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Blood and plasma selenium levels and GSH-Px activities in patients with arterial hypertension and chronic heart disease
dc.creator | Mihailović, M.B. | |
dc.creator | Avramović, D.M. | |
dc.creator | Jovanović, Ivan B. | |
dc.creator | Pešut, O.J. | |
dc.creator | Matić, D.P. | |
dc.creator | Stojanov, V.J. | |
dc.date.accessioned | 2020-06-03T12:38:35Z | |
dc.date.available | 2020-06-03T12:38:35Z | |
dc.date.issued | 1998 | |
dc.identifier.issn | 0731-8898 | |
dc.identifier.uri | https://vet-erinar.vet.bg.ac.rs/handle/123456789/103 | |
dc.description.abstract | The purpose of this study was to examine the relationship between arterial hypertension (HTN), chronic heart disease (CHD), and selenium (Se) status. Blood and plasma Se concentrations and Se-dependent GSH-Px activities were determined in 40 patients (HTN = 20; CHD = 20) and 17 healthy volunteers aged 41 to 66 years. Whole blood and plasma Se concentrations were significantly lower in the patients with HTN (19.1% and 26.3%, respectively) and CHD (33.1% and 29.4%, respectively) compared with the values obtained in the controls. The hypertensive patients had lower plasma SeGSH-Px (26.7%), and those with CHD had both lower whole blood (19.5%) and plasma Se-GSH-Px activities (30.2%). A significant positive correlation between plasma Se- GSH-Px activity and ejection fraction (EF) was found in patients with CHD. There were significant correlations between plasma and whole blood Se concentration, plasma Se concentration and Se-GSH-Px activity, and whole blood Se and Se-GSH-Px activity. Our results showed that hypertensive patients and those with CHD had lower Se levels compared with controls. We conclude that low Se content might be a risk factor for development of HTN and CHD. | en |
dc.publisher | Begell House Inc. | |
dc.rights | restrictedAccess | |
dc.source | Journal of Environmental Pathology, Toxicology and Oncology | |
dc.subject | Arterial hypertension | en |
dc.subject | Glutathione peroxidase | en |
dc.subject | Heart failure | en |
dc.subject | Selenium | en |
dc.title | Blood and plasma selenium levels and GSH-Px activities in patients with arterial hypertension and chronic heart disease | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Пешут, О.Ј.; Матић, Д.П.; Стојанов, В.Ј.; Јовановић, Иван; Михаиловић, М.Б.; Aврамовић, Д.М.; | |
dc.citation.volume | 17 | |
dc.citation.issue | 3-4 | |
dc.citation.spage | 285 | |
dc.citation.epage | 289 | |
dc.citation.other | 17(3-4): 285-289 | |
dc.identifier.pmid | 9726804 | |
dc.identifier.scopus | 2-s2.0-0031874563 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_veterinar_103 | |
dc.type.version | publishedVersion |
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