TY  - JOUR
AU  - Bošnjaković, Dušan
AU  - Nedić, Sreten
AU  - Arsić, Sveta
AU  - Prodanović, Radiša
AU  - Vujanac, Ivan
AU  - Jovanović, Ljubomir
AU  - Stojković, Milica
AU  - Jovanović, Ivan B
AU  - Đuričić, Ivana
AU  - Kirovski, Danijela
PY  - 2024
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/3929
AB  - The dairy industry contributes significantly to anthropogenic methane emissions, which
have an impact on global warming. This study aimed to investigate the effects of a dietary inclusion of brown seaweed Ascophyllum nodosum on enteric methane emissions (EMEs), hematological and blood biochemical profiles, and milk composition in dairy cows. Eighteen Holstein cows were divided into three groups: CON (non-supplemented cows), BS50 (50 mL of 10% A. nodosum), and BS100 (100 mL of 10% A. nodosum). In each cow, measurements of EME, dry matter intake (DMI), and milk yield (MY), as well as blood and milk sampling with respective analyzes, were performed before supplementation (P1), after 15 (P2) days, and after 30 (P3) days of supplementation. A. nodosum reduced (p < 0.05) methane production, methane yield, and methane intensity in both BS50 and BS100, and raised DMI (p < 0.05) only in BS50. Total bilirubin (p < 0.05) was higher in BS50 compared to CON cows in P2, and triacylglycerols were lower (p < 0.05) in BS50 than in CON cows in P3. Higher milk fat content was found in BS50 than in CON cows in P3. C16:0 proportions were higher (p < 0.05) in BS50 and BS100 than in CON cows, while C18:3n-3 was higher (p < 0.05) in BS100 than in BS50 and CON cows in P3. Dietary treatment with A. nodosum reduced EMEs and showed the potential to increase DMI and to improve energy status as well as milk composition in peaklactating dairy cows.
PB  - MDPI
T2  - Animals
T1  - Effects of brown seaweed (Ascophyllum nodosum) supplementation on enteric methane emissions, metabolic status and milk composition in peak-lactating Holstein cows
VL  - 14
SP  - 1520
DO  - 10.3390/ani14111520
ER  - 

@article{
author = "Bošnjaković, Dušan and Nedić, Sreten and Arsić, Sveta and Prodanović, Radiša and Vujanac, Ivan and Jovanović, Ljubomir and Stojković, Milica and Jovanović, Ivan B and Đuričić, Ivana and Kirovski, Danijela",
year = "2024",
abstract = "The dairy industry contributes significantly to anthropogenic methane emissions, which
have an impact on global warming. This study aimed to investigate the effects of a dietary inclusion of brown seaweed Ascophyllum nodosum on enteric methane emissions (EMEs), hematological and blood biochemical profiles, and milk composition in dairy cows. Eighteen Holstein cows were divided into three groups: CON (non-supplemented cows), BS50 (50 mL of 10% A. nodosum), and BS100 (100 mL of 10% A. nodosum). In each cow, measurements of EME, dry matter intake (DMI), and milk yield (MY), as well as blood and milk sampling with respective analyzes, were performed before supplementation (P1), after 15 (P2) days, and after 30 (P3) days of supplementation. A. nodosum reduced (p < 0.05) methane production, methane yield, and methane intensity in both BS50 and BS100, and raised DMI (p < 0.05) only in BS50. Total bilirubin (p < 0.05) was higher in BS50 compared to CON cows in P2, and triacylglycerols were lower (p < 0.05) in BS50 than in CON cows in P3. Higher milk fat content was found in BS50 than in CON cows in P3. C16:0 proportions were higher (p < 0.05) in BS50 and BS100 than in CON cows, while C18:3n-3 was higher (p < 0.05) in BS100 than in BS50 and CON cows in P3. Dietary treatment with A. nodosum reduced EMEs and showed the potential to increase DMI and to improve energy status as well as milk composition in peaklactating dairy cows.",
publisher = "MDPI",
journal = "Animals",
title = "Effects of brown seaweed (Ascophyllum nodosum) supplementation on enteric methane emissions, metabolic status and milk composition in peak-lactating Holstein cows",
volume = "14",
pages = "1520",
doi = "10.3390/ani14111520"
}

Bošnjaković, D., Nedić, S., Arsić, S., Prodanović, R., Vujanac, I., Jovanović, L., Stojković, M., Jovanović, I. B., Đuričić, I.,& Kirovski, D.. (2024). Effects of brown seaweed (Ascophyllum nodosum) supplementation on enteric methane emissions, metabolic status and milk composition in peak-lactating Holstein cows. in Animals
MDPI., 14, 1520.
https://doi.org/10.3390/ani14111520

Bošnjaković D, Nedić S, Arsić S, Prodanović R, Vujanac I, Jovanović L, Stojković M, Jovanović IB, Đuričić I, Kirovski D. Effects of brown seaweed (Ascophyllum nodosum) supplementation on enteric methane emissions, metabolic status and milk composition in peak-lactating Holstein cows. in Animals. 2024;14:1520.
doi:10.3390/ani14111520 .

Bošnjaković, Dušan, Nedić, Sreten, Arsić, Sveta, Prodanović, Radiša, Vujanac, Ivan, Jovanović, Ljubomir, Stojković, Milica, Jovanović, Ivan B, Đuričić, Ivana, Kirovski, Danijela, "Effects of brown seaweed (Ascophyllum nodosum) supplementation on enteric methane emissions, metabolic status and milk composition in peak-lactating Holstein cows" in Animals, 14 (2024):1520,
https://doi.org/10.3390/ani14111520 . .

TY  - CONF
AU  - Valčić, Olivera
AU  - Jovanović, Ivan B.
AU  - Milanović, Svetlana
PY  - 2023
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/3085
AB  - Током раста бројлера долази до адаптивних промена антиоксидативног
статуса. Глутатион пероксидаза (GPx) је један од ензима који штите ћелије од
оксидативног стреса, а малондиалдехид (МДА) настаје током пероксидације
фослипида ћелијске мембране и поуздан је показатељ степена оксидативног
оштећења.
Циљ овог рада је био да се одреде промене активности GPx и концентрације
МДА током прве 4 недеље това (1., 14. и 28. дан), као и ефекат дијетарне
суплементације алфа-токоферолом (100 IU/kg хране).
Оглед је спроведен на товним пилићима старости од 1 дан до 28. дана това.
Пилад су била подељена у 2 огледне групе. Прва група тј. kонтрола (н=10) је
храњена стандардном смешом која задовољава све нутритивне потребе, док је
друга огледна група (н=10) добијала исту храну уз додатак 100 IU/kg хране
алфа-токоферола. У назначеним данима узимани су узорци хепаринисане
крви пункцијом крилне вене из које је у року од 2 часа издвојена крвна плазма,
у којој су одређивани GPx и МДА.
GPx мерена је куплованим тестом (Gunzler и сар. 1974). Принцип мерења је
базиран на спектрофотометријском регистровању утрошка NADPH у
куплованом ензимском систему. Малондиалдехид (МДА) је одређен методом
описаном од стране Андрееве, 1988.
Просечне вредности GPx су се кретале у интервалу од 21,46 до 38,55 µкат/л.
Најниже просечне вредности су забележене 14. дана това, док су највише
просечне вредности забележене 28. дана. Међутим, вредности активности GPx
се нису статистички разликовале (п>0,05), нити између контролне групе и
групе суплементиране алфа-токоферолом, нити приликом поређења група
током посматраног временског периода. Вредности МДА су биле најниже 14.
дана , при чему је контролна група имала сигнификантно (п<0,01) више
вредности МДА у односу на групу суплементирану алфа-токоферолом.
Значајан пораст концентрације МДА у плазми бројлера је забележен 28. дана
това, при чему су вредности концентрације у обе групе скоро утрострућене.
Несуплементирана група је имала сигнификантно веће вредности (п<0,05)
концентрације МДА у односу на суплементирану групу.
Резултати указују да током прве 4 недеље това долази до значајних промена
показатеља антиоксидативне заштите и нивоа пероксидације мембранских фосфолипида. Ефекат суплементираног алфа-токоферола је значајан са
аспекта смањења концентрације МДА у плазми.
AB  - In broilers during the growth stage, adaptive changes in antioxidant status occur.
Glutathione peroxidase (GPx) is one of the enzymes that protect cells from
oxidative stress, and malondialdehyde (MDA) is formed during the peroxidation
of cell membrane phospholipids and is a reliable indicator of the degree of
oxidative damage.
The aim of this work was to determine changes in GPx activity and MDA
concentration during the first 4 weeks of growth (1st, 14th and 28th day), as well
as the effects of dietary supplementation with alpha-tocopherol (100 IU/kg feed)
on the above parameters.
The experiment was conducted on broiler chickens aged from 1 day to 28 days of
fattening. The chicks were divided into 2 experimental groups. The first i.e.
control group (n=10) was fed a standard mixture that meets the needs, while the
second experimental group (n=10) received the same mixture with the addition
of 100 IU/kg of feed alpha-tocopherol. On the indicated days, samples of
heparinized blood were taken by puncture of the wing vein, from which blood
plasma was separated within 2 hours, in which GPx and MDA were determined.
GPx was measured by the coupled test (Gunzler et al. 1974). The test is based on
the spectrophotometric registration of NADPH consumption in the coupled
enzyme system. Malondialdehyde (MDA) was determined based on
spectrophotometric light absorption of the resulting stable pink solution, using
the method described by Andreeva, 1988.
The average values obtained for GPx ranged from 21.46 to 38.55 µkat/l. The lowest
average values were recorded on the 14th day of fattening, while the highest
average values were recorded on the 28th day. However, GPx activity values were
not statistically significantly different (p>0.05), neither between the control
group and the group supplemented with alpha-tocopherol, nor when comparing
the groups during the observed time period. MDA values were the lowest on day
14, where the control group had significantly (p<0.01) higher MDA values
compared to the group supplemented with alpha-tocopherol. A significant
increase in the concentration of MDA in broiler plasma was recorded on the 28th
day of fattening, where the concentration values in both groups were almost
tripled. The non-supplemented group had significantly higher values (p<0.05) of
MDA concentration compared to the supplemented group.
The results indicate that during the first 4 weeks of fattening, there are significant
changes in the indicators of antioxidant protection and the level of peroxidation of membrane phospholipids. The effect of supplemented alpha-tocopherol is
significant from the point of view of reducing the concentration of MDA in
plasma.
PB  - Banja Luka : Veterinarska komora Republike Srpske
C3  - 28. Godišnje savjetovanje doktora veterinarske medicine Republike Srpske (Bosna i Hercegovina), Trebinje, 15 - 17. jun 2023
T1  - Uticaj alfa-tokoferola na aktivnost GPx i koncentraciju MDA u krvnoj plazmi brojlera
T1  - Influence of alpha-tocopherol on GPx activity and MDA concentration in the blood plasma of broilers
SP  - 179
EP  - 182
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_3085
ER  - 

@conference{
author = "Valčić, Olivera and Jovanović, Ivan B. and Milanović, Svetlana",
year = "2023",
abstract = "Током раста бројлера долази до адаптивних промена антиоксидативног
статуса. Глутатион пероксидаза (GPx) је један од ензима који штите ћелије од
оксидативног стреса, а малондиалдехид (МДА) настаје током пероксидације
фослипида ћелијске мембране и поуздан је показатељ степена оксидативног
оштећења.
Циљ овог рада је био да се одреде промене активности GPx и концентрације
МДА током прве 4 недеље това (1., 14. и 28. дан), као и ефекат дијетарне
суплементације алфа-токоферолом (100 IU/kg хране).
Оглед је спроведен на товним пилићима старости од 1 дан до 28. дана това.
Пилад су била подељена у 2 огледне групе. Прва група тј. kонтрола (н=10) је
храњена стандардном смешом која задовољава све нутритивне потребе, док је
друга огледна група (н=10) добијала исту храну уз додатак 100 IU/kg хране
алфа-токоферола. У назначеним данима узимани су узорци хепаринисане
крви пункцијом крилне вене из које је у року од 2 часа издвојена крвна плазма,
у којој су одређивани GPx и МДА.
GPx мерена је куплованим тестом (Gunzler и сар. 1974). Принцип мерења је
базиран на спектрофотометријском регистровању утрошка NADPH у
куплованом ензимском систему. Малондиалдехид (МДА) је одређен методом
описаном од стране Андрееве, 1988.
Просечне вредности GPx су се кретале у интервалу од 21,46 до 38,55 µкат/л.
Најниже просечне вредности су забележене 14. дана това, док су највише
просечне вредности забележене 28. дана. Међутим, вредности активности GPx
се нису статистички разликовале (п>0,05), нити између контролне групе и
групе суплементиране алфа-токоферолом, нити приликом поређења група
током посматраног временског периода. Вредности МДА су биле најниже 14.
дана , при чему је контролна група имала сигнификантно (п<0,01) више
вредности МДА у односу на групу суплементирану алфа-токоферолом.
Значајан пораст концентрације МДА у плазми бројлера је забележен 28. дана
това, при чему су вредности концентрације у обе групе скоро утрострућене.
Несуплементирана група је имала сигнификантно веће вредности (п<0,05)
концентрације МДА у односу на суплементирану групу.
Резултати указују да током прве 4 недеље това долази до значајних промена
показатеља антиоксидативне заштите и нивоа пероксидације мембранских фосфолипида. Ефекат суплементираног алфа-токоферола је значајан са
аспекта смањења концентрације МДА у плазми., In broilers during the growth stage, adaptive changes in antioxidant status occur.
Glutathione peroxidase (GPx) is one of the enzymes that protect cells from
oxidative stress, and malondialdehyde (MDA) is formed during the peroxidation
of cell membrane phospholipids and is a reliable indicator of the degree of
oxidative damage.
The aim of this work was to determine changes in GPx activity and MDA
concentration during the first 4 weeks of growth (1st, 14th and 28th day), as well
as the effects of dietary supplementation with alpha-tocopherol (100 IU/kg feed)
on the above parameters.
The experiment was conducted on broiler chickens aged from 1 day to 28 days of
fattening. The chicks were divided into 2 experimental groups. The first i.e.
control group (n=10) was fed a standard mixture that meets the needs, while the
second experimental group (n=10) received the same mixture with the addition
of 100 IU/kg of feed alpha-tocopherol. On the indicated days, samples of
heparinized blood were taken by puncture of the wing vein, from which blood
plasma was separated within 2 hours, in which GPx and MDA were determined.
GPx was measured by the coupled test (Gunzler et al. 1974). The test is based on
the spectrophotometric registration of NADPH consumption in the coupled
enzyme system. Malondialdehyde (MDA) was determined based on
spectrophotometric light absorption of the resulting stable pink solution, using
the method described by Andreeva, 1988.
The average values obtained for GPx ranged from 21.46 to 38.55 µkat/l. The lowest
average values were recorded on the 14th day of fattening, while the highest
average values were recorded on the 28th day. However, GPx activity values were
not statistically significantly different (p>0.05), neither between the control
group and the group supplemented with alpha-tocopherol, nor when comparing
the groups during the observed time period. MDA values were the lowest on day
14, where the control group had significantly (p<0.01) higher MDA values
compared to the group supplemented with alpha-tocopherol. A significant
increase in the concentration of MDA in broiler plasma was recorded on the 28th
day of fattening, where the concentration values in both groups were almost
tripled. The non-supplemented group had significantly higher values (p<0.05) of
MDA concentration compared to the supplemented group.
The results indicate that during the first 4 weeks of fattening, there are significant
changes in the indicators of antioxidant protection and the level of peroxidation of membrane phospholipids. The effect of supplemented alpha-tocopherol is
significant from the point of view of reducing the concentration of MDA in
plasma.",
publisher = "Banja Luka : Veterinarska komora Republike Srpske",
journal = "28. Godišnje savjetovanje doktora veterinarske medicine Republike Srpske (Bosna i Hercegovina), Trebinje, 15 - 17. jun 2023",
title = "Uticaj alfa-tokoferola na aktivnost GPx i koncentraciju MDA u krvnoj plazmi brojlera, Influence of alpha-tocopherol on GPx activity and MDA concentration in the blood plasma of broilers",
pages = "179-182",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_3085"
}

Valčić, O., Jovanović, I. B.,& Milanović, S.. (2023). Uticaj alfa-tokoferola na aktivnost GPx i koncentraciju MDA u krvnoj plazmi brojlera. in 28. Godišnje savjetovanje doktora veterinarske medicine Republike Srpske (Bosna i Hercegovina), Trebinje, 15 - 17. jun 2023
Banja Luka : Veterinarska komora Republike Srpske., 179-182.
https://hdl.handle.net/21.15107/rcub_veterinar_3085

Valčić O, Jovanović IB, Milanović S. Uticaj alfa-tokoferola na aktivnost GPx i koncentraciju MDA u krvnoj plazmi brojlera. in 28. Godišnje savjetovanje doktora veterinarske medicine Republike Srpske (Bosna i Hercegovina), Trebinje, 15 - 17. jun 2023. 2023;:179-182.
https://hdl.handle.net/21.15107/rcub_veterinar_3085 .

Valčić, Olivera, Jovanović, Ivan B., Milanović, Svetlana, "Uticaj alfa-tokoferola na aktivnost GPx i koncentraciju MDA u krvnoj plazmi brojlera" in 28. Godišnje savjetovanje doktora veterinarske medicine Republike Srpske (Bosna i Hercegovina), Trebinje, 15 - 17. jun 2023 (2023):179-182,
https://hdl.handle.net/21.15107/rcub_veterinar_3085 .

TY  - CONF
AU  - Valčić, Olivera
AU  - Milanović, Svetlana
AU  - Jovanović, Ivan B.
PY  - 2023
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/3107
AB  - Gastrointestinalni trakt predstavlja kompleksan ekosistem koji sadrži veliki broj
metabolički aktivnih mikroorganizama. Među značajnim metabolitima mikrobioma posebno se
ističu masne kiseline kratkih lanaca (SCFA), sekundarne žučne kiseline, poliamini i indol, zajedno
sa neurotransmiterima kao što su gama-aminobutirat, serotonin i kateholamini. Brojni radovi
dokazuju uticaj metabolita mikrobioma na rast, prirast, stres i imunske reakcije organizma.
Međutim, tek u novijim radovima se ukazuje na činjenicu da ne utiče samo mikrobiom svojim
metabolitima na zdrastveni status svinja, već da postoje znatno složenije interakcije između
domaćina i mikrobioma. Ovom prilikom, želimo da istaknemo ne samo već poznat značaj
mikrobioma za zdravlje i performanse svinja, već i najnovija naučna saznanja iz oblasti složenih
interakcija mikrobiom-domaćin (svinja)- mikrobiom- crevno/nervna osovina (gut brain axis).
Cilj ovog rada je da na slikovit i razumljiv način objasni najnovija saznanja iz oblasti
složenih metaboličkih interakcija koje postoje između mikrobioma, hrane, crevno-moždane
osovine i domaćina kako bi se implementirala u intenzivnom farmskom uzgoju svinja u cilju
poboljšanja dobrobiti i zdravlja životinja.
PB  - Požarevac : Sitograf RM
C3  - 20. Simpozijum Zdravstvena zaštita, selekcija i reprodukcija svinja, Srebrno jezero, 8 - 9. jun 2023
T1  - Značaj i interakcije mikrobioma gastrointestinalnog trakta i metabolizma svinja
SP  - 158
EP  - 164
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_3107
ER  - 

@conference{
author = "Valčić, Olivera and Milanović, Svetlana and Jovanović, Ivan B.",
year = "2023",
abstract = "Gastrointestinalni trakt predstavlja kompleksan ekosistem koji sadrži veliki broj
metabolički aktivnih mikroorganizama. Među značajnim metabolitima mikrobioma posebno se
ističu masne kiseline kratkih lanaca (SCFA), sekundarne žučne kiseline, poliamini i indol, zajedno
sa neurotransmiterima kao što su gama-aminobutirat, serotonin i kateholamini. Brojni radovi
dokazuju uticaj metabolita mikrobioma na rast, prirast, stres i imunske reakcije organizma.
Međutim, tek u novijim radovima se ukazuje na činjenicu da ne utiče samo mikrobiom svojim
metabolitima na zdrastveni status svinja, već da postoje znatno složenije interakcije između
domaćina i mikrobioma. Ovom prilikom, želimo da istaknemo ne samo već poznat značaj
mikrobioma za zdravlje i performanse svinja, već i najnovija naučna saznanja iz oblasti složenih
interakcija mikrobiom-domaćin (svinja)- mikrobiom- crevno/nervna osovina (gut brain axis).
Cilj ovog rada je da na slikovit i razumljiv način objasni najnovija saznanja iz oblasti
složenih metaboličkih interakcija koje postoje između mikrobioma, hrane, crevno-moždane
osovine i domaćina kako bi se implementirala u intenzivnom farmskom uzgoju svinja u cilju
poboljšanja dobrobiti i zdravlja životinja.",
publisher = "Požarevac : Sitograf RM",
journal = "20. Simpozijum Zdravstvena zaštita, selekcija i reprodukcija svinja, Srebrno jezero, 8 - 9. jun 2023",
title = "Značaj i interakcije mikrobioma gastrointestinalnog trakta i metabolizma svinja",
pages = "158-164",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_3107"
}

Valčić, O., Milanović, S.,& Jovanović, I. B.. (2023). Značaj i interakcije mikrobioma gastrointestinalnog trakta i metabolizma svinja. in 20. Simpozijum Zdravstvena zaštita, selekcija i reprodukcija svinja, Srebrno jezero, 8 - 9. jun 2023
Požarevac : Sitograf RM., 158-164.
https://hdl.handle.net/21.15107/rcub_veterinar_3107

Valčić O, Milanović S, Jovanović IB. Značaj i interakcije mikrobioma gastrointestinalnog trakta i metabolizma svinja. in 20. Simpozijum Zdravstvena zaštita, selekcija i reprodukcija svinja, Srebrno jezero, 8 - 9. jun 2023. 2023;:158-164.
https://hdl.handle.net/21.15107/rcub_veterinar_3107 .

Valčić, Olivera, Milanović, Svetlana, Jovanović, Ivan B., "Značaj i interakcije mikrobioma gastrointestinalnog trakta i metabolizma svinja" in 20. Simpozijum Zdravstvena zaštita, selekcija i reprodukcija svinja, Srebrno jezero, 8 - 9. jun 2023 (2023):158-164,
https://hdl.handle.net/21.15107/rcub_veterinar_3107 .

TY  - CONF
AU  - Milanović, Svetlana
AU  - Valčić, Olivera
AU  - Gvozdić, Dragan
AU  - Jovanović, Ivan B.
PY  - 2022
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2418
AB  - U intenzivnoj stočarskoj proizvodnji, od muznih krava se očekuje maksimalno iskorišćavanje genetskog potencijala i što veći prinos
mleka. Najveći izazov u tom smislu predstavlja peripartalni period koji obuhvata tri nedelje pre i tri nedelje posle partusa. Tada se u organizmu krave dešavaju velike hormonske, metaboličke i imunološke
promene. Mnogi metabolički poremećaji koji su karakteristični za ovaj
period, posledica su neizbalansirane ishrane i nepravilne pripreme jedinke za ulazak u intenzivnu laktaciju. Masna jetra, ketoza, dislokacija
sirišta i puerperalna pareza predstavljaju glavne poremećaje karakteristične za ovaj period, a oksidativni stres može imati veliku ulogu u
njihovoj pojavi. Osim navedenih poremećaja, zaostajanje posteljice i
pojava mastitisa, mogu takođe biti u vezi sa oksidativnim stresom. U
ovom radu ćemo analizirati podatke iz naših istraživanja i dostupne literature i pokušati da objasnimo ulogu oksidativnog stresa u peripartalnom periodu, sa posebnim osvrtom na primenu antioksidanasa u cilju preveniranja pojave ili posledica metaboličkih poremećaja.
AB  - In intensive production, dairy cows are expected to make the most of their genetic
potential and maximize milk yield. The biggest challenge in this regard is the peripartal
period, which includes three weeks before and three weeks after parturition. In that interval
major hormonal, metabolic and immune changes occur in the cow’s body. Many metabolic
disorders that are characteristic of this period are the result of an unbalanced diet and
improper preparation of the individual to enter intensive lactation. Fatty liver, ketosis,
dislocation of the abomasum, and puerperal paresis are the main disorders which are
characteristic of this period, and oxidative stress can play a major role in their occurrence.
In addition to these disorders, retained placenta and mastitis may also be related to
oxidative stress. In this paper, we will analyze the data from our research and the available literature, and try to explain the role of oxidative stress in the peripartal period, with special
emphasis on the use of antioxidants in the prevention of the occurrence or consequences
of metabolic disorders.
PB  - Fakultet veterinarske medicine, Centar za izdavačku delatnost i promet učila
C3  - Zbornik radova - XLIII seminar inovacija znanja veterinara
T1  - Oksidativni stres kod krava u peripartalnom periodu – uzrok ili posledica metaboličkih poremećaja
T1  - Oxidative stress in cows in the peripartal period – cause or consequence of metabolic disorders
SP  - 67
EP  - 78
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_2418
ER  - 

@conference{
author = "Milanović, Svetlana and Valčić, Olivera and Gvozdić, Dragan and Jovanović, Ivan B.",
year = "2022",
abstract = "U intenzivnoj stočarskoj proizvodnji, od muznih krava se očekuje maksimalno iskorišćavanje genetskog potencijala i što veći prinos
mleka. Najveći izazov u tom smislu predstavlja peripartalni period koji obuhvata tri nedelje pre i tri nedelje posle partusa. Tada se u organizmu krave dešavaju velike hormonske, metaboličke i imunološke
promene. Mnogi metabolički poremećaji koji su karakteristični za ovaj
period, posledica su neizbalansirane ishrane i nepravilne pripreme jedinke za ulazak u intenzivnu laktaciju. Masna jetra, ketoza, dislokacija
sirišta i puerperalna pareza predstavljaju glavne poremećaje karakteristične za ovaj period, a oksidativni stres može imati veliku ulogu u
njihovoj pojavi. Osim navedenih poremećaja, zaostajanje posteljice i
pojava mastitisa, mogu takođe biti u vezi sa oksidativnim stresom. U
ovom radu ćemo analizirati podatke iz naših istraživanja i dostupne literature i pokušati da objasnimo ulogu oksidativnog stresa u peripartalnom periodu, sa posebnim osvrtom na primenu antioksidanasa u cilju preveniranja pojave ili posledica metaboličkih poremećaja., In intensive production, dairy cows are expected to make the most of their genetic
potential and maximize milk yield. The biggest challenge in this regard is the peripartal
period, which includes three weeks before and three weeks after parturition. In that interval
major hormonal, metabolic and immune changes occur in the cow’s body. Many metabolic
disorders that are characteristic of this period are the result of an unbalanced diet and
improper preparation of the individual to enter intensive lactation. Fatty liver, ketosis,
dislocation of the abomasum, and puerperal paresis are the main disorders which are
characteristic of this period, and oxidative stress can play a major role in their occurrence.
In addition to these disorders, retained placenta and mastitis may also be related to
oxidative stress. In this paper, we will analyze the data from our research and the available literature, and try to explain the role of oxidative stress in the peripartal period, with special
emphasis on the use of antioxidants in the prevention of the occurrence or consequences
of metabolic disorders.",
publisher = "Fakultet veterinarske medicine, Centar za izdavačku delatnost i promet učila",
journal = "Zbornik radova - XLIII seminar inovacija znanja veterinara",
title = "Oksidativni stres kod krava u peripartalnom periodu – uzrok ili posledica metaboličkih poremećaja, Oxidative stress in cows in the peripartal period – cause or consequence of metabolic disorders",
pages = "67-78",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_2418"
}

Milanović, S., Valčić, O., Gvozdić, D.,& Jovanović, I. B.. (2022). Oksidativni stres kod krava u peripartalnom periodu – uzrok ili posledica metaboličkih poremećaja. in Zbornik radova - XLIII seminar inovacija znanja veterinara
Fakultet veterinarske medicine, Centar za izdavačku delatnost i promet učila., 67-78.
https://hdl.handle.net/21.15107/rcub_veterinar_2418

Milanović S, Valčić O, Gvozdić D, Jovanović IB. Oksidativni stres kod krava u peripartalnom periodu – uzrok ili posledica metaboličkih poremećaja. in Zbornik radova - XLIII seminar inovacija znanja veterinara. 2022;:67-78.
https://hdl.handle.net/21.15107/rcub_veterinar_2418 .

Milanović, Svetlana, Valčić, Olivera, Gvozdić, Dragan, Jovanović, Ivan B., "Oksidativni stres kod krava u peripartalnom periodu – uzrok ili posledica metaboličkih poremećaja" in Zbornik radova - XLIII seminar inovacija znanja veterinara (2022):67-78,
https://hdl.handle.net/21.15107/rcub_veterinar_2418 .

TY  - JOUR
AU  - Valčić, Olivera
AU  - Milosavljević, Petar
AU  - Jovanović, Ivan B.
AU  - Milanović, Svetlana
PY  - 2022
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/3373
AB  - Глутатион пероксидаза (GPx) је ензим који постоји у 8 изоензимских
облика, од којих GPx-1 је облигаторни интрацелуларни ензим, док је GPx-3
активна у екстрацелуларним течностима, посебно у крвној плазми. Основна
улога GPx се огледа у заштити ћелија од оксидативног стреса којег индукују
слободни кисеонични радикали. Активност GPx се узима као поуздан
индикатор статуса селена у организму људи и животиња. Основни пут уноса
селена у организам је преко ланца исхране. Унети селен се уграђује у облику
селенометионина и селеноцистеина у ткивне протеине, односно ензиме. У
Србији су извршена темељна испитивања садржаја селена у хранивима и
домаћим животињама, посебно код економски значајних врста као што су
живина, свиње, овце и говеда. Међутим, до сада нису детаљно испитани
радни хладнокрвни коњи, посебно они који се хране искључиво локално
узгајаним хранивима, или су на испаши. Услед специфичног начина држања
они су идеални индикатори статуса селена моногастричних биљоједа на
датом локалитету.
Циљ нашег истраживања је био да одредимо статус селена на основу
активности GPx-1 и GPx -3 у узорцима крви несуплементираних радних
коња на територији централне Србије.
У нашем истраживању укупно је испитано 12 узорака крви коња преузетих
са локалитета општина Краљево, Зајечар, Ваљево и Димитровград, и то: 12
узорака крвне плазме и 12 узорака испраних еритроцита. Мерење
активности GPx-3 и GPx-1 је вршено методом по Гунцлеру на таласној
дужини од 366nm. Приликом узорковања за свако грло су евидентирани
подаци о полу, старости, вакцинацији и дехелминтизацији, саставу и
пореклу датих хранива. Просечна активност GPx-1 је 502,02 ± 91,77 μKat/l , а GPx-3 3,46 ± 1,02
μKat/l што указује на постојање маргиналног дефицита селена у популацији
несуплементираних радних коња на територији централне Србије.
AB  - Glutathione peroxidase (GPx) is an enzyme that has 8 isoenzyme forms, of which
GPx-1 is an obligatory intracellular enzyme, while GPx-3 is active in extracellular
fluids, especially in blood plasma. The main role of GPx is the protection of cells
from oxidative stress induced by free oxygen radicals. GPx activity is taken as a
reliable indicator of selenium status in the human and animal organism. Selenium
is introduced in organism mainly through the food chain. Ingested selenium is
incorporated in the form of selenomethionine and selenocysteine into tissue
proteins, i.e. enzymes. Detailed investigation related to the content of selenium in
feed and domestic animals were carried out in Serbia, especially in economically
significant species such as poultry, pigs, sheep and cattle. However, working coldblooded
horses, especially those that are fed exclusively with locally grown feed,
or are on pasture, have not been examined in detail so far. Due to their specific
way of breeding, they are ideal indicators of the selenium status of monogastric
herbivores in a given locality.
The goal of our study was to determine the status of selenium based on the
activity of GPx-1 and GPx-3 in blood samples of non-supplemented working
horses in the territory of central Serbia.
In our study, a total of 12 samples of horse blood taken from the localities of the
municipalities of Kraljevo, Zaječar, Valjevo and Dimitrovgrad were tested as
follows: 12 samples of blood plasma and 12 samples of washed erythrocytes.
Measurement of GPx-3 and GPx-1 activity was carried out using the Guncler
method at a wavelength of 366 nm. For each animal, during sampling, data on
gender, age, vaccination and deworming, composition and origin of the given
nutrients were recorded. The average activity of GPx-1 was 502.02 ± 91.77 μKat/l, and GPx-3 3.46 ± 1.02
μKat/l, which indicates the existence of a marginal selenium deficit in the
population of unsupplemented working horses in the territory of central Serbia.
PB  - Banja Luka : PI Veterinary institute of Republic of Srpska 'Dr Vaso Butozan'
T2  - Veterinary Journal of Republic of Srpska
T1  - Aktivnost selenoenzima GPx-1 i GPx-3 u krvi radnih konja na teritoriji centralne Srbije
T1  - Activity of selenenzymes GPx-1 and GPx-3 in the blood of working horses in the territory of central Serbia
VL  - 22
IS  - 1-2
SP  - 178
EP  - 193
DO  - 10.7251/VETJSR2201178V
DO  - 10.7251/VETJEN2201186V
ER  - 

@article{
author = "Valčić, Olivera and Milosavljević, Petar and Jovanović, Ivan B. and Milanović, Svetlana",
year = "2022",
abstract = "Глутатион пероксидаза (GPx) је ензим који постоји у 8 изоензимских
облика, од којих GPx-1 је облигаторни интрацелуларни ензим, док је GPx-3
активна у екстрацелуларним течностима, посебно у крвној плазми. Основна
улога GPx се огледа у заштити ћелија од оксидативног стреса којег индукују
слободни кисеонични радикали. Активност GPx се узима као поуздан
индикатор статуса селена у организму људи и животиња. Основни пут уноса
селена у организам је преко ланца исхране. Унети селен се уграђује у облику
селенометионина и селеноцистеина у ткивне протеине, односно ензиме. У
Србији су извршена темељна испитивања садржаја селена у хранивима и
домаћим животињама, посебно код економски значајних врста као што су
живина, свиње, овце и говеда. Међутим, до сада нису детаљно испитани
радни хладнокрвни коњи, посебно они који се хране искључиво локално
узгајаним хранивима, или су на испаши. Услед специфичног начина држања
они су идеални индикатори статуса селена моногастричних биљоједа на
датом локалитету.
Циљ нашег истраживања је био да одредимо статус селена на основу
активности GPx-1 и GPx -3 у узорцима крви несуплементираних радних
коња на територији централне Србије.
У нашем истраживању укупно је испитано 12 узорака крви коња преузетих
са локалитета општина Краљево, Зајечар, Ваљево и Димитровград, и то: 12
узорака крвне плазме и 12 узорака испраних еритроцита. Мерење
активности GPx-3 и GPx-1 је вршено методом по Гунцлеру на таласној
дужини од 366nm. Приликом узорковања за свако грло су евидентирани
подаци о полу, старости, вакцинацији и дехелминтизацији, саставу и
пореклу датих хранива. Просечна активност GPx-1 је 502,02 ± 91,77 μKat/l , а GPx-3 3,46 ± 1,02
μKat/l што указује на постојање маргиналног дефицита селена у популацији
несуплементираних радних коња на територији централне Србије., Glutathione peroxidase (GPx) is an enzyme that has 8 isoenzyme forms, of which
GPx-1 is an obligatory intracellular enzyme, while GPx-3 is active in extracellular
fluids, especially in blood plasma. The main role of GPx is the protection of cells
from oxidative stress induced by free oxygen radicals. GPx activity is taken as a
reliable indicator of selenium status in the human and animal organism. Selenium
is introduced in organism mainly through the food chain. Ingested selenium is
incorporated in the form of selenomethionine and selenocysteine into tissue
proteins, i.e. enzymes. Detailed investigation related to the content of selenium in
feed and domestic animals were carried out in Serbia, especially in economically
significant species such as poultry, pigs, sheep and cattle. However, working coldblooded
horses, especially those that are fed exclusively with locally grown feed,
or are on pasture, have not been examined in detail so far. Due to their specific
way of breeding, they are ideal indicators of the selenium status of monogastric
herbivores in a given locality.
The goal of our study was to determine the status of selenium based on the
activity of GPx-1 and GPx-3 in blood samples of non-supplemented working
horses in the territory of central Serbia.
In our study, a total of 12 samples of horse blood taken from the localities of the
municipalities of Kraljevo, Zaječar, Valjevo and Dimitrovgrad were tested as
follows: 12 samples of blood plasma and 12 samples of washed erythrocytes.
Measurement of GPx-3 and GPx-1 activity was carried out using the Guncler
method at a wavelength of 366 nm. For each animal, during sampling, data on
gender, age, vaccination and deworming, composition and origin of the given
nutrients were recorded. The average activity of GPx-1 was 502.02 ± 91.77 μKat/l, and GPx-3 3.46 ± 1.02
μKat/l, which indicates the existence of a marginal selenium deficit in the
population of unsupplemented working horses in the territory of central Serbia.",
publisher = "Banja Luka : PI Veterinary institute of Republic of Srpska 'Dr Vaso Butozan'",
journal = "Veterinary Journal of Republic of Srpska",
title = "Aktivnost selenoenzima GPx-1 i GPx-3 u krvi radnih konja na teritoriji centralne Srbije, Activity of selenenzymes GPx-1 and GPx-3 in the blood of working horses in the territory of central Serbia",
volume = "22",
number = "1-2",
pages = "178-193",
doi = "10.7251/VETJSR2201178V, 10.7251/VETJEN2201186V"
}

Valčić, O., Milosavljević, P., Jovanović, I. B.,& Milanović, S.. (2022). Aktivnost selenoenzima GPx-1 i GPx-3 u krvi radnih konja na teritoriji centralne Srbije. in Veterinary Journal of Republic of Srpska
Banja Luka : PI Veterinary institute of Republic of Srpska 'Dr Vaso Butozan'., 22(1-2), 178-193.
https://doi.org/10.7251/VETJSR2201178V

Valčić O, Milosavljević P, Jovanović IB, Milanović S. Aktivnost selenoenzima GPx-1 i GPx-3 u krvi radnih konja na teritoriji centralne Srbije. in Veterinary Journal of Republic of Srpska. 2022;22(1-2):178-193.
doi:10.7251/VETJSR2201178V .

Valčić, Olivera, Milosavljević, Petar, Jovanović, Ivan B., Milanović, Svetlana, "Aktivnost selenoenzima GPx-1 i GPx-3 u krvi radnih konja na teritoriji centralne Srbije" in Veterinary Journal of Republic of Srpska, 22, no. 1-2 (2022):178-193,
https://doi.org/10.7251/VETJSR2201178V . .

TY  - CONF
AU  - Milanović, Svetlana
AU  - Valčić, Olivera
AU  - Jovanović, Ivan
PY  - 2021
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/3577
AB  - Intenzivna živinarska proizvodnja nosi sa sobom puno izazova, jer je potrebno
za što kraće vreme proizvesti kvalitetan i zdravstveno ispravan proizvod. Kako
bi se maksimalno iskoristio genetski potencijal jedinki, nameće se upotreba
kvalitetnih hraniva koja će u potpunosti zadovoljiti njihove osnovne i proizvodne potrebe. Poseban izazov predstavlja način držanja živine u intenzivnoj proizvodnji koji pogoduje brzom širenju zaraznih bolesti. Zbog svega navedenog,
hrana za živinu sadrži mnoge dodatke koji će poboljšati proizvodne karakteristike, a takođe, uticati na uspešniji razvoj imuniteta nakon vakcinacije i odbranu organizma u slučaju pojave infekcije.
U intenzivnoj proizvodnji dodavanje mikroelemenata predstavlja jedan od
ključnih faktora potrebnih za funkcionisanje organizma. U ovom radu će fokus
biti na njihovom uticaju na imunitet.
PB  - Beograd : Ciiip Živinarstvo
C3  - XXIX Savetovanje živinara, online, 5. 11. 2020
T1  - Uloga i značaj mikroelemenata za imunitet živine
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_3577
ER  - 

@conference{
author = "Milanović, Svetlana and Valčić, Olivera and Jovanović, Ivan",
year = "2021",
abstract = "Intenzivna živinarska proizvodnja nosi sa sobom puno izazova, jer je potrebno
za što kraće vreme proizvesti kvalitetan i zdravstveno ispravan proizvod. Kako
bi se maksimalno iskoristio genetski potencijal jedinki, nameće se upotreba
kvalitetnih hraniva koja će u potpunosti zadovoljiti njihove osnovne i proizvodne potrebe. Poseban izazov predstavlja način držanja živine u intenzivnoj proizvodnji koji pogoduje brzom širenju zaraznih bolesti. Zbog svega navedenog,
hrana za živinu sadrži mnoge dodatke koji će poboljšati proizvodne karakteristike, a takođe, uticati na uspešniji razvoj imuniteta nakon vakcinacije i odbranu organizma u slučaju pojave infekcije.
U intenzivnoj proizvodnji dodavanje mikroelemenata predstavlja jedan od
ključnih faktora potrebnih za funkcionisanje organizma. U ovom radu će fokus
biti na njihovom uticaju na imunitet.",
publisher = "Beograd : Ciiip Živinarstvo",
journal = "XXIX Savetovanje živinara, online, 5. 11. 2020",
title = "Uloga i značaj mikroelemenata za imunitet živine",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_3577"
}

Milanović, S., Valčić, O.,& Jovanović, I.. (2021). Uloga i značaj mikroelemenata za imunitet živine. in XXIX Savetovanje živinara, online, 5. 11. 2020
Beograd : Ciiip Živinarstvo..
https://hdl.handle.net/21.15107/rcub_veterinar_3577

Milanović S, Valčić O, Jovanović I. Uloga i značaj mikroelemenata za imunitet živine. in XXIX Savetovanje živinara, online, 5. 11. 2020. 2021;.
https://hdl.handle.net/21.15107/rcub_veterinar_3577 .

Milanović, Svetlana, Valčić, Olivera, Jovanović, Ivan, "Uloga i značaj mikroelemenata za imunitet živine" in XXIX Savetovanje živinara, online, 5. 11. 2020 (2021),
https://hdl.handle.net/21.15107/rcub_veterinar_3577 .

TY  - CONF
AU  - Milanović, Svetlana
AU  - Valčić, Olivera
AU  - Jovanović, Ivan
PY  - 2021
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/3578
AB  - Selen je mikroelement koji ulazi u sastav mnogih proteina i enzima neophodnih
u odbrani od oksidativnog stresa, aktivaciji i deaktivaciji tireoidnih
hormona i adekvatnom imunskom odgovoru. Poseban izazov u intenzivnoj
živinarskoj proizvodnji predstavlja način držanja ptica, koji pogoduje širenju
zaraznih bolesti, te je pravilna i balansirana ishrana, osim za zadovoljenje
osnovnih i proizvodnih potreba jedinki, neophodna i za pravilan rad imunskog
sistema. Selen je, pored ostalih mikroelemenata, izuzetno važan u tom smislu.
On kao gradivni element proteina i enzima utiče na gotovo sve segmente imunskog
sistema (urođeni i stečeni, celularni i humoralni).
Ova činjenica je važna jer dodavanje u hranu selena u obliku selenocisteina i
selenometionina može imati različit efekat zbog toga što se metabolizam ovih
aminokiselina i neorganskog selena vrlo razlikuju.
PB  - Beograd : Ciiip Živinarstvo
C3  - XXX Savetovanja živinara, Tara, 21 - 24. septembar 2021
T1  - Uticaj selena na imunski sistem živine
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_3578
ER  - 

@conference{
author = "Milanović, Svetlana and Valčić, Olivera and Jovanović, Ivan",
year = "2021",
abstract = "Selen je mikroelement koji ulazi u sastav mnogih proteina i enzima neophodnih
u odbrani od oksidativnog stresa, aktivaciji i deaktivaciji tireoidnih
hormona i adekvatnom imunskom odgovoru. Poseban izazov u intenzivnoj
živinarskoj proizvodnji predstavlja način držanja ptica, koji pogoduje širenju
zaraznih bolesti, te je pravilna i balansirana ishrana, osim za zadovoljenje
osnovnih i proizvodnih potreba jedinki, neophodna i za pravilan rad imunskog
sistema. Selen je, pored ostalih mikroelemenata, izuzetno važan u tom smislu.
On kao gradivni element proteina i enzima utiče na gotovo sve segmente imunskog
sistema (urođeni i stečeni, celularni i humoralni).
Ova činjenica je važna jer dodavanje u hranu selena u obliku selenocisteina i
selenometionina može imati različit efekat zbog toga što se metabolizam ovih
aminokiselina i neorganskog selena vrlo razlikuju.",
publisher = "Beograd : Ciiip Živinarstvo",
journal = "XXX Savetovanja živinara, Tara, 21 - 24. septembar 2021",
title = "Uticaj selena na imunski sistem živine",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_3578"
}

Milanović, S., Valčić, O.,& Jovanović, I.. (2021). Uticaj selena na imunski sistem živine. in XXX Savetovanja živinara, Tara, 21 - 24. septembar 2021
Beograd : Ciiip Živinarstvo..
https://hdl.handle.net/21.15107/rcub_veterinar_3578

Milanović S, Valčić O, Jovanović I. Uticaj selena na imunski sistem živine. in XXX Savetovanja živinara, Tara, 21 - 24. septembar 2021. 2021;.
https://hdl.handle.net/21.15107/rcub_veterinar_3578 .

Milanović, Svetlana, Valčić, Olivera, Jovanović, Ivan, "Uticaj selena na imunski sistem živine" in XXX Savetovanja živinara, Tara, 21 - 24. septembar 2021 (2021),
https://hdl.handle.net/21.15107/rcub_veterinar_3578 .

TY  - JOUR
AU  - Bošnjaković, Dušan
AU  - Petrović, Aleksandra
AU  - Valčić, Olivera
AU  - Jovanović, Ivan B.
AU  - Milanović, Svetlana
PY  - 2018
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2164
AB  - Cilj rada je bio da se utvrdi stabilnost aktivnosti glutation peroksidaza 1 i 3 tokom skladištenja na temperaturi +4°C i -18°C. Krv je uzeta od osam ovaca, a aktivnost enzima je određivana u plazmi (GPx3) i eritrocitima (GPx1) prvog, trećeg, petog i sedmog dana u uzorcima čuvanim na +4°C i nakon jednog i tri meseca u uzorcima čuvanim na -18°C. Aktivnost GPx3 je tokom skladištenja na ovim temperaturama statistički značajno opala dok je aktivnost GPx1 ostala ista nakon tri meseca čuvanja na temperaturi -18°C. Rezultati ovog rada ukazuju na to da se GPx3 mora određivati u svežim uzorcima plazme ovaca, dok se aktivnost GPx1 eritrocita ovaca može određivati i nakon 3 meseca čuvanja na temperaturi -18°C.
AB  - The aim of the study was to determine the stability of the activity of glutathione peroxidases 1 and 3 during storage at +4°C and -18°C. Blood samples were taken from eight sheep and the activity of the enzyme was determined in the plasma (GPx3) and erythrocytes (GPx1) on the first, third, fifth and seventh day in samples stored at +4°C and after one and three months in samples stored at -18°C. GPx3 activity decreased significantly during storage at both temperatures, while GPx1 remained steady even after three months of storage at -18°C. Obtained results indicate that GPx3 activity has to be determined in fresh sheep plasma samples, while the activity of sheep erythrocyte GPx1 can be determined even after 3 months of storage at -18°C.
PB  - Banja Luka : PI Veterinary Institute Republic of Srpska „Dr. Vaso Butozan“
T2  - Veterinarski žurnal Republike Srpske
T1  - Uticaj različitih temperatura skladištenja na aktivnost glutation peroksidaza eritrocita i plazme ovaca
T1  - The effects of different storing temperatures on the activity of sheep blood and plasma glutathione peroxidase
VL  - 18
IS  - 1
SP  - 38
EP  - 53
DO  - 10.7251/VETJ1801038B
ER  - 

@article{
author = "Bošnjaković, Dušan and Petrović, Aleksandra and Valčić, Olivera and Jovanović, Ivan B. and Milanović, Svetlana",
year = "2018",
abstract = "Cilj rada je bio da se utvrdi stabilnost aktivnosti glutation peroksidaza 1 i 3 tokom skladištenja na temperaturi +4°C i -18°C. Krv je uzeta od osam ovaca, a aktivnost enzima je određivana u plazmi (GPx3) i eritrocitima (GPx1) prvog, trećeg, petog i sedmog dana u uzorcima čuvanim na +4°C i nakon jednog i tri meseca u uzorcima čuvanim na -18°C. Aktivnost GPx3 je tokom skladištenja na ovim temperaturama statistički značajno opala dok je aktivnost GPx1 ostala ista nakon tri meseca čuvanja na temperaturi -18°C. Rezultati ovog rada ukazuju na to da se GPx3 mora određivati u svežim uzorcima plazme ovaca, dok se aktivnost GPx1 eritrocita ovaca može određivati i nakon 3 meseca čuvanja na temperaturi -18°C., The aim of the study was to determine the stability of the activity of glutathione peroxidases 1 and 3 during storage at +4°C and -18°C. Blood samples were taken from eight sheep and the activity of the enzyme was determined in the plasma (GPx3) and erythrocytes (GPx1) on the first, third, fifth and seventh day in samples stored at +4°C and after one and three months in samples stored at -18°C. GPx3 activity decreased significantly during storage at both temperatures, while GPx1 remained steady even after three months of storage at -18°C. Obtained results indicate that GPx3 activity has to be determined in fresh sheep plasma samples, while the activity of sheep erythrocyte GPx1 can be determined even after 3 months of storage at -18°C.",
publisher = "Banja Luka : PI Veterinary Institute Republic of Srpska „Dr. Vaso Butozan“",
journal = "Veterinarski žurnal Republike Srpske",
title = "Uticaj različitih temperatura skladištenja na aktivnost glutation peroksidaza eritrocita i plazme ovaca, The effects of different storing temperatures on the activity of sheep blood and plasma glutathione peroxidase",
volume = "18",
number = "1",
pages = "38-53",
doi = "10.7251/VETJ1801038B"
}

Bošnjaković, D., Petrović, A., Valčić, O., Jovanović, I. B.,& Milanović, S.. (2018). Uticaj različitih temperatura skladištenja na aktivnost glutation peroksidaza eritrocita i plazme ovaca. in Veterinarski žurnal Republike Srpske
Banja Luka : PI Veterinary Institute Republic of Srpska „Dr. Vaso Butozan“., 18(1), 38-53.
https://doi.org/10.7251/VETJ1801038B

Bošnjaković D, Petrović A, Valčić O, Jovanović IB, Milanović S. Uticaj različitih temperatura skladištenja na aktivnost glutation peroksidaza eritrocita i plazme ovaca. in Veterinarski žurnal Republike Srpske. 2018;18(1):38-53.
doi:10.7251/VETJ1801038B .

Bošnjaković, Dušan, Petrović, Aleksandra, Valčić, Olivera, Jovanović, Ivan B., Milanović, Svetlana, "Uticaj različitih temperatura skladištenja na aktivnost glutation peroksidaza eritrocita i plazme ovaca" in Veterinarski žurnal Republike Srpske, 18, no. 1 (2018):38-53,
https://doi.org/10.7251/VETJ1801038B . .

TY  - JOUR
AU  - Marković, Radmila
AU  - Ćirić, Jelena
AU  - Drljačić, Aleksandar
AU  - Šefer, Dragan
AU  - Jovanović, Ivan B.
AU  - Jovanović, Dragoljub
AU  - Milanović, Svetlana
AU  - Trbović, Dejana
AU  - Radulović, Stamen
AU  - Baltić, Milan Ž.
AU  - Starcević, Marija
PY  - 2018
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1595
AB  - The present study was conducted to assess effects of selenium (Se)-yeast supplementation on glutathione peroxidase activity, Se levels in tissues, growth performance, carcass, and meat composition in broilers. A total of 275 one-d-old Cobb 500 broilers of both sexes were randomly allotted to 1 of 5 treatments during a 42-d period. The 5 treatments differed only in Se content: group 1 had no additional Se (background only); groups 2, 3, and 4 received 0.3 mg/kg of added Se from the beginning of the trial until d 21, whereas in the second half of the study (from d 22 to 42), these groups received 0.3, 0.6, and 0.9 mg/kg of added Se, respectively; and group 5 received 0.9 mg/kg of Se for the entire experimental period. At the end of the study, the control group showed significantly lower (P < 0.01) glutathione peroxidase activity in blood plasma compared to Se-supplemented groups. Regarding Se concentration in various tissues, the groups receiving Se yeast showed higher plasma, feces, and meat Se contents than the control group (P < 0.01). Supplementation of Se improved broilers body weight, weight gain and feed conversion ratio (P < 0.01). Dressing percentage was lower in the control group and the group with 0.3 mg/kg of added Se compared to other experimental groups (0.6 and 0.9 mg/kg of dietary Se). The proportion of less valuable carcass parts (wings and legs) was higher (P < 0.01) in the group fed the basal diet compared to groups supplemented with 0.9 mg/kg of Se. Initial and ultimate pH values differed among experimental groups (P < 0.05). Supplementation of Se improved the broilers antioxidative resistance, growth performance, carcass quality, and chemical composition of meat.
PB  - Oxford Univ Press, Oxford
T2  - Poultry Science
T1  - The effects of dietary Selenium-yeast level on glutathione peroxidase activity, tissue Selenium content, growth performance, and carcass and meat quality of broilers
VL  - 97
IS  - 8
SP  - 2861
EP  - 2870
DO  - 10.3382/ps/pey117
ER  - 

@article{
author = "Marković, Radmila and Ćirić, Jelena and Drljačić, Aleksandar and Šefer, Dragan and Jovanović, Ivan B. and Jovanović, Dragoljub and Milanović, Svetlana and Trbović, Dejana and Radulović, Stamen and Baltić, Milan Ž. and Starcević, Marija",
year = "2018",
abstract = "The present study was conducted to assess effects of selenium (Se)-yeast supplementation on glutathione peroxidase activity, Se levels in tissues, growth performance, carcass, and meat composition in broilers. A total of 275 one-d-old Cobb 500 broilers of both sexes were randomly allotted to 1 of 5 treatments during a 42-d period. The 5 treatments differed only in Se content: group 1 had no additional Se (background only); groups 2, 3, and 4 received 0.3 mg/kg of added Se from the beginning of the trial until d 21, whereas in the second half of the study (from d 22 to 42), these groups received 0.3, 0.6, and 0.9 mg/kg of added Se, respectively; and group 5 received 0.9 mg/kg of Se for the entire experimental period. At the end of the study, the control group showed significantly lower (P < 0.01) glutathione peroxidase activity in blood plasma compared to Se-supplemented groups. Regarding Se concentration in various tissues, the groups receiving Se yeast showed higher plasma, feces, and meat Se contents than the control group (P < 0.01). Supplementation of Se improved broilers body weight, weight gain and feed conversion ratio (P < 0.01). Dressing percentage was lower in the control group and the group with 0.3 mg/kg of added Se compared to other experimental groups (0.6 and 0.9 mg/kg of dietary Se). The proportion of less valuable carcass parts (wings and legs) was higher (P < 0.01) in the group fed the basal diet compared to groups supplemented with 0.9 mg/kg of Se. Initial and ultimate pH values differed among experimental groups (P < 0.05). Supplementation of Se improved the broilers antioxidative resistance, growth performance, carcass quality, and chemical composition of meat.",
publisher = "Oxford Univ Press, Oxford",
journal = "Poultry Science",
title = "The effects of dietary Selenium-yeast level on glutathione peroxidase activity, tissue Selenium content, growth performance, and carcass and meat quality of broilers",
volume = "97",
number = "8",
pages = "2861-2870",
doi = "10.3382/ps/pey117"
}

Marković, R., Ćirić, J., Drljačić, A., Šefer, D., Jovanović, I. B., Jovanović, D., Milanović, S., Trbović, D., Radulović, S., Baltić, M. Ž.,& Starcević, M.. (2018). The effects of dietary Selenium-yeast level on glutathione peroxidase activity, tissue Selenium content, growth performance, and carcass and meat quality of broilers. in Poultry Science
Oxford Univ Press, Oxford., 97(8), 2861-2870.
https://doi.org/10.3382/ps/pey117

Marković R, Ćirić J, Drljačić A, Šefer D, Jovanović IB, Jovanović D, Milanović S, Trbović D, Radulović S, Baltić MŽ, Starcević M. The effects of dietary Selenium-yeast level on glutathione peroxidase activity, tissue Selenium content, growth performance, and carcass and meat quality of broilers. in Poultry Science. 2018;97(8):2861-2870.
doi:10.3382/ps/pey117 .

Marković, Radmila, Ćirić, Jelena, Drljačić, Aleksandar, Šefer, Dragan, Jovanović, Ivan B., Jovanović, Dragoljub, Milanović, Svetlana, Trbović, Dejana, Radulović, Stamen, Baltić, Milan Ž., Starcević, Marija, "The effects of dietary Selenium-yeast level on glutathione peroxidase activity, tissue Selenium content, growth performance, and carcass and meat quality of broilers" in Poultry Science, 97, no. 8 (2018):2861-2870,
https://doi.org/10.3382/ps/pey117 . .

TY  - CONF
AU  - Milanović, Svetlana
AU  - Valčić, Olivera
AU  - Jovanović, Ivan
PY  - 2018
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/3441
AB  - Komunikacija među živim svetom je vrlo kompleksan proces i može se odvijati na nekoliko načina. Najzastupljeniji oblici komunikacije među životinjama su vizuelna, auditivna i hemijska komunikacija. Kod ptica se smatra da
su najzastupljeniji vizuelni vidovi komunikacije, pa zatim auditivni. Do skoro
se vrlo malo pridavalo značaju proučavanja komunikacije kod ptica pomoću
hemijskih materija (mirisa i feromona) zbog slabo razvijenog olfaktornog bulbusa kod ovih kičmenjaka, kao i odsustva vomeronazalnog organa. Međutim,
novija istraživanja ukazuju na postojanje specifičnih receptora za određene hemijske materije i kod ptica. Kod nekih vrsta ptica, produkt uropigealne žlezde
sadrži materije koje mogu imati odlike feromona i koji nose informaciju o vrsti,
polu, identitetu, populaciji i poreklu. Kod sisara je ovaj vid komunikacije veoma
zastupljen, a kako su neki feromoni već izolovani i sintetski se proizvode, uveliko se koriste i u farmskoj proizvodnji. Zbog toga smo smatrali da je korisno
razmotriti razne mogućnosti primene feromona i u živinarskoj proizvodnji.
PB  - Beograd : Ciiip Živinarstvo
C3  - XXVII Savetovanje živinara, Tara, 2018
T1  - Moguća primena feromona u živinarskoj proizvodnji
SP  - 37
EP  - 45
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_3441
ER  - 

@conference{
author = "Milanović, Svetlana and Valčić, Olivera and Jovanović, Ivan",
year = "2018",
abstract = "Komunikacija među živim svetom je vrlo kompleksan proces i može se odvijati na nekoliko načina. Najzastupljeniji oblici komunikacije među životinjama su vizuelna, auditivna i hemijska komunikacija. Kod ptica se smatra da
su najzastupljeniji vizuelni vidovi komunikacije, pa zatim auditivni. Do skoro
se vrlo malo pridavalo značaju proučavanja komunikacije kod ptica pomoću
hemijskih materija (mirisa i feromona) zbog slabo razvijenog olfaktornog bulbusa kod ovih kičmenjaka, kao i odsustva vomeronazalnog organa. Međutim,
novija istraživanja ukazuju na postojanje specifičnih receptora za određene hemijske materije i kod ptica. Kod nekih vrsta ptica, produkt uropigealne žlezde
sadrži materije koje mogu imati odlike feromona i koji nose informaciju o vrsti,
polu, identitetu, populaciji i poreklu. Kod sisara je ovaj vid komunikacije veoma
zastupljen, a kako su neki feromoni već izolovani i sintetski se proizvode, uveliko se koriste i u farmskoj proizvodnji. Zbog toga smo smatrali da je korisno
razmotriti razne mogućnosti primene feromona i u živinarskoj proizvodnji.",
publisher = "Beograd : Ciiip Živinarstvo",
journal = "XXVII Savetovanje živinara, Tara, 2018",
title = "Moguća primena feromona u živinarskoj proizvodnji",
pages = "37-45",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_3441"
}

Milanović, S., Valčić, O.,& Jovanović, I.. (2018). Moguća primena feromona u živinarskoj proizvodnji. in XXVII Savetovanje živinara, Tara, 2018
Beograd : Ciiip Živinarstvo., 37-45.
https://hdl.handle.net/21.15107/rcub_veterinar_3441

Milanović S, Valčić O, Jovanović I. Moguća primena feromona u živinarskoj proizvodnji. in XXVII Savetovanje živinara, Tara, 2018. 2018;:37-45.
https://hdl.handle.net/21.15107/rcub_veterinar_3441 .

Milanović, Svetlana, Valčić, Olivera, Jovanović, Ivan, "Moguća primena feromona u živinarskoj proizvodnji" in XXVII Savetovanje živinara, Tara, 2018 (2018):37-45,
https://hdl.handle.net/21.15107/rcub_veterinar_3441 .

TY  - JOUR
AU  - Suluburić, Adam
AU  - Milanović, Svetlana
AU  - Vranješ-Đurić, Sanja
AU  - Jovanović, Ivan B.
AU  - Barna, Tomislav
AU  - Stojić, Milica
AU  - Fratrić, Natalija
AU  - Szenci, Otto
AU  - Gvozdić, Dragan
PY  - 2017
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1486
AB  - Early embryonic development may be negatively affected by insufficient progesterone (P4) production. Therefore, the aim of our study was to increase P4 by gonadotropin-releasing hormone (GnRH) and/or human chorionic gonadotropin (hCG) treatments after inducing oestrus by prostaglandin (PG) treatment. Lactating Simmental dairy cows (n = 110), between 1 to 5 lactations, with an average milk production of 6,500 l/305 days, at 40-80 days postpartum were used and grouped as follows: (1) PG + GnRH treatment at AI (GnRH group), (2) PG + hCG treatment at day 7 after AI (hCG group), (3) PG + GnRH at AI + hCG treatment at day 7 after AI (GnRH/hCG group), and (4) spontaneous oestrus (C: control group). All animals were double inseminated (at the time of oestrus detection and 12 +/- 2 h thereafter). Blood serum and milk samples were collected at the day of observed oestrus (day 0), and 14, 21 and 28 days after AI. Serum P4 was determined using a commercial radioimmunoassay (RIA) test (INEP, Zemun), and milk P4 was determined using enzyme-linked immunoassay (ELISA) test (NIV Novi Sad). Pregnancy status was confirmed by ultrasonography between days 28 and 35 after AI. Differences of serum or milk P4 medians, pregnancy (and calving) rate were determined using Dunns Multiple Comparison Tests and Z test, respectively. Serum P4 medians were significantly higher at days 14, 21 and 28 after AI in the hCG-treated animals, indicating increased luteal activity, with a similar tendency in whole milk P4 values. Treatment with hCG during the early luteal phase significantly contributed to the maintenance of gestation at days 28-35 after AI, and also increased the calving rate in Simmental dairy cows.
PB  - Akademiai Kiado Rt, Budapest
T2  - Acta Veterinaria Hungarica
T1  - Progesterone concentration, pregnancy and calving rate in simmental dairy cows after oestrus synchronisation and HCG treatment during the early luteal phase
VL  - 65
IS  - 3
SP  - 446
EP  - 458
DO  - 10.1556/004.2017.042
ER  - 

@article{
author = "Suluburić, Adam and Milanović, Svetlana and Vranješ-Đurić, Sanja and Jovanović, Ivan B. and Barna, Tomislav and Stojić, Milica and Fratrić, Natalija and Szenci, Otto and Gvozdić, Dragan",
year = "2017",
abstract = "Early embryonic development may be negatively affected by insufficient progesterone (P4) production. Therefore, the aim of our study was to increase P4 by gonadotropin-releasing hormone (GnRH) and/or human chorionic gonadotropin (hCG) treatments after inducing oestrus by prostaglandin (PG) treatment. Lactating Simmental dairy cows (n = 110), between 1 to 5 lactations, with an average milk production of 6,500 l/305 days, at 40-80 days postpartum were used and grouped as follows: (1) PG + GnRH treatment at AI (GnRH group), (2) PG + hCG treatment at day 7 after AI (hCG group), (3) PG + GnRH at AI + hCG treatment at day 7 after AI (GnRH/hCG group), and (4) spontaneous oestrus (C: control group). All animals were double inseminated (at the time of oestrus detection and 12 +/- 2 h thereafter). Blood serum and milk samples were collected at the day of observed oestrus (day 0), and 14, 21 and 28 days after AI. Serum P4 was determined using a commercial radioimmunoassay (RIA) test (INEP, Zemun), and milk P4 was determined using enzyme-linked immunoassay (ELISA) test (NIV Novi Sad). Pregnancy status was confirmed by ultrasonography between days 28 and 35 after AI. Differences of serum or milk P4 medians, pregnancy (and calving) rate were determined using Dunns Multiple Comparison Tests and Z test, respectively. Serum P4 medians were significantly higher at days 14, 21 and 28 after AI in the hCG-treated animals, indicating increased luteal activity, with a similar tendency in whole milk P4 values. Treatment with hCG during the early luteal phase significantly contributed to the maintenance of gestation at days 28-35 after AI, and also increased the calving rate in Simmental dairy cows.",
publisher = "Akademiai Kiado Rt, Budapest",
journal = "Acta Veterinaria Hungarica",
title = "Progesterone concentration, pregnancy and calving rate in simmental dairy cows after oestrus synchronisation and HCG treatment during the early luteal phase",
volume = "65",
number = "3",
pages = "446-458",
doi = "10.1556/004.2017.042"
}

Suluburić, A., Milanović, S., Vranješ-Đurić, S., Jovanović, I. B., Barna, T., Stojić, M., Fratrić, N., Szenci, O.,& Gvozdić, D.. (2017). Progesterone concentration, pregnancy and calving rate in simmental dairy cows after oestrus synchronisation and HCG treatment during the early luteal phase. in Acta Veterinaria Hungarica
Akademiai Kiado Rt, Budapest., 65(3), 446-458.
https://doi.org/10.1556/004.2017.042

Suluburić A, Milanović S, Vranješ-Đurić S, Jovanović IB, Barna T, Stojić M, Fratrić N, Szenci O, Gvozdić D. Progesterone concentration, pregnancy and calving rate in simmental dairy cows after oestrus synchronisation and HCG treatment during the early luteal phase. in Acta Veterinaria Hungarica. 2017;65(3):446-458.
doi:10.1556/004.2017.042 .

Suluburić, Adam, Milanović, Svetlana, Vranješ-Đurić, Sanja, Jovanović, Ivan B., Barna, Tomislav, Stojić, Milica, Fratrić, Natalija, Szenci, Otto, Gvozdić, Dragan, "Progesterone concentration, pregnancy and calving rate in simmental dairy cows after oestrus synchronisation and HCG treatment during the early luteal phase" in Acta Veterinaria Hungarica, 65, no. 3 (2017):446-458,
https://doi.org/10.1556/004.2017.042 . .

TY  - JOUR
AU  - Bjelica, Jelena
AU  - Jovanović, Ivan B.
AU  - Ilić, Vesna
AU  - Valčić, Olivera
AU  - Kirovski, Danijela
AU  - Gvozdić, Dragan
AU  - Milanović, Svetlana
PY  - 2017
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1535
AB  - Both selenium, as an effector and regulator of antioxidative enzymes activity, and thyroid hormones are potent immunomodulators. Besides, selenium incorporated into iodothyronine deiodinases is involved in the thyroid function and thus indirectly regulates the immune response. Studies of the mutual infl uence of selenium and thyroid hormones on the immune response are scarce, hence we analyzed the effects of an iodothyronine deiodinases blocker, propylthiouracil (PTU), and selenium defi ciency on the function of peritoneal macrophages, and titer of naturally occurring anti-sheep red blood cells (SRBC) IgM antibodies in juvenile rats. The experiment was carried out on 64 Wistar male rats allotted to 4 groups: controlselenium adequate PTU-group; selenium adequate, PTU+ group; selenium defi cient, PTU-group; and selenium defi cient, PTU+. The selenium adequate and selenium defi cient groups were fed a diet containing 0.334 and 0.031 mg Se/kg, respectively. PTU+ groups received PTU (150 mg/L) in drinking water. After 3 weeks, thyroxine (T-4), triiodothyronine (T-3), and thyroid stimulating hormone (TSH) were determined. The animals having intermediate concentrations of T-3 (1.56-1.69 nmol/L) and T 4 (41-50 nmol/L) were excluded from further analysis. Thus, PTU+ groups included hypothyroid animals (T-3 <= 1.55 nmol/L; T-4 <= 40 nmol/L), while PTU-groups included euthyroid rats (T-3 <= 1.70 nmol/L; T-4 <= 50 nmol/L). Both groups of selenium defi cient rats had, when compared to the control group, a signifi cantly lower activity of glutathione peroxidase GPx1 and GPx3. Neither selenium defi ciency nor PTU infl uenced the adherence of peritoneal macrophages. Selenium defi ciency signifi cantly decreased the peroxide synthesis in macrophages and signifi cantly increased the titer of anti-SRBC IgM. Hypotyroidism alone or in combination with selenium defi ciency had no infl uence on these parameters.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta Veterinaria-Beograd
T1  - Effects of selenium and thyroid hormone deficiency on peritoneal macrophages adhesion and occurrence of natural IGM antibodies in juvenile rats
VL  - 67
IS  - 3
SP  - 340
EP  - 355
DO  - 10.1515/acve-2017-0028
ER  - 

@article{
author = "Bjelica, Jelena and Jovanović, Ivan B. and Ilić, Vesna and Valčić, Olivera and Kirovski, Danijela and Gvozdić, Dragan and Milanović, Svetlana",
year = "2017",
abstract = "Both selenium, as an effector and regulator of antioxidative enzymes activity, and thyroid hormones are potent immunomodulators. Besides, selenium incorporated into iodothyronine deiodinases is involved in the thyroid function and thus indirectly regulates the immune response. Studies of the mutual infl uence of selenium and thyroid hormones on the immune response are scarce, hence we analyzed the effects of an iodothyronine deiodinases blocker, propylthiouracil (PTU), and selenium defi ciency on the function of peritoneal macrophages, and titer of naturally occurring anti-sheep red blood cells (SRBC) IgM antibodies in juvenile rats. The experiment was carried out on 64 Wistar male rats allotted to 4 groups: controlselenium adequate PTU-group; selenium adequate, PTU+ group; selenium defi cient, PTU-group; and selenium defi cient, PTU+. The selenium adequate and selenium defi cient groups were fed a diet containing 0.334 and 0.031 mg Se/kg, respectively. PTU+ groups received PTU (150 mg/L) in drinking water. After 3 weeks, thyroxine (T-4), triiodothyronine (T-3), and thyroid stimulating hormone (TSH) were determined. The animals having intermediate concentrations of T-3 (1.56-1.69 nmol/L) and T 4 (41-50 nmol/L) were excluded from further analysis. Thus, PTU+ groups included hypothyroid animals (T-3 <= 1.55 nmol/L; T-4 <= 40 nmol/L), while PTU-groups included euthyroid rats (T-3 <= 1.70 nmol/L; T-4 <= 50 nmol/L). Both groups of selenium defi cient rats had, when compared to the control group, a signifi cantly lower activity of glutathione peroxidase GPx1 and GPx3. Neither selenium defi ciency nor PTU infl uenced the adherence of peritoneal macrophages. Selenium defi ciency signifi cantly decreased the peroxide synthesis in macrophages and signifi cantly increased the titer of anti-SRBC IgM. Hypotyroidism alone or in combination with selenium defi ciency had no infl uence on these parameters.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta Veterinaria-Beograd",
title = "Effects of selenium and thyroid hormone deficiency on peritoneal macrophages adhesion and occurrence of natural IGM antibodies in juvenile rats",
volume = "67",
number = "3",
pages = "340-355",
doi = "10.1515/acve-2017-0028"
}

Bjelica, J., Jovanović, I. B., Ilić, V., Valčić, O., Kirovski, D., Gvozdić, D.,& Milanović, S.. (2017). Effects of selenium and thyroid hormone deficiency on peritoneal macrophages adhesion and occurrence of natural IGM antibodies in juvenile rats. in Acta Veterinaria-Beograd
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 67(3), 340-355.
https://doi.org/10.1515/acve-2017-0028

Bjelica J, Jovanović IB, Ilić V, Valčić O, Kirovski D, Gvozdić D, Milanović S. Effects of selenium and thyroid hormone deficiency on peritoneal macrophages adhesion and occurrence of natural IGM antibodies in juvenile rats. in Acta Veterinaria-Beograd. 2017;67(3):340-355.
doi:10.1515/acve-2017-0028 .

Bjelica, Jelena, Jovanović, Ivan B., Ilić, Vesna, Valčić, Olivera, Kirovski, Danijela, Gvozdić, Dragan, Milanović, Svetlana, "Effects of selenium and thyroid hormone deficiency on peritoneal macrophages adhesion and occurrence of natural IGM antibodies in juvenile rats" in Acta Veterinaria-Beograd, 67, no. 3 (2017):340-355,
https://doi.org/10.1515/acve-2017-0028 . .

TY  - CONF
AU  - Milanović, Svetlana
AU  - Valčić, Olivera
AU  - Jovanović, Ivan
PY  - 2017
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/3440
AB  - Sve veći zahtevi tržišta za mesom koje sadrži što manje masti i holesterola
doveli su do značajnog porasta proizvodnje živinskog mesa. Ukupna proizvodnja živinskog mesa bila je 2001. godine 70 miliona tona što je osam puta
više od proizvodnje u 1961. godini, a uz godišnju stopu porasta od 2,8%, 2015.
godine je dostigla oko 100 miliona tona. Sa druge strane, pred proizvođače
se postavlja zadatak da za što kraće vreme proizvedu što više kvalitetnog i
zdravstveno-higijenski ispravnog proizvoda. Ovaj zadatak nameće upotrebu
kvalitetnih hraniva kao i dodataka koji će u potpunosti zadovoljiti osnovne i
proizvodne potrebe životinja u uzgoju, maksimalno iskorišćavajući genetske
kapacitete jedinki. Mikroelementi su jedan od ključnih faktora potrebnih za
pravilno funkcionisanje organizma. U intenzivnoj proizvodnji njihova je upotreba obavezna, a sa sve većim potrebama organizma, paralelno se razvijaju
različiti oblici mikroelemenata za koje se smatra da bi mogli imati veću bioiskoristivost. Mikroelementima pripadaju elementi koji su u organizmu zastupljeni sa manje od 100 mg/kg telesne mase. Njihova funkcija u organizmu
vezana je za funkciju proteina, enzima ili kofaktora u čiji sastav ulaze. U ovom
radu biće prikazane biološke funkcije nekih od njih, sa posebnim osvrtom na
bioiskoristivost različith neorganskih i organskih oblika gvožđa, mangana,
bakra, cinka i selena.
PB  - Beograd : Ciiip Živinarstvo
C3  - XXVI Savetovanje živinara, Tara, 2017
T1  - Uloga i značaj mikroelemenata u savremenom živinarstvu
SP  - 36
EP  - 45
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_3440
ER  - 

@conference{
author = "Milanović, Svetlana and Valčić, Olivera and Jovanović, Ivan",
year = "2017",
abstract = "Sve veći zahtevi tržišta za mesom koje sadrži što manje masti i holesterola
doveli su do značajnog porasta proizvodnje živinskog mesa. Ukupna proizvodnja živinskog mesa bila je 2001. godine 70 miliona tona što je osam puta
više od proizvodnje u 1961. godini, a uz godišnju stopu porasta od 2,8%, 2015.
godine je dostigla oko 100 miliona tona. Sa druge strane, pred proizvođače
se postavlja zadatak da za što kraće vreme proizvedu što više kvalitetnog i
zdravstveno-higijenski ispravnog proizvoda. Ovaj zadatak nameće upotrebu
kvalitetnih hraniva kao i dodataka koji će u potpunosti zadovoljiti osnovne i
proizvodne potrebe životinja u uzgoju, maksimalno iskorišćavajući genetske
kapacitete jedinki. Mikroelementi su jedan od ključnih faktora potrebnih za
pravilno funkcionisanje organizma. U intenzivnoj proizvodnji njihova je upotreba obavezna, a sa sve većim potrebama organizma, paralelno se razvijaju
različiti oblici mikroelemenata za koje se smatra da bi mogli imati veću bioiskoristivost. Mikroelementima pripadaju elementi koji su u organizmu zastupljeni sa manje od 100 mg/kg telesne mase. Njihova funkcija u organizmu
vezana je za funkciju proteina, enzima ili kofaktora u čiji sastav ulaze. U ovom
radu biće prikazane biološke funkcije nekih od njih, sa posebnim osvrtom na
bioiskoristivost različith neorganskih i organskih oblika gvožđa, mangana,
bakra, cinka i selena.",
publisher = "Beograd : Ciiip Živinarstvo",
journal = "XXVI Savetovanje živinara, Tara, 2017",
title = "Uloga i značaj mikroelemenata u savremenom živinarstvu",
pages = "36-45",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_3440"
}

Milanović, S., Valčić, O.,& Jovanović, I.. (2017). Uloga i značaj mikroelemenata u savremenom živinarstvu. in XXVI Savetovanje živinara, Tara, 2017
Beograd : Ciiip Živinarstvo., 36-45.
https://hdl.handle.net/21.15107/rcub_veterinar_3440

Milanović S, Valčić O, Jovanović I. Uloga i značaj mikroelemenata u savremenom živinarstvu. in XXVI Savetovanje živinara, Tara, 2017. 2017;:36-45.
https://hdl.handle.net/21.15107/rcub_veterinar_3440 .

Milanović, Svetlana, Valčić, Olivera, Jovanović, Ivan, "Uloga i značaj mikroelemenata u savremenom živinarstvu" in XXVI Savetovanje živinara, Tara, 2017 (2017):36-45,
https://hdl.handle.net/21.15107/rcub_veterinar_3440 .

TY  - JOUR
AU  - Jovanović, Ivan B.
AU  - Velicković, Miljan
AU  - Milanović, Svetlana
AU  - Valčić, Olivera
AU  - Gvozdić, Dragan
AU  - Vranješ-Đurić, Sanja
PY  - 2015
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1182
AB  - The aim of this investigation was to determine the influence of oxidative stress upon general stress in dairy cows on parturition and whether the indicators of stress can be reduced by selenium (Se) supplementation. A total of 36 animals were divided into 3 groups 21 days prepartum and treated with a single-term intra muscular supplement of sodium selenite: Control group - 0 mg; group Se10 - 10 mg; group Se20 - 20 mg. Se supplementation significantly raised blood Se content and glutathione peroxidase (GPx) activity in groups Se10 and Se20, compared to Control, although there was no marked difference between supplemented groups. Plasma malondialdehyde (MDA) and cortisol concentrations were significantly reduced in supplemented groups Se10 and Se20, compared to Control. A negative correlation was detected between blood GPx activity and plasma MDA, while a positive correlation was determined between plasma MDA and cortisol concentrations. These results indicate that prepartum Se supplementation can be utilized for a partial relief of stress in cows during labor by augmenting the antioxidative action of GPx.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta Veterinaria-Beograd
T1  - Supplemental selenium reduces the levels of biomarkers of oxidative and general stress in peripartum dairy cows
VL  - 65
IS  - 2
SP  - 191
EP  - 201
DO  - 10.1515/acve-2015-0016
ER  - 

@article{
author = "Jovanović, Ivan B. and Velicković, Miljan and Milanović, Svetlana and Valčić, Olivera and Gvozdić, Dragan and Vranješ-Đurić, Sanja",
year = "2015",
abstract = "The aim of this investigation was to determine the influence of oxidative stress upon general stress in dairy cows on parturition and whether the indicators of stress can be reduced by selenium (Se) supplementation. A total of 36 animals were divided into 3 groups 21 days prepartum and treated with a single-term intra muscular supplement of sodium selenite: Control group - 0 mg; group Se10 - 10 mg; group Se20 - 20 mg. Se supplementation significantly raised blood Se content and glutathione peroxidase (GPx) activity in groups Se10 and Se20, compared to Control, although there was no marked difference between supplemented groups. Plasma malondialdehyde (MDA) and cortisol concentrations were significantly reduced in supplemented groups Se10 and Se20, compared to Control. A negative correlation was detected between blood GPx activity and plasma MDA, while a positive correlation was determined between plasma MDA and cortisol concentrations. These results indicate that prepartum Se supplementation can be utilized for a partial relief of stress in cows during labor by augmenting the antioxidative action of GPx.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta Veterinaria-Beograd",
title = "Supplemental selenium reduces the levels of biomarkers of oxidative and general stress in peripartum dairy cows",
volume = "65",
number = "2",
pages = "191-201",
doi = "10.1515/acve-2015-0016"
}

Jovanović, I. B., Velicković, M., Milanović, S., Valčić, O., Gvozdić, D.,& Vranješ-Đurić, S.. (2015). Supplemental selenium reduces the levels of biomarkers of oxidative and general stress in peripartum dairy cows. in Acta Veterinaria-Beograd
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 65(2), 191-201.
https://doi.org/10.1515/acve-2015-0016

Jovanović IB, Velicković M, Milanović S, Valčić O, Gvozdić D, Vranješ-Đurić S. Supplemental selenium reduces the levels of biomarkers of oxidative and general stress in peripartum dairy cows. in Acta Veterinaria-Beograd. 2015;65(2):191-201.
doi:10.1515/acve-2015-0016 .

Jovanović, Ivan B., Velicković, Miljan, Milanović, Svetlana, Valčić, Olivera, Gvozdić, Dragan, Vranješ-Đurić, Sanja, "Supplemental selenium reduces the levels of biomarkers of oxidative and general stress in peripartum dairy cows" in Acta Veterinaria-Beograd, 65, no. 2 (2015):191-201,
https://doi.org/10.1515/acve-2015-0016 . .

TY  - JOUR
AU  - Milanović, Svetlana
AU  - Jovanović, Ivan B.
AU  - Valčić, Olivera
PY  - 2015
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1202
AB  - Selenium is an essential trace element with multi significant role in the body. In contrast to other trace elements that appear as cofactors of certain enzymes, its physiological role is directly related to functions of proteins in composition of which it is cotranslationally installed by atypical amino acid selenocysteine. The group of proteins, in which composition selenocysteine is an integral functional part of polypeptides, are referred to as selenoproteins. The first enzyme that has been proven to have selenocysteine incorporated in its composition, is glutathione peroxidase (GPx). So far there have been identified 5 isoenzyme forms of GPx which reduce hydrogen peroxide and organic hydroperoxides, protecting cells from oxidative damage. Iodothyronine deiodinases (ID) are among the most important selenopoteins, being responsible for both activation and deactivation of thyroid hormones. So far there have been found over twenty selenoproteins, but only for some of them a physiological role is known.
AB  - Selen je esencijalni mikroelement sa mnogostrukim i vrlo važnim ulogama u organizmu. Za razliku od ostalih mikroelemenata koji figuriraju kao kofaktori pojedinih enzima, njegove fiziološke uloge direktno su povezane sa funkcijama proteina u čiji sastav se kotranslatorno ugrađuje putem netipične aminokiseline selenocisteina. Grupa proteina koja u svom sastavu ima selenocistein kao integralni funkcionalni deo polipeptida nazivaju se selenoproteini. Prvi enzim za koji je dokazano da u svom sastavu ima ugrađen selenocistein je glutation peroksidaza (GPx). Do sada je identifikovano 5 izoenzimskih formi GPx koje redukuju vodonik-peroksid i organske hidroperokside, štiteći ćelije od oksidativnog oštećenja. Među najznačajnijim selenoenzimima su i jodotironin dejodinaze (ID), odgovorne za aktivaciju i deaktivaciju tireoidnih hormona. Do sada je otkriveno preko dvadeset selenoproteina, a samo za neke od njih je poznata fiziološka uloga.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Veterinarski Glasnik
T1  - Selenoproteins
T1  - Selenoproteini
VL  - 69
IS  - 1-2
SP  - 75
EP  - 89
DO  - 10.2298/VETGL1502075M
ER  - 

@article{
author = "Milanović, Svetlana and Jovanović, Ivan B. and Valčić, Olivera",
year = "2015",
abstract = "Selenium is an essential trace element with multi significant role in the body. In contrast to other trace elements that appear as cofactors of certain enzymes, its physiological role is directly related to functions of proteins in composition of which it is cotranslationally installed by atypical amino acid selenocysteine. The group of proteins, in which composition selenocysteine is an integral functional part of polypeptides, are referred to as selenoproteins. The first enzyme that has been proven to have selenocysteine incorporated in its composition, is glutathione peroxidase (GPx). So far there have been identified 5 isoenzyme forms of GPx which reduce hydrogen peroxide and organic hydroperoxides, protecting cells from oxidative damage. Iodothyronine deiodinases (ID) are among the most important selenopoteins, being responsible for both activation and deactivation of thyroid hormones. So far there have been found over twenty selenoproteins, but only for some of them a physiological role is known., Selen je esencijalni mikroelement sa mnogostrukim i vrlo važnim ulogama u organizmu. Za razliku od ostalih mikroelemenata koji figuriraju kao kofaktori pojedinih enzima, njegove fiziološke uloge direktno su povezane sa funkcijama proteina u čiji sastav se kotranslatorno ugrađuje putem netipične aminokiseline selenocisteina. Grupa proteina koja u svom sastavu ima selenocistein kao integralni funkcionalni deo polipeptida nazivaju se selenoproteini. Prvi enzim za koji je dokazano da u svom sastavu ima ugrađen selenocistein je glutation peroksidaza (GPx). Do sada je identifikovano 5 izoenzimskih formi GPx koje redukuju vodonik-peroksid i organske hidroperokside, štiteći ćelije od oksidativnog oštećenja. Među najznačajnijim selenoenzimima su i jodotironin dejodinaze (ID), odgovorne za aktivaciju i deaktivaciju tireoidnih hormona. Do sada je otkriveno preko dvadeset selenoproteina, a samo za neke od njih je poznata fiziološka uloga.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Veterinarski Glasnik",
title = "Selenoproteins, Selenoproteini",
volume = "69",
number = "1-2",
pages = "75-89",
doi = "10.2298/VETGL1502075M"
}

Milanović, S., Jovanović, I. B.,& Valčić, O.. (2015). Selenoproteins. in Veterinarski Glasnik
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 69(1-2), 75-89.
https://doi.org/10.2298/VETGL1502075M

Milanović S, Jovanović IB, Valčić O. Selenoproteins. in Veterinarski Glasnik. 2015;69(1-2):75-89.
doi:10.2298/VETGL1502075M .

Milanović, Svetlana, Jovanović, Ivan B., Valčić, Olivera, "Selenoproteins" in Veterinarski Glasnik, 69, no. 1-2 (2015):75-89,
https://doi.org/10.2298/VETGL1502075M . .

TY  - JOUR
AU  - Vuković, D.
AU  - Stančić, Ivan
AU  - Gvozdić, Dragan
AU  - Kucević, D.
AU  - Božić, Aleksandar
AU  - Jovanović, Ivan B.
AU  - Milanović, Svetlana
AU  - Stančić, Blagoje
PY  - 2014
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1107
AB  - Fertiliy rate in high milk-yield dairy cows, with prolonged postpartum anestrus, was investigated after treatment by Ovsynch protocol. Thirty cows with follicular cysts or unovulated follicles (around 1.2 cm in diameter), without detected estrus up to 60 days post partum, were treated by Ovsynch protocol. The date of the first GnRH injection was defined as day 0. On day 6. was given prostaglandin F2α (PGF2a) and second GnRH injection 48 h after PGF2 α (day 8). All treated cows were terminally inseminated at day 9 (without estrus detection), i.e. 12-14 h after the last GnRH injection. The blood serum progesterone concentration was determined by ELISA method, in blood samples taken from v. jugularis, at the day of AI.The blood serum concentration of progesterone on the day of AI was low in Ovsynch treated (1.8 ng/mL) and in control cows (1.5 ng/mL). Obtainedcalving rate was not significant different between treated and control cows (57:60%, respectively, p > 0.05). Our results show that Ovsynch protocol treatment can be a successful method for control of prolonged postpartum anestrus in high milk-yield cows.
PB  - Eugen Ulmer Gmbh Co, Stuttgart
T2  - Zuchtungskunde
T1  - Influence of ovsynch-treatment on concentration of progesterone in blood serum and pregnancy rates after artificial insemination in cows [Einfluss einer Ovsynch-Behandlung auf die Progesteronkonzentrationen im Blutserum und Trächtigkeitsraten bei Kühen na
VL  - 86
IS  - 2
SP  - 123
EP  - 129
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_1107
ER  - 

@article{
author = "Vuković, D. and Stančić, Ivan and Gvozdić, Dragan and Kucević, D. and Božić, Aleksandar and Jovanović, Ivan B. and Milanović, Svetlana and Stančić, Blagoje",
year = "2014",
abstract = "Fertiliy rate in high milk-yield dairy cows, with prolonged postpartum anestrus, was investigated after treatment by Ovsynch protocol. Thirty cows with follicular cysts or unovulated follicles (around 1.2 cm in diameter), without detected estrus up to 60 days post partum, were treated by Ovsynch protocol. The date of the first GnRH injection was defined as day 0. On day 6. was given prostaglandin F2α (PGF2a) and second GnRH injection 48 h after PGF2 α (day 8). All treated cows were terminally inseminated at day 9 (without estrus detection), i.e. 12-14 h after the last GnRH injection. The blood serum progesterone concentration was determined by ELISA method, in blood samples taken from v. jugularis, at the day of AI.The blood serum concentration of progesterone on the day of AI was low in Ovsynch treated (1.8 ng/mL) and in control cows (1.5 ng/mL). Obtainedcalving rate was not significant different between treated and control cows (57:60%, respectively, p > 0.05). Our results show that Ovsynch protocol treatment can be a successful method for control of prolonged postpartum anestrus in high milk-yield cows.",
publisher = "Eugen Ulmer Gmbh Co, Stuttgart",
journal = "Zuchtungskunde",
title = "Influence of ovsynch-treatment on concentration of progesterone in blood serum and pregnancy rates after artificial insemination in cows [Einfluss einer Ovsynch-Behandlung auf die Progesteronkonzentrationen im Blutserum und Trächtigkeitsraten bei Kühen na",
volume = "86",
number = "2",
pages = "123-129",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_1107"
}

Vuković, D., Stančić, I., Gvozdić, D., Kucević, D., Božić, A., Jovanović, I. B., Milanović, S.,& Stančić, B.. (2014). Influence of ovsynch-treatment on concentration of progesterone in blood serum and pregnancy rates after artificial insemination in cows [Einfluss einer Ovsynch-Behandlung auf die Progesteronkonzentrationen im Blutserum und Trächtigkeitsraten bei Kühen na. in Zuchtungskunde
Eugen Ulmer Gmbh Co, Stuttgart., 86(2), 123-129.
https://hdl.handle.net/21.15107/rcub_veterinar_1107

Vuković D, Stančić I, Gvozdić D, Kucević D, Božić A, Jovanović IB, Milanović S, Stančić B. Influence of ovsynch-treatment on concentration of progesterone in blood serum and pregnancy rates after artificial insemination in cows [Einfluss einer Ovsynch-Behandlung auf die Progesteronkonzentrationen im Blutserum und Trächtigkeitsraten bei Kühen na. in Zuchtungskunde. 2014;86(2):123-129.
https://hdl.handle.net/21.15107/rcub_veterinar_1107 .

Vuković, D., Stančić, Ivan, Gvozdić, Dragan, Kucević, D., Božić, Aleksandar, Jovanović, Ivan B., Milanović, Svetlana, Stančić, Blagoje, "Influence of ovsynch-treatment on concentration of progesterone in blood serum and pregnancy rates after artificial insemination in cows [Einfluss einer Ovsynch-Behandlung auf die Progesteronkonzentrationen im Blutserum und Trächtigkeitsraten bei Kühen na" in Zuchtungskunde, 86, no. 2 (2014):123-129,
https://hdl.handle.net/21.15107/rcub_veterinar_1107 .

TY  - JOUR
AU  - Milanović, Svetlana
AU  - Jovanović, Ivan B.
AU  - Bjelica, Jelena
AU  - Joksimović, Srđan
AU  - Stefanović, Srđan
AU  - Radović, Magdalena
AU  - Kirovski, Danijela
AU  - Valčić, Olivera
AU  - Gvozdić, Dragan
PY  - 2014
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1121
AB  - In this work there was investigated the influence of selenium and deodinases blockers on juvenile rats body weight during three months. The experiment was carried out on 64 rats divided into eight groups with eight individual animals per group. Following groups were formed: 1. Se+PTU-IA- (control group), 2. Se+PTU+IA+, 3. Se+PTU+IA-, 4. Se+P-TU-IA+, 5. Se-PTU-IA-, 6. Se-PTU+IA+, 7. Se-PTU+IA- and 8. Se-PTU-IA+. The groups labeled (Se+) were selenium adequate and they were fed with food that contained 0.334 mg Se/kg. The groups labeled (Se-) were selenium deficient and obtained food with 0.031 mg Se/kg. As deiodinases blockers there were used propylthiouracil (PTU+) in a dose of 150 mg/L of drinking water and iopanoic acid (IA+) in a dose of 6 mg/100 g TM intraperitoneally. Body weight of experimental rats was measured every seven days. After three weeks of treatment there were taken blood samples of animals from all experimental groups and following parameters were determined: selenium concentration in blood, thyroxine (T4), triiodothyronine (T3) and thyroidstimulating hormone (TSH) in blood plasma. Analysis of the samples showed that the animals from the groups treated with PTU had lower body weight in regard to the control group, as well as lower concentration of T3 and T4 in plasma. Selenium deficient rats had lower average body weight compared to the selenium adequate ones after three weeks, but there were no differences in thyroid hormones concentration. The lowest average body weight was noticed in selenium deficient rats groups treated with PTU.
AB  - U okviru ogleda je ispitivan uticaj selena i blokatora dejodinaza na telesnu masu juvenilnih pacova tokom tri nedelje. Ogled je izveden na 64 pacova podeljenih u osam grupa od po 8 jedinki. Formirane su sledeće grupe: 1. Se+PTU-IA- (kontrolna grupa), 2. Se+PTU+IA+, 3. Se+PTU+IA-, 4. Se+PTU-IA+, 5. Se-PTU-IA-, 6. Se-PTU+IA+, 7. Se-PTU+IA- i 8. Se-PTU-IA+. Grupe sa oznakom (Se+) su bile selenadekvatne i dobijale su hranu koja je sadržala 0,334 mg Se/kg hrane. Grupe sa oznakom (Se-) su bile selendeficitne i dobijale su 0,031 mg mg Se/kg hrane. Kao blokatori dejodinaza su korišćeni propiltiouracil (PTU+) u dozi od 150 mg/L vode za piće i jopanoična kiselina (IA+) u dozi od 6 mg/100g t.m. intraperitonealno. Telesna masa oglednih pacova je merena svakih sedam dana. Nakon tri nedelje tretmana uzeti su uzorci krvi životinja iz svih oglednih grupa i određivani su sledeći parametri: koncentracja selena u punoj krvi, tiroksin (T4), trijodtironin (T3) i tireostimulirajući hormon (TSH) u krvnoj plazmi. Analiza je pokazala da su jedinke iz grupe tretiranih sa PTU imale nižu telesnu masu u odnosu na kontrolnu, kao i nižu koncentraciju T3 i T4 u plazmi. Selendeficitni pacovi su nakon tri nedelje imali nižu prosečnu telesnu masu u odnosu na selenadekvatne, ali nisu uočene razlike u koncentraciji tireoidnih hormona. Najniža prosečna telesna masa zabeležena je kod selendeficitnih grupa pacova tretiranih sa PTU.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Veterinarski Glasnik
T1  - The influence of selenium and deiodinases blockers on juvenile rats body weight
T1  - Vlijanie selena i blokatorov dejodinazy na ves juvenil'nyh krys
T1  - Uticaj selena i blokatora dejodinaza na telesnu masu juvenilnih pacova
VL  - 68
IS  - 1-2
SP  - 3
EP  - 9
DO  - 10.2298/VETGL1402003M
ER  - 

@article{
author = "Milanović, Svetlana and Jovanović, Ivan B. and Bjelica, Jelena and Joksimović, Srđan and Stefanović, Srđan and Radović, Magdalena and Kirovski, Danijela and Valčić, Olivera and Gvozdić, Dragan",
year = "2014",
abstract = "In this work there was investigated the influence of selenium and deodinases blockers on juvenile rats body weight during three months. The experiment was carried out on 64 rats divided into eight groups with eight individual animals per group. Following groups were formed: 1. Se+PTU-IA- (control group), 2. Se+PTU+IA+, 3. Se+PTU+IA-, 4. Se+P-TU-IA+, 5. Se-PTU-IA-, 6. Se-PTU+IA+, 7. Se-PTU+IA- and 8. Se-PTU-IA+. The groups labeled (Se+) were selenium adequate and they were fed with food that contained 0.334 mg Se/kg. The groups labeled (Se-) were selenium deficient and obtained food with 0.031 mg Se/kg. As deiodinases blockers there were used propylthiouracil (PTU+) in a dose of 150 mg/L of drinking water and iopanoic acid (IA+) in a dose of 6 mg/100 g TM intraperitoneally. Body weight of experimental rats was measured every seven days. After three weeks of treatment there were taken blood samples of animals from all experimental groups and following parameters were determined: selenium concentration in blood, thyroxine (T4), triiodothyronine (T3) and thyroidstimulating hormone (TSH) in blood plasma. Analysis of the samples showed that the animals from the groups treated with PTU had lower body weight in regard to the control group, as well as lower concentration of T3 and T4 in plasma. Selenium deficient rats had lower average body weight compared to the selenium adequate ones after three weeks, but there were no differences in thyroid hormones concentration. The lowest average body weight was noticed in selenium deficient rats groups treated with PTU., U okviru ogleda je ispitivan uticaj selena i blokatora dejodinaza na telesnu masu juvenilnih pacova tokom tri nedelje. Ogled je izveden na 64 pacova podeljenih u osam grupa od po 8 jedinki. Formirane su sledeće grupe: 1. Se+PTU-IA- (kontrolna grupa), 2. Se+PTU+IA+, 3. Se+PTU+IA-, 4. Se+PTU-IA+, 5. Se-PTU-IA-, 6. Se-PTU+IA+, 7. Se-PTU+IA- i 8. Se-PTU-IA+. Grupe sa oznakom (Se+) su bile selenadekvatne i dobijale su hranu koja je sadržala 0,334 mg Se/kg hrane. Grupe sa oznakom (Se-) su bile selendeficitne i dobijale su 0,031 mg mg Se/kg hrane. Kao blokatori dejodinaza su korišćeni propiltiouracil (PTU+) u dozi od 150 mg/L vode za piće i jopanoična kiselina (IA+) u dozi od 6 mg/100g t.m. intraperitonealno. Telesna masa oglednih pacova je merena svakih sedam dana. Nakon tri nedelje tretmana uzeti su uzorci krvi životinja iz svih oglednih grupa i određivani su sledeći parametri: koncentracja selena u punoj krvi, tiroksin (T4), trijodtironin (T3) i tireostimulirajući hormon (TSH) u krvnoj plazmi. Analiza je pokazala da su jedinke iz grupe tretiranih sa PTU imale nižu telesnu masu u odnosu na kontrolnu, kao i nižu koncentraciju T3 i T4 u plazmi. Selendeficitni pacovi su nakon tri nedelje imali nižu prosečnu telesnu masu u odnosu na selenadekvatne, ali nisu uočene razlike u koncentraciji tireoidnih hormona. Najniža prosečna telesna masa zabeležena je kod selendeficitnih grupa pacova tretiranih sa PTU.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Veterinarski Glasnik",
title = "The influence of selenium and deiodinases blockers on juvenile rats body weight, Vlijanie selena i blokatorov dejodinazy na ves juvenil'nyh krys, Uticaj selena i blokatora dejodinaza na telesnu masu juvenilnih pacova",
volume = "68",
number = "1-2",
pages = "3-9",
doi = "10.2298/VETGL1402003M"
}

Milanović, S., Jovanović, I. B., Bjelica, J., Joksimović, S., Stefanović, S., Radović, M., Kirovski, D., Valčić, O.,& Gvozdić, D.. (2014). The influence of selenium and deiodinases blockers on juvenile rats body weight. in Veterinarski Glasnik
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 68(1-2), 3-9.
https://doi.org/10.2298/VETGL1402003M

Milanović S, Jovanović IB, Bjelica J, Joksimović S, Stefanović S, Radović M, Kirovski D, Valčić O, Gvozdić D. The influence of selenium and deiodinases blockers on juvenile rats body weight. in Veterinarski Glasnik. 2014;68(1-2):3-9.
doi:10.2298/VETGL1402003M .

Milanović, Svetlana, Jovanović, Ivan B., Bjelica, Jelena, Joksimović, Srđan, Stefanović, Srđan, Radović, Magdalena, Kirovski, Danijela, Valčić, Olivera, Gvozdić, Dragan, "The influence of selenium and deiodinases blockers on juvenile rats body weight" in Veterinarski Glasnik, 68, no. 1-2 (2014):3-9,
https://doi.org/10.2298/VETGL1402003M . .

TY  - JOUR
AU  - Petrujkić, Branko
AU  - Šefer, Dragan
AU  - Jovanović, Ivan B.
AU  - Jovičin, Milovan
AU  - Janković, S.
AU  - Jakovljević, Goran
AU  - Beier, Ross C.
AU  - Anderson, Robin C.
PY  - 2014
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1089
AB  - The aim of this study was to determine how dietary supplementation of inorganic and organic selenium affects the selenium concentration and glutathione peroxidase activity in blood and sperm of sexually mature stud boars. Twenty-four boars of the Large White, Landrace, Pietrain and Duroc breeds of optimal breeding age (on average 2.5 years old) were used. The study lasted 90 days. The boars were randomly assigned to one of three dietary treatment groups: T1 = control; no added selenium (n = 8 boars), T2 = added 0.3 ppm inorganic selenium (sodium selenite, Microgran (R) Se 1% BMP) (n = 8 boars), and T3 = added 0.3 ppm organic selenium (Se-yeast, Sel-Plex 2000 (R)) (n = 8 boars). The concentration of selenium was determined in whole blood and semen, while the activity of glutathione peroxidase (GPx) was measured in blood plasma and semen. In order to measure GPx activity in semen, reactivation of the enzymatic GPx activity was performed. The determined selenium concentration in blood was lowest in the non-supplemented group of boars. Blood plasma GPx activity was higher in boars fed organic selenium than in boars fed a diet without supplemented selenium. While the supplementation of sodium selenite significantly increased GPx activity in boar semen. The highest-concentration of selenium in semen at the end of the trial was determined in the group of boars supplemented with organic selenium, somewhat lower in boars fed supplemented inorganic selenium, and the lowest in the non-supplemented group of boars. The only significant difference between the selenite and Se-yeast diet supplementation was observed in the Se concentration of the semen. The supplementation of selenium affected semen quality, and organic selenium improved the progressive motility of the spermatozoa and increased their resistance in hypo-osmotic and thermal tests. The storage ability of short term preserved semen was improved by organic selenium supplementation, as well as also increasing the fertility rate in gilts.
PB  - Elsevier Science Bv, Amsterdam
T2  - Animal Feed Science and Technology
T1  - Effects of commercial selenium products on glutathione peroxidase activity and semen quality in stud boars
VL  - 197
SP  - 194
EP  - 205
DO  - 10.1016/j.anifeedsci.2014.09.001
ER  - 

@article{
author = "Petrujkić, Branko and Šefer, Dragan and Jovanović, Ivan B. and Jovičin, Milovan and Janković, S. and Jakovljević, Goran and Beier, Ross C. and Anderson, Robin C.",
year = "2014",
abstract = "The aim of this study was to determine how dietary supplementation of inorganic and organic selenium affects the selenium concentration and glutathione peroxidase activity in blood and sperm of sexually mature stud boars. Twenty-four boars of the Large White, Landrace, Pietrain and Duroc breeds of optimal breeding age (on average 2.5 years old) were used. The study lasted 90 days. The boars were randomly assigned to one of three dietary treatment groups: T1 = control; no added selenium (n = 8 boars), T2 = added 0.3 ppm inorganic selenium (sodium selenite, Microgran (R) Se 1% BMP) (n = 8 boars), and T3 = added 0.3 ppm organic selenium (Se-yeast, Sel-Plex 2000 (R)) (n = 8 boars). The concentration of selenium was determined in whole blood and semen, while the activity of glutathione peroxidase (GPx) was measured in blood plasma and semen. In order to measure GPx activity in semen, reactivation of the enzymatic GPx activity was performed. The determined selenium concentration in blood was lowest in the non-supplemented group of boars. Blood plasma GPx activity was higher in boars fed organic selenium than in boars fed a diet without supplemented selenium. While the supplementation of sodium selenite significantly increased GPx activity in boar semen. The highest-concentration of selenium in semen at the end of the trial was determined in the group of boars supplemented with organic selenium, somewhat lower in boars fed supplemented inorganic selenium, and the lowest in the non-supplemented group of boars. The only significant difference between the selenite and Se-yeast diet supplementation was observed in the Se concentration of the semen. The supplementation of selenium affected semen quality, and organic selenium improved the progressive motility of the spermatozoa and increased their resistance in hypo-osmotic and thermal tests. The storage ability of short term preserved semen was improved by organic selenium supplementation, as well as also increasing the fertility rate in gilts.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Animal Feed Science and Technology",
title = "Effects of commercial selenium products on glutathione peroxidase activity and semen quality in stud boars",
volume = "197",
pages = "194-205",
doi = "10.1016/j.anifeedsci.2014.09.001"
}

Petrujkić, B., Šefer, D., Jovanović, I. B., Jovičin, M., Janković, S., Jakovljević, G., Beier, R. C.,& Anderson, R. C.. (2014). Effects of commercial selenium products on glutathione peroxidase activity and semen quality in stud boars. in Animal Feed Science and Technology
Elsevier Science Bv, Amsterdam., 197, 194-205.
https://doi.org/10.1016/j.anifeedsci.2014.09.001

Petrujkić B, Šefer D, Jovanović IB, Jovičin M, Janković S, Jakovljević G, Beier RC, Anderson RC. Effects of commercial selenium products on glutathione peroxidase activity and semen quality in stud boars. in Animal Feed Science and Technology. 2014;197:194-205.
doi:10.1016/j.anifeedsci.2014.09.001 .

Petrujkić, Branko, Šefer, Dragan, Jovanović, Ivan B., Jovičin, Milovan, Janković, S., Jakovljević, Goran, Beier, Ross C., Anderson, Robin C., "Effects of commercial selenium products on glutathione peroxidase activity and semen quality in stud boars" in Animal Feed Science and Technology, 197 (2014):194-205,
https://doi.org/10.1016/j.anifeedsci.2014.09.001 . .

TY  - CONF
AU  - Marković, Radmila
AU  - Drljačić, Aleksandar
AU  - Baltić, Milan Ž.
AU  - Šefer, Dragan
AU  - Jovanović, Ivan
AU  - Jokić, Živan
AU  - Radulović, Stamen
PY  - 2013
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/3844
PB  - Zagreb : Krmiva d.o.o.
C3  - 20. Međunarodno savjetovanje Krmiva, Opatija, 5 - 7. jun, 2013
T1  - Utjecaj korištenja različitih količina organskog selena na aktivnost glutation peroksidaze i sadržaj selena u plazmi brojlera
SP  - 102
EP  - 102
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_3844
ER  - 

@conference{
author = "Marković, Radmila and Drljačić, Aleksandar and Baltić, Milan Ž. and Šefer, Dragan and Jovanović, Ivan and Jokić, Živan and Radulović, Stamen",
year = "2013",
publisher = "Zagreb : Krmiva d.o.o.",
journal = "20. Međunarodno savjetovanje Krmiva, Opatija, 5 - 7. jun, 2013",
title = "Utjecaj korištenja različitih količina organskog selena na aktivnost glutation peroksidaze i sadržaj selena u plazmi brojlera",
pages = "102-102",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_3844"
}

Marković, R., Drljačić, A., Baltić, M. Ž., Šefer, D., Jovanović, I., Jokić, Ž.,& Radulović, S.. (2013). Utjecaj korištenja različitih količina organskog selena na aktivnost glutation peroksidaze i sadržaj selena u plazmi brojlera. in 20. Međunarodno savjetovanje Krmiva, Opatija, 5 - 7. jun, 2013
Zagreb : Krmiva d.o.o.., 102-102.
https://hdl.handle.net/21.15107/rcub_veterinar_3844

Marković R, Drljačić A, Baltić MŽ, Šefer D, Jovanović I, Jokić Ž, Radulović S. Utjecaj korištenja različitih količina organskog selena na aktivnost glutation peroksidaze i sadržaj selena u plazmi brojlera. in 20. Međunarodno savjetovanje Krmiva, Opatija, 5 - 7. jun, 2013. 2013;:102-102.
https://hdl.handle.net/21.15107/rcub_veterinar_3844 .

Marković, Radmila, Drljačić, Aleksandar, Baltić, Milan Ž., Šefer, Dragan, Jovanović, Ivan, Jokić, Živan, Radulović, Stamen, "Utjecaj korištenja različitih količina organskog selena na aktivnost glutation peroksidaze i sadržaj selena u plazmi brojlera" in 20. Međunarodno savjetovanje Krmiva, Opatija, 5 - 7. jun, 2013 (2013):102-102,
https://hdl.handle.net/21.15107/rcub_veterinar_3844 .

TY  - JOUR
AU  - Jovanović, Ivan B.
AU  - Veličković, Miljan
AU  - Vuković, Dragan
AU  - Milanović, Svetlana
AU  - Valčić, Olivera
AU  - Gvozdić, Dragan
PY  - 2013
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1831
AB  - The incidence of retained placenta (RP) in cows increases in cases of parturition induced by prostaglandin F2α. We analyzed the effects of different doses of supplemental selenium and vitamin E on the incidence of RP, blood selenium, plasma thyronines, and malondialdehyde concentration. Thirty-three clinically healthy, multiparous Holstein-Frisian cows were assigned to 3 groups and supplemented with a single intramuscular injection of sodium selenite (SS) and tocopherol acetate (TAc) between days 250 to 255 of gestation: control—unsupplemented; group A—10 mg SS + 400 mg TAc; group B—20 mg SS + 800 mg TAc. Parturition was induced using PGF2α not before day 275 of gestation. The RP incidence was reduced from 66.7% in the control to 38.2 and 30.8% in groups A and B, respectively. Blood selenium and glutathione peroxidase activity in treated groups were significantly higher compared to control, with no significant difference between groups A and B. Plasma malondialdehyde in group B was significantly lower than that in control and group A, while thyronines levels were not affected. Comparison of RP and non-RP cows, independently of supplement treatment, revealed higher blood selenium and glutathione peroxidase activity and lower MDA and thyroxine in non-RP animals, while triiodothyronine level did not differ.
PB  - Hindawi
T2  - Journal of Veterinary Medicine
T1  - Effects of Different Amounts of Supplemental Selenium and Vitamin E on the Incidence of Retained Placenta, Selenium, Malondialdehyde, and Thyronines Status in Cows Treated with Prostaglandin F2α for the Induction of Parturition
VL  - 2013
SP  - 867453
DO  - 10.1155/2013/867453
ER  - 

@article{
author = "Jovanović, Ivan B. and Veličković, Miljan and Vuković, Dragan and Milanović, Svetlana and Valčić, Olivera and Gvozdić, Dragan",
year = "2013",
abstract = "The incidence of retained placenta (RP) in cows increases in cases of parturition induced by prostaglandin F2α. We analyzed the effects of different doses of supplemental selenium and vitamin E on the incidence of RP, blood selenium, plasma thyronines, and malondialdehyde concentration. Thirty-three clinically healthy, multiparous Holstein-Frisian cows were assigned to 3 groups and supplemented with a single intramuscular injection of sodium selenite (SS) and tocopherol acetate (TAc) between days 250 to 255 of gestation: control—unsupplemented; group A—10 mg SS + 400 mg TAc; group B—20 mg SS + 800 mg TAc. Parturition was induced using PGF2α not before day 275 of gestation. The RP incidence was reduced from 66.7% in the control to 38.2 and 30.8% in groups A and B, respectively. Blood selenium and glutathione peroxidase activity in treated groups were significantly higher compared to control, with no significant difference between groups A and B. Plasma malondialdehyde in group B was significantly lower than that in control and group A, while thyronines levels were not affected. Comparison of RP and non-RP cows, independently of supplement treatment, revealed higher blood selenium and glutathione peroxidase activity and lower MDA and thyroxine in non-RP animals, while triiodothyronine level did not differ.",
publisher = "Hindawi",
journal = "Journal of Veterinary Medicine",
title = "Effects of Different Amounts of Supplemental Selenium and Vitamin E on the Incidence of Retained Placenta, Selenium, Malondialdehyde, and Thyronines Status in Cows Treated with Prostaglandin F2α for the Induction of Parturition",
volume = "2013",
pages = "867453",
doi = "10.1155/2013/867453"
}

Jovanović, I. B., Veličković, M., Vuković, D., Milanović, S., Valčić, O.,& Gvozdić, D.. (2013). Effects of Different Amounts of Supplemental Selenium and Vitamin E on the Incidence of Retained Placenta, Selenium, Malondialdehyde, and Thyronines Status in Cows Treated with Prostaglandin F2α for the Induction of Parturition. in Journal of Veterinary Medicine
Hindawi., 2013, 867453.
https://doi.org/10.1155/2013/867453

Jovanović IB, Veličković M, Vuković D, Milanović S, Valčić O, Gvozdić D. Effects of Different Amounts of Supplemental Selenium and Vitamin E on the Incidence of Retained Placenta, Selenium, Malondialdehyde, and Thyronines Status in Cows Treated with Prostaglandin F2α for the Induction of Parturition. in Journal of Veterinary Medicine. 2013;2013:867453.
doi:10.1155/2013/867453 .

Jovanović, Ivan B., Veličković, Miljan, Vuković, Dragan, Milanović, Svetlana, Valčić, Olivera, Gvozdić, Dragan, "Effects of Different Amounts of Supplemental Selenium and Vitamin E on the Incidence of Retained Placenta, Selenium, Malondialdehyde, and Thyronines Status in Cows Treated with Prostaglandin F2α for the Induction of Parturition" in Journal of Veterinary Medicine, 2013 (2013):867453,
https://doi.org/10.1155/2013/867453 . .

TY  - JOUR
AU  - Valčić, Olivera
AU  - Jovanović, Ivan B.
AU  - Milanović, Svetlana
AU  - Gvozdić, Dragan
PY  - 2013
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1007
AB  - A total of 221 feedstuff samples (187 grain samples and 34 hay samples) were collected from 13 different locations on the territory of the Republic of Serbia. The results expressed as μg/kg have shown an average selenium content in grain samples of 34.3 ± 17.1 and 53.8 ± 18.7 in hay samples. However, a distinct difference was noted between samples collected from the locations north of the river Danube (52.8 ± 20.0 and 73.4 ± 21.3 for grain and hay samples, respectively) compared to the locations south of the Danube (23.3 ±15.4 and 41.7 ± 17.1 for grain and hay samples, respectively). GPx activity was measured in a total of 58 blood plasma samples collected from ewes grazing on 5 different locations. The average GPx activity was 157.4 ± 61.9 μkat/L and it followed a pattern similar to the distribution of Se in feedstuffs. GPx activity was higher in samples collected north of the Danube (212.8 ± 91.2 μkat/L), compared to ewes south of the Danube (66.9 ± 14.0 μkat/L). According to the obtained results and literature data Serbia can be described as a selenium deficient area, showing a marked deficiency on the locations south of the Danube.
AB  - Ispitano je ukupno 221 uzoraka biljnih hraniva (187 žitarica i 34 uzoraka sena) sakupljenih sa različitih lokacija na području 15 opština Republike Srbije. Rezultati izraženi u μg/kg pokazali su da je prosečan sadržaj selena 34.3 ± 17.1 μg/kg u uzorcima žitarica i 53.8 ± 18.7 μg/kg u uzorcima sena. Međutim, značajna razlika je uočena između uzoraka koji potiču sa područja severno (52.8 ± 20.0 i 73.4 ± 21.3 za uzorke žitarica i sena) u odnosu na uzorke sa južne strane toka Dunava (23.3 ±15.4 i 41.7 ± 17.1 za uzorke žitarica i sena). Aktivnost GPx je merena u ukupno 58 uzoraka krvne plazme ovaca koje su bile na ispaši na 5 različitih lokacija. Prosečna GPx aktivnost je iznosila 157.4 ± 61.9 μkat/L. Aktivnost GPx je pokazala distribuciju po lokalitetima slično kao i ispitivana biljna hraniva. Naime, aktivnost GPx je bila viša (212.8 ± 91.2 μkat/L) u uzorcima krvi ovaca na ispaši severno od Dunava u odnosu na ovce koje su bile na ispaši na južnim lokalitetima (66.9 ± 14.0 μkat/L). U skladu sa postignutim rezultatima, kao i literaturnim podacima, Srbija može da se svrsta u seleno deficitarne regione, pri čemu lokaliteti južno od toka Dunava pokazuju više izražen deficit. .
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta Veterinaria-Beograd
T1  - Selenium status of feedstuffs and grazing ewes in Serbia
T1  - Status selena u hranivima za ovce na ispaši u Srbiji
VL  - 63
IS  - 5-6
SP  - 665
EP  - 675
DO  - 10.2298/AVB1306665V
ER  - 

@article{
author = "Valčić, Olivera and Jovanović, Ivan B. and Milanović, Svetlana and Gvozdić, Dragan",
year = "2013",
abstract = "A total of 221 feedstuff samples (187 grain samples and 34 hay samples) were collected from 13 different locations on the territory of the Republic of Serbia. The results expressed as μg/kg have shown an average selenium content in grain samples of 34.3 ± 17.1 and 53.8 ± 18.7 in hay samples. However, a distinct difference was noted between samples collected from the locations north of the river Danube (52.8 ± 20.0 and 73.4 ± 21.3 for grain and hay samples, respectively) compared to the locations south of the Danube (23.3 ±15.4 and 41.7 ± 17.1 for grain and hay samples, respectively). GPx activity was measured in a total of 58 blood plasma samples collected from ewes grazing on 5 different locations. The average GPx activity was 157.4 ± 61.9 μkat/L and it followed a pattern similar to the distribution of Se in feedstuffs. GPx activity was higher in samples collected north of the Danube (212.8 ± 91.2 μkat/L), compared to ewes south of the Danube (66.9 ± 14.0 μkat/L). According to the obtained results and literature data Serbia can be described as a selenium deficient area, showing a marked deficiency on the locations south of the Danube., Ispitano je ukupno 221 uzoraka biljnih hraniva (187 žitarica i 34 uzoraka sena) sakupljenih sa različitih lokacija na području 15 opština Republike Srbije. Rezultati izraženi u μg/kg pokazali su da je prosečan sadržaj selena 34.3 ± 17.1 μg/kg u uzorcima žitarica i 53.8 ± 18.7 μg/kg u uzorcima sena. Međutim, značajna razlika je uočena između uzoraka koji potiču sa područja severno (52.8 ± 20.0 i 73.4 ± 21.3 za uzorke žitarica i sena) u odnosu na uzorke sa južne strane toka Dunava (23.3 ±15.4 i 41.7 ± 17.1 za uzorke žitarica i sena). Aktivnost GPx je merena u ukupno 58 uzoraka krvne plazme ovaca koje su bile na ispaši na 5 različitih lokacija. Prosečna GPx aktivnost je iznosila 157.4 ± 61.9 μkat/L. Aktivnost GPx je pokazala distribuciju po lokalitetima slično kao i ispitivana biljna hraniva. Naime, aktivnost GPx je bila viša (212.8 ± 91.2 μkat/L) u uzorcima krvi ovaca na ispaši severno od Dunava u odnosu na ovce koje su bile na ispaši na južnim lokalitetima (66.9 ± 14.0 μkat/L). U skladu sa postignutim rezultatima, kao i literaturnim podacima, Srbija može da se svrsta u seleno deficitarne regione, pri čemu lokaliteti južno od toka Dunava pokazuju više izražen deficit. .",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta Veterinaria-Beograd",
title = "Selenium status of feedstuffs and grazing ewes in Serbia, Status selena u hranivima za ovce na ispaši u Srbiji",
volume = "63",
number = "5-6",
pages = "665-675",
doi = "10.2298/AVB1306665V"
}

Valčić, O., Jovanović, I. B., Milanović, S.,& Gvozdić, D.. (2013). Selenium status of feedstuffs and grazing ewes in Serbia. in Acta Veterinaria-Beograd
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 63(5-6), 665-675.
https://doi.org/10.2298/AVB1306665V

Valčić O, Jovanović IB, Milanović S, Gvozdić D. Selenium status of feedstuffs and grazing ewes in Serbia. in Acta Veterinaria-Beograd. 2013;63(5-6):665-675.
doi:10.2298/AVB1306665V .

Valčić, Olivera, Jovanović, Ivan B., Milanović, Svetlana, Gvozdić, Dragan, "Selenium status of feedstuffs and grazing ewes in Serbia" in Acta Veterinaria-Beograd, 63, no. 5-6 (2013):665-675,
https://doi.org/10.2298/AVB1306665V . .

TY  - JOUR
AU  - Gvozdić, Dragan
AU  - Dovenski, Toni
AU  - Stančić, Ivan
AU  - Stančić, Blagoje
AU  - Božić, Aleksandar
AU  - Jovanović, Ivan B.
AU  - Atanasov, Branko
AU  - Šuluburić, Adam
PY  - 2013
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/975
AB  - Reproduction efficiency in dairy cows is declining all over the world. Epidemiologic studies suggest that diseases have greater effect on herd fertility compared to the parameters like milk production. Immediate solution to the problem of infertility may be the application of some method of hormonal manipulation of estrous cycle in dairy cows. Reproductive system ultrasound examination enables today's veterinarians to visualize ovarian changes during the estrous cycle, giving them a chance to intervene with exogenous hormonal inhibition and/or stimulation of temporary ovarian structures at the appropriate time. Summarizing possible hormonal methods for estrous cycle manipulation we have analyzed following protocols: prostaglandin based protocols, prostaglandin + progestagensin combination, regimes using prostaglandin + gonadotropin-releasing hormone (GnRH) and prostaglandin + GnRH + estradiol protocols. In dairy herds where estrus detection does not represent a significant problem, prostaglandin based or Select Synch protocols are methods of choice for the hormonal manipulation of estrous cycle. However, if there are problems regarding estrus detection Ovsynch or Presynch + Ovsynch could be an effective alternative for the hormonal manipulation of estrous cycle. Furthermore, fixed time artificial insemination (TAI) could be modified to coincide with the second GnRH injection, thus reducing the time and number of visits. .
AB  - Efikasnost reprodukcije kod mlečnih krava ima tendenciju pogoršanja u svim delovima sveta pa i u Republici Srbiji. Epidemiološka ispitivanja ukazuju da se razlozi za smanjenje reproduktivne efikasnosti pre moraju tražiti u parametrima vezanim za pojavu različitih oboljenja nego u porastu proizvodnje mleka. Međutim, trenutno rešenje za problem smanjene plodnosti mlečnih krava najčešće se traži u primeni različitih hormonalnih metoda za manipulaciju estrusnim ciklusom kod mlečnih krava. Ultrazvučni pregled reproduktivnog trakta kod mlečnih krava je omogućio veterinarima da direktno prate promene na jajnicima i uterusu tokom estrusnog ciklusa, otvarajući prostor za pravovremenu primenu hormona radi inhibicije/stimulacije privremenih endokrinih struktura na jajnicima. U našem pokušaju da sumiramo najznačajnije hormonalne metode za manipulaciju estrusnog ciklusa kod mlečnih krava analizirali smo protokole bazirane isključivo na aplikaciji prostaglandina, metode zasnovane na kombinovanju prostaglandina i progestagena, režime manipulacije bazirane na primeni kombinacije prostaglandina i gonadotropnog oslobađajućeg hormona (GnRH), kao i primenu prostaglandina, GnRH i estradiola. U stadima mlečnih krava gde je optimalna detekcija estrusa metoda izbora za hormonalnu manipulaciju estrusnog ciklusa je tzv. Select Synch protokol. Ukoliko je na farmi ustanovljen prisutan problem detekcija estrusa može se primeniti Ovsynch protokol ili kombinacija Presynch i Ovsynch protokola za hormonalnu manipulaciju estrusnog ciklusa. Fiksno vreme veštačkog osemenjavanja koje se sprovodi u toku Ovsynch protokola može se pomeriti tako da se vrši u vreme druge aplikacije GnRH, čime se smanjuje broj fizičkih intervencija i skraćuje trajanje protokola. .
PB  - Univerzitet u Novom Sadu - Poljoprivredni fakultet, Novi Sad i Naučni institut za ratarstvo i povrtarstvo, Novi Sad
T2  - Savremena poljoprivreda
T1  - Hormonal methods for estrous cycle manipulation in dairy cows
T1  - Hormonalne metode za manipulaciju estrusnim ciklusom kod mlečnih krava
VL  - 62
IS  - 3-4
SP  - 319
EP  - 332
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_975
ER  - 

@article{
author = "Gvozdić, Dragan and Dovenski, Toni and Stančić, Ivan and Stančić, Blagoje and Božić, Aleksandar and Jovanović, Ivan B. and Atanasov, Branko and Šuluburić, Adam",
year = "2013",
abstract = "Reproduction efficiency in dairy cows is declining all over the world. Epidemiologic studies suggest that diseases have greater effect on herd fertility compared to the parameters like milk production. Immediate solution to the problem of infertility may be the application of some method of hormonal manipulation of estrous cycle in dairy cows. Reproductive system ultrasound examination enables today's veterinarians to visualize ovarian changes during the estrous cycle, giving them a chance to intervene with exogenous hormonal inhibition and/or stimulation of temporary ovarian structures at the appropriate time. Summarizing possible hormonal methods for estrous cycle manipulation we have analyzed following protocols: prostaglandin based protocols, prostaglandin + progestagensin combination, regimes using prostaglandin + gonadotropin-releasing hormone (GnRH) and prostaglandin + GnRH + estradiol protocols. In dairy herds where estrus detection does not represent a significant problem, prostaglandin based or Select Synch protocols are methods of choice for the hormonal manipulation of estrous cycle. However, if there are problems regarding estrus detection Ovsynch or Presynch + Ovsynch could be an effective alternative for the hormonal manipulation of estrous cycle. Furthermore, fixed time artificial insemination (TAI) could be modified to coincide with the second GnRH injection, thus reducing the time and number of visits. ., Efikasnost reprodukcije kod mlečnih krava ima tendenciju pogoršanja u svim delovima sveta pa i u Republici Srbiji. Epidemiološka ispitivanja ukazuju da se razlozi za smanjenje reproduktivne efikasnosti pre moraju tražiti u parametrima vezanim za pojavu različitih oboljenja nego u porastu proizvodnje mleka. Međutim, trenutno rešenje za problem smanjene plodnosti mlečnih krava najčešće se traži u primeni različitih hormonalnih metoda za manipulaciju estrusnim ciklusom kod mlečnih krava. Ultrazvučni pregled reproduktivnog trakta kod mlečnih krava je omogućio veterinarima da direktno prate promene na jajnicima i uterusu tokom estrusnog ciklusa, otvarajući prostor za pravovremenu primenu hormona radi inhibicije/stimulacije privremenih endokrinih struktura na jajnicima. U našem pokušaju da sumiramo najznačajnije hormonalne metode za manipulaciju estrusnog ciklusa kod mlečnih krava analizirali smo protokole bazirane isključivo na aplikaciji prostaglandina, metode zasnovane na kombinovanju prostaglandina i progestagena, režime manipulacije bazirane na primeni kombinacije prostaglandina i gonadotropnog oslobađajućeg hormona (GnRH), kao i primenu prostaglandina, GnRH i estradiola. U stadima mlečnih krava gde je optimalna detekcija estrusa metoda izbora za hormonalnu manipulaciju estrusnog ciklusa je tzv. Select Synch protokol. Ukoliko je na farmi ustanovljen prisutan problem detekcija estrusa može se primeniti Ovsynch protokol ili kombinacija Presynch i Ovsynch protokola za hormonalnu manipulaciju estrusnog ciklusa. Fiksno vreme veštačkog osemenjavanja koje se sprovodi u toku Ovsynch protokola može se pomeriti tako da se vrši u vreme druge aplikacije GnRH, čime se smanjuje broj fizičkih intervencija i skraćuje trajanje protokola. .",
publisher = "Univerzitet u Novom Sadu - Poljoprivredni fakultet, Novi Sad i Naučni institut za ratarstvo i povrtarstvo, Novi Sad",
journal = "Savremena poljoprivreda",
title = "Hormonal methods for estrous cycle manipulation in dairy cows, Hormonalne metode za manipulaciju estrusnim ciklusom kod mlečnih krava",
volume = "62",
number = "3-4",
pages = "319-332",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_975"
}

Gvozdić, D., Dovenski, T., Stančić, I., Stančić, B., Božić, A., Jovanović, I. B., Atanasov, B.,& Šuluburić, A.. (2013). Hormonal methods for estrous cycle manipulation in dairy cows. in Savremena poljoprivreda
Univerzitet u Novom Sadu - Poljoprivredni fakultet, Novi Sad i Naučni institut za ratarstvo i povrtarstvo, Novi Sad., 62(3-4), 319-332.
https://hdl.handle.net/21.15107/rcub_veterinar_975

Gvozdić D, Dovenski T, Stančić I, Stančić B, Božić A, Jovanović IB, Atanasov B, Šuluburić A. Hormonal methods for estrous cycle manipulation in dairy cows. in Savremena poljoprivreda. 2013;62(3-4):319-332.
https://hdl.handle.net/21.15107/rcub_veterinar_975 .

Gvozdić, Dragan, Dovenski, Toni, Stančić, Ivan, Stančić, Blagoje, Božić, Aleksandar, Jovanović, Ivan B., Atanasov, Branko, Šuluburić, Adam, "Hormonal methods for estrous cycle manipulation in dairy cows" in Savremena poljoprivreda, 62, no. 3-4 (2013):319-332,
https://hdl.handle.net/21.15107/rcub_veterinar_975 .

TY  - CONF
AU  - Šefer, Dragan
AU  - Petrujkić, Branko
AU  - Jovičin, Milovan
AU  - Jovanović, Ivan B.
AU  - Marković, Radmila
AU  - Jovanović, Dragoljub
PY  - 2012
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2675
AB  - Pored učešća u enzimskim sistemima koji šteite organiizam od štetnog dejstva slobodnih radikala, selen je i esencijalni element za očuvanje reprodukcije (spermatogeneze) i embrionalnog razvoja. Problemi koji se najčešće dovode u vezu sa deficitom selena obuhvataju smanjenu plodnost, zadržavanje posteljice krava, nižu proizvodnju mleka i vune (kod ovaca), niži prirast i slabost mišića mladunaca.
Sadržaj selena u hrani biljnog porekla u značajnoj meri varira, tako da koncentracije selena u kukuruzu gajenom na zemljištu siromašnom u selenu može biti i do pet puta manja u poređenju sa kukuruzom gajenom na zemljištu bogatom u selenu. Zbog pomenutog kao i činjenice da je Srbija područje izraženog do umerenog deficita, selen se dodaje u hranu za životinje.
Veliki broj istraživača je potvrdio da je selen neophodan element za normalan razvoj spermatozoida, pre svega zbog činjenice da se ugrađuje u proteine membrane mitohondrija. Selen je, takođe, komponenta enzimskog sistema glutation peroksidaze, enzima koji štiti ćeliju od štetnog dejstva slobodnih radikala, odnosno deluje kao antioksidans, i štiti lipide membrane. Dodavanje selena u hranu za životinje, utiče na smanjenje broja patološki izmenjenih spermatozoida, kod sisara i ptica. Upotreba selena kao dodatka hrani za životinje ima nutritivno, medicinsko i ekonomsko opravdanje.
PB  - Beograd : Fakultet veterinarske medicine Univerziteta u Beogradu, Katedra za porodiljstvo, sterilitet i veštačko osemenjavanje, Naučna KMD
C3  - Naučni simpozijum Reprodukcija domaćih životinja i bolesti novorođenčadi, Divčibare, 4-7. oktobar 2012.
T1  - Uticaj selena u hrani na kvalitet sperme
SP  - 3
EP  - 12
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_2675
ER  - 

@conference{
author = "Šefer, Dragan and Petrujkić, Branko and Jovičin, Milovan and Jovanović, Ivan B. and Marković, Radmila and Jovanović, Dragoljub",
year = "2012",
abstract = "Pored učešća u enzimskim sistemima koji šteite organiizam od štetnog dejstva slobodnih radikala, selen je i esencijalni element za očuvanje reprodukcije (spermatogeneze) i embrionalnog razvoja. Problemi koji se najčešće dovode u vezu sa deficitom selena obuhvataju smanjenu plodnost, zadržavanje posteljice krava, nižu proizvodnju mleka i vune (kod ovaca), niži prirast i slabost mišića mladunaca.
Sadržaj selena u hrani biljnog porekla u značajnoj meri varira, tako da koncentracije selena u kukuruzu gajenom na zemljištu siromašnom u selenu može biti i do pet puta manja u poređenju sa kukuruzom gajenom na zemljištu bogatom u selenu. Zbog pomenutog kao i činjenice da je Srbija područje izraženog do umerenog deficita, selen se dodaje u hranu za životinje.
Veliki broj istraživača je potvrdio da je selen neophodan element za normalan razvoj spermatozoida, pre svega zbog činjenice da se ugrađuje u proteine membrane mitohondrija. Selen je, takođe, komponenta enzimskog sistema glutation peroksidaze, enzima koji štiti ćeliju od štetnog dejstva slobodnih radikala, odnosno deluje kao antioksidans, i štiti lipide membrane. Dodavanje selena u hranu za životinje, utiče na smanjenje broja patološki izmenjenih spermatozoida, kod sisara i ptica. Upotreba selena kao dodatka hrani za životinje ima nutritivno, medicinsko i ekonomsko opravdanje.",
publisher = "Beograd : Fakultet veterinarske medicine Univerziteta u Beogradu, Katedra za porodiljstvo, sterilitet i veštačko osemenjavanje, Naučna KMD",
journal = "Naučni simpozijum Reprodukcija domaćih životinja i bolesti novorođenčadi, Divčibare, 4-7. oktobar 2012.",
title = "Uticaj selena u hrani na kvalitet sperme",
pages = "3-12",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_2675"
}

Šefer, D., Petrujkić, B., Jovičin, M., Jovanović, I. B., Marković, R.,& Jovanović, D.. (2012). Uticaj selena u hrani na kvalitet sperme. in Naučni simpozijum Reprodukcija domaćih životinja i bolesti novorođenčadi, Divčibare, 4-7. oktobar 2012.
Beograd : Fakultet veterinarske medicine Univerziteta u Beogradu, Katedra za porodiljstvo, sterilitet i veštačko osemenjavanje, Naučna KMD., 3-12.
https://hdl.handle.net/21.15107/rcub_veterinar_2675

Šefer D, Petrujkić B, Jovičin M, Jovanović IB, Marković R, Jovanović D. Uticaj selena u hrani na kvalitet sperme. in Naučni simpozijum Reprodukcija domaćih životinja i bolesti novorođenčadi, Divčibare, 4-7. oktobar 2012.. 2012;:3-12.
https://hdl.handle.net/21.15107/rcub_veterinar_2675 .

Šefer, Dragan, Petrujkić, Branko, Jovičin, Milovan, Jovanović, Ivan B., Marković, Radmila, Jovanović, Dragoljub, "Uticaj selena u hrani na kvalitet sperme" in Naučni simpozijum Reprodukcija domaćih životinja i bolesti novorođenčadi, Divčibare, 4-7. oktobar 2012. (2012):3-12,
https://hdl.handle.net/21.15107/rcub_veterinar_2675 .

TY  - JOUR
AU  - Valčić, Olivera
AU  - Jovanović, Ivan B.
AU  - Milanović, Svetlana
AU  - Veličković, Miljan
AU  - Gvozdić, Dragan
PY  - 2011
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2077
AB  - Vreme oko partusa kod mlečnih krava smatra se najosetljivijim periodom sa više aspekata, među kojima se posebno ističu prestrojavanje metabolizma u pravcu laktacije i posledično povećanje oksidativnog stresa organizma. Osim toga, indukcija porođaja uz pomoć PGF2α dodatno povećava učestalost retencije posteljice.
U sistem odbrane od oksidativnog stresa ukljuceni su neenzimski molekuli (vitamini C i E i glutation) i enzimi: superoksid dismutaza, katalaza i glutation peroksidaza. Selenoenzim glutation peroksidaza redukuje nastale hidroperokside masnih kiselina, čime prekida lančanu reakciju oštećenja lipida ćelijske membrane. malondialdehid (MDA), nastao neenzimskim cepanjem lipidnih hidroperoksida, može ukankrsno da se veže za druge biološke molekule, čime dovodi do citotoksičnosti i mutagenosti. Koncentracija MDA u krvnoj plazmi predstavlja dobar indikator stepena oksidativnog oštećenja lipida u organizmu.
Cilj našeg rada je bio da ustanovimo promene koncentracije MDA u krvnoj plazmi tokom teljenja i u peripartalnom periodu, 12 sati pre i nakon partusa, kao i uspešnost izbacivanja posteljice kod krava čiji je porođaj indukovan prostaglandinom.
Ogled je izvršen na kravama Holštajn-frizijske rase podeljenim u tri grupe: 1) nesumplementirana kontrolna grupa (n=9), 2) grupa tretirana sa 20 ml (n=11) i 3) sa 40 ml (n=13) Promtselena® 30 dana pre partusa. Koncentracija MDA u krvi je određivana spektrofotometrijski.
Koncentracije MDA u plazmi krava suplementiranih sa 20 ml Promtselena 12 časova pre porođaja (4,59 ± 1,20), tokom porođaja (4,44 ± 0,68) i 12 časova nakon porođaja (4,67 ± 0,80), bile su značajno niže u odnosu na kontrolnu grupu. Grupa tretirana sa 40 ml Promtselena je od svih posmatranih životinja imala najizrazitije smanjene vrednosti MDA u plazmi 12 sati pre partusa. Tretmani sa 20 ml i 40 ml Promtselena® rezultirali su značajnim smanjenjem učestalosti retencije posteljice (38,2% i 30,8%) u odnosu na netretiranu grupu (66,67%).
Možemo zaključiti da aplikacija 20 ml i 40 ml Promtselena 30 dana pre indukcije porođaja rezultira statistički značajnim smanjenjem MDA u plazmi tokom peripartalnog perioda, kao i značajnim smanjenjem učestalosti zaostajanja posteljice.
AB  - The time close to calving in dairy cows is considered as the most sensitive period from more aspects, among which most relevant are the metabolic shift due to lactation and subsequently increased oxidative stress. Besides, PGF2 induction of delivery additionally increases the incidence of retained placenta. The oxidative stress defense mechanisms consist of nonenzymatic molecules (vitamins C and E, glutathione) and enzymes: superoxide dismutase, catalase and glutathione peroxidase. 
The selenoenzyme glutathione peroxidase reduces the formed fatty acids hydroperoxides, thus interruptting the chain reaction of damage to the cell membrane lipids. Malondialdehyde (MDA), formed by nonenzymatic fission can cross link to other biological molecules which results in cytotoxicity and mutations. The concentration of MDA in blood plasma is a good indicator of the degree of oxidative damage in the organism. 
The aim of this study was to determine changes in MDA concentration in the blood plasma during calving and in the peripartal period, 12h before and after calving, as well as the success rate in the expulsion of the placenta in cows with prostaglandin induced delivery. 
The experiment was done on dairy Holstein Friesian cows allotted into 3 groups: 1) not supplemented control group (n=9), 2) group treated with 20 mL (n=11) and 3) with 40 mL (n=13) Promtselen® 30 days before calving. MDA plasma concentration was measured spectrophotometrically. 
Plasma MDA concentrations in cows supplemented with 20 mL Promtselen® 12h before calving were (4.59 ± 1.20), at calving (4.44 ± 0.68) and 12h after delivery (4.67 ± 0.80), were significantly lower compared to the control group. The group treated with 40 mL Promtselen® had the lowest MDA results of all groups at 12h after calving. Treatments with 20 mL and 40 mL Promtselen® resulted in a significant decrease in placenta retention (38.2% and 30.8%) compared with the control group (66.67%). 
It can be concluded that application of 20 and 40 mL Promtselen® 30 days before induction of calving resulted in a statistically significant reduction of plasma MDA concentrations during the peripartal period, as well as with a significant reduction in retained placenta.
PB  - Banja Luka : PI Veterinary Institute Republic of Srpska „Dr. Vaso Butozan“
T2  - Veterinarski žurnal Republike Srpske
T1  - Efekat dodavanja selena (Promtselen®) na koncentraciju MDA i učestalost zaostajanja posteljice kod krava kojima je indukovan partus
T1  - Effects of selenium supplementation (Promtselen®) on MDA concentration and frequency of retaind placenta in cows with induced calving
VL  - 11
IS  - 2
SP  - 148
EP  - 154
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_2077
ER  - 

@article{
author = "Valčić, Olivera and Jovanović, Ivan B. and Milanović, Svetlana and Veličković, Miljan and Gvozdić, Dragan",
year = "2011",
abstract = "Vreme oko partusa kod mlečnih krava smatra se najosetljivijim periodom sa više aspekata, među kojima se posebno ističu prestrojavanje metabolizma u pravcu laktacije i posledično povećanje oksidativnog stresa organizma. Osim toga, indukcija porođaja uz pomoć PGF2α dodatno povećava učestalost retencije posteljice.
U sistem odbrane od oksidativnog stresa ukljuceni su neenzimski molekuli (vitamini C i E i glutation) i enzimi: superoksid dismutaza, katalaza i glutation peroksidaza. Selenoenzim glutation peroksidaza redukuje nastale hidroperokside masnih kiselina, čime prekida lančanu reakciju oštećenja lipida ćelijske membrane. malondialdehid (MDA), nastao neenzimskim cepanjem lipidnih hidroperoksida, može ukankrsno da se veže za druge biološke molekule, čime dovodi do citotoksičnosti i mutagenosti. Koncentracija MDA u krvnoj plazmi predstavlja dobar indikator stepena oksidativnog oštećenja lipida u organizmu.
Cilj našeg rada je bio da ustanovimo promene koncentracije MDA u krvnoj plazmi tokom teljenja i u peripartalnom periodu, 12 sati pre i nakon partusa, kao i uspešnost izbacivanja posteljice kod krava čiji je porođaj indukovan prostaglandinom.
Ogled je izvršen na kravama Holštajn-frizijske rase podeljenim u tri grupe: 1) nesumplementirana kontrolna grupa (n=9), 2) grupa tretirana sa 20 ml (n=11) i 3) sa 40 ml (n=13) Promtselena® 30 dana pre partusa. Koncentracija MDA u krvi je određivana spektrofotometrijski.
Koncentracije MDA u plazmi krava suplementiranih sa 20 ml Promtselena 12 časova pre porođaja (4,59 ± 1,20), tokom porođaja (4,44 ± 0,68) i 12 časova nakon porođaja (4,67 ± 0,80), bile su značajno niže u odnosu na kontrolnu grupu. Grupa tretirana sa 40 ml Promtselena je od svih posmatranih životinja imala najizrazitije smanjene vrednosti MDA u plazmi 12 sati pre partusa. Tretmani sa 20 ml i 40 ml Promtselena® rezultirali su značajnim smanjenjem učestalosti retencije posteljice (38,2% i 30,8%) u odnosu na netretiranu grupu (66,67%).
Možemo zaključiti da aplikacija 20 ml i 40 ml Promtselena 30 dana pre indukcije porođaja rezultira statistički značajnim smanjenjem MDA u plazmi tokom peripartalnog perioda, kao i značajnim smanjenjem učestalosti zaostajanja posteljice., The time close to calving in dairy cows is considered as the most sensitive period from more aspects, among which most relevant are the metabolic shift due to lactation and subsequently increased oxidative stress. Besides, PGF2 induction of delivery additionally increases the incidence of retained placenta. The oxidative stress defense mechanisms consist of nonenzymatic molecules (vitamins C and E, glutathione) and enzymes: superoxide dismutase, catalase and glutathione peroxidase. 
The selenoenzyme glutathione peroxidase reduces the formed fatty acids hydroperoxides, thus interruptting the chain reaction of damage to the cell membrane lipids. Malondialdehyde (MDA), formed by nonenzymatic fission can cross link to other biological molecules which results in cytotoxicity and mutations. The concentration of MDA in blood plasma is a good indicator of the degree of oxidative damage in the organism. 
The aim of this study was to determine changes in MDA concentration in the blood plasma during calving and in the peripartal period, 12h before and after calving, as well as the success rate in the expulsion of the placenta in cows with prostaglandin induced delivery. 
The experiment was done on dairy Holstein Friesian cows allotted into 3 groups: 1) not supplemented control group (n=9), 2) group treated with 20 mL (n=11) and 3) with 40 mL (n=13) Promtselen® 30 days before calving. MDA plasma concentration was measured spectrophotometrically. 
Plasma MDA concentrations in cows supplemented with 20 mL Promtselen® 12h before calving were (4.59 ± 1.20), at calving (4.44 ± 0.68) and 12h after delivery (4.67 ± 0.80), were significantly lower compared to the control group. The group treated with 40 mL Promtselen® had the lowest MDA results of all groups at 12h after calving. Treatments with 20 mL and 40 mL Promtselen® resulted in a significant decrease in placenta retention (38.2% and 30.8%) compared with the control group (66.67%). 
It can be concluded that application of 20 and 40 mL Promtselen® 30 days before induction of calving resulted in a statistically significant reduction of plasma MDA concentrations during the peripartal period, as well as with a significant reduction in retained placenta.",
publisher = "Banja Luka : PI Veterinary Institute Republic of Srpska „Dr. Vaso Butozan“",
journal = "Veterinarski žurnal Republike Srpske",
title = "Efekat dodavanja selena (Promtselen®) na koncentraciju MDA i učestalost zaostajanja posteljice kod krava kojima je indukovan partus, Effects of selenium supplementation (Promtselen®) on MDA concentration and frequency of retaind placenta in cows with induced calving",
volume = "11",
number = "2",
pages = "148-154",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_2077"
}

Valčić, O., Jovanović, I. B., Milanović, S., Veličković, M.,& Gvozdić, D.. (2011). Efekat dodavanja selena (Promtselen®) na koncentraciju MDA i učestalost zaostajanja posteljice kod krava kojima je indukovan partus. in Veterinarski žurnal Republike Srpske
Banja Luka : PI Veterinary Institute Republic of Srpska „Dr. Vaso Butozan“., 11(2), 148-154.
https://hdl.handle.net/21.15107/rcub_veterinar_2077

Valčić O, Jovanović IB, Milanović S, Veličković M, Gvozdić D. Efekat dodavanja selena (Promtselen®) na koncentraciju MDA i učestalost zaostajanja posteljice kod krava kojima je indukovan partus. in Veterinarski žurnal Republike Srpske. 2011;11(2):148-154.
https://hdl.handle.net/21.15107/rcub_veterinar_2077 .

Valčić, Olivera, Jovanović, Ivan B., Milanović, Svetlana, Veličković, Miljan, Gvozdić, Dragan, "Efekat dodavanja selena (Promtselen®) na koncentraciju MDA i učestalost zaostajanja posteljice kod krava kojima je indukovan partus" in Veterinarski žurnal Republike Srpske, 11, no. 2 (2011):148-154,
https://hdl.handle.net/21.15107/rcub_veterinar_2077 .

TY  - CONF
AU  - Gvozdić, Dragan
AU  - Jovanović, Ivan
AU  - Milanović, Svetlana
AU  - Fratrić, Natalija
PY  - 2011
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/3807
PB  - Beograd : Naučna KMD
C3  - Naučni simpozijum Reprodukcija domaćih životinja, Divčibare, 13 - 16. oktobar 2011
T1  - Efikasnost reprodukcije mlečnih krava
SP  - 3
EP  - 14
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_3807
ER  - 

@conference{
author = "Gvozdić, Dragan and Jovanović, Ivan and Milanović, Svetlana and Fratrić, Natalija",
year = "2011",
publisher = "Beograd : Naučna KMD",
journal = "Naučni simpozijum Reprodukcija domaćih životinja, Divčibare, 13 - 16. oktobar 2011",
title = "Efikasnost reprodukcije mlečnih krava",
pages = "3-14",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_3807"
}

Gvozdić, D., Jovanović, I., Milanović, S.,& Fratrić, N.. (2011). Efikasnost reprodukcije mlečnih krava. in Naučni simpozijum Reprodukcija domaćih životinja, Divčibare, 13 - 16. oktobar 2011
Beograd : Naučna KMD., 3-14.
https://hdl.handle.net/21.15107/rcub_veterinar_3807

Gvozdić D, Jovanović I, Milanović S, Fratrić N. Efikasnost reprodukcije mlečnih krava. in Naučni simpozijum Reprodukcija domaćih životinja, Divčibare, 13 - 16. oktobar 2011. 2011;:3-14.
https://hdl.handle.net/21.15107/rcub_veterinar_3807 .

Gvozdić, Dragan, Jovanović, Ivan, Milanović, Svetlana, Fratrić, Natalija, "Efikasnost reprodukcije mlečnih krava" in Naučni simpozijum Reprodukcija domaćih životinja, Divčibare, 13 - 16. oktobar 2011 (2011):3-14,
https://hdl.handle.net/21.15107/rcub_veterinar_3807 .