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dc.creatorPlecas-Solarović, Bosiljka
dc.creatorĐelić, Ninoslav
dc.creatorBajić, Vladan
dc.creatorŽivković, Lada
dc.creatorSpremo-Potparević, Biljana
dc.date.accessioned2020-06-03T13:48:30Z
dc.date.available2020-06-03T13:48:30Z
dc.date.issued2014
dc.identifier.issn0534-0012
dc.identifier.urihttp://vet-erinar.vet.bg.ac.rs/handle/123456789/1101
dc.description.abstractAlzheimers disease (AD) is the most frequent progressive neurodegenerative disorder in elderly associated with irreversible cognitive impairment and dementia. The vast majority of AD patients are sporadic (SAD) in which the disease develops after age of 65. Despite of century of research, we lack understanding of the SAD etiology and pathogenesis. Several hypotheses try to explain the main causes of brain degeneration in SAD, one of them assuming that genomic instability and the reentry of certain neurons into the incomplete cell cycle may be the pathogenic basis of the disease. Although the brain is the most affected organ in AD, numerous studies showed structural and functional alterations in peripheral tissues, suggesting that AD is a generalized systemic disorder. Diverse changes in peripheral cells from AD patients are described in literature including cell cycle aberration and chromosome instability, alterations in cell viability, proliferation and apoptosis, oxidative metabolism, amyloid precursor protein and amyloid beta protein metabolism, and other cellular processes. The aim of this paper was to summarize and review the results of our investigations and the growing literature data concerning the multiple chromosomal alterations in peripheral cells of AD patients and to consider their possible role in the disease pathogenesis as well as the importance of such investigations.en
dc.publisherDruštvo genetičara Srbije, Beograd
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173034/RS//
dc.rightsopenAccess
dc.sourceGenetika
dc.subjectAlzheimer's diseaseen
dc.subjectchromosome instabilityen
dc.subjectperipheral cellsen
dc.titleCytogenetic alterations in peripheral cells of Alzheimer s disease patientsen
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractБајић, Владан; Плецас-Соларовић, Босиљка; Спремо-Потпаревић, Биљана; Ђелић, Нинослав; Живковић, Лада;
dc.citation.volume46
dc.citation.issue1
dc.citation.spage315
dc.citation.epage330
dc.citation.other46(1): 315-330
dc.citation.rankM23
dc.identifier.wos000338930500031
dc.identifier.doi10.2298/GENSR1401315P
dc.identifier.scopus2-s2.0-84900399583
dc.identifier.fulltexthttp://veterinar.vet.bg.ac.rs/bitstream/id/92/1100.pdf
dc.identifier.rcubconv_1994
dc.type.versionpublishedVersion


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