dc.creator | Aljančić, Ivana | |
dc.creator | Vucković, Ivan | |
dc.creator | Jadranin, Milka | |
dc.creator | Pesić, Milica | |
dc.creator | Đorđević, Iris | |
dc.creator | Podolski-Renić, Ana | |
dc.creator | Stojković, Sonja | |
dc.creator | Menković, Nebojša | |
dc.creator | Vajs, Vlatka | |
dc.creator | Milosavljević, Slobodan M. | |
dc.date.accessioned | 2020-06-03T13:48:34Z | |
dc.date.available | 2020-06-03T13:48:34Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 0031-9422 | |
dc.identifier.uri | https://vet-erinar.vet.bg.ac.rs/handle/123456789/1102 | |
dc.description.abstract | Dimers tomoroside A (1) and tomoroside B (2) of the co-occuring known chalcone monomer (3), along with the seven known flavonoid glucosides (4-10), were isolated from the aerial parts of Helichrysum zivojinii Cernjavski & Soska. The structures of the isolated compounds were elucidated by spectroscopic techniques. Compound 1 inhibited topo Ha and hif-1 alpha expression and stimulated doxorubicin anticancer effect, while 2 increased the expression of hif-1 alpha a, probably acting as antioxidant and redox status modulator. Notably, 2 synergized with Tipifarnib showing potential to improve the action of this new chemotherapeutic involved in the modulation of mitogene activated protein (MAP) kinase signaling pathway. | en |
dc.publisher | Pergamon-Elsevier Science Ltd, Oxford | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172053/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41031/RS// | |
dc.rights | restrictedAccess | |
dc.source | Phytochemistry | |
dc.subject | Helichrysum zivojinii | en |
dc.subject | Asteraceae | en |
dc.subject | Chalcone glucoside dimers | en |
dc.subject | Flavonoid glucoside | en |
dc.subject | Topoisomerase II alpha | en |
dc.subject | HIF-1 alpha | en |
dc.subject | MAP kinase pathway | en |
dc.subject | Drug combination | en |
dc.title | Two structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell lines | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Aљанчић, Ивана; Милосављевић, Слободан М.; Вуцковић, Иван; Јадранин, Милка; Ђорђевић, Ирис; Менковић, Небојша; Вајс, Влатка; Стојковић, Соња; Подолски-Ренић, Aна; Песић, Милица; | |
dc.citation.volume | 98 | |
dc.citation.spage | 190 | |
dc.citation.epage | 196 | |
dc.citation.other | 98: 190-196 | |
dc.citation.rank | M21 | |
dc.identifier.wos | 000331020000022 | |
dc.identifier.doi | 10.1016/j.phytochem.2013.11.025 | |
dc.identifier.pmid | 24361288 | |
dc.identifier.scopus | 2-s2.0-84892946345 | |
dc.type.version | publishedVersion | |