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dc.creatorAljančić, Ivana
dc.creatorVucković, Ivan
dc.creatorJadranin, Milka
dc.creatorPesić, Milica
dc.creatorĐorđević, Iris
dc.creatorPodolski-Renić, Ana
dc.creatorStojković, Sonja
dc.creatorMenković, Nebojša
dc.creatorVajs, Vlatka
dc.creatorMilosavljević, Slobodan M.
dc.date.accessioned2020-06-03T13:48:34Z
dc.date.available2020-06-03T13:48:34Z
dc.date.issued2014
dc.identifier.issn0031-9422
dc.identifier.urihttp://vet-erinar.vet.bg.ac.rs/handle/123456789/1102
dc.description.abstractDimers tomoroside A (1) and tomoroside B (2) of the co-occuring known chalcone monomer (3), along with the seven known flavonoid glucosides (4-10), were isolated from the aerial parts of Helichrysum zivojinii Cernjavski & Soska. The structures of the isolated compounds were elucidated by spectroscopic techniques. Compound 1 inhibited topo Ha and hif-1 alpha expression and stimulated doxorubicin anticancer effect, while 2 increased the expression of hif-1 alpha a, probably acting as antioxidant and redox status modulator. Notably, 2 synergized with Tipifarnib showing potential to improve the action of this new chemotherapeutic involved in the modulation of mitogene activated protein (MAP) kinase signaling pathway.en
dc.publisherPergamon-Elsevier Science Ltd, Oxford
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172053/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41031/RS//
dc.rightsrestrictedAccess
dc.sourcePhytochemistry
dc.subjectHelichrysum zivojiniien
dc.subjectAsteraceaeen
dc.subjectChalcone glucoside dimersen
dc.subjectFlavonoid glucosideen
dc.subjectTopoisomerase II alphaen
dc.subjectHIF-1 alphaen
dc.subjectMAP kinase pathwayen
dc.subjectDrug combinationen
dc.titleTwo structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell linesen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractAљанчић, Ивана; Милосављевић, Слободан М.; Вуцковић, Иван; Јадранин, Милка; Ђорђевић, Ирис; Менковић, Небојша; Вајс, Влатка; Стојковић, Соња; Подолски-Ренић, Aна; Песић, Милица;
dc.citation.volume98
dc.citation.spage190
dc.citation.epage196
dc.citation.other98: 190-196
dc.citation.rankM21
dc.identifier.wos000331020000022
dc.identifier.doi10.1016/j.phytochem.2013.11.025
dc.identifier.pmid24361288
dc.identifier.scopus2-s2.0-84892946345
dc.identifier.rcubconv_1976
dc.type.versionpublishedVersion


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