Cyclosporine A (CsA) treatment of chronic autoimune-mediated keratoconjunctivitis sicca in dogs
Ciklosporin A u terapiji hroničnog autoimunog keratoconjunctivitis sica kod pasa
Апстракт
The paper is a five year retrospective study of the efficacy of 0.2% Cyclosporine A eye cream in the treatment of chronic autoimmunemediated KCS in dogs. 114 dogs of 32 breeds, both sexes, and different ages with chronic autoimmune-mediated KCS were treated with 0.2% Cyclosporine A in the form of eye cream (Optimmune®, Schering - Plough Animal Health) applied to the lower lid conjunctiva at a dose of 6 mm length of the cream strip every 12 hours, during 90 days. Dogs treated with CsA had an improved STT score, specially dogs which had STT values >5 mm/min at the start. Improvement of the clinical picture and healing of superficial corneal lesions were also recorded.
U ovom radu je izneta petogodišnja retrospektivna studija o efikasnosti ciklosporin A kreme za oči u terapiji hroničnog autoimunog keratoconjunctivitis sicca kod pasa. Ukupno 114 pasa, 32 rase, oba pola i različite starosti sa hroničnim autoimunim KCS tretirano je ciklosporinom A u vidu kreme za oči (Optimmune®, Schering-Plough Ainimal Health), aplikovanjem na konjunktivu donjeg kapka u dozi od 6 mm dužine kreme na svakih 12 sati tokom 90 dana. Kod pasa tretiranih sa CsA došlo je do povećanja vrednosti Širmerovog suznog testa, naročito kod pasa koji su na početku imali STT vrednost >5 mm/min. Takođe je došlo i do poboljšanja kliničke slike i izlečenja površinskih kornealnih lezija.
Кључне речи:
autoimmune-mediated / Cyclosporine A / dogs / keratoconjunctivitis sicca / Schirmer Tear TestИзвор:
Acta Veterinaria-Beograd, 2013, 63, 5-6, 677-685Издавач:
- Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
DOI: 10.2298/AVB1306677H
ISSN: 0567-8315
WoS: 000329380800017
Scopus: 2-s2.0-84894327123
Колекције
Институција/група
Fakultet veterinarske medicineTY - JOUR AU - Hadži-Milić, Milan AU - Đorđević, Jelena AU - Krstić, Nikola PY - 2013 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1005 AB - The paper is a five year retrospective study of the efficacy of 0.2% Cyclosporine A eye cream in the treatment of chronic autoimmunemediated KCS in dogs. 114 dogs of 32 breeds, both sexes, and different ages with chronic autoimmune-mediated KCS were treated with 0.2% Cyclosporine A in the form of eye cream (Optimmune®, Schering - Plough Animal Health) applied to the lower lid conjunctiva at a dose of 6 mm length of the cream strip every 12 hours, during 90 days. Dogs treated with CsA had an improved STT score, specially dogs which had STT values >5 mm/min at the start. Improvement of the clinical picture and healing of superficial corneal lesions were also recorded. AB - U ovom radu je izneta petogodišnja retrospektivna studija o efikasnosti ciklosporin A kreme za oči u terapiji hroničnog autoimunog keratoconjunctivitis sicca kod pasa. Ukupno 114 pasa, 32 rase, oba pola i različite starosti sa hroničnim autoimunim KCS tretirano je ciklosporinom A u vidu kreme za oči (Optimmune®, Schering-Plough Ainimal Health), aplikovanjem na konjunktivu donjeg kapka u dozi od 6 mm dužine kreme na svakih 12 sati tokom 90 dana. Kod pasa tretiranih sa CsA došlo je do povećanja vrednosti Širmerovog suznog testa, naročito kod pasa koji su na početku imali STT vrednost >5 mm/min. Takođe je došlo i do poboljšanja kliničke slike i izlečenja površinskih kornealnih lezija. PB - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd T2 - Acta Veterinaria-Beograd T1 - Cyclosporine A (CsA) treatment of chronic autoimune-mediated keratoconjunctivitis sicca in dogs T1 - Ciklosporin A u terapiji hroničnog autoimunog keratoconjunctivitis sica kod pasa VL - 63 IS - 5-6 SP - 677 EP - 685 DO - 10.2298/AVB1306677H ER -
@article{ author = "Hadži-Milić, Milan and Đorđević, Jelena and Krstić, Nikola", year = "2013", abstract = "The paper is a five year retrospective study of the efficacy of 0.2% Cyclosporine A eye cream in the treatment of chronic autoimmunemediated KCS in dogs. 114 dogs of 32 breeds, both sexes, and different ages with chronic autoimmune-mediated KCS were treated with 0.2% Cyclosporine A in the form of eye cream (Optimmune®, Schering - Plough Animal Health) applied to the lower lid conjunctiva at a dose of 6 mm length of the cream strip every 12 hours, during 90 days. Dogs treated with CsA had an improved STT score, specially dogs which had STT values >5 mm/min at the start. Improvement of the clinical picture and healing of superficial corneal lesions were also recorded., U ovom radu je izneta petogodišnja retrospektivna studija o efikasnosti ciklosporin A kreme za oči u terapiji hroničnog autoimunog keratoconjunctivitis sicca kod pasa. Ukupno 114 pasa, 32 rase, oba pola i različite starosti sa hroničnim autoimunim KCS tretirano je ciklosporinom A u vidu kreme za oči (Optimmune®, Schering-Plough Ainimal Health), aplikovanjem na konjunktivu donjeg kapka u dozi od 6 mm dužine kreme na svakih 12 sati tokom 90 dana. Kod pasa tretiranih sa CsA došlo je do povećanja vrednosti Širmerovog suznog testa, naročito kod pasa koji su na početku imali STT vrednost >5 mm/min. Takođe je došlo i do poboljšanja kliničke slike i izlečenja površinskih kornealnih lezija.", publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd", journal = "Acta Veterinaria-Beograd", title = "Cyclosporine A (CsA) treatment of chronic autoimune-mediated keratoconjunctivitis sicca in dogs, Ciklosporin A u terapiji hroničnog autoimunog keratoconjunctivitis sica kod pasa", volume = "63", number = "5-6", pages = "677-685", doi = "10.2298/AVB1306677H" }
Hadži-Milić, M., Đorđević, J.,& Krstić, N.. (2013). Cyclosporine A (CsA) treatment of chronic autoimune-mediated keratoconjunctivitis sicca in dogs. in Acta Veterinaria-Beograd Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 63(5-6), 677-685. https://doi.org/10.2298/AVB1306677H
Hadži-Milić M, Đorđević J, Krstić N. Cyclosporine A (CsA) treatment of chronic autoimune-mediated keratoconjunctivitis sicca in dogs. in Acta Veterinaria-Beograd. 2013;63(5-6):677-685. doi:10.2298/AVB1306677H .
Hadži-Milić, Milan, Đorđević, Jelena, Krstić, Nikola, "Cyclosporine A (CsA) treatment of chronic autoimune-mediated keratoconjunctivitis sicca in dogs" in Acta Veterinaria-Beograd, 63, no. 5-6 (2013):677-685, https://doi.org/10.2298/AVB1306677H . .