in the ascarid nematode Ascaris suum: a target for drug action",
volume = "90",
number = "6",
pages = "698-705",
doi = "10.1017/S0022149X15000978"
}
Trailović, S., Sapundžić Zurovac, Z., Gruborović, S., Marjanović, Đ.,& Nedeljković-Trailović, J.. (2016). Presynaptic and postsynaptic regulation of muscle contractions in the ascarid nematode Ascaris suum: a target for drug action. in Journal of Helminthology
Cambridge Univ Press, Cambridge., 90(6), 698-705.
https://doi.org/10.1017/S0022149X15000978
Trailović S, Sapundžić Zurovac Z, Gruborović S, Marjanović Đ, Nedeljković-Trailović J. Presynaptic and postsynaptic regulation of muscle contractions in the ascarid nematode Ascaris suum: a target for drug action. in Journal of Helminthology. 2016;90(6):698-705.
doi:10.1017/S0022149X15000978 .
Trailović, Saša, Sapundžić Zurovac, Zorana, Gruborović, S., Marjanović, Đorđe, Nedeljković-Trailović, Jelena, "Presynaptic and postsynaptic regulation of muscle contractions in the ascarid nematode Ascaris suum: a target for drug action" in Journal of Helminthology, 90, no. 6 (2016):698-705,
https://doi.org/10.1017/S0022149X15000978 . .
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