Cytogenetic alterations in peripheral cells of Alzheimer s disease patients
2014
Authors
Plecas-Solarović, BosiljkaĐelić, Ninoslav
Bajić, Vladan
Živković, Lada
Spremo-Potparević, Biljana
Article (Published version)
Metadata
Show full item recordAbstract
Alzheimers disease (AD) is the most frequent progressive neurodegenerative disorder in elderly associated with irreversible cognitive impairment and dementia. The vast majority of AD patients are sporadic (SAD) in which the disease develops after age of 65. Despite of century of research, we lack understanding of the SAD etiology and pathogenesis. Several hypotheses try to explain the main causes of brain degeneration in SAD, one of them assuming that genomic instability and the reentry of certain neurons into the incomplete cell cycle may be the pathogenic basis of the disease. Although the brain is the most affected organ in AD, numerous studies showed structural and functional alterations in peripheral tissues, suggesting that AD is a generalized systemic disorder. Diverse changes in peripheral cells from AD patients are described in literature including cell cycle aberration and chromosome instability, alterations in cell viability, proliferation and apoptosis, oxidative metabolism..., amyloid precursor protein and amyloid beta protein metabolism, and other cellular processes. The aim of this paper was to summarize and review the results of our investigations and the growing literature data concerning the multiple chromosomal alterations in peripheral cells of AD patients and to consider their possible role in the disease pathogenesis as well as the importance of such investigations.
Keywords:
Alzheimer's disease / chromosome instability / peripheral cellsSource:
Genetika, 2014, 46, 1, 315-330Publisher:
- Društvo genetičara Srbije, Beograd
Funding / projects:
- Cell Cycle Aberrations and the Impact of Oxidative Stress in Neurodegenerative Processes and Malignant Transformation of the Cell (RS-MESTD-Basic Research (BR or ON)-173034)
DOI: 10.2298/GENSR1401315P
ISSN: 0534-0012
WoS: 000338930500031
Scopus: 2-s2.0-84900399583
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Fakultet veterinarske medicineTY - JOUR AU - Plecas-Solarović, Bosiljka AU - Đelić, Ninoslav AU - Bajić, Vladan AU - Živković, Lada AU - Spremo-Potparević, Biljana PY - 2014 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1101 AB - Alzheimers disease (AD) is the most frequent progressive neurodegenerative disorder in elderly associated with irreversible cognitive impairment and dementia. The vast majority of AD patients are sporadic (SAD) in which the disease develops after age of 65. Despite of century of research, we lack understanding of the SAD etiology and pathogenesis. Several hypotheses try to explain the main causes of brain degeneration in SAD, one of them assuming that genomic instability and the reentry of certain neurons into the incomplete cell cycle may be the pathogenic basis of the disease. Although the brain is the most affected organ in AD, numerous studies showed structural and functional alterations in peripheral tissues, suggesting that AD is a generalized systemic disorder. Diverse changes in peripheral cells from AD patients are described in literature including cell cycle aberration and chromosome instability, alterations in cell viability, proliferation and apoptosis, oxidative metabolism, amyloid precursor protein and amyloid beta protein metabolism, and other cellular processes. The aim of this paper was to summarize and review the results of our investigations and the growing literature data concerning the multiple chromosomal alterations in peripheral cells of AD patients and to consider their possible role in the disease pathogenesis as well as the importance of such investigations. PB - Društvo genetičara Srbije, Beograd T2 - Genetika T1 - Cytogenetic alterations in peripheral cells of Alzheimer s disease patients VL - 46 IS - 1 SP - 315 EP - 330 DO - 10.2298/GENSR1401315P ER -
@article{ author = "Plecas-Solarović, Bosiljka and Đelić, Ninoslav and Bajić, Vladan and Živković, Lada and Spremo-Potparević, Biljana", year = "2014", abstract = "Alzheimers disease (AD) is the most frequent progressive neurodegenerative disorder in elderly associated with irreversible cognitive impairment and dementia. The vast majority of AD patients are sporadic (SAD) in which the disease develops after age of 65. Despite of century of research, we lack understanding of the SAD etiology and pathogenesis. Several hypotheses try to explain the main causes of brain degeneration in SAD, one of them assuming that genomic instability and the reentry of certain neurons into the incomplete cell cycle may be the pathogenic basis of the disease. Although the brain is the most affected organ in AD, numerous studies showed structural and functional alterations in peripheral tissues, suggesting that AD is a generalized systemic disorder. Diverse changes in peripheral cells from AD patients are described in literature including cell cycle aberration and chromosome instability, alterations in cell viability, proliferation and apoptosis, oxidative metabolism, amyloid precursor protein and amyloid beta protein metabolism, and other cellular processes. The aim of this paper was to summarize and review the results of our investigations and the growing literature data concerning the multiple chromosomal alterations in peripheral cells of AD patients and to consider their possible role in the disease pathogenesis as well as the importance of such investigations.", publisher = "Društvo genetičara Srbije, Beograd", journal = "Genetika", title = "Cytogenetic alterations in peripheral cells of Alzheimer s disease patients", volume = "46", number = "1", pages = "315-330", doi = "10.2298/GENSR1401315P" }
Plecas-Solarović, B., Đelić, N., Bajić, V., Živković, L.,& Spremo-Potparević, B.. (2014). Cytogenetic alterations in peripheral cells of Alzheimer s disease patients. in Genetika Društvo genetičara Srbije, Beograd., 46(1), 315-330. https://doi.org/10.2298/GENSR1401315P
Plecas-Solarović B, Đelić N, Bajić V, Živković L, Spremo-Potparević B. Cytogenetic alterations in peripheral cells of Alzheimer s disease patients. in Genetika. 2014;46(1):315-330. doi:10.2298/GENSR1401315P .
Plecas-Solarović, Bosiljka, Đelić, Ninoslav, Bajić, Vladan, Živković, Lada, Spremo-Potparević, Biljana, "Cytogenetic alterations in peripheral cells of Alzheimer s disease patients" in Genetika, 46, no. 1 (2014):315-330, https://doi.org/10.2298/GENSR1401315P . .