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dc.creatorMarinković, Darko
dc.creatorMilčić-Matić, Natalija
dc.creatorJovanović, Milan
dc.creatorVučićević, Ivana
dc.creatorNešić, Slađan
dc.creatorAničić, Milan
dc.creatorAleksić-Kovačević, Sanja
dc.date.accessioned2020-06-03T13:55:15Z
dc.date.available2020-06-03T13:55:15Z
dc.date.issued2015
dc.identifier.issn0567-8315
dc.identifier.urihttp://vet-erinar.vet.bg.ac.rs/handle/123456789/1199
dc.description.abstractMast cell neoplasia in dogs can occur in two different forms: common as cutaneous tumor, or less common as a systemic form of neoplastic mast cell proliferation - systemic mastocytosis. The aim of this study was to compare the histological and cytological features, KIT receptor expression and presence of c-KIT proto-oncogene mutations in neoplastic cells of dogs with canine cutaneous mast cell tumor (CMCT) and systemic mastocytosis. Microscopical examination of the cytological smears obtained from all selected dogs revealed that cellular specimens were constituted mostly of round cells with a central nuclei and fine to coarse purple cytoplasmic granules. Histopathological examination of skin samples of dogs with CMCT and a dog with systemic mastocytosis showed proliferation of the neoplastic mast cells in the superficial and/or deep dermis. Similar findings were observed in tissue samples derived from lymph nodes, spleen, liver, myocardium and kidneys of a dog with systemic mastocytosis. Three dogs with high grade CMCT as well as one dog with systemic mastocytosis showed cytoplasmic CD117 expression, while 3 dogs with low grade CMCT, had membranous expression of CD117. Based on our study, histological features and cytoplasmic CD117 expression in neoplastic cells of dogs with systemic mastocytosis are similar to those in dogs with high grade CMCTs. Nevertheless, mutations of c-KIT proto-oncogene were not found in tumor samples either from dogs with CMCT or dog with systemic mastocytosis.en
dc.publisherUniverzitet u Beogradu - Fakultet veterinarske medicine, Beograd
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/31087/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46002/RS//
dc.rightsopenAccess
dc.sourceActa veterinaria - Beograd
dc.subjectdogen
dc.subjectsystemic mastocytosisen
dc.subjectcutaneous mast cell tumoren
dc.subjectKIT receptor expressionen
dc.subjecthistopathologyen
dc.subjectcytologyen
dc.titleMorphological features and kit receptor expression in canine cutaneous mast cell tumor and systemic mastocytosisen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМилчић-Матић, Наталија; Aлексић-Ковачевић, Сања; Јовановић, Милан; Нешић, Слађан; Вучићевић, Ивана; Маринковић, Дарко; Aничић, Милан;
dc.citation.volume65
dc.citation.issue2
dc.citation.spage226
dc.citation.epage237
dc.citation.other65(2): 226-237
dc.citation.rankM22
dc.identifier.wos000356832100007
dc.identifier.doi10.1515/acve-2015-0019
dc.identifier.scopus2-s2.0-84933518837
dc.identifier.fulltexthttp://veterinar.vet.bg.ac.rs/bitstream/id/179/1198.pdf
dc.identifier.rcubconv_2087
dc.type.versionpublishedVersion


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