Combined effects of plant extracts and xenobiotics on liposomal lipid peroxidation. Part 1. Marigold extract-ciprofloxacin/pyralene
Апстракт
Methanolic (70%) extracts of marigold flower, leaf, stem and root, after solvent removal, were successively extracted with ether, chloroform, ethyl acetate, and n-butanol - the residue being the corresponding aqueous extract. All five extracts were evaporated to dryness and then dissolved in 50% EtOH to obtain 6% (w/v) solutions. These solutions, either alone or in combination with different doses of ciprofloxacin or pyralene, were used to study their effect on liposomal lipid peroxidation (LPx) induced by Fe 2+ and ascorbic acid. The majority of the extracts of marigold flower, leaf and stem showed an antioxidant effect, the butanol extract of roots exhibiting a pro-oxidative character. At lower doses, ciprofloxacin did not affect LPx, at higher doses a dose-dependent increase in LPx was observed. The extracts in combination with ciprofloxacin showed a protective effect, which was also dose-dependent. The butanolic extract of root snowed no synergistic effect with ciprofloxacin. Pyral...ene alone exhibited a pro-oxidative action on liposomal LPx. Aqueous and butanolic extracts of flower, leaf, and stem had a protective effect in combination with pyralene. The butanolic extract of root showed a pro-oxidative synergistic effect with pyralene.
Кључне речи:
marigold / polychlorinated biphenyls / liposomes / lipid peroxidationИзвор:
Oxidation Communications, 1999, 22, 4, 487-494Издавач:
- Scibulcom Ltd, Sofia
Колекције
Институција/група
Fakultet veterinarske medicineTY - JOUR AU - Popović, M. AU - Kaurinović, B AU - Mimica-Dukić, Neda AU - Vojinović-Miloradov, Mirjana AU - Ćupić, Vitomir PY - 1999 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/120 AB - Methanolic (70%) extracts of marigold flower, leaf, stem and root, after solvent removal, were successively extracted with ether, chloroform, ethyl acetate, and n-butanol - the residue being the corresponding aqueous extract. All five extracts were evaporated to dryness and then dissolved in 50% EtOH to obtain 6% (w/v) solutions. These solutions, either alone or in combination with different doses of ciprofloxacin or pyralene, were used to study their effect on liposomal lipid peroxidation (LPx) induced by Fe 2+ and ascorbic acid. The majority of the extracts of marigold flower, leaf and stem showed an antioxidant effect, the butanol extract of roots exhibiting a pro-oxidative character. At lower doses, ciprofloxacin did not affect LPx, at higher doses a dose-dependent increase in LPx was observed. The extracts in combination with ciprofloxacin showed a protective effect, which was also dose-dependent. The butanolic extract of root snowed no synergistic effect with ciprofloxacin. Pyralene alone exhibited a pro-oxidative action on liposomal LPx. Aqueous and butanolic extracts of flower, leaf, and stem had a protective effect in combination with pyralene. The butanolic extract of root showed a pro-oxidative synergistic effect with pyralene. PB - Scibulcom Ltd, Sofia T2 - Oxidation Communications T1 - Combined effects of plant extracts and xenobiotics on liposomal lipid peroxidation. Part 1. Marigold extract-ciprofloxacin/pyralene VL - 22 IS - 4 SP - 487 EP - 494 UR - https://hdl.handle.net/21.15107/rcub_veterinar_120 ER -
@article{ author = "Popović, M. and Kaurinović, B and Mimica-Dukić, Neda and Vojinović-Miloradov, Mirjana and Ćupić, Vitomir", year = "1999", abstract = "Methanolic (70%) extracts of marigold flower, leaf, stem and root, after solvent removal, were successively extracted with ether, chloroform, ethyl acetate, and n-butanol - the residue being the corresponding aqueous extract. All five extracts were evaporated to dryness and then dissolved in 50% EtOH to obtain 6% (w/v) solutions. These solutions, either alone or in combination with different doses of ciprofloxacin or pyralene, were used to study their effect on liposomal lipid peroxidation (LPx) induced by Fe 2+ and ascorbic acid. The majority of the extracts of marigold flower, leaf and stem showed an antioxidant effect, the butanol extract of roots exhibiting a pro-oxidative character. At lower doses, ciprofloxacin did not affect LPx, at higher doses a dose-dependent increase in LPx was observed. The extracts in combination with ciprofloxacin showed a protective effect, which was also dose-dependent. The butanolic extract of root snowed no synergistic effect with ciprofloxacin. Pyralene alone exhibited a pro-oxidative action on liposomal LPx. Aqueous and butanolic extracts of flower, leaf, and stem had a protective effect in combination with pyralene. The butanolic extract of root showed a pro-oxidative synergistic effect with pyralene.", publisher = "Scibulcom Ltd, Sofia", journal = "Oxidation Communications", title = "Combined effects of plant extracts and xenobiotics on liposomal lipid peroxidation. Part 1. Marigold extract-ciprofloxacin/pyralene", volume = "22", number = "4", pages = "487-494", url = "https://hdl.handle.net/21.15107/rcub_veterinar_120" }
Popović, M., Kaurinović, B., Mimica-Dukić, N., Vojinović-Miloradov, M.,& Ćupić, V.. (1999). Combined effects of plant extracts and xenobiotics on liposomal lipid peroxidation. Part 1. Marigold extract-ciprofloxacin/pyralene. in Oxidation Communications Scibulcom Ltd, Sofia., 22(4), 487-494. https://hdl.handle.net/21.15107/rcub_veterinar_120
Popović M, Kaurinović B, Mimica-Dukić N, Vojinović-Miloradov M, Ćupić V. Combined effects of plant extracts and xenobiotics on liposomal lipid peroxidation. Part 1. Marigold extract-ciprofloxacin/pyralene. in Oxidation Communications. 1999;22(4):487-494. https://hdl.handle.net/21.15107/rcub_veterinar_120 .
Popović, M., Kaurinović, B, Mimica-Dukić, Neda, Vojinović-Miloradov, Mirjana, Ćupić, Vitomir, "Combined effects of plant extracts and xenobiotics on liposomal lipid peroxidation. Part 1. Marigold extract-ciprofloxacin/pyralene" in Oxidation Communications, 22, no. 4 (1999):487-494, https://hdl.handle.net/21.15107/rcub_veterinar_120 .