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dc.creatorMitrović, Branislava
dc.creatorJovanović, Milijan
dc.creatorLazarević-Macanović, Mirjana
dc.creatorJanacković, Đorđe
dc.creatorKrstić, Nikola
dc.creatorStojanović, Mirjana
dc.creatorMirilović, Milorad
dc.date.accessioned2020-06-03T13:54:59Z
dc.date.available2020-06-03T13:54:59Z
dc.date.issued2015
dc.identifier.issn0301-634X
dc.identifier.urihttp://vet-erinar.vet.bg.ac.rs/handle/123456789/1195
dc.description.abstractThe use of phosphate mineral products in animal nutrition, as a major source of phosphor and calcium, can lead to uranium entering the food chain. The aim of the present study was to determine the protective effect of natural sepiolite and sepiolite treated with acid for broilers after oral intake of uranium. The broilers were contaminated for 7 days with 25 mg/uranyl nitrate per day. Two different adsorbents (natural sepiolite and sepiolite treated with acid) were given via gastric tube immediately after the oral administration of uranium. Natural sepiolite reduced uranium distribution by 57 % in kidney, 80 % in liver, 42 % in brain, and 56 % in muscle. A lower protective effect was observed after the administration of sepiolite treated with acid, resulting in significant damage of intestinal villi in the form of shortening, fragmentation, and necrosis, and histopathological lesions on kidney in the form of edema and abruption of epithelial cells in tubules. When broilers received only sepiolite treated with acid (no uranyl nitrate), shortening of intestinal villi occurred. Kidney injuries were evident when uranium concentrations in kidney were 0.88 and 1.25 A mu g/g dry weight. It is concluded that adding of natural sepiolite to the diets of broilers can reduce uranium distribution in organs by significant amount without adverse side effects.en
dc.publisherSpringer, New York
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/31003/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34013/RS//
dc.rightsrestrictedAccess
dc.sourceRadiation and Environmental Biophysics
dc.subjectAdsorbentsen
dc.subjectBroilersen
dc.subjectHistopathologyen
dc.subjectSepioliteen
dc.subjectToxicityen
dc.subjectUraniumen
dc.titleEfficiency of sepiolite in broilers diet as uranium adsorbenten
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЈанацковић, Ђорђе; Јовановић, Милијан; Мириловић, Милорад; Стојановић, Мирјана; Лазаревић-Мацановић, Мирјана; Крстић, Никола; Митровић, Бранислава;
dc.citation.volume54
dc.citation.issue2
dc.citation.spage217
dc.citation.epage224
dc.citation.other54(2): 217-224
dc.citation.rankM22
dc.identifier.wos000353356700008
dc.identifier.doi10.1007/s00411-015-0589-2
dc.identifier.pmid25652083
dc.identifier.scopus2-s2.0-84939960269
dc.identifier.rcubconv_2064
dc.type.versionpublishedVersion


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