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dc.creatorRadaković, Milena
dc.creatorĐelić, Ninoslav
dc.creatorStevanović, Jevrosima
dc.creatorSoković, Marina
dc.creatorRadović, Dejan
dc.creatorvan Griensven, Leo J. L. D.
dc.creatorStanimirović, Zoran
dc.date.accessioned2020-06-03T13:54:13Z
dc.date.available2020-06-03T13:54:13Z
dc.date.issued2015
dc.identifier.issn1521-9437
dc.identifier.urihttp://vet-erinar.vet.bg.ac.rs/handle/123456789/1184
dc.description.abstractThe aim of this investigation was to evaluate the possible protective activity of Agaricus brasiliensis (=A. blazei sensu Murrill) ethanol extract against thymol-induced DNA damage in human lymphocytes. Before we studied the possible interaction of thymol and A. brasiliensis extract, each component was tested in the comet assay. Thymol significantly increased DNA damage in human lymphocytes at higher concentrations (20, 50, 100, 150, and 200 mu g/mL), whereas no genotoxic effect of A. brasiliensis ethanol extract was observed. In simultaneous treatment with thymol (200 mu g/mL) and A. brasiliensis ethanol extract (50, 100, 150, and 200 mu g/mL), the latter failed to reduce a thymol-induced DNA damaging effect regardless of the applied concentrations. To confirm that thymol induces DNA damage via reactive oxygen species, we performed cotreatment with quercetin. Cotreatment with quercetin (100 and 500 mu g/mL) significantly reduced DNA damage caused by thymol (200 mu g/mL), indicating that thymol exhibits genotoxicity mainly through induction of reactive oxygen species.en
dc.publisherBegell House Inc, Danbury
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46002/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173032/RS//
dc.rightsrestrictedAccess
dc.sourceInternational Journal of Medicinal Mushrooms
dc.subjectmedicinal mushroomsen
dc.subjectthymolen
dc.subjectAgaricus brasiliensisen
dc.subjectquercetinen
dc.subjecthuman lymphocytesen
dc.subjectcomet assayen
dc.titleEvaluation of the Antigenotoxic Effects of the Royal Sun Mushroom, Agaricus brasiliensis (Higher Basidiomycetes) in Human Lymphocytes Treated with Thymol in the Comet Assayen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСтанимировић, Зоран; Соковић, Марина; ван Гриенсвен, Лео Ј. Л. Д.; Ђелић, Нинослав; Стевановић, Јевросима; Радовић, Дејан; Радаковић, Милена;
dc.citation.volume17
dc.citation.issue4
dc.citation.spage321
dc.citation.epage330
dc.citation.other17(4): 321-330
dc.citation.rankM23
dc.identifier.wos000354909800001
dc.identifier.doi10.1615/IntJMedMushrooms.v17.i4.10
dc.identifier.pmid25954958
dc.identifier.scopus2-s2.0-84932179539
dc.identifier.rcubconv_2081
dc.type.versionpublishedVersion


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