Effects of estrogen and luteinizing-releasing hormone on chromatin in CA3 region of male rat hippocampus
Efekti estrogena i luteinizirajućeg - oslobađajućeg hormona na hromatin u CA3 regionu hipokampusa mužjaka pacova
2015
Authors
Petrović, BojanaDrekić, Dmitar
Zorić, Zoran
Jović, Slavoljub
Nikolić, Milica
Ćupić Miladinović, Dejana
Article (Published version)
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The structure of heterochromatin protects genome from undesirable recombinations, while estrogen and luteinizing-releasing hormone (LHRH) cause changes in structure of chromatin. The objective of this study was to prove the connection of neonatally applied estrogen and LHRH, with shown effects on chromatin in hippocampus of adult male rats. Stereological results have shown that total surface of neuron area in estrogen treated animals significantly reduced in regard to the control group as well as groups treated with LHRH. The number of heterochromatin granules in either estrogen or LHRH treated groups significantly increased, while in the last fourth group treated with both estrogen and LHRH the difference is even more expressed, both in regard to the control group and other groups.
Struktura heterohromatina štiti genom od neželjenih rekombinacija, dok estrogen i luteinizirajući-oslobađajući hormon (LHRH) uzrokuju promene u samoj strukturi hromatina. Studija je napravljena sa ciljem dokazivanja povezanosti neonatalno aplikovanog estrogena i LHRH, sa ispoljenim efektima na hromatinu u hipokampusu odraslih mužjaka pacova. Stereološki rezultati su pokazali da je ukupna površina neurona kod životinja tretiranih estrogenom značajno smanjena u odnosu na kontrolnu i grupe tretirane LHRH. Broj granula heterohromatina u grupama tretiranim estrogenom i LHRH je primetno povećan, dok je u poslednjoj, četvrtoj grupi tretiranoj i estrogenom i LHRH ova razlika još izraženija, kako u odnosu na kontrolnu, tako i u odnosu na ostale grupe.
Keywords:
CA3 region / estrogen / hippocampus / LHRH / male rat / CA3 region / estrogen / hipokampus / LHRH / mužjak pacovaSource:
Veterinarski Glasnik, 2015, 69, 3-4, 163-175Publisher:
- Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
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Fakultet veterinarske medicineTY - JOUR AU - Petrović, Bojana AU - Drekić, Dmitar AU - Zorić, Zoran AU - Jović, Slavoljub AU - Nikolić, Milica AU - Ćupić Miladinović, Dejana PY - 2015 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1208 AB - The structure of heterochromatin protects genome from undesirable recombinations, while estrogen and luteinizing-releasing hormone (LHRH) cause changes in structure of chromatin. The objective of this study was to prove the connection of neonatally applied estrogen and LHRH, with shown effects on chromatin in hippocampus of adult male rats. Stereological results have shown that total surface of neuron area in estrogen treated animals significantly reduced in regard to the control group as well as groups treated with LHRH. The number of heterochromatin granules in either estrogen or LHRH treated groups significantly increased, while in the last fourth group treated with both estrogen and LHRH the difference is even more expressed, both in regard to the control group and other groups. AB - Struktura heterohromatina štiti genom od neželjenih rekombinacija, dok estrogen i luteinizirajući-oslobađajući hormon (LHRH) uzrokuju promene u samoj strukturi hromatina. Studija je napravljena sa ciljem dokazivanja povezanosti neonatalno aplikovanog estrogena i LHRH, sa ispoljenim efektima na hromatinu u hipokampusu odraslih mužjaka pacova. Stereološki rezultati su pokazali da je ukupna površina neurona kod životinja tretiranih estrogenom značajno smanjena u odnosu na kontrolnu i grupe tretirane LHRH. Broj granula heterohromatina u grupama tretiranim estrogenom i LHRH je primetno povećan, dok je u poslednjoj, četvrtoj grupi tretiranoj i estrogenom i LHRH ova razlika još izraženija, kako u odnosu na kontrolnu, tako i u odnosu na ostale grupe. PB - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd T2 - Veterinarski Glasnik T1 - Effects of estrogen and luteinizing-releasing hormone on chromatin in CA3 region of male rat hippocampus T1 - Efekti estrogena i luteinizirajućeg - oslobađajućeg hormona na hromatin u CA3 regionu hipokampusa mužjaka pacova VL - 69 IS - 3-4 SP - 163 EP - 175 DO - 10.2298/VETGL1504163P ER -
@article{ author = "Petrović, Bojana and Drekić, Dmitar and Zorić, Zoran and Jović, Slavoljub and Nikolić, Milica and Ćupić Miladinović, Dejana", year = "2015", abstract = "The structure of heterochromatin protects genome from undesirable recombinations, while estrogen and luteinizing-releasing hormone (LHRH) cause changes in structure of chromatin. The objective of this study was to prove the connection of neonatally applied estrogen and LHRH, with shown effects on chromatin in hippocampus of adult male rats. Stereological results have shown that total surface of neuron area in estrogen treated animals significantly reduced in regard to the control group as well as groups treated with LHRH. The number of heterochromatin granules in either estrogen or LHRH treated groups significantly increased, while in the last fourth group treated with both estrogen and LHRH the difference is even more expressed, both in regard to the control group and other groups., Struktura heterohromatina štiti genom od neželjenih rekombinacija, dok estrogen i luteinizirajući-oslobađajući hormon (LHRH) uzrokuju promene u samoj strukturi hromatina. Studija je napravljena sa ciljem dokazivanja povezanosti neonatalno aplikovanog estrogena i LHRH, sa ispoljenim efektima na hromatinu u hipokampusu odraslih mužjaka pacova. Stereološki rezultati su pokazali da je ukupna površina neurona kod životinja tretiranih estrogenom značajno smanjena u odnosu na kontrolnu i grupe tretirane LHRH. Broj granula heterohromatina u grupama tretiranim estrogenom i LHRH je primetno povećan, dok je u poslednjoj, četvrtoj grupi tretiranoj i estrogenom i LHRH ova razlika još izraženija, kako u odnosu na kontrolnu, tako i u odnosu na ostale grupe.", publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd", journal = "Veterinarski Glasnik", title = "Effects of estrogen and luteinizing-releasing hormone on chromatin in CA3 region of male rat hippocampus, Efekti estrogena i luteinizirajućeg - oslobađajućeg hormona na hromatin u CA3 regionu hipokampusa mužjaka pacova", volume = "69", number = "3-4", pages = "163-175", doi = "10.2298/VETGL1504163P" }
Petrović, B., Drekić, D., Zorić, Z., Jović, S., Nikolić, M.,& Ćupić Miladinović, D.. (2015). Effects of estrogen and luteinizing-releasing hormone on chromatin in CA3 region of male rat hippocampus. in Veterinarski Glasnik Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 69(3-4), 163-175. https://doi.org/10.2298/VETGL1504163P
Petrović B, Drekić D, Zorić Z, Jović S, Nikolić M, Ćupić Miladinović D. Effects of estrogen and luteinizing-releasing hormone on chromatin in CA3 region of male rat hippocampus. in Veterinarski Glasnik. 2015;69(3-4):163-175. doi:10.2298/VETGL1504163P .
Petrović, Bojana, Drekić, Dmitar, Zorić, Zoran, Jović, Slavoljub, Nikolić, Milica, Ćupić Miladinović, Dejana, "Effects of estrogen and luteinizing-releasing hormone on chromatin in CA3 region of male rat hippocampus" in Veterinarski Glasnik, 69, no. 3-4 (2015):163-175, https://doi.org/10.2298/VETGL1504163P . .