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dc.creatorMaletić, Jelena
dc.creatorĐelić, Ninoslav
dc.creatorRadaković, Milena
dc.creatorMaletić, Milan
dc.creatorLakić, Nada
dc.creatorKukolj, Vladimir
dc.creatorAleksić, Nevenka
dc.creatorAnđelković, Marko
dc.creatorStanimirović, Zoran
dc.date.accessioned2020-06-03T13:54:08Z
dc.date.available2020-06-03T13:54:08Z
dc.date.issued2015
dc.identifier.issn0534-0012
dc.identifier.urihttp://vet-erinar.vet.bg.ac.rs/handle/123456789/1183
dc.description.abstractTulathromycin is a relatively new semi-synthetic macrolide antibiotic, a member of the triamilide group, approved primarly for the treatment of respiratory diseases in cattle and swine. Various genotoxicological studies indicated that tulathromycin is not genotoxic, but no available published data originate from the single-cell gel electrophoresis (Comet) assay. Therefore, the objective of this study was to examine whether it can induce primary DNA damage using in vitro Comet assay in isolated rat lymphocytes. Lymphocytes were treated with a broad spectrum of tulathromycin concentrations (from 1 to 100 mu M) and co-treatment with an antioxidant, catalase (100 IU/mL and 500 IU/mL) was performed. The highest concentrations of tulathromycin (50 and 100 mu M) caused significant increase of DNA damage in rat lymphocytes and catalase did not significantly reduce the DNA-damaging effect of tulathromycin. The results of this study indicate that tulathromycin induces genotoxic effects at high concentrations, that catalase does not exert protective effect in this case.en
dc.publisherDruštvo genetičara Srbije, Beograd
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46002/RS//
dc.rightsopenAccess
dc.sourceGenetika
dc.subjectcomet assayen
dc.subjectDNA damageen
dc.subjectrat lymphocytesen
dc.subjecttulathromycinen
dc.titleEvaluation of DNA damage in rat lymphocytes exposed to tulathromycin in vitroen
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractСтанимировић, Зоран; Малетић, Јелена; Ђелић, Нинослав; Малетић, Милан; Кукољ, Владимир; Радаковић, Милена; Aнђелковић, Марко; Лакић, Нада; Aлексић, Невенка;
dc.citation.volume47
dc.citation.issue1
dc.citation.spage339
dc.citation.epage348
dc.citation.other47(1): 339-348
dc.citation.rankM23
dc.identifier.wos000355248900030
dc.identifier.doi10.2298/GENSR1501339M
dc.identifier.scopus2-s2.0-84929301003
dc.identifier.fulltexthttp://veterinar.vet.bg.ac.rs/bitstream/id/164/1182.pdf
dc.identifier.rcubconv_2083
dc.type.versionpublishedVersion


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